Experts and Doctors on in France


Locale: France

Top Publications

  1. Berthier A, Lemaire Ewing S, Prunet C, Montange T, Vejux A, Pais de Barros J, et al. 7-Ketocholesterol-induced apoptosis. Involvement of several pro-apoptotic but also anti-apoptotic calcium-dependent transduction pathways. FEBS J. 2005;272:3093-104 pubmed
    ..Therefore, it appears that 7-ketocholesterol-induced apoptosis is a complex phenomenon resulting from calcium-dependent activation of several pro-apoptotic pathways and also one survival pathway. ..
  2. el Zein L, Omran H, Bouvagnet P. Lateralization defects and ciliary dyskinesia: lessons from algae. Trends Genet. 2003;19:162-7 pubmed
    ..In this article, we will discuss how information gained from studies on algae has aided research into these human diseases. These studies found a variety of functions that was previously unsuspected, renewing interest in cilia. ..
  3. Marrari Y, Rouviere C, Houliston E. Complementary roles for dynein and kinesins in the Xenopus egg cortical rotation. Dev Biol. 2004;271:38-48 pubmed
    ..Consistent with this model for the cortical rotation, photobleach analysis revealed both microtubules that translocated with the vegetal cytoplasm relative to the cortex, and ones that moved with the cortex relative to the cytoplasm. ..
  4. Boëda B, Weil D, Petit C. A specific promoter of the sensory cells of the inner ear defined by transgenesis. Hum Mol Genet. 2001;10:1581-9 pubmed
    ..This is the first report of regulatory sequences sufficient to target the expression of a gene exclusively in sensory cells of the inner ear. It also opens up the possibility for the analysis of the hair cell transcriptome. ..
  5. Januschke J, Gervais L, Dass S, Kaltschmidt J, Lopez Schier H, St Johnston D, et al. Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation. Curr Biol. 2002;12:1971-81 pubmed
    ..Furthermore, Kinesin-dependent localization of Dynein suggests that both motors are components of the same complex and therefore might cooperate in recycling each other to the opposite microtubule pole. ..
  6. Boëda B, El Amraoui A, Bahloul A, Goodyear R, Daviet L, Blanchard S, et al. Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. EMBO J. 2002;21:6689-99 pubmed
    ..We propose that the shaping of the hair bundle relies on a functional unit composed of myosin VIIa, harmonin b and cadherin 23 that is essential to ensure the cohesion of the stereocilia. ..
  7. Bonnafe E, Touka M, AitLounis A, Baas D, Barras E, Ucla C, et al. The transcription factor RFX3 directs nodal cilium development and left-right asymmetry specification. Mol Cell Biol. 2004;24:4417-27 pubmed
    ..In conclusion, RFX3 is essential for the differentiation of nodal monocilia and hence for LR body axis determination. ..
  8. Lajoix A, Gross R, Aknin C, Dietz S, Granier C, Laune D. Cellulose membrane supported peptide arrays for deciphering protein-protein interaction sites: the case of PIN, a protein with multiple natural partners. Mol Divers. 2004;8:281-90 pubmed
  9. Boucrot E, Henry T, Borg J, Gorvel J, Méresse S. The intracellular fate of Salmonella depends on the recruitment of kinesin. Science. 2005;308:1174-8 pubmed
    ..Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics. ..

More Information


  1. Lefevre G, Michel V, Weil D, Lepelletier L, Bizard E, Wolfrum U, et al. A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth. Development. 2008;135:1427-37 pubmed publisher
  2. Kussel Andermann P, El Amraoui A, Safieddine S, Hardelin J, Nouaille S, Camonis J, et al. Unconventional myosin VIIA is a novel A-kinase-anchoring protein. J Biol Chem. 2000;275:29654-9 pubmed
    ..Our results strongly suggest that myosin VIIA is a novel protein kinase A-anchoring protein that targets protein kinase A to definite subcellular sites of these sensory cells. ..
  3. Lajoix A, Badiou S, Peraldi Roux S, Chardes T, Dietz S, Aknin C, et al. Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion. Diabetes. 2006;55:3279-88 pubmed
  4. Delcros J, Prigent C, Giet R. Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells. J Cell Sci. 2006;119:4431-41 pubmed
    ..The contribution of the dynein-dynactin complex to synchronous chromosome segregation and cytokinesis is discussed. ..
  5. Adato A, Michel V, Kikkawa Y, Reiners J, Alagramam K, Weil D, et al. Interactions in the network of Usher syndrome type 1 proteins. Hum Mol Genet. 2005;14:347-56 pubmed
    ..We propose that via its binding to myosin VIIa and/or harmonin, sans controls the hair bundle cohesion and proper development by regulating the traffic of USH1 proteins en route to the stereocilia. ..
  6. El Amraoui A, Schonn J, Küssel Andermann P, Blanchard S, Desnos C, Henry J, et al. MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. EMBO Rep. 2002;3:463-70 pubmed
    ..The defect of this molecular complex is likely to account for the perinuclear mislocalization of the melanosomes observed in the retinal pigment epithelium cells of myosinVIIa-defective mice. ..
  7. Coquelle F, Caspi M, Cordelières F, Dompierre J, Dujardin D, Koifman C, et al. LIS1, CLIP-170's key to the dynein/dynactin pathway. Mol Cell Biol. 2002;22:3089-102 pubmed
    ..This work suggests that LIS1 is a regulated adapter between CLIP-170 and cytoplasmic dynein at sites involved in cargo-MT loading, and/or in the control of MT dynamics. ..
  8. Guichard C, Harricane M, Lafitte J, Godard P, Zaegel M, Tack V, et al. Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome). Am J Hum Genet. 2001;68:1030-5 pubmed
    ..Finally, this study demonstrates a link between ciliary function and situs determination, since compound mutation heterozygosity in DNAI1 results in PCD with situs solitus or situs inversus (KS). ..
  9. Kussel Andermann P, El Amraoui A, Safieddine S, Nouaille S, Perfettini I, Lecuit M, et al. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. EMBO J. 2000;19:6020-9 pubmed
    ..In myosin VIIA-defective mutants, inactivity of the vezatin-myosin VIIA complex at both sites could account for splaying out of the hair cell stereocilia. ..