Experts and Doctors on hmga1a protein in Germany
Topic: hmga1a protein
Vogel B, Löschberger A, Sauer M, Hock R. Cross-linking of DNA through HMGA1 suggests a DNA scaffold. Nucleic Acids Res. 2011;39:7124-33 pubmed publisher
..This capacity has profound implications for the spatial organization of DNA in the cell nucleus and suggests cross-linking activities for additional nuclear proteins. ..
Maurizio E, WiÅ›niewski J, Ciani Y, Amato A, Arnoldo L, Penzo C, et al
. Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer. Mol Cell Proteomics. 2016;15:109-23 pubmed publisher
..These factors are druggable targets that could be exploited for the development of new, targeted therapeutic approaches in triple-negative breast cancer. ..
Leger H, Sock E, Renner K, Grummt F, Wegner M. Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y. Mol Cell Biol. 1995;15:3738-47 pubmed
Hirning Folz U, Wilda M, Rippe V, Bullerdiek J, Hameister H. The expression pattern of the Hmgic gene during development. Genes Chromosomes Cancer. 1998;23:350-7 pubmed
..In contrast, Hmgiy is expressed also in tissues with no proliferative activity, such as the cortical plate of the telencephalon and the spinal cord at late gestational stages. ..
Piekielko A, Drung A, Rogalla P, Schwanbeck R, Heyduk T, Gerharz M, et al
. Distinct organization of DNA complexes of various HMGI/Y family proteins and their modulation upon mitotic phosphorylation. J Biol Chem. 2001;276:1984-92 pubmed
..Our results provide first insights into the molecular basis of functional specificity of proteins of the HMGI/Y family and their regulation by phosphorylation. ..
Murua Escobar H, Soller J, Richter A, Meyer B, Winkler S, Flohr A, et al
. The canine HMGA1. Gene. 2004;330:93-9 pubmed
..Furthermore, we compared the coding sequence(s) (CDS) of both splice variants for 12 different breeds, screened them for single nucleotide polymorphisms (SNPs) and characterised a basic expression pattern. ..
Thomae A, Pich D, Brocher J, Spindler M, Berens C, Hock R, et al
. Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins. Proc Natl Acad Sci U S A. 2008;105:1692-7 pubmed publisher
..Our experiments indicate that chromatin proteins can target ORC to DNA, suggesting they might specify origins of DNA replication in metazoan cells. ..
Nezhad M, Drieschner N, Helms S, Meyer A, Tadayyon M, Klemke M, et al
. 6p21 rearrangements in uterine leiomyomas targeting HMGA1. Cancer Genet Cytogenet. 2010;203:247-52 pubmed publisher
..Nevertheless, compared to fibroids with a normal karyotype, the upregulation of the HMGA1 mRNA in these cases was much less strong than that of HMGA2 mRNA in case of 12q14?15 aberrations identified in previous studies. ..
Maurus K, Hufnagel A, Geiger F, Graf S, Berking C, Heinemann A, et al
. The AP-1 transcription factor FOSL1 causes melanocyte reprogramming and transformation. Oncogene. 2017;36:5110-5121 pubmed publisher
..Overall, we demonstrate that FOSL1 is a novel reprogramming factor for melanocytes with potent tumor transformation potential. ..