Genomes and Genes
Experts and Doctors on hypertension in United States
Locale: United States
Publications545 found, 100 shown here
- Okere I, Chess D, McElfresh T, Johnson J, Rennison J, Ernsberger P, et al. High-fat diet prevents cardiac hypertrophy and improves contractile function in the hypertensive dahl salt-sensitive rat. Clin Exp Pharmacol Physiol. 2005;32:825-31 pubmed..It remains to be determined whether preventing cardiac hypertrophic adaptations would be deleterious to the heart if the hypertensive stress is maintained long term. ..
- Gadonski G, LaMarca B, Sullivan E, Bennett W, Chandler D, Granger J. Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of interleukin 6. Hypertension. 2006;48:711-6 pubmed
- Hernandez Prada J, Ferreira A, Katovich M, Shenoy V, Qi Y, Santos R, et al. Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension. 2008;51:1312-7 pubmed publisher..We conclude that structure-based screening can help identify compounds that activate ACE2, decrease blood pressure, and reverse tissue remodeling. Administration of ACE2 activators may be a valid strategy for antihypertensive therapy. ..
- Stewart S, Oroszi G, Randall P, Anton R. COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study. Am J Hypertens. 2009;22:87-91 pubmed publisher..2 mm Hg systolic (P = 0.070) and -1.5 mm Hg diastolic (P < 0.05). Findings suggest that alcohol-induced BP elevation may be related to the effects of catecholamines and their genetically determined inactivation. ..
- Murrock C, Gary F. A culturally-specific dance intervention to increase functional capacity in African American women. J Cult Divers. 2008;15:168-73 pubmed..The increase at 18 weeks in the experimental group remained when controlling for baseline covariates. This study supported culturally-specific dance as an intervention to improve functional capacity in African American women. ..
- Adler S, Huang H. Impaired regulation of renal oxygen consumption in spontaneously hypertensive rats. J Am Soc Nephrol. 2002;13:1788-94 pubmed..By lowering intrarenal oxygen levels, reduced NO may contribute to susceptibility to injury and renal fibrosis. Increasing NO production, decreasing oxidant stress, or both might prevent these changes by improving renal oxygenation. ..
- Hall J. Historical perspective of the renin-angiotensin system. Mol Biotechnol. 2003;24:27-39 pubmed
- Prabha K, Balan K, Martin R, Lamanna J, Haxhiu M, Dick T. Chronic intermittent hypoxia-induced augmented cardiorespiratory outflow mediated by vasopressin-V?A receptor signaling in the medulla. Adv Exp Med Biol. 2011;701:319-25 pubmed publisher..Our findings indicate that vasopressin is the neuropeptide released from PVN neurons that modulates cardiorespiratory output via the RVLM and rostral ventral respiratory column. ..
- Stefan M, Rothberg M, Priya A, Pekow P, Au D, Lindenauer P. Association between ?-blocker therapy and outcomes in patients hospitalised with acute exacerbations of chronic obstructive lung disease with underlying ischaemic heart disease, heart failure or hypertension. Thorax. 2012;67:977-84 pubmed publisher..Until additional evidence becomes available, ?1-selective ? blockers may be superior to treatment with a non-selective ? blocker. ..
- Fox E, Musani S, Singh P, Bidulescu A, Nagarajarao H, Samdarshi T, et al. Association of plasma B-type natriuretic peptide concentrations with longitudinal blood pressure tracking in African Americans: findings from the Jackson Heart Study. Hypertension. 2013;61:48-54 pubmed publisher..12). In our community-based sample of African Americans, higher BNP concentrations predicted a longitudinal increase in systolic and diastolic BPs and progression of BP stage. ..
- Nigg J. Attention-deficit/hyperactivity disorder and adverse health outcomes. Clin Psychol Rev. 2013;33:215-28 pubmed publisher..It concludes by suggesting the need for new avenues of research on mechanisms of association and the potential for ADHD to be an early warning sign for secondary prevention of some poor health outcomes. ..
- Cuffee Y, Hargraves J, Rosal M, Briesacher B, Schoenthaler A, Person S, et al. Reported racial discrimination, trust in physicians, and medication adherence among inner-city African Americans with hypertension. Am J Public Health. 2013;103:e55-62 pubmed publisher..Patient, physician and system approaches to increase "earned" trust may enhance existing interventions for promoting medication adherence. ..
- Bili A, Schroeder L, Ledwich L, Kirchner H, Newman E, Wasko M. Patterns of preventive health services in rheumatoid arthritis patients compared to a primary care patient population. Rheumatol Int. 2011;31:1159-65 pubmed publisher..The RA patients with traditional cardiovascular risk factors are more likely to be tested for dyslipidemia. Further work is warranted to improve testing for modifiable CVD risk factors in this group with multiple co-morbidities. ..
- Christiansen S, Schatz M, Yang S, Ngor E, Chen W, Zuraw B. Hypertension and Asthma: A Comorbid Relationship. J Allergy Clin Immunol Pract. 2016;4:76-81 pubmed publisher..15, CI 1.10-1.19, nÂ = 53,690 cases and 53,690 controls) after adjusting for potential confounders. Asthmatic subjects with comorbid hypertension display evidence of enhanced of asthma morbidity. ..
- Cooper R, Durazo Arvizu R. Hypertension detection and control: population and policy implications. Cardiol Clin. 2002;20:187-94 pubmed..Improvement in information technology, including an electronic medical record and on-line risk equations, will also be required before its full value can be realized...
- Wright J, Dunn J, Cutler J, Davis B, Cushman W, Ford C, et al. Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril. JAMA. 2005;293:1595-608 pubmed
- Shrimpton A, Schelper R, Linke R, Hardy J, Crook R, Dickson D, et al. A presenilin 1 mutation (L420R) in a family with early onset Alzheimer disease, seizures and cotton wool plaques, but not spastic paraparesis. Neuropathology. 2007;27:228-32 pubmed..p.L420R (g.1508T > G) is the mutation responsible for EOAD, seizures and CWP without SP in this family...
- Norris S, Kansagara D, Bougatsos C, Fu R. Screening adults for type 2 diabetes: a review of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;148:855-68 pubmed..Intensive lifestyle and pharmacotherapeutic interventions reduce the progression of prediabetes to diabetes, but few data examine the effect of these interventions on long-term health outcomes. ..
- Schneider D, Hardison R, Lopes N, Sobel B, Brooks M. Association between increased platelet P-selectin expression and obesity in patients with type 2 diabetes: a BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) substudy. Diabetes Care. 2009;32:944-9 pubmed publisher..Our results suggest that obesity and insulin resistance that accompanies obesity may influence platelet reactivity in patients with type 2 diabetes. ..
- Mathis K, Venegas Pont M, Masterson C, Stewart N, Wasson K, Ryan M. Oxidative stress promotes hypertension and albuminuria during the autoimmune disease systemic lupus erythematosus. Hypertension. 2012;59:673-9 pubmed publisher..These data suggest that renal oxidative stress plays an important mechanistic role in the development of autoimmune-mediated hypertension...
- Savvides P, Nagaiah G, Lavertu P, Fu P, Wright J, Chapman R, et al. Phase II trial of sorafenib in patients with advanced anaplastic carcinoma of the thyroid. Thyroid. 2013;23:600-4 pubmed publisher..Sorafenib has activity in ATC, but at a low frequency and similar to our previous experience with fosbretabulin. One patient with a response had previously progressed on fosbretabulin. Toxicities were both predictable and manageable. ..
- Williamson J, Launer L, Bryan R, Coker L, Lazar R, Gerstein H, et al. Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial. JAMA Intern Med. 2014;174:324-33 pubmed publisher..Intensive BP control was associated with greater decline in TBV at 40 months relative to standard therapy. TRIAL REGISTRATION clinicaltrials.gov Identifier: NCT00000620. ..
- Spradley F, Ho D, Pollock J. Dahl SS rats demonstrate enhanced aortic perivascular adipose tissue-mediated buffering of vasoconstriction through activation of NOS in the endothelium. Am J Physiol Regul Integr Comp Physiol. 2016;310:R286-96 pubmed publisher..Thus, the PVAT serves a vasoprotective role in Dahl SS rats on normal-salt diet. ..
- Zhou Y, Luo P, Chang H, Huang H, Yang T, Dong Z, et al. Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension. Kidney Int. 2008;74:1040-8 pubmed publisher..Our results show that PPAR alpha pathway induces renal tubular 20-HETE production which affects sodium retention and blood pressure regulation in DOCA-salt-treated mice. ..
- Lohmeier T, Iliescu R. Chronic lowering of blood pressure by carotid baroreflex activation: mechanisms and potential for hypertension therapy. Hypertension. 2011;57:880-6 pubmed publisher..Although feasibility studies have been promising, firm conclusions regarding the value of this device-based therapy for the treatment of resistant hypertension awaits the results of current multicenter trials. ..
- Thompson M, Dana T, Bougatsos C, Blazina I, Norris S. Screening for hypertension in children and adolescents to prevent cardiovascular disease. Pediatrics. 2013;131:490-525 pubmed publisher..Additional studies are needed to improve diagnosis and risk stratification of children with elevated blood pressure and to quantify risks and benefits of interventions. ..
- Pingili A, Davidge K, Thirunavukkarasu S, Khan N, Katsurada A, Majid D, et al. 2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice. Hypertension. 2017;69:1104-1112 pubmed publisher..Therefore, 2-methoxyestradiol could serve as a therapeutic agent for treating hypertension and associated pathogenesis in postmenopausal females, and in males. ..
- Zile M, Richardson K, Cowles M, Buckley J, Koide M, Cowles B, et al. Constitutive properties of adult mammalian cardiac muscle cells. Circulation. 1998;98:567-79 pubmed..Changes in viscous damping and myofilament activation in combination may cause pressure-hypertrophied cardiocytes to resist changes in shape during diastole and contribute to diastolic dysfunction. ..
- Zineh I, Beitelshees A, Gaedigk A, Walker J, Pauly D, Eberst K, et al. Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension. Clin Pharmacol Ther. 2004;76:536-44 pubmed..However, there was no association between variable pharmacokinetics or CYP2D6 genotype and beta-blocker-induced adverse effects or efficacy. ..
- Wetmore J, Mahnken J, Rigler S, Ellerbeck E, Mukhopadhyay P, Hou Q, et al. Impact of race on cumulative exposure to antihypertensive medications in dialysis. Am J Hypertens. 2013;26:234-42 pubmed publisher..The causes of differences by race in exposure to antihypertensive medications over the course of time should be further examined. ..
- Gonzalez Vicente A, Garvin J. Angiotensin II-induced hypertension increases plasma membrane Na pump activity by enhancing Na entry in rat thick ascending limbs. Am J Physiol Renal Physiol. 2013;305:F1306-14 pubmed publisher..We concluded that in ANG II-induced hypertension Na pump activity is increased in the plasma membrane of TALs and that this increase is caused by the chronically enhanced Na entry occurring in this model. ..
- Coulon S, Wilson D, Alia K, Van Horn M. Multilevel Associations of Neighborhood Poverty, Crime, and Satisfaction With Blood Pressure in African-American Adults. Am J Hypertens. 2016;29:90-5 pubmed publisher..Prevention efforts should further investigate whether attending to issues of poverty and related neighborhood perceptions reduces high BP in at-risk African-American communities. ..
- Dibaba D, Xun P, Song Y, Rosanoff A, Shechter M, He K. The effect of magnesium supplementation on blood pressure in individuals with insulin resistance, prediabetes, or noncommunicable chronic diseases: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 2017;106:921-929 pubmed publisher..18 mm Hg in SBP and 2.27 mm Hg in DBP.Conclusion: The pooled results suggest that magnesium supplementation significantly lowers BP in individuals with insulin resistance, prediabetes, or other noncommunicable chronic diseases. ..
- Sun Z, Cade R, Katovich M, Fregly M. Body fluid distribution in rats with cold-induced hypertension. Physiol Behav. 1999;65:879-84 pubmed..The results also imply that exposure to cold induces a dehydration in rats...
- Barton C, Barton J, O Brien J, Bergauer N, Sibai B. Mild gestational hypertension: differences in ethnicity are associated with altered outcomes in women who undergo outpatient treatment. Am J Obstet Gynecol. 2002;186:896-8 pubmed..Differences in outcomes are observed between ethnic groups even when the women undergo the same intensive outpatient monitoring for mild gestational hypertension. ..
- Reusser M, DiRienzo D, Miller G, McCarron D. Adequate nutrient intake can reduce cardiovascular disease risk in African Americans. J Natl Med Assoc. 2003;95:188-95 pubmed
- Sharma N, Okere I, Duda M, Johnson J, Yuan C, Chandler M, et al. High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet. Am J Hypertens. 2007;20:403-9 pubmed..These results demonstrate that a high fructose diet consumed during hypertension increases mortality and left ventricular (LV) wall thickness compared to either a high fat, high starch, or a "western" diet. ..
- Schneider P, Murphy J, Pedersen C. Impact of medication packaging on adherence and treatment outcomes in older ambulatory patients. J Am Pharm Assoc (2003). 2008;48:58-63 pubmed publisher..Providing medications in a package that identifies the day each dose is intended to be taken and provides information on proper self-administration can improve treatment regimen adherence and treatment outcomes in elderly patients. ..
- Bhattacharjee R, Kheirandish Gozal L, Pillar G, Gozal D. Cardiovascular complications of obstructive sleep apnea syndrome: evidence from children. Prog Cardiovasc Dis. 2009;51:416-33 pubmed publisher..In this review, we will present the specific cardiovascular complications that have thus far been described in children with OSAS, with reference to pertinent mechanisms, and potential implications. ..
- Roberts T, Chapman A, Cipolla M. PPAR-gamma agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension. Am J Physiol Heart Circ Physiol. 2009;297:H1347-53 pubmed publisher..Our findings suggest that PPAR-gamma may be a key regulator of blood-brain barrier permeability and a potential therapeutic target during hypertension. ..
- PRICE E, Pacanowski M, Martin M, Cooper Dehoff R, Pepine C, Zineh I, et al. Liver X receptor ? gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study. Pharmacogenet Genomics. 2011;21:333-40 pubmed publisher..LXRA genotypes were associated with variable risk for cardiovascular outcomes and pharmacogenetic effect in INVEST-GENES. These novel findings suggest that LXRA is a genetic/pharmacogenetic target that should be further explored. ..
- Kulemina L, Ostrov D. Prediction of off-target effects on angiotensin-converting enzyme 2. J Biomol Screen. 2011;16:878-85 pubmed publisher..These data demonstrate that libraries of approved drugs can be rapidly screened to identify potential side effects due to interactions with specific proteins other than the intended targets. ..
- Crassous P, Couloubaly S, Huang C, Zhou Z, Baskaran P, Kim D, et al. Soluble guanylyl cyclase is a target of angiotensin II-induced nitrosative stress in a hypertensive rat model. Am J Physiol Heart Circ Physiol. 2012;303:H597-604 pubmed publisher..This result indicates that cysteine 516 of sGC mediates ANG II-induced desensitization to NO in cells. ..
- Bunch T, May H, Bair T, Weiss J, Crandall B, Osborn J, et al. Atrial fibrillation ablation patients have long-term stroke rates similar to patients without atrial fibrillation regardless of CHADS2 score. Heart Rhythm. 2013;10:1272-7 pubmed publisher..In our study populations, AF ablation patients have a significantly lower risk of stroke compared to AF patients who do not undergo ablation independent of baseline stroke risk score. ..
- Whittle J, Lynch A, Tanner R, Simpson L, Davis B, Rahman M, et al. Visit-to-Visit Variability of BP and CKD Outcomes: Results from the ALLHAT. Clin J Am Soc Nephrol. 2016;11:471-80 pubmed publisher..Higher visit-to-visit variability of BP is associated with higher risk of renal outcomes independent of mean BP. ..
- Nashar K, Nguyen J, Jesri A, Morrow J, Egan B. Angiotensin receptor blockade improves arterial distensibility and reduces exercise-induced pressor responses in obese hypertensive patients with the metabolic syndrome. Am J Hypertens. 2004;17:477-82 pubmed..In addition to lowering basal BP, angiotensin receptor blockade in patients with metabolic syndrome improves arterial compliance and reduces pressor reactivity to exercise. ..
- Caro J, Migliaccio Walle K, Ishak K, Proskorovsky I. The morbidity and mortality following a diagnosis of peripheral arterial disease: long-term follow-up of a large database. BMC Cardiovasc Disord. 2005;5:14 pubmed..Given that the majority has additional comorbidities, these risks are further increased. ..
- Xuan Y, Guo Y, Zhu Y, Wang O, Rokosh G, Bolli R. Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C epsilon p44/42 mitogen-activated protein kinase pSer-signal transducers and activators of transcription1/3 pat. Circulation. 2007;116:535-44 pubmed..The effects of eNOS-derived NO are reproduced by exogenous NO (NO donors), implying that nitrates can upregulate cardiac cyclooxygenase-2. ..
- Kwon Y, Apostolidis E, Kim Y, Shetty K. Health benefits of traditional corn, beans, and pumpkin: in vitro studies for hyperglycemia and hypertension management. J Med Food. 2007;10:266-75 pubmed
- Wexler R, Elton T, Taylor C, Pleister A, Feldman D. Physician reported perception in the treatment of high blood pressure does not correspond to practice. BMC Fam Pract. 2009;10:23 pubmed publisher..These data provide crucial formative data to enhance the content validity of physician education efforts currently underway to improve the treatment of blood pressure in the primary care setting. ..
- White W, Schnitzer T, Fleming R, Duquesroix B, Beekman M. Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis. Am J Cardiol. 2009;104:840-5 pubmed publisher..04), naproxcinod 375 mg (14%, p = 0.055), and placebo (15.6%, p = 0.155). In conclusion, naproxcinod did not induce elevations of BP seen with naproxen, and it had similar effects on BP to that of placebo in patients with osteoarthritis. ..
- Wright J, Lacourciere Y, Samuel R, Zappe D, Purkayastha D, Black H. 24-Hour ambulatory blood pressure response to combination valsartan/hydrochlorothiazide and amlodipine/hydrochlorothiazide in stage 2 hypertension by ethnicity: the EVALUATE study. J Clin Hypertens (Greenwich). 2010;12:833-40 pubmed publisher..9/-9.7 vs -14.2/-7.2; P=.20/P=.17). Based on ABP monitoring, valsartan/HCTZ is more effective than amlodipine/HCTZ in lowering ABP in Caucasians. In African Americans and Hispanics, both regimens are similarly effective. ..
- Erdos B, Kirichenko N, Whidden M, Basgut B, Woods M, Cudykier I, et al. Effect of age on high-fat diet-induced hypertension. Am J Physiol Heart Circ Physiol. 2011;301:H164-72 pubmed publisher..In conclusion, our experiments led to the surprising finding that HF diet has a more serious impact on cardiovascular regulation in young animals compared with old. ..
- Feng T, Elston R, Zhu X. Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS). Genet Epidemiol. 2011;35:398-409 pubmed publisher..We demonstrated that family data are extremely informative in searching for rare variants underlying complex traits, and the odds ratio weighted sum statistic is more efficient than currently existing methods. ..
- Smith S, Gong Y, Turner S, Cooper Dehoff R, Beitelshees A, Chapman A, et al. Blood pressure responses and metabolic effects of hydrochlorothiazide and atenolol. Am J Hypertens. 2012;25:359-65 pubmed publisher..We aimed to determine whether AMEs are correlated with BP response in uncomplicated hypertensives...
- Gepner A, Colangelo L, Blondon M, Korcarz C, De Boer I, Kestenbaum B, et al. 25-hydroxyvitamin D and parathyroid hormone levels do not predict changes in carotid arterial stiffness: the Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34:1102-9 pubmed publisher..After nearly a decade of follow-up, neither baseline PTH nor 25(OH)D concentrations were associated with progression of carotid arterial stiffness. ..
- Sil P, Gupta S, Young D, Sen S. Regulation of myotrophin gene by pressure overload and stretch. Mol Cell Biochem. 2004;262:79-89 pubmed
- Lee Y, Bastarrika G, Schoepf U. Intra-atrial course of the right coronary artery demonstrated at computed tomography coronary angiography. J Thorac Imaging. 2010;25:W115-7 pubmed publisher..We present a case of intra-atrial course of the right coronary artery noninvasively diagnosed by dual-source computed tomography coronary angiography. ..
- Holzer R, Qureshi S, Ghasemi A, Vincent J, Sievert H, Gruenstein D, et al. Stenting of aortic coarctation: acute, intermediate, and long-term results of a prospective multi-institutional registry--Congenital Cardiovascular Interventional Study Consortium (CCISC). Catheter Cardiovasc Interv. 2010;76:553-63 pubmed publisher
- Wang W, Cui Y, Shen J, Jiang J, Chen S, Peng J, et al. Salt-sensitive hypertension and cardiac hypertrophy in transgenic mice expressing a corin variant identified in blacks. Hypertension. 2012;60:1352-8 pubmed publisher..The results indicate that corin defects may represent an important mechanism in salt-sensitive hypertension and cardiac hypertrophy in blacks. ..
- Narayanan K, Uy Evanado A, Teodorescu C, Reinier K, Nichols G, Gunson K, et al. Mitral valve prolapse and sudden cardiac arrest in the community. Heart Rhythm. 2016;13:498-503 pubmed publisher..Since SCA patients with MVP were characterized by younger age and relatively low cardiovascular comorbidity, a focus on imaging for valve structure/insufficiency as well as genetics could aid future risk stratification approaches. ..
- Prewitt R. Teaching vascular adaptations to mechanical stress. Am J Physiol. 1999;277:S211-3 pubmed..The applications to peripheral vascular disease, myocardial infarctions, hypertension and tumor growth are readily apparent...
- Thongboonkerd V, Gozal E, Sachleben L, Arthur J, Pierce W, Cai J, et al. Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension. J Biol Chem. 2002;277:34708-16 pubmed..Transgenic hKLK1 animals were protected from EH-induced hypertension. We conclude that EH-induced hypertension may result, at least in part, from altered regulation of the renal kallikrein system. ..
- Tian N, Thrasher K, Gundy P, Hughson M, Manning R. Antioxidant treatment prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension. Hypertension. 2005;45:934-9 pubmed..Antioxidant treatment with vitamins C and E improves renal dysfunction, lessens renal injury, and decreases arterial pressure in Dahl salt-sensitive hypertension. ..
- Grigore D, Ojeda N, Robertson E, Dawson A, Huffman C, Bourassa E, et al. Placental insufficiency results in temporal alterations in the renin angiotensin system in male hypertensive growth restricted offspring. Am J Physiol Regul Integr Comp Physiol. 2007;293:R804-11 pubmed..Therefore, temporal alterations in renal RAS are observed in IUGR offspring and may play a key role in the etiology of IUGR hypertension. ..
- Carlson M, Silberbach M. Dissection of the aorta in Turner syndrome: two cases and review of 85 cases in the literature. J Med Genet. 2007;44:745-9 pubmed..A TS aortic dissection registry has been established to better determine the natural history and risk factors (http://www.tssus.org/readweb.asp?wid = 3092). ..
- Wang L, Larson E, Sonnen J, Shofer J, McCormick W, Bowen J, et al. Blood pressure and brain injury in older adults: findings from a community-based autopsy study. J Am Geriatr Soc. 2009;57:1975-81 pubmed publisher..The association between high SBP and cerebrovascular damage in untreated older adults (65-80) suggests that adequate hypertension treatment may reduce dementia risk by minimizing microvascular injury to cerebrum. ..
- White W, Bresalier R, Kaplan A, Palmer B, Riddell R, Lesogor A, et al. Safety and tolerability of the direct renin inhibitor aliskiren: a pooled analysis of clinical experience in more than 12,000 patients with hypertension. J Clin Hypertens (Greenwich). 2010;12:765-75 pubmed publisher..At the registered doses of 150 mg and 300 mg daily, aliskiren has safety and tolerability profiles similar to placebo, other RAS blockers, and diuretics. Cough rates are lower with aliskiren compared with ACE inhibitors. ..
- Sasser J, Molnar M, Baylis C. Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(?)-nitro-L-arginine methyl ester hypertensive rats. Hypertension. 2011;58:197-204 pubmed publisher..These data suggest that the vasodilatory effects of relaxin are dependent on a functional NO synthase system and increased NO bioavailability possibly because of a reduction in oxidative stress. ..
- Vermehren Schmaedick A, Jenkins V, Hsieh H, Brown A, Page M, Brooks V, et al. Upregulation of brain-derived neurotrophic factor expression in nodose ganglia and the lower brainstem of hypertensive rats. J Neurosci Res. 2013;91:220-9 pubmed publisher..A dramatic increase in BDNF in the NG was also detected in DOCA-salt hypertensive rats. Together, our study identifies BDNF as a candidate molecular mediator of activity-dependent changes at baroafferent synapses during hypertension. ..
- Adeagbo A, Zhang X, Patel D, Joshua I, Wang Y, Sun X, et al. Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. J Hypertens. 2005;23:1025-36 pubmed
- Krakoff L. Diuretics for hypertension. Circulation. 2005;112:e127-9 pubmed
- De Boer I, Sachs M, Cleary P, Hoofnagle A, Lachin J, Molitch M, et al. Circulating vitamin D metabolites and kidney disease in type 1 diabetes. J Clin Endocrinol Metab. 2012;97:4780-8 pubmed publisher..In contrast, we did not find evidence linking impaired vitamin D metabolism to early GFR loss or the development of hypertension. ..
- Mustafa R, Bdair F, Akl E, Garg A, Thiessen Philbrook H, Salameh H, et al. Effect of Lowering the Dialysate Temperature in Chronic Hemodialysis: A Systematic Review and Meta-Analysis. Clin J Am Soc Nephrol. 2016;11:442-57 pubmed publisher..High-quality, large, multicenter, randomized trials are needed to determine whether reduced temperature dialysis affects patient mortality and major adverse cardiovascular events. ..
- Hong H, Stegemann J. 2D and 3D collagen and fibrin biopolymers promote specific ECM and integrin gene expression by vascular smooth muscle cells. J Biomater Sci Polym Ed. 2008;19:1279-93 pubmed publisher..These results illuminate the short-term responses of VSMC to 2D and 3D biopolymer matrices, and have relevance to tissue engineering and cardiovascular biology. ..
- Hilgers R, Todd J, Webb R. Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats. J Hypertens. 2007;25:1687-97 pubmed..This enhanced signaling leads to increased MLCP phosphorylation, resulting in vascular hyper-reactivity. ..
- Smith S, Carris N, Dietrich E, Gums J, Uribe L, Coffey C, et al. Physician-pharmacist collaboration versus usual care for treatment-resistant hypertension. J Am Soc Hypertens. 2016;10:307-17 pubmed publisher..Additional research is needed regarding the long-term impact of these models and to identify patients most likely to benefit from team-based interventions. ..
- Chao J, Zhang J, Lin K, Chao L. Adenovirus-mediated kallikrein gene delivery reverses salt-induced renal injury in Dahl salt-sensitive rats. Kidney Int. 1998;54:1250-60 pubmed..Adenovirus-mediated kallikrein gene delivery is effective in reversing salt-induced cardiac hypertrophy and renal injury in Dahl-salt sensitive rats. ..
- Karanja N, Obarzanek E, Lin P, McCullough M, Phillips K, Swain J, et al. Descriptive characteristics of the dietary patterns used in the Dietary Approaches to Stop Hypertension Trial. DASH Collaborative Research Group. J Am Diet Assoc. 1999;99:S19-27 pubmed..In addition, the distinct food grouping pattern across the 3 diets resulted in substantial differences in the levels of vitamins A, C, E, folate, B-6, and zinc. ..
- Sun Z. Genetic AVP deficiency abolishes cold-induced diuresis but does not attenuate cold-induced hypertension. Am J Physiol Renal Physiol. 2006;290:F1472-7 pubmed
- Krambeck A, Gettman M, Rohlinger A, Lohse C, Patterson D, Segura J. Diabetes mellitus and hypertension associated with shock wave lithotripsy of renal and proximal ureteral stones at 19 years of followup. J Urol. 2006;175:1742-7 pubmed..The incidence of these conditions was significantly higher than in a cohort of conservatively treated patients with nephrolithiasis. ..