Experts and Doctors on humans in United States

Summary

Locale: United States
Topic: humans

Top Publications

  1. Tepas J, Pracht E, Orban B, Flint L. High-volume trauma centers have better outcomes treating traumatic brain injury. J Trauma Acute Care Surg. 2013;74:143-7; discussion 147-8 pubmed publisher
    ..Survival and discharge status from severe traumatic brain injury (TBI) patients treated during the past 11 years in seven state-designated Level I trauma centers was analyzed to test for a relationship between patient volume and outcome...
  2. Lee J, Elmer H, Ross K, Kelley T. Isoprenoid-mediated control of SMAD3 expression in a cultured model of cystic fibrosis epithelial cells. Am J Respir Cell Mol Biol. 2004;31:234-40 pubmed
  3. Newell A, Akkari Y, Torimaru Y, Rosenthal A, Reifsteck C, Cox B, et al. Interstrand crosslink-induced radials form between non-homologous chromosomes, but are absent in sex chromosomes. DNA Repair (Amst). 2004;3:535-42 pubmed
    ..Both X and Y chromosomes were notably not involved in radials. These observations suggest that ICL repair may involve short stretches of homology, resulting in aberrant radial formation in the absence of FA proteins. ..
  4. Du H, Chen L, Chavda K, Pandey R, Zhang H, Xie X, et al. Genomic Characterization of Enterobacter cloacae Isolates from China That Coproduce KPC-3 and NDM-1 Carbapenemases. Antimicrob Agents Chemother. 2016;60:2519-23 pubmed publisher
    ..blaKPC-3is located on a Tn3-ΔblaTEM-1-blaKPC-3-ΔTn1722element, flanked by two 9-bp direct-repeat sequences and harbored on an IncX6 plasmid. ..
  5. Bit Ivan E, Suh E, Shim H, Weintraub S, Hyman B, Arnold S, et al. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. J Neuropathol Exp Neurol. 2014;73:467-73 pubmed publisher
    ..We present the clinical, pathologic, and genetic findings on 6 cases from 4 families, 5 of which were shown to have a novel GRN c.708+6_+9delTGAG mutation. ..
  6. Francis P, Wang S, Zhang Y, Brown A, Hwang T, McFarland T, et al. Subretinal transplantation of forebrain progenitor cells in nonhuman primates: survival and intact retinal function. Invest Ophthalmol Vis Sci. 2009;50:3425-31 pubmed publisher
    ..The authors explored donor cell behavior using human cortical neural progenitor cells (hNPC(ctx)) introduced into the subretinal space of normal rhesus macaques...
  7. Phillips N, Racca J, Chen Y, Singh R, Jancso Radek A, Radek J, et al. Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex. J Biol Chem. 2011;286:36787-807 pubmed publisher
    ..Our results have demonstrated a nonlocal coupling between DNA-directed protein folding and protein-directed DNA bending. Perturbation of this coupling is associated with a genetic switch poised at the threshold of activity. ..
  8. Boyd Tressler A, Lane G, Dubyak G. Up-regulated Ectonucleotidases in Fas-Associated Death Domain Protein- and Receptor-Interacting Protein Kinase 1-Deficient Jurkat Leukemia Cells Counteract Extracellular ATP/AMP Accumulation via Pannexin-1 Channels during Chemotherapeutic Drug-Induce. Mol Pharmacol. 2017;92:30-47 pubmed publisher
  9. Asimaki A, Protonotarios A, James C, Chelko S, Tichnell C, Murray B, et al. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016;9:e003688 pubmed publisher
    ..These cells may prove useful in future studies of disease mechanisms and drug screens for effective therapies in arrhythmogenic cardiomyopathy. ..

More Information

Publications6511 found, 100 shown here

  1. Jiang Y, Boehler C, Nönnig N, Duzel E, Hopf J, Heinze H, et al. Binding 3-D object perception in the human visual cortex. J Cogn Neurosci. 2008;20:553-62 pubmed
    ..The assembly is fed forward to achieve coherent perception of a 3-D object within 500 msec. ..
  2. Hilliard J, COOPER A, Slusser J, Davido D. A flow cytometric assay for the study of E3 ubiquitin ligase activity. Cytometry A. 2009;75:634-41 pubmed publisher
    ..Our results suggest that it is possible to examine the live activity of an E3 ubiquitin ligase (via one of its targets) in cell culture by FCM analysis. ..
  3. Schubert L, Westerly D, Tome W, Mehta M, Soisson E, Mackie T, et al. A comprehensive assessment by tumor site of patient setup using daily MVCT imaging from more than 3,800 helical tomotherapy treatments. Int J Radiat Oncol Biol Phys. 2009;73:1260-9 pubmed publisher
    ..Patient setup can be improved if daily imaging is performed. This analysis can assess the utilization of daily image guidance and allows for further investigation into improved anatomic site-specific and patient-specific treatments. ..
  4. Varvel N, Bhaskar K, Kounnas M, Wagner S, Yang Y, Lamb B, et al. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009;119:3692-702 pubmed publisher
  5. Zolkiewski M, Chesnokova L, Witt S. Reactivation of Aggregated Proteins by the ClpB/DnaK Bi-Chaperone System. Curr Protoc Protein Sci. 2016;83:28.10.1-28.10.18 pubmed publisher
    ..The procedures for purification of these chaperones are also described. ..
  6. Rege T, Stewart J, Dranka B, Benveniste E, Silverstein R, Gladson C. Thrombospondin-1-induced apoptosis of brain microvascular endothelial cells can be mediated by TNF-R1. J Cell Physiol. 2009;218:94-103 pubmed publisher
    ..These data identify a novel mechanism whereby TSP-1 can inhibit angiogenesis-through induction of apoptosis in a process mediated by TNF-R1. ..
  7. Robert Schnatter A, Kerzic P, Zhou Y, Chen M, Nicolich M, Lavelle K, et al. Peripheral blood effects in benzene-exposed workers. Chem Biol Interact. 2010;184:174-81 pubmed publisher
    ..8-8.2 ppm. Toluene exposure is a potential confounder for some peripheral blood effects, pointing to the need to scrutinize levels of both compounds in the occupational environment. ..
  8. Fang L, Zhang G, Li C, Zheng X, Zhu L, Xiao J, et al. Discovery of a daunorubicin analogue that exhibits potent antitumor activity and overcomes P-gp-mediated drug resistance. J Med Chem. 2006;49:932-41 pubmed
    ..These data suggest that sugar modifications of anthracyclines avert P-gp binding, abolish P-gp-mediated drug efflux, increase intracellular drug concentration, and thus overcome P-gp-mediated drug resistance in cancer therapy. ..
  9. Callahan C, Saudek D, Shillingford A, Creighton S, Hill G, Johnson W, et al. Single-Stage Repair of Coarctation of the Aorta and Ventricular Septal Defect: A Comparison of Surgical Strategies and Resource Utilization. World J Pediatr Congenit Heart Surg. 2017;8:559-563 pubmed publisher
    ..We sought to compare clinical outcomes and resource utilization for two surgical approaches for single-stage repair of coarctation of the aorta and ventricular septal defect (VSD)...
  10. Minor V, Marris C, McGorray S, Yezierski R, Fillingim R, Logan H, et al. Effects of preoperative ibuprofen on pain after separator placement. Am J Orthod Dentofacial Orthop. 2009;136:510-7 pubmed publisher
    ..No contributions to pain were found for psychological factors or sex. Preemptive administration of analgesics should be recommended to orthodontic patients before separator placement. ..
  11. Smith D, Murphy P, Phillips M, Paulsen M, Vislosky F, Wilde M, et al. The implementation of an innovative statewide quality improvement initiative. J Neurosci Nurs. 2009;41:106-14 pubmed
    ..This discussion highlights how a relatively small task force has transformed into a growing nonprofit organization, becoming a model for best practices. ..
  12. Hall L, Le Febre K, Deml S, Wohlfiel S, Wengenack N. Evaluation of the Yeast Traffic Light PNA FISH probes for identification of Candida species from positive blood cultures. J Clin Microbiol. 2012;50:1446-8 pubmed publisher
    ..The YTL provides rapid, reliable identification of the five common Candida species found in blood cultures. ..
  13. Vendrov A, Vendrov K, Smith A, Yuan J, Sumida A, Robidoux J, et al. NOX4 NADPH Oxidase-Dependent Mitochondrial Oxidative Stress in Aging-Associated Cardiovascular Disease. Antioxid Redox Signal. 2015;23:1389-409 pubmed publisher
    ..Regulating NOX4 activity/expression and using mitochondrial antioxidants are potential approaches to reducing aging-associated CVD. ..
  14. Van Tine B, Knops J, Shaw G, May W. Assignment of human MFNG, manic fringe Drosophila homolog, to 22q13.1 using tyramide fluorescence in situ hybridization (T-FISH). Cytogenet Cell Genet. 1999;87:132-3 pubmed
  15. Schaal S, Barr C. Management of macular holes: a comparison of 1-year outcomes of 3 surgical techniques. Retina. 2009;29:1091-6 pubmed publisher
    ..To evaluate the contribution of internal limiting membrane (ILM) peeling with and without indocyanine green (ICG) to hole closure and functional results in patients with idiopathic macular hole...
  16. Wheeler Hegland K, Huber J, Pitts T, Davenport P, Sapienza C. Lung volume measured during sequential swallowing in healthy young adults. J Speech Lang Hear Res. 2011;54:777-86 pubmed publisher
    ..This may reflect obligate differences in airway protection strategy and prolonged competition for respiratory resources. ..
  17. Skoura A, Hla T. Regulation of vascular physiology and pathology by the S1P2 receptor subtype. Cardiovasc Res. 2009;82:221-8 pubmed publisher
    ..These studies suggest that selective modulation of S1P2 receptor function by pharmacological tools may be useful in a variety of pathological conditions. ..
  18. Ghosh D, Jiang W, Lo J, Egbuta C. Higher order organization of human placental aromatase. Steroids. 2011;76:753-8 pubmed publisher
    ..Furthermore, the amino acids involved in the intermolecular contact appear to be specific for aromatase. Higher order organization of aromatase monomers may have implications in lipid integration and catalysis. ..
  19. Chiou S, Hoa N. Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. Apoptosis. 2009;14:1341-51 pubmed publisher
    ..These findings confirm a role for GADD45alpha in NSAID-induced cytotoxicity, a mechanism for the anti-neoplastic effect of NSAIDs in colon tumorigenesis and cancer growth. ..
  20. Beier J, McClain C. Mechanisms and cell signaling in alcoholic liver disease. Biol Chem. 2010;391:1249-64 pubmed publisher
    ..The purpose of this review is to summarize the established and proposed mechanisms by which chronic alcohol abuse damages the liver and to highlight key signaling events known or hypothesized to mediate these effects. ..
  21. Gdula Argasińska J, Czepiel J, Totoń Żurańska J, Wołkow P, Librowski T, Czapkiewicz A, et al. n-3 Fatty acids regulate the inflammatory-state related genes in the lung epithelial cells exposed to polycyclic aromatic hydrocarbons. Pharmacol Rep. 2016;68:319-28 pubmed publisher
    ..It remains to be shown whether these pleiotropic and protective actions of n-3 FAs contribute to fish oil's therapeutic effect in asthma. ..
  22. Jacob A, O BRIEN D, Singh R, Comiskey D, Littleton R, Mohammad F, et al. Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma. Neoplasia. 2013;15:1049-63 pubmed
  23. Gu W, Novak R. Predicting the impact of insecticide-treated bed nets on malaria transmission: the devil is in the detail. Malar J. 2009;8:256 pubmed publisher
    ..It is necessary to test efficacy of treated nets on local dominant vector mosquitoes, at least in laboratory, for monitoring and evaluation of ITN programmes. ..
  24. Samuels I, Seibenhener M, Neidigh K, Wooten M. Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation. J Cell Biochem. 2001;82:452-66 pubmed
    ..Collectively, these findings demonstrate that ZIP/p62 acts as a shuttling protein involved in routing activated aPKC to an endosomal compartment and is required for mediating NGF's biological properties. ..
  25. Wu J, Liu Q, Lee R. A folate receptor-targeted liposomal formulation for paclitaxel. Int J Pharm. 2006;316:148-53 pubmed
    ..The FR-targeted paclitaxel formulation is potentially useful for treatment of FR+ tumors and warrants further investigation. ..
  26. Bartee E, Eyster C, Viswanathan K, Mansouri M, Donaldson J, Fruh K. Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. PLoS ONE. 2010;5:e15132 pubmed publisher
    ..Our data thus suggest a role of MARCH-VIII and MARCH-IV in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins. ..
  27. Pestilli F. Test-retest measurements and digital validation for in vivo neuroscience. Sci Data. 2015;2:140057 pubmed publisher
  28. Jarmolowicz D, Bickel W, Carter A, Franck C, Mueller E. Using crowdsourcing to examine relations between delay and probability discounting. Behav Processes. 2012;91:308-12 pubmed publisher
    ..Taken together, these findings suggest that delay and probability discounting may be related, but are not manifestations of a single construct (e.g., impulsivity). ..
  29. Liu Y, Osborn C, Qian H, Yin L, Xiao D, Ruan Y, et al. Barriers and Facilitators of Linkage to and Engagement in HIV Care Among HIV-Positive Men Who Have Sex with Men in China: A Qualitative Study. AIDS Patient Care STDS. 2016;30:70-7 pubmed publisher
    ..Findings from our study provide research and policy guidance for how current HIV prevention and care interventions can be enhanced to link and engage HIV-positive MSM in HIV care. ..
  30. Atha W. Heat-related illness. Emerg Med Clin North Am. 2013;31:1097-108 pubmed publisher
    ..An understanding of the mechanisms of thermoregulation and how those mechanisms fail with extreme heat stress is critical for management of the patient with elevated body temperature in the emergency department. ..
  31. Ohkuma R, Crawford T, Brown P, Grimm J, Magruder J, Kilic A, et al. A Novel Risk Score to Predict the Need for Nutrition Support After Cardiac Surgery. Ann Thorac Surg. 2017;104:1306-1312 pubmed publisher
    ..This easily calculable and highly predictive screening tool may expedite timing of initiation of NS in patients at high risk for not being able to physically take in adequate nutrition. ..
  32. Hameed M, Blacksin M, Das K, Patterson F, Benevenia J, Aisner S. Cortical chondroblastoma: report of a case and literature review of this lesion reported in unusual locations. Skeletal Radiol. 2006;35:295-7 pubmed
    ..Biopsy revealed a chondroblastoma, and the patient subsequently underwent a total curettage of the lesion with cancellous bone graft from the iliac crest...
  33. Ginther D, Schaffer W, Schnell J, Masimore B, Liu F, Haak L, et al. Race, ethnicity, and NIH research awards. Science. 2011;333:1015-9 pubmed publisher
    ..Our results suggest some leverage points for policy intervention. ..
  34. Lustberg M, Reinbolt R, Shapiro C. Bone health in adult cancer survivorship. J Clin Oncol. 2012;30:3665-74 pubmed publisher
    ..This review will summarize the mechanisms by which cancer treatments cause bone loss as well provide screening and treatment recommendations for the management of bone loss. ..
  35. Lodise T, Drusano G, Butterfield J, Scoville J, Gotfried M, Rodvold K. Penetration of vancomycin into epithelial lining fluid in healthy volunteers. Antimicrob Agents Chemother. 2011;55:5507-11 pubmed publisher
  36. Schoepf U, Kucher N, Kipfmueller F, Quiroz R, Costello P, Goldhaber S. Right ventricular enlargement on chest computed tomography: a predictor of early death in acute pulmonary embolism. Circulation. 2004;110:3276-80 pubmed
    ..00; 95% CI, 1.04 to 3.86; P=0.039), and age (hazard ratio, 1.03; 95% CI, 1.01 to 1.05; P=0.005). In patients with acute PE, RV enlargement on reconstructed CT 4-CH view helps predict early death. ..
  37. Ahn S, Kearbey J, Li C, Duke C, Miller D, Dalton J. Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice. Drug Metab Dispos. 2011;39:636-43 pubmed publisher
    ..The results of these drug metabolism and pharmacokinetic studies provide the foundation for future structural modification of this pharmacophore to improve stability of drugs with potent anticancer effects in cancer patients. ..
  38. Mallow M, Baer H, Moroz A, Nguyen V. Entrustable Professional Activities For Residency Training in Physical Medicine and Rehabilitation. Am J Phys Med Rehabil. 2017;96:762-764 pubmed publisher
    ..Using a modified Delphi process, residency program directors in the field reviewed and validated a set of entrustable professional activities. The final set of 19 entrustable professional activities is presented in this article. ..
  39. Prins R, Rademacher B, Mongoue Tchokote S, Alumkal J, Graff J, Eilers K, et al. C-reactive protein as an adverse prognostic marker for men with castration-resistant prostate cancer (CRPC): confirmatory results. Urol Oncol. 2012;30:33-7 pubmed publisher
    ..CRP is a readily measurable biomarker that has the potential to improve prognostic models and should be validated in a prospective clinical trial. ..
  40. Das A, Banik N, Ray S. Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes. Cancer. 2010;116:164-76 pubmed publisher
    ..Apigenin, (-)-epigallocatechin, EGCG, and genistein did not induce apoptosis in human normal astrocytes. Results strongly suggest that flavonoids are potential therapeutic agents for induction of apoptosis in human glioblastoma cells. ..
  41. Wani M, Haynes L, Kim J, Bronson C, Chaudhury C, Mohanty S, et al. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc Natl Acad Sci U S A. 2006;103:5084-9 pubmed
    ..This experiment of nature affirms our hypothesis that FcRn binds IgG and albumin, salvages both from a degradative fate, and maintains their physiologic concentrations. ..
  42. Kusunose K, Motoki H, Popovic Z, Thomas J, Klein A, Marwick T. Independent association of left atrial function with exercise capacity in patients with preserved ejection fraction. Heart. 2012;98:1311-7 pubmed publisher
    ..The association of reduced LA function with impaired exercise capacity was similar to that of elevated LVE/e', emphasising the role of ventriculo-atrial coupling to cardiac dysfunction with preserved LVEF. ..
  43. Casamassimo P. Relationships between oral and systemic health. Pediatr Clin North Am. 2000;47:1149-57 pubmed
    ..Cooperation between dentist and physician can mean good overall health for children, including oral health...
  44. Cobb S, Wider C, Ross O, Mata I, Adler C, Rajput A, et al. GCH1 in early-onset Parkinson's disease. Mov Disord. 2009;24:2070-5 pubmed publisher
    ..This study does not support a significant role for genetic variation at the GCH1 locus in EOPD. However, our results further highlight the relevance of PRKN screening in familial EOPD. ..
  45. Abcejo A, Sathish V, Smelter D, Aravamudan B, Thompson M, Hartman W, et al. Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PLoS ONE. 2012;7:e44343 pubmed publisher
    ..Overall, these data demonstrate that NTs activate signaling pathways in human ASM that lead to enhanced [Ca(2+)](i) responses via increased regulatory protein expression, thus enhancing airway contractility. ..
  46. Niederhaus S, Leverson G, Lorentzen D, Robillard D, Sollinger H, Pirsch J, et al. Acute cellular and antibody-mediated rejection of the pancreas allograft: incidence, risk factors and outcomes. Am J Transplant. 2013;13:2945-55 pubmed publisher
  47. Awad H, Santilli S, Ohr M, Roth A, Yan W, Fernandez S, et al. The effects of steep trendelenburg positioning on intraocular pressure during robotic radical prostatectomy. Anesth Analg. 2009;109:473-8 pubmed publisher
    ..Surgical duration and ETco(2) were the only significant predictors of IOP increase in the Trendelenburg position (T4-T5). ..
  48. Robinson G, Tsay Y, Kienzle B, Smith Monroy C, Bishop R. Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation. Mol Cell Biol. 1993;13:2706-17 pubmed
    ..cerevisiae and S. pombe cells or in cultured human fibroblasts by treatment with the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor lovastatin resulted in elevated levels of squalene synthetase mRNA in all three cell types. ..
  49. Holwerda S, Restaino R, Manrique C, Lastra G, Fisher J, Fadel P. Augmented pressor and sympathetic responses to skeletal muscle metaboreflex activation in type 2 diabetes patients. Am J Physiol Heart Circ Physiol. 2016;310:H300-9 pubmed publisher
    ..Greater CPT responses suggest that a heightened central sympathetic reactivity may be involved. ..
  50. Yendamuri S, Battoo A, Dy G, Chen H, Gomez J, Singh A, et al. Transcervical Extended Mediastinal Lymphadenectomy: Experience From a North American Cancer Center. Ann Thorac Surg. 2017;104:1644-1649 pubmed publisher
    ..TEMLA is a safe procedure and superior to PET-CT for restaging of the mediastinum after neoadjuvant therapy for non-small cell lung cancer. However, this increased accuracy comes with a high postoperative pneumonia rate. ..
  51. Pechauer A, Hwang T, Hagag A, Liu L, Tan O, Zhang X, et al. Assessing total retinal blood flow in diabetic retinopathy using multiplane en face Doppler optical coherence tomography. Br J Ophthalmol. 2018;102:126-130 pubmed publisher
    ..To assess total retinal blood flow (TRBF) in diabetic retinopathy (DR) using multiplane en face Doppler optical coherence tomography (OCT)...
  52. Umapathy N, Zemskov E, Gonzales J, Gorshkov B, Sridhar S, Chakraborty T, et al. Extracellular beta-nicotinamide adenine dinucleotide (beta-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement. J Cell Physiol. 2010;223:215-23 pubmed publisher
    ..With these results, we conclude that beta-NAD regulates the pulmonary EC barrier integrity via small GTPase Rac1- and MLCP- dependent signaling pathways. ..
  53. Sarawate C, Patel P, Schumacher H, Yang W, Brewer K, Bakst A. Serum urate levels and gout flares: analysis from managed care data. J Clin Rheumatol. 2006;12:61-5 pubmed
    ..0 mg/dL may be attributed to lack of awareness of optimal SUA, allopurinol dosing, compliance, and efficacy. Patients who did not achieve target SUA were at increased flare risk. ..
  54. Alnahdi A, Zeni J, Snyder Mackler L. Gait after unilateral total knee arthroplasty: frontal plane analysis. J Orthop Res. 2011;29:647-52 pubmed publisher
    ..While the non-operated knee loading was not different from controls, there may be greater risk of cumulative loading in the non-operated knee of the TKA group given the shorter step length. ..
  55. Oates J, Levesque M, Hobbs M, Smith E, Molano I, Page G, et al. Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. J Rheumatol. 2003;30:60-7 pubmed
    ..The extent of linkage disequilibrium between the G-954C and CCTTT-8 repeat NOS2 promoter polymorphisms suggests that they were co-inherited. ..
  56. Malik B, Hemenway C. CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3. FEBS Lett. 2013;587:3038-44 pubmed publisher
    ..In contrast, CBX8 overexpression results in increased ENaC? mRNA levels and this effect can be partially overcome by co-overexpression of AF9. ..
  57. Johnson K, Zeddam J, Ball L. Characterization and construction of functional cDNA clones of Pariacoto virus, the first Alphanodavirus isolated outside Australasia. J Virol. 2000;74:5123-32 pubmed
    ..Transcription of these plasmids in cells recreated the replication of PaV RNA1 and RNA2, synthesis of subgenomic RNA3, and translation of viral proteins A and alpha...
  58. Landen C, Goodman B, Katre A, Steg A, Nick A, Stone R, et al. Targeting aldehyde dehydrogenase cancer stem cells in ovarian cancer. Mol Cancer Ther. 2010;9:3186-99 pubmed publisher
    ..This enzyme may be important for identification and targeting of chemoresistant cell populations in ovarian cancer. ..
  59. Oh S, Alapati A, Claussen G, Vernino S. Myokymia, neuromyotonia, dermatomyositis, and voltage-gated K+ channel antibodies. Muscle Nerve. 2003;27:757-60 pubmed
    ..The presence of antibodies to voltage-gated potassium channels and the association with dermatomyositis indicated an autoimmune cause for myokymia, which may have been due to reversible peripheral nerve hyperexcitability...
  60. Trobridge G, Wu R, Beard B, Chiu S, Munoz N, Von Laer D, et al. Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection. PLoS ONE. 2009;4:e7693 pubmed publisher
    ..This approach should allow for high levels of HIV-protected cells in AIDS patients to evaluate AIDS gene therapy. ..
  61. Natalizio B, Muniz L, Arhin G, Wilusz J, Lutz C. Upstream elements present in the 3'-untranslated region of collagen genes influence the processing efficiency of overlapping polyadenylation signals. J Biol Chem. 2002;277:42733-40 pubmed
    ..Taken together, these data demonstrate that USEs are important auxiliary polyadenylation elements in mammalian genes. ..
  62. Golde T, Koo E, Felsenstein K, Osborne B, Miele L. ?-Secretase inhibitors and modulators. Biochim Biophys Acta. 2013;1828:2898-907 pubmed publisher
    ..This article is part of a Special Issue entitled: Intramembrane Proteases. ..
  63. Li Q, Qu H, Rentfro A, Grove M, Mirza S, Lu Y, et al. PNPLA3 polymorphisms and liver aminotransferase levels in a Mexican American population. Clin Invest Med. 2012;35:E237-45 pubmed
    ..The strong genetic association found in women ? 50 years old, but not in women > 50 years old, suggests that sex hormones may mediate the sex effect. ..
  64. Blumberg N, Heal J, Hicks G, Risher W. Association of ABO-mismatched platelet transfusions with morbidity and mortality in cardiac surgery. Transfusion. 2001;41:790-3 pubmed
    ..As this association has been found in three cohort studies in various clinical settings, further investigation of this association is warranted. ..
  65. Rodova M, Brownback K, Werle M. Okadaic acid augments utrophin in myogenic cells. Neurosci Lett. 2004;363:163-7 pubmed
    ..Control of utrophin promoter activation could then be used to increase the expression of utrophin, and thus ameliorate the symptoms of Duchenne muscular dystrophy. ..
  66. Plum A, Sobin L, Tatum S. Intraoperative hypotension associated with massive deep space neck abscesses in a 9-month old: A case report. Int J Pediatr Otorhinolaryngol. 2016;83:215-7 pubmed publisher
  67. Liu Y, HOWARD D, Rector K, Swiderski C, Brandon J, Schook L, et al. Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth. PLoS ONE. 2012;7:e44979 pubmed publisher
    ..These results are consistent with a tumor suppressor role for latexin and suggest that latexin may have clinical efficacy in the treatment of malignancies. ..
  68. Patel P, Borovskiy Y, Killian A, Verdino R, Epstein A, Callans D, et al. Optimal QT interval correction formula in sinus tachycardia for identifying cardiovascular and mortality risk: Findings from the Penn Atrial Fibrillation Free study. Heart Rhythm. 2016;13:527-35 pubmed publisher
    ..Future work may validate these findings and result in changes to automated algorithms for QT interval assessment. ..
  69. Ghosh B, Barbosa E, Singh I. Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression. Mol Cell Biochem. 1995;151:77-81 pubmed
    ..The expression of palmitoyl-CoA ligase in various tissue parallels the function of this enzyme in the metabolism of fatty acids in these tissues. ..
  70. Bonkovsky H, Naishadham D, Lambrecht R, Chung R, Hoefs J, Nash S, et al. Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C. Gastroenterology. 2006;131:1440-51 pubmed
    ..009). Although HFE mutations (especially the most frequent H63D mutation) are associated with increased iron loading, they are also associated with increased sustained virologic responses in US patients with advanced chronic hepatitis C. ..
  71. Tosh P, Poland G. Emerging vaccines for influenza. Expert Opin Emerg Drugs. 2008;13:21-40 pubmed
    ..With the possibility of an influenza pandemic increasing the need to develop new vaccines, the global research community has made large strides to meet this challenge. ..
  72. Dunn C, Chalupny N, Sutherland C, Dosch S, Sivakumar P, Johnson D, et al. Human cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against natural killer cell cytotoxicity. J Exp Med. 2003;197:1427-39 pubmed
    ..The intracellular sequestration of NKG2D ligands by UL16 represents a novel HCMV immune evasion mechanism to add to the well-documented viral strategies directed against antigen presentation by classical MHC molecules. ..
  73. Selvendiran K, Bratasz A, Kuppusamy M, Tazi M, Rivera B, Kuppusamy P. Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3. Int J Cancer. 2009;125:2198-204 pubmed publisher
    ..The results have important clinical implications for the treatment of hypoxic ovarian tumors using STAT3-specific inhibitors. ..
  74. Bagge C, Borges G. Acute Substance Use as a Warning Sign for Suicide Attempts: A Case-Crossover Examination of the 48 Hours Prior to a Recent Suicide Attempt. J Clin Psychiatry. 2017;78:691-696 pubmed publisher
    ..76; 95% CI, 1.02-75.44). Findings suggest the importance of considering acute alcohol use and use of CNS depressants, and the concurrent use of both substances, when evaluating short-term risk for suicide attempts in clinical settings. ..
  75. Milivojevic V, Kranzler H, Gelernter J, Burian L, Covault J. Variation in genes encoding the neuroactive steroid synthetic enzymes 5?-reductase type 1 and 3?-reductase type 2 is associated with alcohol dependence. Alcohol Clin Exp Res. 2011;35:946-52 pubmed publisher
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    ..These data will facilitate evaluation of the immunogenicity of replication incompetent smallpox vaccines such as modified vaccinia Ankara and contribute to knowledge of poxvirus epitopes that are associated with long-lived T cell memory...
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    ..Collections that support case management require a relatively small group of core journals. Students and health care professionals will need to search across disciplines to identify appropriate literature. ..
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    ..Guaifenesin is not detected by the primary screening methods employed by some labs and may be missed in toxicological analyses of overdoses unless specifically suspected. ..
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    ..To examine ammonia levels, pharmacokinetics, and safety of glycerol phenylbutyrate (GPB; also referred to as HPN-100) and sodium phenylbutyrate (NaPBA) in young children with urea cycle disorders (UCDs)...
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