Experts and Doctors on humans in Japan


Locale: Japan
Topic: humans

Top Publications

  1. Kano M, Fukao T, Yamaguchi S, Orii T, Osumi T, Hashimoto T. Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene. Gene. 1991;109:285-90 pubmed
    ..A CAT assay revealed that a 101-bp DNA fragment immediately upstream from the cap site has promoter activity, and suggested that a DNA fragment from bp -888 to -102 probably contains a negative regulatory element(s). ..
  2. Fukuyama Y, Nihei K, Matsumoto S, Ebina T, Kamoshita S, Sato T, et al. Clinical effects of MND-19 (Inosiplex) on subacute sclerosing panencephalitis--a multi-institutional collaborative study--The Inosiplex-SSPE Research Committee. Brain Dev. 1987;9:270-82 pubmed
    ..The measles virus antibody titer was in no way affected in the former group. Side effects of MND-19 were observed in 17 of the 89 treated cases (19.1%)...
  3. Eizuru Y, Minamishima Y. Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts. Intervirology. 1988;29:339-45 pubmed
    ..These included one laboratory strain (GR2757), four fresh isolates from primary kidney cell cultures of African green monkeys, and four fresh isolates from the salivary glands of the Macaca monkeys captured from the wild in Japan. ..
  4. Akiyama K, Nagao K, Oshida T, Tsutsui K, Yoshida M, Seki S. Cloning, sequence analysis, and chromosomal assignment of the mouse Apex gene. Genomics. 1995;26:63-9 pubmed
    ..The 0.8-kb region from position -410 (5' flanking region) to position +386 (intron II) contains a CpG island. The Apex gene locus was mapped to mouse chromosome 14C2-D1 using in situ hybridization. ..
  5. Nenoi M, Mita K, Ichimura S, Cartwright I. Novel structure of a Chinese hamster polyubiquitin gene. Biochim Biophys Acta. 1994;1204:271-8 pubmed
    ..The two genes, and their respective transcripts, differ in size because of variation in the relative number of repeating ubiquitin coding units. ..
  6. Takano H, Onodera O, Tanaka H, Mori H, Sakimura K, Hori T, et al. Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel. Biochem Biophys Res Commun. 1993;197:922-6 pubmed
    ..By the fluorescence in situ hybridization, we mapped the genes for the epsilon 1, epsilon 3 and zeta 1 subunits of the human NMDA receptor channel to chromosomes 16p13, 17q25 and 9q34, respectively. ..
  7. Yamada M, Sodeyama N, Itoh Y, Suematsu N, Otomo E, Matsushita M, et al. Association of presenilin-1 polymorphism with cerebral amyloid angiopathy in the elderly. Stroke. 1997;28:2219-21 pubmed
    ..A significant decrease of PS-1 2/2 genotype frequency was associated with severe or moderate CAA. Our results suggest that PS-1 intronic polymorphism may be associated with the severity of CAA in the elderly. ..
  8. Fujino T, Nagata Y. HTLV-I transmission from mother to child. J Reprod Immunol. 2000;47:197-206 pubmed
    ..The placenta can be infected by HTLV-I, but infection does not reach the fetus, possibly apoptosis of placental villous cells because it is induced by HTLV-I infection. ..
  9. Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R. SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen. J Biochem. 2003;133:271-7 pubmed
    ..Our results provide a basis for understanding the scavenger function of SRCL as to carbohydrate-containing ligands. ..

More Information

Publications1170 found, 100 shown here

  1. Sugimoto R, Kumagai Y, Nakai Y, Ishii T. 9,10-Phenanthraquinone in diesel exhaust particles downregulates Cu,Zn-SOD and HO-1 in human pulmonary epithelial cells: intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis. Free Radic Biol Med. 2005;38:388-95 pubmed
    ..The present findings suggest that PQ causes iron-mediated oxidative damage that is exacerbated by the concomitant down-regulation of Cu,Zn-SOD. ..
  2. Kataoka M, Fukura Y, Shinohara Y, Baba Y. Analysis of mitochondrial membrane potential in the cells by microchip flow cytometry. Electrophoresis. 2005;26:3025-31 pubmed
    ..0 microM DiOC(6)(3) was observed after treatment with 10 microM FCCP for 30 min. These results indicate that the Agilent 2100 bioanalyzer is potentially useful for monitoring DeltaPsi(m) in cell assays. ..
  3. Yamazaki K, McGovern D, Ragoussis J, Paolucci M, Butler H, Jewell D, et al. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet. 2005;14:3499-506 pubmed
    ..Our results suggest that the genetic variations in the TNFSF15 gene contribute to the susceptibility to IBD in the Japanese and European populations. ..
  4. Honda M, Ogura Y, Toyoda W, Taguchi M, Nozawa T, Inoue H, et al. Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers. Biol Pharm Bull. 2006;29:772-8 pubmed
    ..On the other hand, CYP2C9*3, CYP2C19*2, CYP2C19*3, CYP3A5*3, UGT2B7*2, and MDR1 C3435T did not significantly affect the pharmacokinetics of carvedilol in Japanese subjects. ..
  5. Miyata K, Nakayama M, Mizuta S, Hokimoto S, Sugamura K, Oshima S, et al. Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. Biochem Biophys Res Commun. 2008;365:207-13 pubmed
  6. Ishihara T, Goto M, Kodera K, Kanazawa H, Murakami Y, Mizushima Y, et al. Intracellular delivery of siRNA by cell-penetrating peptides modified with cationic oligopeptides. Drug Deliv. 2009;16:153-9 pubmed publisher
    ..These different properties of CPPs emphasize the importance of careful peptide selection and design when attempting the application of CPP technology. ..
  7. Matsumoto K, Zhao Q, Niu Y, Fujiwara H, Tanaka K, Sasaki Hamada S, et al. Kampo formulations, chotosan, and yokukansan, for dementia therapy: existing clinical and preclinical evidence. J Pharmacol Sci. 2013;122:257-69 pubmed
    ..Further studies are needed to clarify the active ingredients of these formulae and their target endogenous molecules implicated in the anti-dementia drug-like actions. ..
  8. Morishima Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, et al. Hyperphosphorylation of tau in PHF. Neurobiol Aging. 1995;16:365-71; discussion 371-80 pubmed
    ..This extraphosphorylation may provide PHF-tau with the unusual characteristics including assembly incompetence. ..
  9. Imai K, Yokohama Y, Nakanishi I, Ohuchi E, Fujii Y, Nakai N, et al. Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties. J Biol Chem. 1995;270:6691-7 pubmed
    ..These results suggest that in vivo MMP-7 may play a role in degradation of extracellular matrix macromolecules in concert with MMP-1, -3, and -9 under pathological conditions. ..
  10. Kikkawa M, Nakamura T, Sakamoto K, Sugihara H, Azuma A, Sawada T, et al. Assessment of left ventricular diastolic function from quantitative electrocardiographic-gated 99mTc-tetrofosmin myocardial SPET. Eur J Nucl Med. 2001;28:593-601 pubmed
    ..Also, this program will be useful for detecting LV diastolic dysfunction in various cardiac diseases before LV systolic dysfunction becomes evident. ..
  11. Bassuny W, Ihara K, Kimura J, Ichikawa S, Kuromaru R, Miyako K, et al. Association study between interleukin-12 receptor beta1/beta2 genes and type 1 diabetes or asthma in the Japanese population. Immunogenetics. 2003;55:189-192 pubmed publisher
    ..Further analysis in individuals with susceptibility to intracellular pathogens may elucidate the importance of the IL-12R genes. ..
  12. Yanagisawa O, Miyanaga Y, Shiraki H, Shimojo H, Mukai N, Niitsu M, et al. The effects of various therapeutic measures on shoulder strength and muscle soreness after baseball pitching. J Sports Med Phys Fitness. 2003;43:189-201 pubmed
    ..The findings of this study suggested that ILSE was the optimal therapeutic measure against decreased shoulder strength or increased shoulder muscle soreness resulting from the repetitive baseball pitching. ..
  13. Ahmed A, Kawamoto H, Inouye K, Hashiwata Y, Sakaki M, Seno M, et al. Genomic analysis of a multidrug-resistant strain of enterohaemorrhagic Escherichia coli O157:H7 causing a family outbreak in Japan. J Med Microbiol. 2005;54:867-72 pubmed
    ..To the authors' knowledge, this is the first report of the identification of a beta-lactamase gene in EHEC O157. ..
  14. Yonezawa H, Otagaki Y, Miyake Y, Okamoto Y, Yamawaki S. No differences are seen in the regional cerebral blood flow in the restricting type of anorexia nervosa compared with the binge eating/purging type. Psychiatry Clin Neurosci. 2008;62:26-33 pubmed publisher
    ..There were no significant differences in cerebral blood flow between patients with AN-R and AN-BP. Abnormalities of the neuronal circuits containing the SCG, midbrain and PCG are possibly relevant to trait-related AN. ..
  15. Takenaga M, Ohta Y, Tokura Y, Hamaguchi A, Shudo K, Okano H, et al. The effect of Am-80, a synthetic retinoid, on spinal cord injury-induced motor dysfunction in rats. Biol Pharm Bull. 2009;32:225-31 pubmed
    ..Its efficacy may be partly ascribed to promotion of cell viability and differentiation of neural stem cells through increased TrkB expression. ..
  16. Ishikawa Y, Miyakoshi N, Kasukawa Y, Hongo M, Shimada Y. Spinal curvature and postural balance in patients with osteoporosis. Osteoporos Int. 2009;20:2049-53 pubmed publisher
    ..417-0.551, p < 0.001). Lumbar kyphosis, but not thoracic kyphosis, affecting spinal inclination and postural balance may represent a risk factor for falls. ..
  17. Moi M, Lim C, Kotaki A, Takasaki T, Kurane I. Development of an antibody-dependent enhancement assay for dengue virus using stable BHK-21 cell lines expressing Fc gammaRIIA. J Virol Methods. 2010;163:205-9 pubmed publisher
    ..The new ADE assay using BHK-Fc gammaRIIA cells is simple and practical, and is useful for defining the role of ADE in the pathogenesis of DENV infection. ..
  18. Tsolmon S, Han J, Isoda H. Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells. J Biosci Bioeng. 2010;110:262-8 pubmed publisher
    ..Moreover, differentiation marker CD11b was also expressed in the treated cells...
  19. Ishii K, Inaba Y, Mochida Y, Saito T. Good long-term outcome of synovectomy in advanced stages of the rheumatoid elbow. Acta Orthop. 2012;83:374-8 pubmed publisher
    ..Our findings suggest that synovectomy for the rheumatoid elbow gives a good long-term outcome for radiographically judged destroyed joints of Larsen grades 3-4. ..
  20. Murata A, Baba Y, Watanabe M, Shigaki H, Miyake K, Ishimoto T, et al. Methylation levels of LINE-1 in primary lesion and matched metastatic lesions of colorectal cancer. Br J Cancer. 2013;109:408-15 pubmed publisher
    ..Alteration of LINE-1 methylation level may occur in early CRC tumorigenesis, and the LINE-1 methylation level is relatively stable during CRC progression. ..
  21. Akashi M, Sakamoto S, Ohta M, Kitagawa S, Yoshida M, Saito M, et al. Treatment of multiple myeloma with carboquone-prednisolone. Eur J Haematol. 1989;42:265-9 pubmed
    ..Further clinical trials should be conducted to establish a new drug combination in which CQ is included. ..
  22. Kozasa T, Itoh H, Tsukamoto T, Kaziro Y. Isolation and characterization of the human Gs alpha gene. Proc Natl Acad Sci U S A. 1988;85:2081-5 pubmed
    ..In the 5' flanking region, there are several blocks of sequences that are similar to the sequences of the 5' flanking region of the human c-Ki-ras2 gene. ..
  23. Miyazaki M, Shirataki H, Kohno H, Kaibuchi K, Tsugita A, Takai Y. Identification as beta-adducin of a protein interacting with rabphilin-3A in the presence of Ca2+ and phosphatidylserine. Biochem Biophys Res Commun. 1994;205:460-6 pubmed
    ..The Rabphilin-3A-interacting protein also binds to protein kinase C in the presence of Ca2+ and phosphatidylserine. These results indicate that Rabphilin-3A binds to beta-adducin in the presence of Ca2+ and phosphatidylserine. ..
  24. Itami A, Ando I, Kukita A. Perforating lichen nitidus. Int J Dermatol. 1994;33:382-4 pubmed
    ..At the lateral margin of the infiltrate, rete ridges extended downward in the manner of a claw clutching a ball. In a periodic-acid-Schiff (PAS)-stained section, a basement defect was observed around the channel. ..
  25. Kobayashi E, Tachibana M, Ikadai H, Kunieda T. Localization of a Na+,K(+)-ATPase alpha 2 subunit gene, Atp1a2, on rat chromosome 13. Mamm Genome. 1995;6:889 pubmed
  26. Toki T, Itoh J, Kitazawa J, Arai K, Hatakeyama K, Akasaka J, et al. Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. Oncogene. 1997;14:1901-10 pubmed
    ..The results suggest that the small Maf family proteins function in human cells through interaction with various basic-leucine zipper-type transcription factors. ..
  27. Tsubokawa M, Tohyama Y, Tohyama K, Asahi M, Inazu T, Nakamura H, et al. Interleukin-3 activates Syk in a human myeloblastic leukemia cell line, AML193. Eur J Biochem. 1997;249:792-6 pubmed
    ..Since the IL-3 receptor beta subunit is known to mediate growth signaling, our results indicate that Syk may be involved in the proliferation of myeloid cells. ..
  28. Simamura E, Hirai K, Shimada H, Koyama J. Apoptosis and epithelial phagocytosis in mitomycin C-treated human pulmonary adenocarcinoma A549 cells. Tissue Cell. 2001;33:161-8 pubmed
    ..These results indicate that mitomycin C induces apoptosis in A549 cells and concurrently stimulates epithelial phagocytotic activity against their own damaged cells...
  29. Ishiguro H, Okubo Y, Ohtsuki T, Yamakawa Kobayashi K, Arinami T. Mutation analysis of the retinoid X receptor beta, nuclear-related receptor 1, and peroxisome proliferator-activated receptor alpha genes in schizophrenia and alcohol dependence: possible haplotype association of nuclear-related receptor 1 gene to al. Am J Med Genet. 2002;114:15-23 pubmed
  30. Tonooka N, Tomura H, Takahashi Y, Onigata K, Kikuchi N, Horikawa Y, et al. High frequency of mutations in the HNF-1alpha gene in non-obese patients with diabetes of youth in Japanese and identification of a case of digenic inheritance. Diabetologia. 2002;45:1709-12 pubmed
    ..A considerable number of non-obese Japanese patients with non-Type 1 diabetes of youth have HNF-1alpha-deficient diabetes. Lack of obesity could well be a characteristic feature of this form of diabetes. ..
  31. Katoh M, Katoh M. Identification and characterization of human FNBP1L gene in silico. Int J Mol Med. 2004;13:157-62 pubmed
    ..11-q34.13. This is the first report on comprehensive characterization of FNBP1L, which is predicted to function as a scaffold protein for microtubule, Rho family proteins, Formin-homology proteins and WAPS family proteins. ..
  32. Taniguchi A, Urano W, Yamanaka M, Yamanaka H, Hosoyamada M, Endou H, et al. A common mutation in an organic anion transporter gene, SLC22A12, is a suppressing factor for the development of gout. Arthritis Rheum. 2005;52:2576-7 pubmed
  33. Kamitani S, Tsutamoto Y, Hanasawa K, Tani T. Laparoscopic cholecystectomy in situs inversus totalis with "inferior" cystic artery: a case report. World J Gastroenterol. 2005;11:5232-4 pubmed
    ..Laparoscopic surgeon should be careful for view of reversed relationships and also existence of other anomalies. ..
  34. Yamamoto H, Tani Y, Kobayashi K, Taketani Y, Sato T, Arai H, et al. Alternative promoters and renal cell-specific regulation of the mouse type IIa sodium-dependent phosphate cotransporter gene. Biochim Biophys Acta. 2005;1732:43-52 pubmed
    ..These data suggested that two alternative promoters control the renal expression of Npt2a gene and both Npt2a variant transcripts are down regulated in Hyp mice. ..
  35. Watanabe J, Minami M, Kobayashi M. Antitumor activity of TZT-1027 (Soblidotin). Anticancer Res. 2006;26:1973-81 pubmed
    ..TZT-1027 (Soblidotin), a newly synthesized dolastatin 10 derivative that depolymerizes microtubules, has potent antitumor activity...
  36. Tanaka E, Maruyama H, Morino H, Nakajima E, Kawakami H. The CNTN4 c.4256C>T mutation is rare in Japanese with inherited spinocerebellar ataxia. J Neurol Sci. 2008;266:180-1 pubmed
    ..Mutations in other populations should be analyzed. Pathological examinations and molecular biological examinations are needed to confirm that this mutation is a true cause of SCA16. ..
  37. Koda A, Wakida N, Toriyama K, Yamamoto K, Iijima H, Tomita K, et al. Urinary prostasin in humans: relationships among prostasin, aldosterone and epithelial sodium channel activity. Hypertens Res. 2009;32:276-81 pubmed publisher
    ..However, it is not clear, at the present time, whether endogenous aldosterone regulates prostasin expression or vice versa. ..
  38. Miura K, Ono H, Endou H, Nagata T, Kougo M, Oono M, et al. [Treatment of a persistent postoperative chylothorax with octreotide]. Kyobu Geka. 2009;62:885-7 pubmed
    ..In this study, we report a patient with refractory chylothorax in whom treatment with octreotide acetate was successful, although the chylorrhea site could not be determined during additional thoracotomy...
  39. Yamaji K, Okamoto T, Yokota S, Watanabe A, Horikoshi Y, Asami K, et al. Minimal residual disease-based augmented therapy in childhood acute lymphoblastic leukemia: a report from the Japanese Childhood Cancer and Leukemia Study Group. Pediatr Blood Cancer. 2010;55:1287-95 pubmed publisher
    ..These results suggest that augmented therapy for MRD-positive patients at TP2 contributed to better outcomes of the ALL2000 study. ..
  40. Tamaki S, Kawakami M, Ishitani A, Kawashima W, Kasuda S, Yamanaka Y, et al. Soluble MICB serum levels correlate with disease stage and survival rate in patients with oral squamous cell carcinoma. Anticancer Res. 2010;30:4097-101 pubmed
    ..Serum levels of soluble MICA have been shown to be of diagnostic significance in malignant diseases...
  41. Kitada M, Ozawa K, Sato K, Matsuda Y, Hayashi S, Tokusashi Y, et al. Alpha-fetoprotein-producing primary lung carcinoma: a case report. World J Surg Oncol. 2011;9:47 pubmed publisher
    ..As of this writing, no sign of tumor recurrence has been noted. This case is presented here with a review of the literature. ..
  42. Nakahashi W, Wakano J, Henrich J. Adaptive social learning strategies in temporally and spatially varying environments : how temporal vs. spatial variation, number of cultural traits, and costs of learning influence the evolution of conformist-biased transmission, payoff-biased trans. Hum Nat. 2012;23:386-418 pubmed publisher
    ..Throughout we emphasize how our models generate empirical predictions suitable for laboratory testing. ..
  43. Sasaki T, Tanabe S, Ishido K, Azuma M, Katada C, Higuchi K, et al. Recommended sedation and intraprocedural monitoring for gastric endoscopic submucosal dissection. Dig Endosc. 2013;25 Suppl 1:79-85 pubmed publisher
    ..Endoscopists should become more familiar with sedatives, analgesics, and emergency procedures in the future. ..
  44. Makino Y, Shimofusa R, Hayakawa M, Yajima D, Inokuchi G, Motomura A, et al. Massive gas embolism revealed by two consecutive postmortem computed-tomography examinations. Forensic Sci Int. 2013;231:e4-10 pubmed publisher
    ..Our findings also indicate that performance of two PMCT examinations may be useful for differentiation of embolized gas from gas produced by putrefaction. ..
  45. Nakagawa T, Hosaka M, Torii S, Watanabe T, Murakami K, Nakayama K. Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. J Biochem. 1993;113:132-5 pubmed
    ..These observations suggest that PC6 is a candidate for a processing endoprotease responsible for the maturation of gastrointestinal peptides. ..
  46. Fukuda M, Kojima T, Kabayama H, Mikoshiba K. Mutation of the pleckstrin homology domain of Bruton's tyrosine kinase in immunodeficiency impaired inositol 1,3,4,5-tetrakisphosphate binding capacity. J Biol Chem. 1996;271:30303-6 pubmed
    ..Our data suggest that B cell differentiation is closely correlated with the IP4 binding capacity of the PH domain of Btk. ..
  47. Amasaki Y, Adachi S, Ishida Y, Iwata M, Arai N, Arai K, et al. A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells. J Biol Chem. 2002;277:25640-8 pubmed
    ..Our data suggest that NFATx is involved in the regulation of co-receptor expression during differentiation into the CD4 single-positive stage. ..
  48. Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, et al. Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain. Nat Struct Biol. 2002;9:527-31 pubmed
  49. Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Okada M, et al. Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2006;14:6847-58 pubmed
    ..58 microM. Moreover, 15e was found to be selective for p110alpha over other PI3K isoforms and protein kinases, making it the first example of a selective PI3K p110alpha inhibitor. ..
  50. Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y, Inui H. Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1? in a low androgen environment. J Steroid Biochem Mol Biol. 2011;123:58-64 pubmed publisher
    ..These results indicate that hypoxia leads to HIF-1?-mediated AR transactivation independent of HIF-1 activity and that HIF-1?/ARNT is not necessarily required for the transactivation. ..
  51. Maki S, Aramomi M, Matsuura Y, Furuya T, Ota M, Iijima Y, et al. Paravertebral foramen screw fixation for posterior cervical spine fusion: biomechanical study and description of a novel technique. J Neurosurg Spine. 2017;27:415-420 pubmed publisher
    ..This study suggests that PVFS tend to provide stronger fixation than LMS for initial applications and fixation equal to LMS for salvage applications. If placement of LMS fails, PVFS can serve as a salvage fixation technique. ..
  52. Tomimoto H, Akiguchi I, Wakita H, Suenaga T, Nakamura S, Kimura J. Regressive changes of astroglia in white matter lesions in cerebrovascular disease and Alzheimer's disease patients. Acta Neuropathol. 1997;94:146-52 pubmed
    ..These cytochemical features collectively suggest that clasmatodendritic astroglia incorporate edema fluid and phagocytose cellular debris, and eventually degenerate as a result of cerebral edema...
  53. Tsuji T, Watanabe Y, Katoh H, Sato K, Kunieda T. Cloning and mapping of the mouse Gpx2 gene encoding gastrointestinal glutathione peroxidase. J Vet Med Sci. 1998;60:651-4 pubmed
    ..Linkage analysis using backcross mouse progeny indicated the mouse Cpx2 gene and its pseudogene to be located on mouse chromosomes 12 and 7, respectively. ..
  54. Suzuki Yamamoto T, Nishizawa M, Fukui M, Okuda Ashitaka E, Nakajima T, Ito S, et al. cDNA cloning, expression and characterization of human prostaglandin F synthase. FEBS Lett. 1999;462:335-40 pubmed
    ..These results support the notion that human PGFS plays an important role in the pathogenesis of allergic diseases such as asthma. ..
  55. Inoue M, Ikeda Y, Kikui M, Ogawa T, Yasumitsu T. Mucin-producing tumor of the pancreas associated with pyothorax: report of a case. Surg Today. 2001;31:538-41 pubmed
    ..While MPTP is recognized as a low-grade malignancy, some cases of invasive disease have been reported. To the best of our knowledge, this is the first case of MPTP associated with pyothorax due to fistula formation. ..
  56. Itoh H, Nagano T, Takeyama M. Effect of nizatidine on paracetamol and its metabolites in human plasma. J Pharm Pharmacol. 2002;54:869-73 pubmed
    ..The effects of nizatidine could result from the inhibition of glucuronyltransferase. Thus, care is necessary when paracetamol and nizatidine are coadministered. ..
  57. Imanaka K, Nishimura M, Masuoka A, Ogiwara M, Kato M, Asano H, et al. Lethal thrombus in the carotid artery during operation for acute aortic dissection with cerebral malperfusion. Ann Thorac Surg. 2004;77:1448-9 pubmed
    ..During the subsequent aortic procedure, both arteries were used for arterial inflow. Such thrombi can cause grave postoperative neurologic dysfunction. Carotid artery cannulation is mandatory in such cases. ..
  58. Watanabe J, Kushihata F, Honda K, Sugita A, Tateishi N, Mominoki K, et al. Prognostic significance of Bcl-xL in human hepatocellular carcinoma. Surgery. 2004;135:604-12 pubmed
    ..These results showed Bcl-xL in HCC specimens, suggesting that Bcl-xL was a significant prognostic factor for disease progression in human HCC. ..
  59. Katsuragi N, Nakajima Y, Shiraishi Y, Hashizume M, Takahashi N. [Chronic tuberculous methicillin-resistant Staphylococcus aureus (MRSA) empyema with bronchopleural fistulae treated by open window thoracostomy followed by thoracoplasty and latissimus dorsi muscle transposition]. Kyobu Geka. 2005;58:1121-4 pubmed
    ..A two-stage operation, open window thoracostomy to control infection followed by thoracoplasty and transposition of the latissimus dorsi muscle, is useful in cases of chronic tuberculous MRSA empyema with bronchopleural fistulae. ..
  60. Kaji R, Goto S, Tamiya G, Ando S, Makino S, Lee L. Molecular dissection and anatomical basis of dystonia: X-linked recessive dystonia-parkinsonism (DYT3). J Med Invest. 2005;52 Suppl:280-3 pubmed
    ..Therapeutic intervention may become possible through pharmacological measures that affect gene expression. ..
  61. Tanaka Y, Ota K, Kameoka M, Itaya A, Yoshihara K. Up-regulation of NFkappaB-responsive gene expression by DeltaNp73alpha in p53 null cells. Exp Cell Res. 2006;312:1254-64 pubmed
    ..Taken together, these results demonstrate that TAD-truncated p73alpha can activate NFkappaB. ..
  62. Tsatsralt Od B, Takahashi M, Endo K, Buyankhuu O, Baatarkhuu O, Nishizawa T, et al. Infection with hepatitis A, B, C, and delta viruses among patients with acute hepatitis in Mongolia. J Med Virol. 2006;78:542-50 pubmed
    ..The distribution of HBV genotypes among the 67 HBV isolates was A (1.5%, n = 1) and D (98.5%, n = 66). The present study indicates that de novo infections of HAV, HBV, HCV, and HDV are prevalent among young adults in Mongolia. ..
  63. Kitano K, Yoshihara N, Hakoshima T. Crystal structure of the HRDC domain of human Werner syndrome protein, WRN. J Biol Chem. 2007;282:2717-28 pubmed
    ..Coupled with the unique long linker region in WRN, the WRN HRDC may be adapted to play a distinct function in WRN that involves protein-protein interactions. ..
  64. Takihara Y, Inatani M, Fukushima M, Iwao K, Iwao M, Tanihara H. Trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factors for surgical failure. Am J Ophthalmol. 2009;147:912-8, 918.e1 pubmed publisher
    ..To evaluate the prognostic factors for surgical outcomes of trabeculectomy with mitomycin C (MMC) for neovascular glaucoma (NVG)...
  65. Hiki Y. O-linked oligosaccharides of the IgA1 hinge region: roles of its aberrant structure in the occurrence and/or progression of IgA nephropathy. Clin Exp Nephrol. 2009;13:415-423 pubmed publisher
    ..Clin Ex Nephrol 12:332-338, 2008), this review focuses on the process by which I developed the idea of aberrant O-glycosylation in IgA1 molecules in IgAN patients and summarizes our recent observations concerning IgA1 molecules. ..
  66. Masunami T, Okazaki S, Maekawa H. Decision-making patterns and sensitivity to reward and punishment in children with attention-deficit hyperactivity disorder. Int J Psychophysiol. 2009;72:283-8 pubmed
    ..However, we were unable to specify whether large reward SCRs or small punishment SCRs is generated in ADHD children. ..
  67. Sato K, Seimiya M, Kodera Y, Kitamura A, Nomura F. Application of Fourier-transform infrared (FT-IR) spectroscopy for simple and easy determination of chylomicron-triglyceride and very low density lipoprotein-triglyceride. Clin Chim Acta. 2010;411:285-90 pubmed publisher
    ..Serum chylomicron-TG and VLDL-TG concentrations can be determined with FT-IR spectroscopy. This rapid and simple test may have a great impact on the management of patients with dyslipidemia. ..
  68. Miwa K, Doyama H, Ito R, Nakanishi H, Hirano K, Inagaki S, et al. Can magnifying endoscopy with narrow band imaging be useful for low grade adenomas in preoperative biopsy specimens?. Gastric Cancer. 2012;15:170-8 pubmed publisher
  69. Matsumura T, Saito T, Fujimura H, Shinno S, Sakoda S. Lung inflation training using a positive end-expiratory pressure valve in neuromuscular disorders. Intern Med. 2012;51:711-6 pubmed
    ..Consecutive training can improve lung condition even in advanced cases. Early introduction of PIC training could be effective at preventing respiratory complications in patients with neuromuscular disorders. ..
  70. Srivastava S, Koya D, Kanasaki K. MicroRNAs in kidney fibrosis and diabetic nephropathy: roles on EMT and EndMT. Biomed Res Int. 2013;2013:125469 pubmed publisher
    ..These miRNAs can be utilized as a potential novel drug target for the studying of underlying mechanism and treatment of kidney fibrosis. ..
  71. Kato K, Iwama H, Yamashita T, Kobayashi K, Fujihara S, Fujimori T, et al. The anti-diabetic drug metformin inhibits pancreatic cancer cell proliferation in vitro and in vivo: Study of the microRNAs associated with the antitumor effect of metformin. Oncol Rep. 2016;35:1582-92 pubmed publisher
    ..Our results revealed that metformin inhibits human pancreatic cancer cell proliferation and tumor growth, possibly by suppressing the cell cycle-related molecules via alteration of miRNAs. ..
  72. Muramoto A, Imagama S, Ito Z, Hirano K, Ishiguro N, Hasegawa Y. Spinal sagittal balance substantially influences locomotive syndrome and physical performance in community-living middle-aged and elderly women. J Orthop Sci. 2016;21:216-21 pubmed publisher
    ..SIA is a useful spinal parameter to evaluate the risk of LS, and its cutoff value is 6°. ..
  73. Takanashi Y, Tajima S, Hayakawa T, Neyatani H, Funai K. KRAS mutation-positive bronchial surface epithelium (BSE)-type lung adenocarcinoma with strong expression of TTF-1: a case providing a further insight as for the role of TTF-1 in the oncogenesis. Int J Clin Exp Pathol. 2015;8:15338-43 pubmed
    ..This case is important in that it sheds some light on the largely unknown pathogenic mechanism of BSE-type adenocarcinoma. ..
  74. Maru Y, Peters K, Afar D, Shibuya M, Witte O, Smithgall T. Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS. Mol Cell Biol. 1995;15:835-42 pubmed
    ..These data provide evidence that BCR couples the cytoplasmic protein-tyrosine kinase and RAS signaling pathways. ..
  75. Mineura K, Shioya H, Kowada M, Ogawa T, Hatazawa J, Uemura K. Subependymoma of the septum pellucidum: characterization by PET. J Neurooncol. 1997;32:143-7 pubmed
    ..The tumor showed exceedingly low rates of glucose metabolism (rCMRG1) and kinetic constants (K1, K2, and K3). This hypometabolism indicates low cellular density and slow growth...
  76. Saito T, Endo T, Kawaguchi A, Ikeda M, Nakazato M, Kogai T, et al. Increased expression of the Na+/I- symporter in cultured human thyroid cells exposed to thyrotropin and in Graves' thyroid tissue. J Clin Endocrinol Metab. 1997;82:3331-6 pubmed
    ..The amount of NIS protein was also increased 3.1-fold in Graves' thyroid tissue compared with that in normal thyroid tissue. The increased expression of NIS may thus contribute to the development of Graves' disease. ..
  77. Uchida Y, Maeda Y, Kimura E, Yamashita S, Nishida Y, Arima T, et al. Effective repetitive dystrophin gene transfer into skeletal muscle of adult mdx mice using a helper-dependent adenovirus vector expressing the coxsackievirus and adenovirus receptor (CAR) and dystrophin. J Gene Med. 2005;7:1010-22 pubmed
    ..This result suggests that our new HDAd vector will provide a novel gene therapy strategy for Duchenne muscular dystrophy, raising the prospects for gene therapy of other hereditary myopathies. ..
  78. Oguni A, Umeda M, Shigeta T, Takahashi H, Komori T. The influence of surgical procedure and the effect of chemotherapy on nodal and distant metastases of human malignant melanomas that have been grafted into nude mice. Int J Oral Maxillofac Surg. 2010;39:42-9 pubmed publisher
    ..Prognosis for oral melanoma patients may be better when surgery and postoperative chemotherapy are performed simultaneously without preoperative surgical procedures. ..
  79. Kawazoe N, Inoue C, Tateishi T, Chen G. A cell leakproof PLGA-collagen hybrid scaffold for cartilage tissue engineering. Biotechnol Prog. 2010;26:819-26 pubmed publisher
    ..The cell leakproof PLGA-collagen hybrid scaffolds should be useful for applications in cartilage tissue engineering. ..
  80. Tohyama J, Kato M, Kawasaki S, Harada N, Kawara H, Matsui T, et al. Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient. Am J Med Genet A. 2011;155A:130-3 pubmed publisher
    ..1 might contribute to the dysmorphic facial appearance. A milder phenotype as the Dandy-Walker malformation in our patient supports the idea that modifying loci/genes can influence the development of cerebellar malformation. ..
  81. Liu L, Yang W, Nagahara Y, Li Y, Lamooki S, Muramatsu T, et al. The impact of image resolution on computation of fractional flow reserve: coronary computed tomography angiography versus 3-dimensional quantitative coronary angiography. Int J Cardiovasc Imaging. 2016;32:513-23 pubmed publisher
    ..Acceptable correlation between FFRCTA and FFRQCA was observed, while their agreement in distinguishing functional significant stenosis was moderate. Our results suggest that image resolution has a significant impact on FFR computation. ..
  82. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 1992;258:607-14 pubmed
    ..Such prolonged activation of protein kinase C is essential for long-term cellular responses such as cell proliferation and differentiation. ..
  83. Nagata T, Kato T, Morita T, Nozaki M, Kubota H, Yagi H, et al. Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene. Nucleic Acids Res. 1991;19:2441-7 pubmed
    ..These results indicate that these two mRNAs are transcribed from a single gene and maintained differently during the cell cycle, perhaps to maintain a partially replication-dependent level of histone H2A.X. ..
  84. Sugawa H, Mori T, Imura H. Establishment of 8-azaguanine-resistant mutants from rat thyroid cell line FRTL-5. Mol Cell Endocrinol. 1989;62:319-26 pubmed
  85. Kamada S, Nakano Y, Kakunaga T. Structure of 3'-downstream segment of the human smooth muscle (aortic-type) alpha-actin-encoding gene and isolation of the specific DNA probe. Gene. 1989;84:455-62 pubmed
    ..7-kb RNA transcript in an aortic tissue-specific manner. ..
  86. Matsui Y, Natori S, Obinata M. Isolation of the cDNA clone for mouse glycophorin, erythroid-specific membrane protein. Gene. 1989;77:325-32 pubmed
    ..The glycophorin mRNA is absent in all non-erythroid organs or cell lines examined. The glycophorin mRNA is induced during the differentiation of murine erythroleukemia cells with dimethyl sulfoxide. ..
  87. Ashino J, Okano Y, Suyama I, Yamazaki T, Yoshino M, Furuyama J, et al. Molecular characterization of galactosemia (type 1) mutations in Japanese. Hum Mutat. 1995;6:36-43 pubmed
  88. Haraguchi M, Yamashiro S, Yamamoto A, Takamiya K, Lloyd K, Shiku H, et al. Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. Proc Natl Acad Sci U S A. 1994;91:10455-9 pubmed
    ..The sequence also predicted the presence of a sialyl motif similar to that found in the other sialyltransferases cloned so far. As expected, mRNA of this gene (2.6 kb) was strongly expressed in human melanoma lines. ..
  89. Kitamura K, Ichiki Y, Tanaka M, Kawamoto M, Emura J, Sakakibara S, et al. Immunoreactive adrenomedullin in human plasma. FEBS Lett. 1994;341:288-90 pubmed
    ..Plasma immunoreactive adrenomedullin significantly increased in patients with hypertension, with a progressive rise proportionate to disease severity. ..
  90. Kunieda K, Saji S, Tanaka Y, Katoh M, Fukada D, Shimokawa K. An abdominal desmoid tumor involving the xyphoid and costal chondrium associated with pregnancy: report of a case. Surg Today. 1999;29:927-30 pubmed
    ..There has been no evidence of recurrence in the 6 months since her operation. This case is of interest with regard to the possible contribution of sex hormones, especially estrogen, to desmoid tumor development...
  91. Matsuo T, Yamane T, Ohtsuki H. Heredity versus abnormalities in pregnancy and delivery as risk factors for different types of comitant strabismus. J Pediatr Ophthalmol Strabismus. 2001;38:78-82 pubmed
  92. Kimura N, Shimada N, Fukuda M, Ishijima Y, Miyazaki H, Ishii A, et al. Regulation of cellular functions by nucleoside diphosphate kinases in mammals. J Bioenerg Biomembr. 2000;32:309-15 pubmed
    ..They may have an ability to lead cells to both proliferative and differentiated states by modulating responsiveness to environmental factors, but their fate seems to depend on their surrounding milieu. ..