Genomes and Genes
Experts and Doctors on homeostasis in Israel
- Inbal A, Dardik R. Role of coagulation factor XIII (FXIII) in angiogenesis and tissue repair. Pathophysiol Haemost Thromb. 2006;35:162-5 pubmed..In this review we discuss the role of FXIII in angiogenesis and the molecular mechanisms underlying its pro-angiogenic effect. In addition, FXIII role in wound repair is discussed. ..
- Eisenberg Bord M, Schuldiner M. Mitochatting - If only we could be a fly on the cell wall. Biochim Biophys Acta Mol Cell Res. 2017;1864:1469-1480 pubmed publisher..This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. ..
- Breslavsky A, Frand J, Matas Z, Boaz M, Barnea Z, Shargorodsky M. Effect of high doses of vitamin D on arterial properties, adiponectin, leptin and glucose homeostasis in type 2 diabetic patients. Clin Nutr. 2013;32:970-5 pubmed publisher..This beneficial vascular effect was not associated with improvement in glucose homeostasis parameters. ..
- Levy S, Kafri M, Carmi M, Barkai N. The competitive advantage of a dual-transporter system. Science. 2011;334:1408-12 pubmed publisher..Dual-transporter systems appear to prolong preparation for starvation and to facilitate subsequent recovery, which may optimize sensing of nutrient depletion by integrating internal and external information about nutrient availability. ..
- Katchman H, Tal O, Eventov Friedman S, Shezen E, Aronovich A, Tchorsh D, et al. Embryonic porcine liver as a source for transplantation: advantage of intact liver implants over isolated hepatoblasts in overcoming homeostatic inhibition by the quiescent host liver. Stem Cells. 2008;26:1347-55 pubmed publisher..The marked proliferation and functional maturation exhibited by the pig fetal liver fragments suggests that it could afford a preferable source for transplantation. ..
- Kipnis J, Avidan H, Markovich Y, Mizrahi T, Hauben E, Prigozhina T, et al. Low-dose gamma-irradiation promotes survival of injured neurons in the central nervous system via homeostasis-driven proliferation of T cells. Eur J Neurosci. 2004;19:1191-8 pubmed
- Hart Y, Alon U. The utility of paradoxical components in biological circuits. Mol Cell. 2013;49:213-21 pubmed publisher..In particular, we summarize how paradoxical components can provide robustness, generate temporal pulses, and provide fold-change detection, in which circuits respond to relative rather than absolute changes in signals. ..
- Conacci Sorrell M, Simcha I, Ben Yedidia T, Blechman J, Savagner P, Ben Ze ev A. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol. 2003;163:847-57 pubmed..This autoregulation of E-cadherin by cell-cell adhesion involving Slug, beta-catenin and ERK could be important in tumorigenesis. ..
- Birnberg T, Bar On L, Sapoznikov A, Caton M, Cervantes Barragan L, Makia D, et al. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity. 2008;29:986-97 pubmed publisher..Our data identify a critical role of cDCs in the control of steady-state hematopoiesis, revealing a feedback loop that links peripheral cDCs to myelogenesis through soluble growth factors, such as Flt3 ligand. ..
- Rousso Noori L, Knobler H, Levy Apter E, Kuperman Y, Neufeld Cohen A, Keshet Y, et al. Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab. 2011;13:562-72 pubmed publisher..RPTPe is therefore an inhibitor of hypothalamic leptin signaling in vivo, and provides controlled negative-feedback regulation of this pathway following its activation. ..
- Palty R, Silverman W, Hershfinkel M, Caporale T, Sensi S, Parnis J, et al. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc Natl Acad Sci U S A. 2010;107:436-41 pubmed publisher..Taken together, our results converge to the conclusion that NCLX is the long-sought mitochondrial Na(+)/Ca(2+) exchanger. ..
- Thaiss C, Levy M, Suez J, Elinav E. The interplay between the innate immune system and the microbiota. Curr Opin Immunol. 2014;26:41-8 pubmed publisher..While microbial sensing by pattern-recognition receptors is required for stable microbial composition, the presence of the microbiota, in turn, is necessary for proper development and function of the immune system. ..
- Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, et al. Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat Immunol. 2005;6:1038-46 pubmed..Thus, chemokine translocation across the blood-bone marrow barrier allows effective transfer of functional SDF-1 from the periphery to the stem cell niche in the bone marrow during both homeostasis and 'alarm' situations. ..
- Radomir L, Cohen S, Kramer M, Bakos E, Lewinsky H, Barak A, et al. T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP. J Immunol. 2017;199:2745-2757 pubmed publisher..Thus, naive T cells regulate B cell survival in a SLAMF6- and SAP-dependent manner. ..
- Simsa Maziel S, Zaretsky J, Reich A, Koren Y, Shahar R, Monsonego Ornan E. IL-1RI participates in normal growth plate development and bone modeling. Am J Physiol Endocrinol Metab. 2013;305:E15-21 pubmed publisher..These results suggest that IL-1RI is involved in normal growth plate development and ECM homeostasis and that it is significant in the physiological process of bone modeling. ..
- Faltin Z, Holland D, Velcheva M, Tsapovetsky M, Roeckel Drevet P, Handa A, et al. Glutathione peroxidase regulation of reactive oxygen species level is crucial for in vitro plant differentiation. Plant Cell Physiol. 2010;51:1151-62 pubmed publisher..Our results clearly demonstrate the essential role of ROS in the early stages of in vitro shoot organogenesis and the possible involvement of PHGPx in maintaining ROS homeostasis at this point. ..
- Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, et al. Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc. J Cell Physiol. 2010;224:567-74 pubmed publisher..Our findings support the conclusion that ZHP expression is regulated by crosstalk between synaptic and intracellular pools of Zn(2+). ..
- Pewzner Jung Y, Brenner O, Braun S, Laviad E, Ben Dor S, Feldmesser E, et al. A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy. J Biol Chem. 2010;285:10911-23 pubmed publisher..We propose a functional rationale for the synthesis of sphingolipids with very long acyl chains in liver homeostasis and in cell physiology...
- Rosenwasser S, Graff van Creveld S, Schatz D, Malitsky S, Tzfadia O, Aharoni A, et al. Mapping the diatom redox-sensitive proteome provides insight into response to nitrogen stress in the marine environment. Proc Natl Acad Sci U S A. 2014;111:2740-5 pubmed publisher..We propose that redox regulation of nitrogen metabolism allows rapid metabolic plasticity to ensure cellular homeostasis, and thus is essential for the ecological success of diatoms in the marine ecosystem. ..
- Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, et al. p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2017;31:959-972 pubmed publisher..Hence, p53 helps maintain DNA methylation homeostasis and clonal homogeneity, a function that may contribute to its tumor suppressor activity. ..
- Napoletano F, Gibert B, Yacobi Sharon K, Vincent S, Favrot C, Mehlen P, et al. p53-dependent programmed necrosis controls germ cell homeostasis during spermatogenesis. PLoS Genet. 2017;13:e1007024 pubmed publisher..Drosophila and mouse spermatogenesis will thus be useful models to identify inducers of necrosis to treat cancers that are refractory to apoptosis. ..
- Padan E, Schuldiner S. Molecular physiology of the Na+/H+ antiporter in Escherichia coli. J Exp Biol. 1994;196:443-56 pubmed..5. Mutating all the histidines of NhaA shows that His-226 is part of the 'pH sensor' of NhaA. ..
- Pewzner Jung Y, Park H, Laviad E, Silva L, Lahiri S, Stiban J, et al. A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem. 2010;285:10902-10 pubmed publisher..Together, these results demonstrate novel modes of cross-talk and regulation between the various branches of lipid metabolic pathways upon inhibition of very long acyl chain ceramide synthesis. ..
- Erez O, Kahana C. Screening for modulators of spermine tolerance identifies Sky1, the SR protein kinase of Saccharomyces cerevisiae, as a regulator of polyamine transport and ion homeostasis. Mol Cell Biol. 2001;21:175-84 pubmed..While deletion or overexpression of SKY1 did not significantly affect Pma1p activity, the ability of overexpressed Sky1p, Ptk1p, and Ptk2p to increase sensitivity to LiCl depends on the integrity of PPZ1 but not of ENA1. ..
- Varol C, Vallon Eberhard A, Elinav E, Aychek T, Shapira Y, Luche H, et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity. 2009;31:502-12 pubmed publisher..Our results highlight the critical importance of the lpDC subset balance for robust gut homeostasis. ..
- Erez O, Kahana C. Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Deltatrk2Delta mutant cells exert dual effect on ion homeostasis. Biochem Biophys Res Commun. 2002;295:1142-9 pubmed..A model that integrates these results to explain the mechanism of ion transport across the plasma membrane is proposed. ..
- Garty H, Lindzen M, Fuzesi M, Aizman R, Goldshleger R, Asher C, et al. A specific functional interaction between CHIF and Na,K-ATPase: role of FXYD proteins in the cellular regulation of the pump. Ann N Y Acad Sci. 2003;986:395-400 pubmed..Taken together with data by others, it appears that FXYD proteins are tissue-specific subunits or regulators of the Na,K-ATPase whose function is to adjust the pump kinetics to particular physiological needs. ..
- Ginzburg L, Futerman A. Defective calcium homeostasis in the cerebellum in a mouse model of Niemann-Pick A disease. J Neurochem. 2005;95:1619-28 pubmed..We discuss possible pathological mechanisms related to calcium dysfunction that may cause Purkinje cell degeneration, and as a result, the onset of neuropathology in Niemann-Pick A disease. ..
- Cohen J, Zimmerman G, Melamed Book N, Friedman A, Dori A, Soreq H. Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cells. Hippocampus. 2008;18:182-92 pubmed..Our findings suggest that replacement of AChE-S with AChE-R serves to maintain DG homeostasis and associated cognitive tasks, highlighting the role of cholinergic signaling in adult hippocampal neurogenesis and functioning. ..
- Lewinson O, Padan E, Bibi E. Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis. Proc Natl Acad Sci U S A. 2004;101:14073-8 pubmed..coli from an obligatory neutrophile into an alkalitolerant bacterium, and they suggest a previously uncharacterized physiological role for MdfA in pH homeostasis. ..
- Karo Atar D, Bordowitz A, Wand O, Pasmanik Chor M, Fernandez I, Itan M, et al. A protective role for IL-13 receptor Î± 1 in bleomycin-induced pulmonary injury and repair. Mucosal Immunol. 2016;9:240-53 pubmed publisher..These data highlight underappreciated protective roles for IL-13RÎ±1 in lung injury and homeostasis. ..
- Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14:392-404 pubmed publisher..In this Review, we discuss the evidence that has dramatically changed our understanding of monocyte and macrophage development, and the maintenance of these cells in the steady state...
- Rosenberg E, Litus I, Schwarzfuchs N, Sinay R, Schlesinger P, Golenser J, et al. pfmdr2 confers heavy metal resistance to Plasmodium falciparum. J Biol Chem. 2006;281:27039-45 pubmed..In contrast, the resistant line harbors a full-length, active protein. These findings strongly suggest that the PFMDR2 protein acts as an efflux pump of heavy metals. ..
- Zigmond E, Jung S. Intestinal macrophages: well educated exceptions from the rule. Trends Immunol. 2013;34:162-8 pubmed publisher..Manipulation of monocyte fates in the intestine might hold promise for the disease management of inflammatory bowel disorders. ..
- Pasvolsky R, Grabovsky V, Giagulli C, Shulman Z, Shamri R, Feigelson S, et al. RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9. J Immunol. 2008;180:2815-23 pubmed
- Shechter R, Ronen A, Rolls A, London A, Bakalash S, Young M, et al. Toll-like receptor 4 restricts retinal progenitor cell proliferation. J Cell Biol. 2008;183:393-400 pubmed publisher..Thus, our study attributes a novel role to TLR4 as a negative regulator of RPC proliferation. ..
- Goldstein I, Ezra O, Rivlin N, Molchadsky A, Madar S, Goldfinger N, et al. p53, a novel regulator of lipid metabolism pathways. J Hepatol. 2012;56:656-62 pubmed publisher..In this study we aimed at characterizing the regulation of hepatic metabolic pathways by the p53 transcription factor...
- Mor A, Kloog Y, Keren G, George J. Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice. Eur J Pharmacol. 2009;616:301-5 pubmed publisher..Ras inhibition might therefore be worth developing as a new treatment modality in patients with type 1 diabetes...
- Heifetz Y, Rivlin P. Beyond the mouse model: using Drosophila as a model for sperm interaction with the female reproductive tract. Theriogenology. 2010;73:723-39 pubmed publisher..Furthermore, we discuss how the study of multiple sperm storage organ types in Drosophila may help us identify factors essential for sperm viability and, moreover, factors that promote long-term sperm survivorship. ..
- Tuvia S, Taglicht D, Erez O, Alroy I, Alchanati I, Bicoviski V, et al. The ubiquitin E3 ligase POSH regulates calcium homeostasis through spatial control of Herp. J Cell Biol. 2007;177:51-61 pubmed..Altogether, these results establish a critical role for POSH-mediated ubiquitination in the maintenance of calcium homeostasis through the spatial control of Herp. ..
- Székely P, Sheftel H, Mayo A, Alon U. Evolutionary tradeoffs between economy and effectiveness in biological homeostasis systems. PLoS Comput Biol. 2013;9:e1003163 pubmed publisher..We applied this approach to estimate parameters in three biological systems: response to heat shock and response to DNA damage in bacteria, and calcium homeostasis in mammals. ..
- Mildner A, Chapnik E, Manor O, Yona S, Kim K, Aychek T, et al. Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. Blood. 2013;121:1016-27 pubmed publisher..The results of our study establish a novel role for miRNAs in myeloid cell specification and define miR-142 as a pivotal genetic component in the maintenance of CD4+ DCs. ..
- Tarasiuk A, Levi A, Assadi M, Troib A, Segev Y. Orexin Plays a Role in Growth Impediment Induced by Obstructive Sleep Breathing in Rats. Sleep. 2016;39:887-97 pubmed publisher..Administration of almorexant restored sleep and improved GP width in AO animals. In AO animals, enhanced expression of orexin and OX1R plays a role in respiratory induced sleep and growth abnormalities. ..
- Wolf Y, Boura Halfon S, Cortese N, Haimon Z, Sar Shalom H, Kuperman Y, et al. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nat Immunol. 2017;18:665-674 pubmed publisher..Collectively, we report a previously unappreciated homeostatic role for macrophages in the control of tissue innervation. Disruption of this circuit in BAT resulted in metabolic imbalance. ..
- Padan E, Schuldiner S. Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells. J Bioenerg Biomembr. 1993;25:647-69 pubmed..The identification of Histidine 226 in the "pH sensor" of NhaA is a step forward towards the understanding of the pH regulation of these proteins. ..