Experts and Doctors on hela cells in United States

Summary

Locale: United States
Topic: hela cells

Top Publications

  1. Huang J, Nueda A, Yoo S, Dynan W. Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase. J Biol Chem. 1997;272:26009-16 pubmed
    ..The ability of HSF1 to interact with both components of DNA-PK provides a potential mechanism for the activation of DNA-PK in response to heat and other forms of stress. ..
  2. Kasof G, Gomes B. Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem. 2001;276:3238-46 pubmed
    ..This was associated with an increase in DNA fragmentation and in DEVD-like caspase activity. Thus, disruption of Livin may provide a strategy to induce apoptosis in certain cancer cells. ..
  3. Cai Y, Jin J, Tomomori Sato C, Sato S, Sorokina I, Parmely T, et al. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. J Biol Chem. 2003;278:42733-6 pubmed
    ..Taken together, our findings shed new light on the structure and function of the mammalian TRRAP/TIP60 histone acetyltransferase complex. ..
  4. Fu J, Jin Y, Arend L. Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. J Biol Chem. 2003;278:52660-72 pubmed
    ..Smac3-accelerated XIAP destabilization is, at least in part, attributed to its ability to enhance XIAP ubiquitination. Our study demonstrates that Smac3 is functionally additive to, but independent of, Smac/DIABLO. ..
  5. Yin G, Zheng Q, Yan C, Berk B. GIT1 is a scaffold for ERK1/2 activation in focal adhesions. J Biol Chem. 2005;280:27705-12 pubmed
    ..In summary, the present study further supports a key role for GIT1 (a MEK1-binding protein) as a scaffold for signal transduction in focal adhesions. ..
  6. Parish J, Rosa J, Wang X, Lahti J, Doxsey S, Androphy E. The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. J Cell Sci. 2006;119:4857-65 pubmed
    ..We conclude that human ChlR1 is required for sister chromatid cohesion and, hence, normal mitotic progression. These functions are important to maintain genetic fidelity. ..
  7. Layon M, Ackley C, West R, Lowrey C. Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression. J Mol Biol. 2007;366:737-44 pubmed
    ..These results imply that GATA-1 is sufficient to direct chromatin structure reorganization within the beta-globin LCR and an erythroid pattern of gene expression in the absence of other hematopoietic transcription factors. ..
  8. Sun J, Schoborg R. The host adherens junction molecule nectin-1 is degraded by chlamydial protease-like activity factor (CPAF) in Chlamydia trachomatis-infected genital epithelial cells. Microbes Infect. 2009;11:12-9 pubmed publisher
    ..Collectively, these results indicate that nectin-1 is degraded by CPAF in C. trachomatis-infected cells, a novel strategy that chlamydiae may use to aid their dissemination. ..
  9. Marchese A. Ubiquitination of chemokine receptors. Methods Enzymol. 2009;460:413-22 pubmed publisher
    ..Here we describe a simple biochemical assay that we have used to study the ubiquitination of CXCR4 that can be easily applied to study the ubiquitination of any GPCR. ..

More Information

Publications637 found, 100 shown here

  1. Majumder S, Alinari L, Roy S, Miller T, Datta J, SIF S, et al. Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription. J Cell Biochem. 2010;109:553-63 pubmed publisher
    ..These data suggest a key role of PRMT5 and the two methylated histones in regulating rRNA promoter activity. ..
  2. Sommer G, Dittmann J, Kuehnert J, Reumann K, Schwartz P, Will H, et al. The RNA-binding protein La contributes to cell proliferation and CCND1 expression. Oncogene. 2011;30:434-44 pubmed publisher
    ..In conclusion, this study establishes a role of La in cell proliferation and CCND1 expression and demonstrates for the first time an overexpression of the RNA-binding protein La in solid tumors. ..
  3. Knowlton A, Brown H, Richards T, Andreolas L, Patel R, Grieshaber S. Chlamydia trachomatis infection causes mitotic spindle pole defects independently from its effects on centrosome amplification. Traffic. 2011;12:854-66 pubmed publisher
    ..We hypothesize that these combined effects on mitotic spindle architecture identifies a possible mechanism for Chlamydia as a cofactor in cervical cancer formation. ..
  4. Ding Y, Hubert C, Herman J, Corrin P, Toledo C, Skutt Kakaria K, et al. Cancer-Specific requirement for BUB1B/BUBR1 in human brain tumor isolates and genetically transformed cells. Cancer Discov. 2013;3:198-211 pubmed publisher
    ..Moreover, the results further suggest that sister KT distances at metaphase may predict sensitivity to anticancer therapeutics targeting KT function. ..
  5. Wang E, Zhou Y, Huang Q, Pang L, Qiao H, Yu F, et al. 5-Hydroxymethylfurfural modified rhodamine B dual-function derivative: Highly sensitive and selective optical detection of pH and Cu(2+). Spectrochim Acta A Mol Biomol Spectrosc. 2016;152:327-35 pubmed publisher
    ..2) aqueous buffer solution as well as other metal ions had no obvious interference. Moreover, RBF has been successfully applied to detect Cu(2+) in real water samples. ..
  6. Herrera R, Morris M, Rosbe K, Feng Z, Weinberg A, Tugizov S. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. Virology. 2016;487:172-87 pubmed publisher
    ..The anti-HIV effect of combining hBD2 and hBD3 was substantially higher than that of the individual peptides. These findings advance our understanding of the mechanisms of anti-HIV resistance in adult oral epithelium. ..
  7. Selfridge A, Cavadas M, Scholz C, Campbell E, Welch L, Lecuona E, et al. Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia. J Biol Chem. 2016;291:11800-8 pubmed publisher
    ..Therefore, hypercapnia may play a key role in the pathophysiology of diseases where HIF is implicated. ..
  8. Duke G, Palmenberg A. Cloning and synthesis of infectious cardiovirus RNAs containing short, discrete poly(C) tracts. J Virol. 1989;63:1822-6 pubmed
  9. Bebok Z, Mazzochi C, King S, Hong J, Sorscher E. The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary. J Biol Chem. 1998;273:29873-8 pubmed
  10. Higashikawa F, Chang L. Kinetic analyses of stability of simple and complex retroviral vectors. Virology. 2001;280:124-31 pubmed
    ..Analyses of these stability factors may improve future production and applications of retroviral and lentiviral vectors. ..
  11. Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch S, Goodman R. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell. 2003;115:177-86 pubmed
    ..Finally, reduction in CtBP levels, either by genetic knockout or siRNA, promoted apoptosis in p53-deficient cells. These findings provide a pathway for UV-induced apoptosis in cells lacking p53. ..
  12. Zhu H, Hasman R, Barron V, Luo G, Lou H. A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators. Mol Biol Cell. 2006;17:5105-14 pubmed
    ..These studies define not only the first neuron-specific regulator of the calcitonin/CGRP system but also the first nuclear function of Hu proteins. ..
  13. Siow D, Wattenberg B. An assay system for measuring the acute production of sphingosine 1-phosphate in intact monolayers. Anal Biochem. 2007;371:184-93 pubmed
    ..Overall, this assay is ideal for future studies to identify changes in S1P production in intact cells such as those that result from the differential intracellular targeting of sphingosine kinase...
  14. Neznanov N, Kondratova A, Chumakov K, Neznanova L, Kondratov R, Banerjee A, et al. Quercetinase pirin makes poliovirus replication resistant to flavonoid quercetin. DNA Cell Biol. 2008;27:191-8 pubmed
    ..The results suggest that quercetinase activity of pirin determines the resistance of poliovirus infection to quercetin. ..
  15. Graci J, Too K, Smidansky E, Edathil J, Barr E, Harki D, et al. Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. Antimicrob Agents Chemother. 2008;52:971-9 pubmed publisher
    ..These purine nucleoside analogues represent promising lead compounds in the development of clinically useful antiviral therapies based on the strategy of lethal mutagenesis. ..
  16. Puckett C, Barton J. Mechanism of cellular uptake of a ruthenium polypyridyl complex. Biochemistry. 2008;47:11711-6 pubmed publisher
    ..Uptake decreases when cells are depolarized with high potassium buffer and increases when cells are hyperpolarized with valinomycin. These results support passive diffusion of Ru(DIP) 2dppz (2+) into the cell. ..
  17. Shulla A, Gallagher T. Role of spike protein endodomains in regulating coronavirus entry. J Biol Chem. 2009;284:32725-34 pubmed publisher
    ..These studies reveal a previously unappreciated role for covalently attached lipids on the endodomains of viral proteins eliciting membrane fusion reactions. ..
  18. Platt E, Kozak S, Durnin J, Hope T, Kabat D. Rapid dissociation of HIV-1 from cultured cells severely limits infectivity assays, causes the inactivation ascribed to entry inhibitors, and masks the inherently high level of infectivity of virions. J Virol. 2010;84:3106-10 pubmed publisher
    ..This kinetic competition underlies inhibitory effects of CCR5 antagonists and explains why adaptive HIV-1 mutations overcome many cell entry limitations by accelerating entry. ..
  19. Chambers R, Takimoto T. Trafficking of Sendai virus nucleocapsids is mediated by intracellular vesicles. PLoS ONE. 2010;5:e10994 pubmed publisher
  20. Weaver L, Ems McClung S, Stout J, Leblanc C, Shaw S, Gardner M, et al. Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation. Curr Biol. 2011;21:1500-6 pubmed publisher
    ..Our modeling predicts that both fast motility and a low off rate from the MT end are important for Kif18A function. In addition, our studies provide new insight into how depolymerizing and capping enzymes can lead to MT destabilization. ..
  21. Yang Z, Waldman A, Wyatt M. Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics. Biochem Pharmacol. 2012;83:741-6 pubmed publisher
    ..Collectively, the data suggest that interference with the activation of RAD51-mediated HR represents a potentially useful anticancer target for combination therapies. ..
  22. Pham T, Gao X, Tsai K, Olsen R, Wan F, Hardwidge P. Functional differences and interactions between the Escherichia coli type III secretion system effectors NleH1 and NleH2. Infect Immun. 2012;80:2133-40 pubmed publisher
    ..Taken together, our data show that NleH1 and NleH2 have pronounced functional differences in their ability to alter host transcriptional responses to bacterial infection...
  23. Cho J, Cho C, Kao C, Chen C, Tseng C, Lee Y, et al. Crude aqueous extracts of Pluchea indica (L.) Less. inhibit proliferation and migration of cancer cells through induction of p53-dependent cell death. BMC Complement Altern Med. 2012;12:265 pubmed publisher
    ..indica root. The in vitro anti-cancer effects of crude aqueous extracts of P. indica leaf and root indicate that it has sufficient potential to warrant further examination and development as a new anti-cancer agent. ..
  24. Mahdavi A, Szychowski J, Ngo J, Sweredoski M, Graham R, Hess S, et al. Identification of secreted bacterial proteins by noncanonical amino acid tagging. Proc Natl Acad Sci U S A. 2014;111:433-8 pubmed publisher
    ..This approach should be widely useful for the identification of virulence factors in microbial pathogens and the development of potential new targets for antimicrobial therapy. ..
  25. Kozak S, Platt E, Madani N, Ferro F, Peden K, Kabat D. CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1. J Virol. 1997;71:873-82 pubmed
    ..We propose that cooperative binding of macrophage-tropic HIV-1 onto CCR-5 and CD4 may enhance virus adsorption and infectivity for cells that have only a trace of CD4. ..
  26. Lyapina S, Cope G, Serino G, Tsuge T, Zhou C, Wolf D, et al. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science. 2001;292:1382-5 pubmed
  27. Park J, Wood M, Cole M. BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation. Mol Cell Biol. 2002;22:1307-16 pubmed
    ..Using deletion mutants of BAF53, we show that BAF53 is critical for c-Myc oncogenic activity. Our results indicate that BAF53 plays a functional role in c-Myc-interacting nuclear complexes. ..
  28. Aminev A, Amineva S, Palmenberg A. Encephalomyocarditis virus (EMCV) proteins 2A and 3BCD localize to nuclei and inhibit cellular mRNA transcription but not rRNA transcription. Virus Res. 2003;95:59-73 pubmed
    ..The data suggest that nuclear targeting by 2A and 3BCD may be responsible for regulating cellular mRNA and rRNA transcription during infection, perhaps via a proteolytic mechanism catalyzed by the endogenous 3C(pro) sequence. ..
  29. Gu H, Schoenberg D. U2AF modulates poly(A) length control by the poly(A)-limiting element. Nucleic Acids Res. 2003;31:6264-71 pubmed
    ..This reverted to a discrete, <20 nt poly(A) tail in cells expressing U2AF65. Our results suggest that U2AF modulates the function of the PLE, perhaps by facilitating the binding of another protein to the element. ..
  30. Grossman C, Qian Y, Banki K, Perl A. ZNF143 mediates basal and tissue-specific expression of human transaldolase. J Biol Chem. 2004;279:12190-205 pubmed
    ..Thus, ZNF143 plays a key role in basal and tissue-specific expression of transaldolase and regulation of the metabolic network controlling cell survival and differentiation. ..
  31. Jeong S, Rose A, Joseph J, Dasso M, Meier I. Plant-specific mitotic targeting of RanGAP requires a functional WPP domain. Plant J. 2005;42:270-82 pubmed
    ..These results indicate that plant and animal RanGAPs undergo different migration patterns during cell division, which require their kingdom-specific targeting domains. ..
  32. Vig P, Wei J, Shao Q, Hebert M, Subramony S, Sutton L. Role of tissue transglutaminase type 2 in calbindin-D28k interaction with ataxin-1. Neurosci Lett. 2007;420:53-7 pubmed
    ..In addition, aggregates of mutant ataxin-l may recruit CaB via TG2 mediated covalent crosslinking, further supporting the argument that ataxin-l aggregates may be toxic to neurons. ..
  33. Sun J, Xu H, Negi S, Subramony S, Hebert M. Differential effects of polyglutamine proteins on nuclear organization and artificial reporter splicing. J Neurosci Res. 2007;85:2306-17 pubmed
    ..These results support the hypothesis that different mutant proteins vary in their ability to disrupt nuclear organization and function. ..
  34. Zhang Z, Verheyden J, Hassell J, Sun X. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev Cell. 2009;16:607-13 pubmed publisher
    ..This finding elucidates a novel aspect of the mechanism coordinating limb development along the A-P and P-D axes...
  35. Yang X, Lu X, Liu J. Identification of a novel splicing isoform of murine CGI-58. FEBS Lett. 2010;584:903-10 pubmed publisher
    ..Overexpression of mCGI-58S failed to promote lipid droplet turnover and loss of intracellular triacylglycerols. These results suggest that this splicing event may be involved in the regulation of lipid homeostasis. ..
  36. Tae S, Karkhanis V, Velasco K, Yaneva M, Erdjument Bromage H, Tempst P, et al. Bromodomain protein 7 interacts with PRMT5 and PRC2, and is involved in transcriptional repression of their target genes. Nucleic Acids Res. 2011;39:5424-38 pubmed publisher
    ..These findings highlight the role played by BRD7 in PRMT5- and PRC2-induced transcriptional silencing, and indicate that recruitment of specific RDMs and KDMs is required for efficient transcriptional derepression. ..
  37. Broome H, Hebert M. In vitro RNase and nucleic acid binding activities implicate coilin in U snRNA processing. PLoS ONE. 2012;7:e36300 pubmed publisher
    ..These findings present new characteristics of coilin in vitro, and suggest additional functions of the protein in vivo. ..
  38. Tsakalozou E, Adane E, Kuo K, Daily A, Moscow J, Leggas M. The effect of breast cancer resistance protein, multidrug resistant protein 1, and organic anion-transporting polypeptide 1B3 on the antitumor efficacy of the lipophilic camptothecin 7-t-butyldimethylsilyl-10-hydroxycamptothecin (AR-67) in vitro. Drug Metab Dispos. 2013;41:1404-13 pubmed publisher
    ..In conclusion, BCRP- and MDR1-mediated efflux of AR-67 lactone confers resistance to AR-67, but OATP1B3-mediated uptake of the AR-67 carboxylate does not sensitize OATP1B3-expressing tumor cells...
  39. Herjan T, Yao P, Qian W, Li X, Liu C, Bulek K, et al. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. J Immunol. 2013;191:640-9 pubmed publisher
    ..Furthermore, HuR deletion in distal lung epithelium attenuated IL-17-induced neutrophilia. In summary, HuR functions to couple receptor-proximal signaling to posttranscriptional machinery, contributing to IL-17-induced inflammation. ..
  40. Chukwurah E, Handy I, Patel R. ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element. Biochem J. 2017;474:1241-1257 pubmed publisher
    ..Our results highlight an important pathway by which HIV-1 transcripts subvert the host cell's antiviral activities to enhance their translation. ..
  41. Sun Y, Gao X. Eliminating the Animal Species Constraints in Antibody Selection for Multicolor Immunoassays. Bioconjug Chem. 2017;28:1499-1504 pubmed publisher
    ..This simple and general self-assembly technology eliminates the animal species constraints in multicolor immunoassays, offering exciting new opportunities for a wide range of biomedical and clinical applications...
  42. Dalton T, Bittel D, Andrews G. Reversible activation of mouse metal response element-binding transcription factor 1 DNA binding involves zinc interaction with the zinc finger domain. Mol Cell Biol. 1997;17:2781-9 pubmed
    ..Thus, mouse MTF-1 functions as a reversibly activated sensor of free zinc pools in the cell. ..
  43. Yi P, Driscoll M, Huang J, Bhagat S, Hilf R, Bambara R, et al. The effects of estrogen-responsive element- and ligand-induced structural changes on the recruitment of cofactors and transcriptional responses by ER alpha and ER beta. Mol Endocrinol. 2002;16:674-93 pubmed
    ..The ability of ER alpha to differentially recruit a cofactor could contribute to ER subtype-specific gene responses. ..
  44. Leigh S, Wise K. Identification and functional mapping of the Mycoplasma fermentans P29 adhesin. Infect Immun. 2002;70:4925-35 pubmed
  45. Morasco B, Sharma N, Parilla J, Flanegan J. Poliovirus cre(2C)-dependent synthesis of VPgpUpU is required for positive- but not negative-strand RNA synthesis. J Virol. 2003;77:5136-44 pubmed
    ..The pool of excess VPgpUpU synthesized on the cre(2C) hairpin should support high levels of positive-strand synthesis and thereby promote the asymmetric replication of poliovirus RNA. ..
  46. Zhang C, Dowd D, Staal A, Gu C, Lian J, Van Wijnen A, et al. Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. J Biol Chem. 2003;278:35325-36 pubmed
  47. Navenot J, Wang Z, Chopin M, Fujii N, Peiper S. Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins. Cancer Res. 2005;65:10450-6 pubmed
    ..The ability of Kp-10 to inhibit signaling and chemotaxis induced by SDF-1 indicates that activation of GPR54 signaling may negatively regulate the role of CXCR4 in programming tumor metastasis. ..
  48. Franco S, Senetar M, Simonson W, Huttenlocher A, McCann R. The conserved C-terminal I/LWEQ module targets Talin1 to focal adhesions. Cell Motil Cytoskeleton. 2006;63:563-81 pubmed
  49. Listman J, Race J, Walker Kopp N, Unlu S, Auron P. Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator. Mol Immunol. 2008;45:2667-77 pubmed publisher
    ..This inhibition is likely the result of competition between Spi-1 and C/EBPbeta, thus blunting gene induction. ..
  50. Knollman P, Conn P. Multiple G proteins compete for binding with the human gonadotropin releasing hormone receptor. Arch Biochem Biophys. 2008;477:92-7 pubmed publisher
    ..Studies were conducted in different human (COS7, HeLa) and rodent-derived (CHO-K1, GH(3)) cell lines in order to confirm that G protein promiscuity observed with the GnRHR was not limited to a particular cell type. ..
  51. Kaufmann A, Toro Ramos A, Krise J. Assessment of golgi apparatus versus plasma membrane-localized multi-drug resistance-associated protein 1. Mol Pharm. 2008;5:787-94 pubmed publisher
    ..Additionally, we show that a number of human leukemic cell lines appear to have an inefficient Golgi apparatus to PM secretory pathway that could be responsible for the Golgi localization of MRP1. ..
  52. Gorbatyuk M, Knox T, Lavail M, Gorbatyuk O, Noorwez S, Hauswirth W, et al. Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78. Proc Natl Acad Sci U S A. 2010;107:5961-6 pubmed publisher
    ..Thus, the preservation of photoreceptor function resulting from elevated levels of BiP is due to suppression of apoptosis rather than to a promotion of rhodopsin folding. ..
  53. Basu A, Das P, Chaudhuri S, Bevilacqua E, Andrews J, Barik S, et al. Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites. Mol Cell Biol. 2011;31:4482-99 pubmed publisher
    ..This work reveals a novel mechanism operating on a cohort of cellular IRESs that involves rRNA methylation for proper 80S complex assembly and efficient translation initiation. ..
  54. Gottschalk A, Trivedi R, Conaway J, Conaway R. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1·PARP1·nucleosome intermediate. J Biol Chem. 2012;287:43527-32 pubmed publisher
    ..Taken together, our findings are consistent with the model that PAR present on PARylated PARP1 acts as an allosteric effector of ALC1 nucleosome remodeling activity. ..
  55. Su Y, Gao C, Liu Y, Guo S, Wang A, Wang B, et al. Monoubiquitination of filamin B regulates vascular endothelial growth factor-mediated trafficking of histone deacetylase 7. Mol Cell Biol. 2013;33:1546-60 pubmed publisher
    ..Taken together, our data show that VEGF and PKC promote degradation-independent protein ubiquitination of FLNB to control intracellular trafficking of HDAC7. ..
  56. Decarreau J, Wagenbach M, Lynch E, Halpern A, Vaughan J, KOLLMAN J, et al. The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation. Nat Cell Biol. 2017;19:384-390 pubmed publisher
    ..The activity of Kif25 during interphase is required to maintain a centred nucleus to ensure the spindle is stably oriented at the onset of mitosis. ..
  57. Zahler A, Lane W, Stolk J, Roth M. SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev. 1992;6:837-47 pubmed
    ..In four of the family members a repeated protein sequence that encompasses an RNA recognition motif was observed. We discuss the potential role of this highly conserved, functionally related set of proteins in pre-mRNA splicing. ..
  58. van der Bliek A, Redelmeier T, Damke H, Tisdale E, Meyerowitz E, Schmid S. Mutations in human dynamin block an intermediate stage in coated vesicle formation. J Cell Biol. 1993;122:553-63 pubmed
    ..These results demonstrate that mutations in the GTP-binding domain of dynamin block Tfn-endocytosis in mammalian cells and suggest that a functional dynamin GTPase is required for receptor-mediated endocytosis via clathrin-coated pits. ..
  59. Martin L, Duke G, Osorio J, Hall D, Palmenberg A. Mutational analysis of the mengovirus poly(C) tract and surrounding heteropolymeric sequences. J Virol. 1996;70:2027-31 pubmed
  60. Kekuda R, Prasad P, Wu X, Wang H, Fei Y, Leibach F, et al. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem. 1998;273:15971-9 pubmed
    ..This potential-sensitive organic cation transporter, designated as OCT3, represents a new member of the OCT gene family. ..
  61. Boronenkov I, Loijens J, Umeda M, Anderson R. Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol Biol Cell. 1998;9:3547-60 pubmed
    ..The putative absence of membranes at these sites suggests novel mechanisms for the generation of phosphoinositides within these structures. ..
  62. Ding W, Albrecht B, Kelley R, Muthusamy N, Kim S, Altschuld R, et al. Human T-cell lymphotropic virus type 1 p12(I) expression increases cytoplasmic calcium to enhance the activation of nuclear factor of activated T cells. J Virol. 2002;76:10374-82 pubmed
  63. Himeda C, Ranish J, Angello J, Maire P, Aebersold R, Hauschka S. Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer. Mol Cell Biol. 2004;24:2132-43 pubmed
    ..Our proteomics strategy will be useful for identifying transcription factors from complex mixtures using only defined DNA fragments for purification. ..
  64. Becker K, Hannun Y. Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D. J Biol Chem. 2004;279:28251-6 pubmed
    ..Taken together, these results define specific biochemical and cellular actions of PKCbetaII when compared with PKCbetaI. ..
  65. Yamane K, Taylor K, Kinsella T. Mismatch repair-mediated G2/M arrest by 6-thioguanine involves the ATR-Chk1 pathway. Biochem Biophys Res Commun. 2004;318:297-302 pubmed
    ..Our results indicate that 6-TG DNA mismatches activate the ATR-Chk1 pathway in the MMR(+) cells, resulting in a G2/M checkpoint response ..
  66. Huan J, Streicher J, Bleyle L, Koop D. Proteasome-dependent degradation of cytochromes P450 2E1 and 2B1 expressed in tetracycline-regulated HeLa cells. Toxicol Appl Pharmacol. 2004;199:332-43 pubmed
    ..Furthermore, the addition of the hsp90 inhibitors geldanamycin, herbimycin, and radicicol had no effect on the turnover of CYP2E1, differentiating the degradation of CYP2E1 from other substrates for proteasome-dependent degradation. ..
  67. Fornek J, Korth M, Katze M. Use of functional genomics to understand influenza-host interactions. Adv Virus Res. 2007;70:81-100 pubmed
    ..Progress is also being made toward using functional genomics in the diagnosis and prognosis of acute lung infections and in the development of more effective influenza vaccines and antivirals. ..
  68. Mandl A, Sarkes D, Carricaburu V, Jung V, Rameh L. Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN. Mol Cell Biol. 2007;27:8098-112 pubmed
  69. Pereira E, Chen Y, Sanchez Y. Conserved ATRMec1 phosphorylation-independent activation of Chk1 by single amino acid substitution in the GD domain. Cell Cycle. 2009;8:1788-93 pubmed
    ..Therefore, we have uncovered a conserved mechanism for Chk1 regulation separate from the role of known ATR phosphorylation sites. ..
  70. Brooks Y, Wang G, Yang Z, Smith K, Bieberich E, Ko L. Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation. J Biol Chem. 2009;284:18033-46 pubmed publisher
    ..The alternative splicing imbalance of CoAA and RBM4, because of loss of their common enhancer in cancer, may deregulate stem/progenitor cell differentiation. ..
  71. Beach J, Egelhoff T. Myosin II recruitment during cytokinesis independent of centralspindlin-mediated phosphorylation. J Biol Chem. 2009;284:27377-83 pubmed publisher
  72. Lo K, Li Z, Wang F, Marcotte E, Johnson A. Ribosome stalk assembly requires the dual-specificity phosphatase Yvh1 for the exchange of Mrt4 with P0. J Cell Biol. 2009;186:849-62 pubmed publisher
    ..The initial assembly of the ribosome with Mrt4 may provide functional compartmentalization of ribosome assembly in addition to the spatial separation afforded by the nuclear envelope. ..
  73. Jin Z, Wallace L, Harper S, Yang J. PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. J Biol Chem. 2010;285:34493-502 pubmed publisher
    ..So far, we have identified an alternative translation isoform and a caspase cleavage product of B56?. The significance of post-transcriptional regulation of B56? is discussed...
  74. Al Ayoubi A, Zheng H, Liu Y, Bai T, Eblen S. Mitogen-activated protein kinase phosphorylation of splicing factor 45 (SPF45) regulates SPF45 alternative splicing site utilization, proliferation, and cell adhesion. Mol Cell Biol. 2012;32:2880-93 pubmed publisher
    ..These data identify SPF45 as the first splicing factor regulated by multiple MAP kinase pathways and show effects of both SPF45 overexpression and phosphorylation. ..
  75. Ray A, Milum K, Battu A, Wani G, Wani A. NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites. DNA Repair (Amst). 2013;12:273-83 pubmed publisher
    ..These findings demonstrate a novel function of DDB2 and XPC in maintaining a vital cross-talk with checkpoint proteins, and thereby coordinating subsequent repair and checkpoint activation. ..
  76. Arango D, Morohashi K, Yilmaz A, Kuramochi K, Parihar A, Brahimaj B, et al. Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets. Proc Natl Acad Sci U S A. 2013;110:E2153-62 pubmed publisher
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