Experts and Doctors on helminth proteins in United States

Summary

Locale: United States
Topic: helminth proteins

Top Publications

  1. Wu X, Sabat G, Brown J, Zhang M, Taft A, Peterson N, et al. Proteomic analysis of Schistosoma mansoni proteins released during in vitro miracidium-to-sporocyst transformation. Mol Biochem Parasitol. 2009;164:32-44 pubmed publisher
    ..g., those involved in stress responses, proteolysis/inhibition, antioxidant and detoxication, and immune modulation, that may play a parasite protective role during this crucial period of transition. ..
  2. Seeger M, Beattie C. Attraction versus repulsion: modular receptors make the difference in axon guidance. Cell. 1999;97:821-4 pubmed
  3. Arur S, Uche U, Rezaul K, Fong M, Scranton V, Cowan A, et al. Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell. 2003;4:587-98 pubmed
    ..These results provide novel mechanistic insights into how apoptotic cells are removed and may explain a pathogenic mechanism of chronic inflammatory diseases where annexin I autoantibodies have been described. ..
  4. Doe C. Cell polarity: the PARty expands. Nat Cell Biol. 2001;3:E7-9 pubmed
    ..This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors. ..
  5. Buchwitz B, Ahmad K, Moore L, Roth M, Henikoff S. A histone-H3-like protein in C. elegans. Nature. 1999;401:547-8 pubmed
  6. Luitjens C, Gallegos M, Kraemer B, Kimble J, Wickens M. CPEB proteins control two key steps in spermatogenesis in C. elegans. Genes Dev. 2000;14:2596-609 pubmed
    ..In sum, our results demonstrate that, in C. elegans, two CPEB proteins have distinct functions in the germ line, both in spermatogenesis: FOG-1 specifies the sperm cell fate and CPB-1 executes that decision. ..
  7. Grote P, Conradt B. The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans. Dev Cell. 2006;11:561-73 pubmed
    ..Similar interactions may function in sex determination and developmental regulation in other species. ..
  8. Shim Y, Bonner J, Blumenthal T. Activity of a C. elegans GATA transcription factor, ELT-1, expressed in yeast. J Mol Biol. 1995;253:665-76 pubmed
    ..We conclude that, although ELT-1 having only its C-terminal finger is capable of activation in response to the WGATAR site, the presence of the upstream finger supplies additional base specificity. ..
  9. Clandinin T, DeModena J, Sternberg P. Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell. 1998;92:523-33 pubmed
    ..Our results demonstrate that one mechanism by which receptor tyrosine kinases can evoke tissue-specific responses is through activation of distinct signal transduction cascades in different tissues. ..

More Information

Publications91

  1. Clark K, Howe D, Gafner K, Kusuma D, Ping S, Estes S, et al. Selfish little circles: transmission bias and evolution of large deletion-bearing mitochondrial DNA in Caenorhabditis briggsae nematodes. PLoS ONE. 2012;7:e41433 pubmed publisher
    ..briggsae, offering a powerful new system to study selfish mtDNA dynamics in metazoans. ..
  2. Patterson J, Wood M, Schisa J. Assembly of RNP granules in stressed and aging oocytes requires nucleoporins and is coordinated with nuclear membrane blebbing. Dev Biol. 2011;353:173-85 pubmed publisher
    ..These new insights may have general implications for better understanding how germ cells preserve their integrity when fertilization is delayed and how cells respond to stress. ..
  3. Priess J. Establishment of initial asymmetry in early Caenorhabditis elegans embryos. Curr Opin Genet Dev. 1994;4:563-8 pubmed
    ..These gene products should provide important tools for understanding how asymmetries are established initially in nematode embryogenesis. ..
  4. Milligan J, Jolly E. Identification and characterization of a Mef2 transcriptional activator in schistosome parasites. PLoS Negl Trop Dis. 2012;6:e1443 pubmed publisher
    ..We also show that Mef2 is expressed during several stages of schistosome development by quantitative PCR and that it can bind to conserved Mef2 DNA consensus binding sequences...
  5. Garcia L, Mehta P, Sternberg P. Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating. Cell. 2001;107:777-88 pubmed
    ..The male gonad then lengthens the duration of EGL-19-mediated prolonged muscle contraction. This regulation of muscle contraction provides a paradigm to explain how animals initiate, monitor, and maintain a behavioral motor program...
  6. Moeslein F, Myers M, Landreth G. The CLK family kinases, CLK1 and CLK2, phosphorylate and activate the tyrosine phosphatase, PTP-1B. J Biol Chem. 1999;274:26697-704 pubmed
    ..These findings demonstrate that the CLK kinases activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. ..
  7. Kawasaki I, Shim Y, Kirchner J, Kaminker J, Wood W, Strome S. PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans. Cell. 1998;94:635-45 pubmed
    ..Elimination of PGL-1 results in defective germ granules and sterility. Interestingly, PGL-1 function is required for fertility only at elevated temperatures, suggesting that germline development is inherently sensitive to temperature. ..
  8. Henderson S, Gao D, Lambie E, Kimble J. lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans. Development. 1994;120:2913-24 pubmed
    ..Taking these results together, we propose that lag-2 may encode a signaling ligand for GLP-1/LIN-12 and that the entire LAG-2 protein may be taken up into the receiving cell during induction by GLP-1 and lateral signaling by LIN-12. ..
  9. Olsen P, Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol. 1999;216:671-80 pubmed
  10. Mohler W, Shemer G, del Campo J, Valansi C, Opoku Serebuoh E, Scranton V, et al. The type I membrane protein EFF-1 is essential for developmental cell fusion. Dev Cell. 2002;2:355-62 pubmed
    ..Thus, EFF-1 is a key component in the mechanism of cell fusion, a process essential to normal animal development. ..
  11. Zorio D, Blumenthal T. U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans. RNA. 1999;5:487-94 pubmed
    ..We demonstrate by RNA interference that both U2AF genes, uaf-1 (which encodes U2AF65) and uaf-2, are required for viability, whereas cyp-13 is apparently not. ..
  12. Li D, He X. Desiccation induced structural alterations in a 66-amino acid fragment of an anhydrobiotic nematode late embryogenesis abundant (LEA) protein. Biomacromolecules. 2009;10:1469-77 pubmed publisher
    ..The Lennard-Jones interactions (van der Waals interactions) are the least important in determining the protein structure and its stability during water deficit. ..
  13. Taft A, Vermeire J, Bernier J, Birkeland S, Cipriano M, Papa A, et al. Transcriptome analysis of Schistosoma mansoni larval development using serial analysis of gene expression (SAGE). Parasitology. 2009;136:469-85 pubmed publisher
    ..In addition, 53 and 45 tags, respectively, were differentially expressed in 6-day and 20-day cultured sporocysts, due to the effects of exposure to Bge cell-conditioned medium...
  14. Patel King R, King S. A prefoldin-associated WD-repeat protein (WDR92) is required for the correct architectural assembly of motile cilia. Mol Biol Cell. 2016;27:1204-9 pubmed publisher
    ..These observations suggest that WDR92 is part of a previously unrecognized cytoplasmic chaperone system that is specifically required to fold key components necessary to build motile ciliary axonemes. ..
  15. Barr M, DeModena J, Braun D, Nguyen C, Hall D, Sternberg P. The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr Biol. 2001;11:1341-6 pubmed
  16. Xu L, Paulsen J, Yoo Y, Goodwin E, Strome S. Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development. Genetics. 2001;159:1007-17 pubmed
    ..We propose that MES-3 acts epigenetically to induce a germline state that is inherited through both meiosis and mitosis and that is essential for survival of the germline...
  17. Friedman L, Santa Anna Arriola S, Hodgkin J, Kimble J. gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans. Dev Biol. 2000;228:350-62 pubmed
    ..We conclude that gon-4 is a regulator of the early lineage of Z1 and Z4 and suggest that it is a part of a genetic program common to the regulation of both hermaphrodite and male gonadogenesis. ..
  18. Huang L, Tzou P, Sternberg P. The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development. Mol Biol Cell. 1994;5:395-411 pubmed
    ..We have identified a molecular null allele of lin-15 and have used it to analyze the role of lin-15 in the signaling pathway. We find that lin-15 acts upstream of let-23 and in parallel to the inductive signal. ..
  19. Yoshino T, Wu X, Liu H, Gonzalez L, Deelder A, Hokke C. Glycotope sharing between snail hemolymph and larval schistosomes: larval transformation products alter shared glycan patterns of plasma proteins. PLoS Negl Trop Dis. 2012;6:e1569 pubmed publisher
    ..mansoni LTPs to plasma proteins of susceptible and resistant B. glabrata strains may significantly impact early anti-larval immune reactivity, and in turn, compatibility, in this parasite-host system. ..
  20. Roehl H, Bosenberg M, Blelloch R, Kimble J. Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor. EMBO J. 1996;15:7002-12 pubmed
    ..We speculate that one possible function for the ANK repeat domain is to act as a transcriptional co-activator with LAG-1. ..
  21. Allen A, Maher K, Wani K, Betts K, Chase D. Coexpressed D1- and D2-like dopamine receptors antagonistically modulate acetylcholine release in Caenorhabditis elegans. Genetics. 2011;188:579-90 pubmed publisher
    ..Thus, coexpressed D1- and D2-like dopamine receptors act antagonistically in vivo to modulate acetylcholine release from the cholinergic motor neurons of C. elegans...
  22. Lie T, Leigh J. A novel repressor of nif and glnA expression in the methanogenic archaeon Methanococcus maripaludis. Mol Microbiol. 2003;47:235-46 pubmed
    ..NrpR represents a new family of regulators unique to the Euryarchaeota...
  23. Birnby D, Link E, Vowels J, Tian H, Colacurcio P, Thomas J. A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans. Genetics. 2000;155:85-104 pubmed
    ..These results demonstrate that cGMP is a prominent second messenger in C. elegans chemosensory transduction and suggest a previously unknown role for Hsp90 in regulating cGMP levels. ..
  24. Moghal N, Sternberg P. A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans. Development. 2003;130:57-69 pubmed
    ..Thus, the glutamine-rich region contributes to specificity of this class of mediator protein. ..
  25. Steiner F, Talbert P, Kasinathan S, Deal R, Henikoff S. Cell-type-specific nuclei purification from whole animals for genome-wide expression and chromatin profiling. Genome Res. 2012;22:766-77 pubmed publisher
    ..This method should be universally applicable to all model systems that allow transgenesis and will make it possible to determine epigenetic and expression profiles of different tissues and cell types. ..
  26. Lee I, Lehner B, Crombie C, Wong W, Fraser A, Marcotte E. A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans. Nat Genet. 2008;40:181-8 pubmed publisher
    ..We conclude that an analogous network for human genes might be similarly predictive and thus facilitate identification of disease genes and rational therapeutic targets. ..
  27. Patel A, Chojnowski A, Gaskill K, De Martini W, Goldberg R, Siekierka J. The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses. Mol Biochem Parasitol. 2011;176:90-7 pubmed publisher
    ..malayi which plays a role in protecting the parasite from ROS. Inhibition of this pathway may have therapeutic benefit in treating filariasis by increasing the sensitivity of filarial parasites to ROS and other reactive intermediates...
  28. Choe K, Leung C, Miyamoto M. Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance. Drug Metab Rev. 2012;44:209-23 pubmed publisher
    ..Protein alignment and phylogenetic analyses indicate that these differences are shared among many nematodes, making SKN-1 a candidate for specifically targeting nematode detoxification and antioxidation...
  29. Westmoreland J, McEwen J, Moore B, Jin Y, Condie B. Conserved function of Caenorhabditis elegans UNC-30 and mouse Pitx2 in controlling GABAergic neuron differentiation. J Neurosci. 2001;21:6810-9 pubmed
    ..Our results suggest that some of the mechanisms regulating GABAergic differentiation are evolutionarily conserved. ..
  30. Moore L, Roth M. HCP-4, a CENP-C-like protein in Caenorhabditis elegans, is required for resolution of sister centromeres. J Cell Biol. 2001;153:1199-208 pubmed
    ..These chromosomes also failed to form a functional kinetochore. Thus, the CENP-C-like protein HCP-4 is essential for both resolution sister centromeres and attachment to the mitotic spindle. ..
  31. Xu L, Fong Y, Strome S. The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos. Proc Natl Acad Sci U S A. 2001;98:5061-6 pubmed
    ..Our results suggest that the two C. elegans Polycomb group homologs (MES-2 and MES-6) associate with a novel partner (MES-3) to regulate germ-line development in C. elegans. ..
  32. Sedensky M, Siefker J, Morgan P. Model organisms: new insights into ion channel and transporter function. Stomatin homologues interact in Caenorhabditis elegans. Am J Physiol Cell Physiol. 2001;280:C1340-8 pubmed
    ..Western blots indicate that UNC-24 probably affects the stability of the UNC-1 protein. UNC-24 may therefore be necessary for the correct placement of UNC-1 in the cell membrane and organization of lipid rafts...
  33. Wolgemuth C, Miao L, Vanderlinde O, Roberts T, Oster G. MSP dynamics drives nematode sperm locomotion. Biophys J. 2005;88:2462-71 pubmed
    ..This model explains the mechanism by which disassembly of the cytoskeleton generates the force necessary to pull the cell body forward and suggests further experiments that can test the validity of the models. ..
  34. Hill R, Sternberg P. The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature. 1992;358:470-6 pubmed
    ..Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal...
  35. Grigsby I, Rutledge E, Morton C, Finger F. Functional redundancy of two C. elegans homologs of the histone chaperone Asf1 in germline DNA replication. Dev Biol. 2009;329:64-79 pubmed publisher
  36. Kipreos E, Gohel S, Hedgecock E. The C. elegans F-box/WD-repeat protein LIN-23 functions to limit cell division during development. Development. 2000;127:5071-82 pubmed
    ..In contrast, lin-23 functions cell autonomously to negatively regulate cell cycle progression, thereby allowing cell cycle exit in response to developmental signals. ..
  37. Polinko E, Strome S. Depletion of a Cks homolog in C. elegans embryos uncovers a post-metaphase role in both meiosis and mitosis. Curr Biol. 2000;10:1471-4 pubmed
    ..Specifically, cks-1(RNAi) embryos fail to exit M phase properly. We propose that CKS-1 has an essential role in the inactivation of MPF during early C. elegans embryogenesis...
  38. Ambros V. Cell cycle-dependent sequencing of cell fate decisions in Caenorhabditis elegans vulva precursor cells. Development. 1999;126:1947-56 pubmed
    ..Coupling developmental decisions to cell cycle transitions may provide a mechanism for prioritizing or ordering choices of cell fates for multipotential cells...
  39. Gissendanner C, Sluder A. nhr-25, the Caenorhabditis elegans ortholog of ftz-f1, is required for epidermal and somatic gonad development. Dev Biol. 2000;221:259-72 pubmed
    ..In addition, somatic gonad development is defective in these larvae. These results further establish the importance of FTZ-F1 nuclear receptors in molting and developmental control across evolutionarily distant phyla. ..
  40. Hong Y, Lee R, Ambros V. Structure and function analysis of LIN-14, a temporal regulator of postembryonic developmental events in Caenorhabditis elegans. Mol Cell Biol. 2000;20:2285-95 pubmed
    ..These results support the view that LIN-14 controls developmental timing in C. elegans by regulating gene expression in the nucleus. ..
  41. Weinshenker D, Wei A, Salkoff L, Thomas J. Block of an ether-a-go-go-like K(+) channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans. J Neurosci. 1999;19:9831-40 pubmed
    ..Similar inhibition is observed with the mouse homolog MEAG, suggesting that inhibition of EAG-like channels may mediate some clinical side effects of this class of antidepressants. ..
  42. Herman M, Ch ng Q, Hettenbach S, Ratliff T, Kenyon C, Herman R. EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans. Development. 1999;126:1055-64 pubmed
    ..Overlaps in the phenotypes of egl-27 and Wnt pathway mutants suggest that the EGL-27 protein interacts with Wnt signaling pathways in C. elegans. ..
  43. Zhang L, Plow E. Identification and reconstruction of the binding site within alphaMbeta2 for a specific and high affinity ligand, NIF. J Biol Chem. 1997;272:17558-64 pubmed
    ..Verifying this localization, when these segments were introduced into the alphaXI-domain, the resulting chimeric receptor was converted into a high affinity NIF-binding protein. ..
  44. Costa M, Raich W, Agbunag C, Leung B, Hardin J, Priess J. A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. J Cell Biol. 1998;141:297-308 pubmed
    ..This putative catenin-cadherin system is not essential for general cell adhesion in the C. elegans embryo, but rather mediates specific aspects of morphogenetic cell shape change and cytoskeletal organization. ..
  45. Hajdu Cronin Y, Chen W, Patikoglou G, Koelle M, Sternberg P. Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity. Genes Dev. 1999;13:1780-93 pubmed
    ..elegans, and that G(o)alpha negatively regulates the G(q) pathway, possibly via EAT-16 or SAG-1. We propose that a major cellular role of G(o) is to antagonize signaling by G(q). ..
  46. Durant F, Morokuma J, Fields C, Williams K, ADAMS D, Levin M. Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous Bioelectric Gradients. Biophys J. 2017;112:2231-2243 pubmed publisher
    ..Hence, bioelectric properties can stably override genome-default target morphology, and provide a tractable control point for investigating cryptic phenotypes and the stochasticity of large-scale epigenetic controls. ..
  47. Culbertson M. RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer. Trends Genet. 1999;15:74-80 pubmed
    ..The NMD pathway has a direct impact on hundreds of genetic disorders in the human population, where about a quarter of all known mutations are predicted to trigger NMD...
  48. Sepulveda J, Shoemaker C. Design and testing of PCR primers for the construction of scFv libraries representing the immunoglobulin repertoire of rats. J Immunol Methods. 2008;332:92-102 pubmed publisher
    ..The primers and methods developed for rat scFvs should be of use to others seeking to characterize the antibody repertoire and/or prepare recombinant antibodies from this model. ..
  49. Cali B, Kuchma S, Latham J, Anderson P. smg-7 is required for mRNA surveillance in Caenorhabditis elegans. Genetics. 1999;151:605-16 pubmed
    ..We provide evidence that smg-7 is cotranscribed with the previously characterized gene lin-45 and show that null alleles of smg-7 confer a temperature-sensitive defect in NMD. ..
  50. Parihar M, Minton R, Flowers S, Holloway A, Morehead B, Paille J, et al. The genome of the nematode Pristionchus pacificus encodes putative homologs of RXR/Usp and EcR. Gen Comp Endocrinol. 2010;167:11-7 pubmed publisher
    ..The identification of a putative ecdysone receptor in a nematode amenable to genetic analysis provides a powerful system to investigate the function and evolution of ecdysone receptor signaling in the Nematoda. ..
  51. Lee C, Chronis D, Kenning C, Peret B, Hewezi T, Davis E, et al. The novel cyst nematode effector protein 19C07 interacts with the Arabidopsis auxin influx transporter LAX3 to control feeding site development. Plant Physiol. 2011;155:866-80 pubmed publisher
    ..We propose that Hs19C07 most likely increases LAX3-mediated auxin influx and may provide a mechanism for cyst nematodes to modulate auxin flow into root cells, stimulating cell wall hydrolysis for syncytium development. ..
  52. Page B, Zhang W, Steward K, Blumenthal T, Priess J. ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos. Genes Dev. 1997;11:1651-61 pubmed
    ..The ELT-1 protein is expressed in epidermal cells and in their precursors. We propose that elt-1 functions at an early step in the specification of epidermal cell fates. ..
  53. Moss E, Lee R, Ambros V. The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA. Cell. 1997;88:637-46 pubmed
    ..Deleting the LCE produces a dominant gain-of-function allele that causes a retarded phenotype, indicating that lin-28 activity is a switch that controls choices of stage-specific fates. ..
  54. Estevez M, Attisano L, Wrana J, Albert P, Massague J, Riddle D. The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature. 1993;365:644-9 pubmed
    ..When expressed in monkey COS cells, the daf-4 receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family. ..
  55. Lee J, Jongeward G, Sternberg P. unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein. Genes Dev. 1994;8:60-73 pubmed
    ..We have sequenced the mutant alleles of unc-101 identified in various genetic screens and shown that all but one are deletions or nonsense mutations, suggesting that these alleles severely reduce unc-101 function...
  56. Srinivasan J, Dillman A, Macchietto M, Heikkinen L, Lakso M, Fracchia K, et al. The draft genome and transcriptome of Panagrellus redivivus are shaped by the harsh demands of a free-living lifestyle. Genetics. 2013;193:1279-95 pubmed publisher
  57. Shinya R, Morisaka H, Takeuchi Y, Futai K, Ueda M. Making headway in understanding pine wilt disease: what do we perceive in the postgenomic era?. J Biosci Bioeng. 2013;116:1-8 pubmed publisher
    ..Here, we review the recent advances in genomic and proteomic approaches that address some of the longstanding questions behind the pathogenesis of pine wilt disease and have identified future questions and directions in this regard...
  58. Bowerman B, Eaton B, Priess J. skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo. Cell. 1992;68:1061-75 pubmed
    ..We propose that the maternally expressed skn-1 gene product acts to specify the fate of the EMS blastomere. ..
  59. Capowski E, Tracy J. Ribosomal RNA processing and the role of SmMAK16 in ribosome biogenesis in Schistosoma mansoni. Mol Biochem Parasitol. 2003;132:67-74 pubmed
    ..Co-immunoprecipitation data and polysome analysis support the hypothesis that SmMAK16 associates with pre-ribosomal precursor complexes. This work represents the first analysis of this important and complex process in schistosomes...
  60. Shelton C, Carter J, Ellis G, Bowerman B. The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis. J Cell Biol. 1999;146:439-51 pubmed
    ..An mlc-4/green fluorescent protein transgene is expressed in lateral rows of hypodermal cells and these cells fail to properly change shape in mlc-4 mutant animals during elongation. ..
  61. Ambros V. Control of developmental timing in Caenorhabditis elegans. Curr Opin Genet Dev. 2000;10:428-33 pubmed
    ..These regulators interact with each other to elaborate stage-specific regulatory switches and act through downstream effectors to control the timing of cell-type-specific developmental events. ..
  62. Moore L, Morrison M, Roth M. HCP-1, a protein involved in chromosome segregation, is localized to the centromere of mitotic chromosomes in Caenorhabditis elegans. J Cell Biol. 1999;147:471-80 pubmed
    ..These results suggest that HCP-1 is a centromere-associated protein that is involved in the fidelity of chromosome segregation. ..
  63. Lewis P, Perez Tur J, Golde T, Hardy J. The presenilin 1 C92S mutation increases abeta 42 production. Biochem Biophys Res Commun. 2000;277:261-3 pubmed
    ..elegans into a context whereby its effect on mammalian cells can be evaluated suggests that all FAD-linked PS1 mutants result in increased Abeta42 production through a partial loss of function mechanism. ..
  64. Lamont L, Crittenden S, Bernstein D, Wickens M, Kimble J. FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline. Dev Cell. 2004;7:697-707 pubmed
    ..Therefore, fbf-1 and fbf-2 provide a paradigm for how recently duplicated genes can diverge to fine-tune patterning during animal development. ..
  65. Hermann G, Leung B, Priess J. Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway. Development. 2000;127:3429-40 pubmed
    ..We show that the anterior-posterior asymmetry in intestinal twist involves the kinase LIT-1, which is part of a signaling pathway in early embryogenesis that generates anterior-posterior differences between sister cells. ..
  66. Lundquist E, Reddien P, Hartwieg E, Horvitz H, Bargmann C. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development. 2001;128:4475-88 pubmed
    ..CED-5 DOCK180, which acts with CED-10 Rac in cell-corpse phagocytosis, acted with MIG-2 but not CED-10 in axon pathfinding. Thus, distinct regulatory proteins modulate Rac activation and function in different developmental processes. ..
  67. Koppen M, Simske J, Sims P, Firestein B, Hall D, Radice A, et al. Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia. Nat Cell Biol. 2001;3:983-91 pubmed
    ..We conclude that LET-413 and DLG-1 cooperatively control AJM-1 localization and that AJM-1 controls the integrity of a distinct apical junctional domain in C. elegans. ..
  68. Browning H, Strome S. A sperm-supplied factor required for embryogenesis in C. elegans. Development. 1996;122:391-404 pubmed
    ..In contrast to the many known maternal factors required for embryogenesis, SPE-11 is the first paternally contributed factor to be genetically identified and molecularly characterized. ..
  69. Mello C, Schubert C, Draper B, Zhang W, Lobel R, Priess J. The PIE-1 protein and germline specification in C. elegans embryos. Nature. 1996;382:710-2 pubmed
    ..The localization and genetic properties of pie-1 provide an example of a repressor-based mechanism for preserving pluripotency within a stem cell lineage. ..
  70. Draper B, Mello C, Bowerman B, Hardin J, Priess J. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell. 1996;87:205-16 pubmed
    ..We propose that MEX-3 contributes to anterior-posterior asymmetry by regulating one or more mRNAs involved in specifying the fate of the posterior blastomere. ..
  71. Xu L, Strome S. Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans. Genetics. 2001;159:1019-29 pubmed
    ..Our results suggest that SET-2 participates along with the MES proteins in promoting normal germline development...
  72. Barr M, Sternberg P. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature. 1999;401:386-9 pubmed
    ..PKD-2, the C. elegans homologue of PKD2, is localized to the same neurons as LOV-1, suggesting that they function in the same pathway...
  73. Chamberlin H, Brown K, Sternberg P, Thomas J. Characterization of seven genes affecting Caenorhabditis elegans hindgut development. Genetics. 1999;153:731-42 pubmed
    ..Our results suggest that a combination of different factors contribute to normal C. elegans hindgut development. ..
  74. Ann K, Kowalchyk J, Loyet K, Martin T. Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis. J Biol Chem. 1997;272:19637-40 pubmed
  75. Bowerman B, Severson A. Cell division: plant-like properties of animal cell cytokinesis. Curr Biol. 1999;9:R658-60 pubmed
    ..Recent evidence that a syntaxin is required for cytokinesis in Caenorhabditis elegans embryos suggests that the mechanism of cell division in plant and animal cells may be more similar than previously imagined. ..
  76. Page M, Carr B, Anders K, Grimson A, Anderson P. SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol. 1999;19:5943-51 pubmed
    ..We discuss these results with regard to the in vivo functions of SMG-2 and NMD...
  77. Hu R, Wu W, Niles E, LoVerde P. Isolation and characterization of Schistosoma mansoni constitutive androstane receptor. Mol Biochem Parasitol. 2006;148:31-43 pubmed publisher
    ..The AGTGCA half site is essential for binding of SmCAR to the p14 gene upstream region. Therefore, AGTGCA probably serves as a high affinity binding half site for ESCKA containing nuclear receptors...
  78. Nance J, Priess J. Cell polarity and gastrulation in C. elegans. Development. 2002;129:387-97 pubmed
    ..We provide evidence that ingression times are determined by genes that control cell fate, though interactions with neighboring cells can prevent ingression. ..
  79. Bui Y, Sternberg P. Caenorhabditis elegans inositol 5-phosphatase homolog negatively regulates inositol 1,4,5-triphosphate signaling in ovulation. Mol Biol Cell. 2002;13:1641-51 pubmed
    ..ipp-5 acts downstream of let-23, and interacts with let-23-mediated IP(3) signaling pathway genes. We infer that IPP-5 negatively regulates IP(3) signaling to ensure proper spermathecal contraction. ..
  80. Johnson A, Fitzsimmons D, Hagman J, Chamberlin H. EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development. Development. 2001;128:2857-65 pubmed
    ..These experiments demonstrate a functional link between Pax and Ovo transcription factors, and provide a model for how Pax transcription factors can regulate different target genes in different cells. ..
  81. Anders K, Grimson A, Anderson P. SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 2003;22:641-50 pubmed
    ..Our results suggest that PP2A is the SMG-2 phosphatase, and the role of SMG-5 is to direct PP2A to its SMG-2 substrate. We discuss cycles of SMG-2 phosphorylation and their roles in NMD. ..
  82. Fantappi M, Osman A, Ericsson C, Niles E, LoVerde P. Cloning of Schistosoma mansoni Seven in Absentia (SmSINA)(+) homologue cDNA, a gene involved in ubiquitination of SmRXR1 and SmRXR2. Mol Biochem Parasitol. 2003;131:45-54 pubmed
    ..Our findings suggest that SmSINA regulates ubiquitination and ubiquitin-induced degradation of schistosome nuclear receptors (RXR1 and RXR2) via the ubiquitin-proteasome pathway...