Experts and Doctors on humans in Japan


Locale: Japan
Topic: humans

Top Publications

  1. Fukamiya N, Okano M, Miyamoto M, Tagahara K, Lee K. Antitumor agents, 127. Bruceoside C, a new cytotoxic quassinoid glucoside, and related compounds from Brucea javanica. J Nat Prod. 1992;55:468-75 pubmed
    ..Bruceoside C showed potent cytotoxicities against KB, A-549, RPMI, and TE-671 tumor cells. ..
  2. Namikawa C, Salter Cid L, Flajnik M, Kato Y, Nonaka M, Sasaki M. Isolation of Xenopus LMP-7 homologues. Striking allelic diversity and linkage to MHC. J Immunol. 1995;155:1964-71 pubmed
    ..The great allelic diversity can be explained either by coselection with particular class I alleles or by differential silencing of MHC genes in the polyploid X. laevis. ..
  3. Osuga J, Inaba T, Harada K, Yagyu H, Shimada M, Yazaki Y, et al. Cloning and structural analysis of the mouse apolipoprotein B mRNA editing protein gene. Biochem Biophys Res Commun. 1995;214:653-62 pubmed
    ..The gene spans 12 kb and contains 5 exons and 4 introns. Sequencing of the 5'-flanking region revealed that a canonical TATA box is absent and the consensus recognition sequences for several transcription factors have been identified. ..
  4. Fukami Kobayashi K, Tomoda S, Go M. Evolutionary clustering and functional similarity of RNA-binding proteins. FEBS Lett. 1993;335:289-93 pubmed
    ..In light of these observation, one can assume the function of an RNA-binding protein, based on the evolutionary relationship between its RNA-binding domain(s) and domain organization, as compared with other RNPs. ..
  5. Iizaka M, Han H, Akashi H, Furukawa Y, Nakajima Y, Sugano S, et al. Isolation and chromosomal assignment of a novel human gene, CORO1C, homologous to coronin-like actin-binding proteins. Cytogenet Cell Genet. 2000;88:221-4 pubmed
    ..We assigned this novel gene to chromosome 12q24.1 by fluorescence in situ hybridization. ..
  6. Matsui Y, Fujikawa K, Oka H, Fukuzawa S, Takeuchi H. Ureteroarterial fistula in a patient with a single functioning kidney. Int J Urol. 2001;8:128-9 pubmed
    ..Even after embolization, the tissue surrounding a fistula remains very fragile, so the fistula may easily recur as a result of slight injury or inflammation. ..
  7. Mishiro Y, Sakagami M, Takahashi Y, Kitahara T, Kajikawa H, Kubo T. Tympanoplasty with and without mastoidectomy for non-cholesteatomatous chronic otitis media. Eur Arch Otorhinolaryngol. 2001;258:13-5 pubmed
    ..6% in group A and 90.4% in group B, without a statistically significant difference. Mastoidectomy is not helpful in tympanoplasty for non-cholesteatomatous COM, even if the ear is discharging. ..
  8. Watanabe K, Ogura G, Tajino T, Hoshi N, Suzuki T. Myofibrosarcoma of the bone: a clinicopathologic study. Am J Surg Pathol. 2001;25:1501-7 pubmed
    ..Myofibrosarcoma of the bone has distinctive histopathologic features, which should be distinguished from those of other bone tumors with myoid differentiation...
  9. Kamitani S, Sugihara H, Shiomi H, Tani T, Hattori T. Intratumoral regional variations in copy number of the chromosomal part revealed by microdissection and combined ploidy and comparative genomic hybridization analyses in esophageal squamous cell carcinoma. Cancer Genet Cytogenet. 2002;132:30-5 pubmed
    ..This method of temporal analysis may enable us to extract important early events from numerous aberrations screened by CGH in individual tumors. ..

More Information

Publications900 found, 100 shown here

  1. Taniuchi K, Nishimori I, Takeuchi T, Fujikawa Adachi K, Ohtsuki Y, Onishi S. Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain. Neuroscience. 2002;112:93-9 pubmed
    ..From the findings in the present study on the distribution and the developmental expression of CA-RP VIII, X, and XI in the human brain we suggest that these CA-RPs play roles in various biological process of the CNS. ..
  2. Kawaguchi Y, Furushima K, Sugimori K, Inoue I, Kimura T. Association between polymorphism of the transforming growth factor-beta1 gene with the radiologic characteristic and ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2003;28:1424-6 pubmed
    ..A study was conducted to examine the relation between the transforming growth factor-beta1 (TGF-beta1) polymorphism (T-->C transition in the signal sequence) and ossification of the posterior longitudinal ligament (OPLL)...
  3. Watanabe S, Ichimura T, Fujita N, Tsuruzoe S, Ohki I, Shirakawa M, et al. Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. Proc Natl Acad Sci U S A. 2003;100:12859-64 pubmed
    ..These data suggest that MBD1 cooperates with MPG for transcriptional repression and DNA repair. We hypothesize that MBD1 functions as a reservoir for MPG and senses the base damage in chromatin ..
  4. Makiishi T, Araki S, Koya D, Maeda S, Kashiwagi A, Haneda M. C-106T polymorphism of AKR1B1 is associated with diabetic nephropathy and erythrocyte aldose reductase content in Japanese subjects with type 2 diabetes mellitus. Am J Kidney Dis. 2003;42:943-51 pubmed
    ..The TT genotype of the C-106T polymorphism of AKR1B1 increases the risk for DN in Japanese subjects with type 2 diabetes mellitus, which could be linked in part to greater expression of AR. ..
  5. Takemura J, Saeki S, Hachisuka K, Aritome K. Prevalence of post-polio syndrome based on a cross-sectional survey in Kitakyushu, Japan. J Rehabil Med. 2004;36:1-3 pubmed
    ..0 per population of 100,000. This survey revealed the number of polio survivors, and the prevalence of post-polio syndrome in Kitakyushu, Japan. ..
  6. Uchiyama Kokubu N, Naito M, Nakajima M, Tsuruo T. Transport of somatostatin and substance P by human P-glycoprotein. FEBS Lett. 2004;574:55-61 pubmed
    ..These findings suggested that certain bioactive peptides such as somatostatin and substance P directly interact with human P-glycoprotein as endogenous substrates for P-glycoprotein-mediated transport. ..
  7. Hayashi K, Sugawara J, Komine H, Maeda S, Yokoi T. Effects of aerobic exercise training on the stiffness of central and peripheral arteries in middle-aged sedentary men. Jpn J Physiol. 2005;55:235-9 pubmed
    ..These results suggest that in contrast with central arterial stiffness, peripheral arterial stiffness is difficult to change with aerobic exercise training. ..
  8. Yoshida C, Komori T. Role of Runx proteins in chondrogenesis. Crit Rev Eukaryot Gene Expr. 2005;15:243-54 pubmed
    ..It also highlights how Runx proteins regulate transcription of target genes and how Runx proteins are regulated in the cartilaginous skeleton. ..
  9. Yanagi T, Shibaki A, Tsuji Abe Y, Yokota K, Shimizu H. Epidermodysplasia verruciformis and generalized verrucosis: the same disease?. Clin Exp Dermatol. 2006;31:390-3 pubmed
    ..Therefore, we propose that an abnormal susceptibility specific to HPV, which is the most characteristic feature in EV, should be regarded as a differential point in these two diseases. ..
  10. Shimotsuma M, Matsuzaki H, Tanabe O, Campbell A, Engel J, Fukamizu A, et al. Linear distance from the locus control region determines epsilon-globin transcriptional activity. Mol Cell Biol. 2007;27:5664-72 pubmed
    ..Thus, the epsilon-globin gene differs in its distance sensitivity to the LCR from the other beta-like globin genes, which is, at least in part, determined by the transcription factor EKLF. ..
  11. Itoh M, Wu W, Sun D, Yao L, Li Z, Islam M, et al. Confirmation of elimination of lymphatic filariasis by an IgG4 enzyme-linked immunosorbent assay with urine samples in Yongjia, Zhejiang Province and Gaoan, Jiangxi Province, People's Republic of China. Am J Trop Med Hyg. 2007;77:330-3 pubmed
    ..If similar results are obtained in different filariasis-endemic countries, this method may be useful in global filariasis elimination programs...
  12. Ugajin M, Miwa S, Shirai M, Ohba H, Eifuku T, Nakamura H, et al. Usefulness of serum procalcitonin levels in pulmonary tuberculosis. Eur Respir J. 2011;37:371-5 pubmed publisher
    ..0001). Serum PCT is not habitually elevated in HIV-negative PTB patients and is a useful biomarker for discriminating between PTB and CAP; however, when serum PCT is outside the normal range, it is a poor prognostic marker. ..
  13. Siqin -, Nakai M, Hagi T, Kato S, Pitia A, Kotani M, et al. Partial cDNA sequence of a relaxin-like factor (RLF) receptor, LGR8 and possible existence of the RLF ligand-receptor system in goat testes. Anim Sci J. 2010;81:681-6 pubmed publisher
  14. Hori J, Yasunaga Y, Yamasaki T, Yoshida T, Oshima S, Yamasaki K, et al. Mid-term results of acetabular reconstruction using a Kerboull-type acetabular reinforcement device. Int Orthop. 2012;36:23-6 pubmed publisher
    ..The purpose of this study was to investigate the mid-term results of 32 acetabular reconstructions performed using a Kerboull-type acetabular reinforcement device and bone graft between June 1997 and January 2009...
  15. Tamada T, Sone T, Higashi H, Jo Y, Yamamoto A, Kanki A, et al. Prostate cancer detection in patients with total serum prostate-specific antigen levels of 4-10 ng/mL: diagnostic efficacy of diffusion-weighted imaging, dynamic contrast-enhanced MRI, and T2-weighted imaging. AJR Am J Roentgenol. 2011;197:664-70 pubmed publisher
    ..Combined T2-weighted imaging, DWI, and DCE-MRI findings appear to be potentially useful for detecting and managing prostate cancer, even when performed for patients with gray-zone PSA levels. ..
  16. Kitabayashi T, Sato S, Adachi M. [A case of anaphylaxis due to rose-flavored soft-serve ice cream with pollen food allergy syndrome]. Arerugi. 2013;62:574-8 pubmed
    ..It is believed that the labeling method should be improved in the future. ..
  17. Kumai Y, Kodama N, Murakami D, Yumoto E. Comparison of vocal outcome following two different procedures for immediate RLN reconstruction. Eur Arch Otorhinolaryngol. 2016;273:967-72 pubmed publisher
    ..e., ACN or GAN) provided both excellent long-term postoperative phonatory function and stroboscopic findings, and there was little difference in vocal outcome between the two procedures. ..
  18. Liu Y, Ishibashi H, Takeshita K, Mizumoto A, Hirano M, Sako S, et al. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Dissemination from Small Bowel Malignancy: Results from a Single Specialized Center. Ann Surg Oncol. 2016;23:1625-31 pubmed publisher
    ..Until more data become available, a reasonable strategy for the treatment of SBM is CRS and HIPEC. It can be applied with acceptable safety in selected patients with peritoneal dissemination from SBM. ..
  19. Misaki R, Fukura N, Kajiura H, Yasugi M, Kubota Koketsu R, Sasaki T, et al. Recombinant production and characterization of human anti-influenza virus monoclonal antibodies identified from hybridomas fused with human lymphocytes. Biologicals. 2016;44:394-402 pubmed publisher
    ..Here we demonstrated that recombinants of antibodies identified from hybridomas fused with SPYMEG have normal N-glycans and that their neutralizing activities bear comparison with those of the original antibodies. ..
  20. Taylor R, Lindorfer M, Cook E, Beurskens F, Schuurman J, Parren P, et al. Hexamerization-enhanced CD20 antibody mediates complement-dependent cytotoxicity in serum genetically deficient in C9. Clin Immunol. 2017;181:24-28 pubmed publisher
    ..The Ca2+ signal is retained concomitantly with TOPRO-3 (viability dye) staining, thereby confirming that Ca2+ influx represents the most proximate mediator of cell death by CDC. ..
  21. Okazumi S, Isono K, Enomoto K, Kikuchi T, Ozaki M, Yamamoto H, et al. Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment. J Nucl Med. 1992;33:333-9 pubmed
    ..After treatment, k3 decreased according to the effectiveness of therapy and thus may be a useful index for quantitatively assessing tumor viability. ..
  22. Kamei T, Futatsuya R, Seto H, Soya T, Kakishita M, Tsukishiro T, et al. A case of liver echinococcosis mimicing a solid liver tumor. Radiat Med. 1991;9:101-4 pubmed
    ..When a solid tumor is noted in the liver, proper history taking and awareness of this disease will decrease the chance of misdiagnosis...
  23. Imai Y, Kohsaka S. Structure of rat annexin V gene and molecular diversity of its transcripts. Eur J Biochem. 1995;232:327-34 pubmed
    ..We also demonstrated the presence of at least four species of rat annexin V transcripts that were generated by distinct transcription initiation and alternative splicing. ..
  24. Minami M, Mutoh H, Ohishi N, Honda Z, Bito H, Shimizu T. Amino-acid sequence and tissue distribution of guinea-pig leukotriene A4 hydrolase. Gene. 1995;161:249-51 pubmed
    ..The previously characterized zinc-binding motif and a putative active site were highly conserved, supporting the aminopeptidase activity described for this enzyme. RNA blot analysis demonstrated ubiquitous expression of the LTA4H mRNA. ..
  25. Motoo Y, Sawabu N, Minamoto T, Kawakami H, Ohta H, Okai T, et al. Rapidly growing mucinous cholangiocarcinoma. Intern Med. 1993;32:116-21 pubmed
  26. Aoki N, Kishi M, Taniguchi Y, Adachi T, Nakamura R, Matsuda T. Molecular cloning of glycoprotein antigens MGP57/53 recognized by monoclonal antibodies raised against bovine milk fat globule membrane. Biochim Biophys Acta. 1995;1245:385-91 pubmed
    ..0 kb mRNA of lactating bovine mammary gland. These results strongly support our previous report that the two MFGM antigens originate from a single gene and are isoforms with different N-linked sugar chains. ..
  27. Choi B, Bando M, Hasegawa S, Horikoshi M. Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histones H2B and H3. Gene. 1996;169:263-7 pubmed
    ..Additionally, the C-terminal region was found to contain similarities with histones H2B and H3. Northern blot analysis showed mRNA corresponding to hp22 to be expressed in all tissues examined. ..
  28. Hayashi H, Mizushima N, Yoshinaga H, Kawamitsu H, Matsuda S, Tanoue M, et al. The relationship between lipoprotein(a) and low density lipoprotein receptors during the treatment of hyperthyroidism. Horm Metab Res. 1996;28:384-7 pubmed
  29. Miyaki M, Nishio J, Konishi M, Kikuchi Yanoshita R, Tanaka K, Muraoka M, et al. Drastic genetic instability of tumors and normal tissues in Turcot syndrome. Oncogene. 1997;15:2877-81 pubmed
    ..Additional unknown germline mutation may contribute to the genetic instability in normal tissues. ..
  30. Hikasa H, Hori K, Shiokawa K. Structure of aldolase A (muscle-type) cDNA and its regulated expression in oocytes, embryos and adult tissues of Xenopus laevis. Biochim Biophys Acta. 1997;1354:189-203 pubmed
  31. Morita M, Wang H. Relationship of sulcular sulfide level to severity of periodontal disease and BANA test. J Periodontol. 2001;72:74-8 pubmed
    ..Hence, the aims of this study were to: 1) examine the relationship between sulcular sulfide (pS) levels and severity of periodontal disease and 2) examine the link between pS level and the BANA (benzoyl-DL-arginine-naphthylamide) test...
  32. Asano T, Kushida H, Sadakane C, Ishihara K, Wakui Y, Yanagisawa T, et al. Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001;24:678-82 pubmed
    ..We concluded that these in vitro inhibitions of cephaeline and emetine would hardly increase plasma concentrations of co-administered drugs in clinical therapy. ..
  33. Nomura T. [Chemistry and biosynthesis of prenylflavonoids]. Yakugaku Zasshi. 2001;121:535-56 pubmed
    ..Furthermore, the prenylphenols isolated from licorice were summarized according to the origin of the materials. ..
  34. Nagayama S, Jono H, Suzaki H, Sakai K, Tsuruya E, Yamatsu I, et al. Carbenoxolone, a new inducer of heat shock protein 70. Life Sci. 2001;69:2867-73 pubmed
    ..We assessed here whether carbenoxolone induces Hsp70 expression in human cell lines. We found that carbenoxolone increased the expression of Hsp70 protein and mRNA, and Hsp70 promoter activity. ..
  35. Mizutani J, Fukuoka M, Tsubouchi S, Otsuka T, Tono Y, Shimizu S, et al. A rare case of lumbosacral meningioma: nondural attachment and possible enlargement by orally administered sex steroid. Spine (Phila Pa 1976). 2002;27:E377-81 pubmed
    ..Care must be taken in the management of lumbosacral intradural tumors because tumors resembling neurilemmoma may in fact represent meningioma, some subtypes of which possess a high rate of recurrence. ..
  36. Kuno Sakai H, Kimura M. Safety and efficacy of acellular pertussis vaccine in Japan, evaluated by 23 years of its use for routine immunization. Pediatr Int. 2004;46:650-5 pubmed
    ..With the use of acellular pertussis vaccine which has been accepted by the public, pertussis has been well controlled in Japan. ..
  37. Yoshida K. Cell-cycle-dependent regulation of the human and mouse Tome-1 promoters. FEBS Lett. 2005;579:1488-92 pubmed
  38. Ikeuchi M, Takahashi T, Tani T. Localized synovial hypertrophy in the anteromedial compartment of the osteoarthritic knee. Arthroscopy. 2005;21:1457-61 pubmed
    ..Arthroscopic partial synovectomy was effective, especially for those who complained of intraoperative pain during synovectomy under local anesthesia. Level IV. ..
  39. Ushiro Y, Hashimoto O, Seki M, Hachiya A, Shoji H, Hasegawa Y. Analysis of the function of activin betaC subunit using recombinant protein. J Reprod Dev. 2006;52:487-95 pubmed
    ..This suggests that activin betaC subunit may have been present and that it may exert its effect as inhibin C. ..
  40. Wakitani S, Nawata M, Kawaguchi A, Okabe T, Takaoka K, Tsuchiya T, et al. Serum keratan sulfate is a promising marker of early articular cartilage breakdown. Rheumatology (Oxford). 2007;46:1652-6 pubmed
    ..084). The serum concentration of KS correlated with the damage of the articular cartilage and it was significantly increased even at an early stage after the injury. ..
  41. Kaneyama K, Segami N, Hatta T. Congenital deformities and developmental abnormalities of the mandibular condyle in the temporomandibular joint. Congenit Anom (Kyoto). 2008;48:118-25 pubmed publisher
    ..In addition, the molecular-based etiology of anomalies of the mandibular condyle is also discussed...
  42. Inoue M, Kamikubo H, Kataoka M, Kato R, Yoshimori T, Wakatsuki S, et al. Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B. Traffic. 2008;9:2180-9 pubmed publisher
    ..ATP hydrolysis would eliminate this interaction and subsequent nucleotide release causes the domains to rotate, which together lead to the disassembly of the SKD1 oligomer. ..
  43. Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, et al. Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2010;30:1598-605 pubmed publisher
    ..These effects may induce antiatherogenic effects in hypertensive patients. ..
  44. Satoh J. MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains. J Pharmacol Sci. 2010;114:269-75 pubmed
    ..This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains. ..
  45. Kimura Y, Sumiyoshi M. Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. Eur J Pharmacol. 2011;661:124-32 pubmed publisher
    ..Furthermore, the inhibitory effects of baicalein on UVB-irradiated hyperplasia of skin epidermis may be due to the stimulation of HIF-1? expression. ..
  46. Kyo S, Maida Y, Inoue M. Stem cells in endometrium and endometrial cancer: accumulating evidence and unresolved questions. Cancer Lett. 2011;308:123-33 pubmed publisher
    ..These studies help us to understand the mechanisms of endometrial regeneration as well as endometrial carcinogenesis and will hopefully help in establishing novel molecular-based cancer therapies targeting stem cells. ..
  47. Harada M, Inoue T, Hamano K. Choriocarcinoma of the sigmoid colon: report of a case. Surg Today. 2012;42:93-6 pubmed publisher
    ..Radical surgery combined with chemotherapy gives the best chance of long-term survival...
  48. Hirakawa M, Fukada H, Tsukawaki R, Higuchi M. [Studies regarding the goals of indirect request]. Shinrigaku Kenkyu. 2012;82:532-9 pubmed
    ..Therefore, we concluded that these four goals which have positive effects are reasonable goals for indirect requests. ..
  49. Saheki T, Inoue K, Ono H, Katsura N, Yokogawa M, Yoshidumi Y, et al. Effects of supplementation on food intake, body weight and hepatic metabolites in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse model of human citrin deficiency. Mol Genet Metab. 2012;107:322-9 pubmed publisher
  50. Shioi Y, Nakamura S, Kawamura S, Kasami M. Nipple adenoma arising from axillary accessory breast: a case report. Diagn Pathol. 2012;7:162 pubmed publisher
    ..The virtual slide(s) for this article can be found here: ..
  51. Watanabe K, Nagata N, Shimbo T, Nakashima R, Furuhata E, Sakurai T, et al. Accuracy of endoscopic diagnosis of Helicobacter pylori infection according to level of endoscopic experience and the effect of training. BMC Gastroenterol. 2013;13:128 pubmed publisher
    ..We identified the diagnostic yield of endoscopy for H. pylori infection at various endoscopist career levels and the effect of two years of training on diagnostic yield...
  52. Kasama S, Toyama T, Sato M, Sano H, Ueda T, Sasaki T, et al. Prognostic value of myocardial perfusion single photon emission computed tomography for major adverse cardiac cerebrovascular and renal events in patients with chronic kidney disease: results from first year of follow-up of the Gunma-CKD SPECT multic. Eur J Nucl Med Mol Imaging. 2016;43:302-11 pubmed publisher
    ..05). Patients with low eGFR and high SDS had a significantly higher MACCRE rate than the other subgroups (p < 0.05). Myocardial perfusion SPECT can provide reliable prognostic markers for patients with CKD. ..
  53. Ito S, Iwasaki A, Syundo J, Tamura Y, Kishi S, Mori H, et al. Characterization of antibody against human liver guanase by immunoblotting and immunohistochemical staining of human liver guanase by a direct labeling antibody-enzyme method. J Histochem Cytochem. 1989;37:611-5 pubmed
    ..In tissue sections, the immunohistochemical reaction with this antibody was positive in the same locations as the histochemical guanase reaction with DAB (3,3'-diaminobenzidine tetrahydrochloride). ..
  54. Hashimoto S, Tsukada S, Matsushita M, Miyawaki T, Niida Y, Yachie A, et al. Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan. Blood. 1996;88:561-73 pubmed
    ..The protein analysis also clarified the different effects of missense mutations on kinase activity and protein stability. ..
  55. Karim M, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, et al. Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Genomics. 1996;31:167-76 pubmed
    ..Fluorescence in situ hybridization, using cDNA and a genome DNA fragment of the ESP1/CRP2 as probes, confirms this assignment and relegates regional localization to band 14q32.3. ..
  56. Sugiuchi H, Irie T, Uji Y, Ueno T, Chaen T, Uekama K, et al. Homogeneous assay for measuring low-density lipoprotein cholesterol in serum with triblock copolymer and alpha-cyclodextrin sulfate. Clin Chem. 1998;44:522-31 pubmed
    ..There was a good correlation between the results of LDL-C assayed by the proposed method and the beta-quantification reference method involving 161 sera with triglyceride concentrations ranging from 0.3 to 22.6 mmol/L. ..
  57. Sadik G, Kaji H, Takeda K, Yamagata F, Kameoka Y, Hashimoto K, et al. In vitro processing of amyloid precursor protein by cathepsin D. Int J Biochem Cell Biol. 1999;31:1327-37 pubmed
    ..However, our results suggest that cathepsin D could generate the pathogenic beta A4 amyloid peptides from its precursor in vitro, which may indicate a role in the amyloidogenesis of Alzheimer's disease. ..
  58. Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T. The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1. Mol Cell. 1999;4:793-803 pubmed
    ..Sequence analysis based on the structure suggests that the ACC finger fold is widespread in Rho effector proteins. ..
  59. Wada N, Seki M, Saikawa Y, Satoh M, Toizumi A, Tamura Y, et al. Jejunal limb obstruction caused by a cholesterol stone 15 years after a total gastrectomy and 20 years after a cholecystectomy: report of a case. Surg Today. 2000;30:181-4 pubmed
    ..This report is thought to be the first to describe jejunal limb obstruction caused by a gallstone incarcerated in the jejunal limb after a total gastrectomy in a patient with a history of cholecystectomy. ..
  60. Yuasa H, Tanaka H, Hayashi T, Wakita T, Nakamura H, Nishioka J, et al. Bovine protein C inhibitor has a unique reactive site and can transiently inhibit plasmin. Thromb Haemost. 2000;83:262-7 pubmed
    ..These findings suggest that bovine PCI plays a role not only in the protein C pathway but also in the fibrinolytic activity of bovine hemostatic system. ..
  61. Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Habata Y, Hinuma S, et al. Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J Biol Chem. 2000;275:21068-74 pubmed
    ..The identification of a specific and functional receptor for neuromedin U will facilitate studies on their physiological roles and the search for receptor agonists and antagonists. ..
  62. Saito M, Kinishi M, Amatsu M. Acoustic analyses clarify voiced-voiceless distinction in tracheoesophageal speech. Acta Otolaryngol. 2000;120:771-7 pubmed
    ..TE speakers with low intelligibility of [p] had lower values of VOT during [p] production compared with those with high intelligibility. It is concluded that these characteristic acoustic cues reflect voicing ability in TE speech. ..
  63. Nishiyama T, Sugenoya J, Matsumoto T, Iwase S, Mano T. Irregular activation of individual sweat glands in human sole observed by a videomicroscopy. Auton Neurosci. 2001;88:117-26 pubmed
    ..the activity of each sweat gland may fluctuate temporally as the result of irregular activation of sudomotor fibers and possibly some intrinsic factors of the gland...
  64. Miyamoto C, Yashiro S, Nagata Y, Nagataki S. [Ocular complications in patients infected with human immunodeficiency virus seen at the Acquired Immunodeficiency Syndrome Clinical Center]. Nippon Ganka Gakkai Zasshi. 2001;105:483-7 pubmed
    ..To examine the ocular complications in patients infected with human immunodeficiency virus(HIV) in Japan...
  65. Takeuchi T, Ohtsuki Y. Recent progress in T-cadherin (CDH13, H-cadherin) research. Histol Histopathol. 2001;16:1287-93 pubmed publisher
    ..In this manuscript, we review current advances in T-cadherin research. ..
  66. Yui N, Ooya T, Kawashima T, Saito Y, Tamai I, Sai Y, et al. Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter. Bioconjug Chem. 2002;13:582-7 pubmed
    ..Therefore, our data clearly suggests that supramolecular structure in the polyrotaxane conjugates contributes considerably to the inhibitory effect via multivalent binding of Val-Lys groups with hPEPT1. ..
  67. Murakami M, Ikeda T, Ogawa K, Funaba M. Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor. Biochem Biophys Res Commun. 2003;311:4-10 pubmed
    ..In addition, not only other MITF isoforms but also TFE3, another member of the family, activated mMCP-9 transcription through this nucleotide sequence inserted one base within the E-box. ..
  68. Noji Y, Shimizu M, Ino H, Higashikata T, Yamaguchi M, Nohara A, et al. Increased circulating matrix metalloproteinase-2 in patients with hypertrophic cardiomyopathy with systolic dysfunction. Circ J. 2004;68:355-60 pubmed
    ..These results suggest that changes in the release and activity of MMP-2 and TIMP-2 may be associated with the mechanisms responsible for cardiac remodeling in patients with HCM. ..
  69. Tamaki M, Saito R, Ogawa O, Yoshimura N, Ueda T. Possible mechanisms inducing glomerulations in interstitial cystitis: relationship between endoscopic findings and expression of angiogenic growth factors. J Urol. 2004;172:945-8 pubmed
    ..Thus, it seems likely that neovascularization promoted by angiogenic growth factors has an important role in the pathogenesis of IC, inducing glomerulations during hydrodistension. ..
  70. Yoshimura D, Ohwaki I, Akashi T, Kitamura Y, Ihara E, Ochiai T, et al. [Intestinal tuberculosis of the terminal ileum causing obstructive ileus and tuberculous peritonitis and presenting numerous peritoneal small red nodules: a case report]. Nihon Shokakibyo Gakkai Zasshi. 2008;105:1213-9 pubmed
    ..Histopathological examination revealed ileal tuberculosis causing ulcerative stricture, and mesenteric tuberculous lymphadenitis. The small red nodules were formed of hemorrhagic tuberculous nodules...
  71. Islam M, Tsuji N, Miyoshi T, Alim M, Huang X, Hatta T, et al. The Kunitz-like modulatory protein haemangin is vital for hard tick blood-feeding success. PLoS Pathog. 2009;5:e1000497 pubmed publisher
    ..Moreover, our results provide novel insights into the blood-feeding strategies that enable hard ticks to persistently feed and ensure full blood-meals through the modulation of angiogenesis and wound healing processes. ..
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