Genomes and Genes
Experts and Doctors on heart in United States
Locale: United States
Publications392 found, 100 shown here
- Hariharan N, Ikeda Y, Hong C, Alcendor R, Usui S, Gao S, et al. Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS ONE. 2013;8:e51632 pubmed publisher..These results suggest that autophagy and FoxO1 play an essential role in mediating regression of cardiac hypertrophy during mechanical unloading. ..
- Cote B, Carlson L, Rao D, Alani A. Combinatorial resveratrol and quercetin polymeric micelles mitigate doxorubicin induced cardiotoxicity in vitro and in vivo. J Control Release. 2015;213:128-133 pubmed publisher..Concurrent administration of mRQ with ADR at 10:10:1 ratio provides a viable strategy to mitigate acute ADR induced cardiotoxicity. ..
- Cacioppo J, Uchino B, Berntson G. Individual differences in the autonomic origins of heart rate reactivity: the psychometrics of respiratory sinus arrhythmia and preejection period. Psychophysiology. 1994;31:412-9 pubmed..Reactivity classifications may therefore be significantly improved by attention to concurrent estimates of the activity of both autonomic branches. ..
- Thayer J, Lane R. Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev. 2009;33:81-8 pubmed publisher..Low HRV is a risk factor for pathophysiology and psychopathology. Finally we review recent work on the genetics of HRV and suggest that low HRV may be an endophenotype for a broad range of dysfunctions. ..
- Nam H, Wang C, Zhang L, Zhang W, Hojyo S, Fukada T, et al. ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Haematologica. 2013;98:1049-57 pubmed publisher..Our results provide insight into the potential contributions of these transporters to tissue iron uptake during iron deficiency and overload. ..
- Knabb R, Rasbach D, Leamy A, Fernando D, Mackin W, Boswell G, et al. Persistent cardioprotection by azapropazone in a canine model of coronary artery thrombosis and thrombolysis. J Cardiovasc Pharmacol. 1991;17:390-6 pubmed..These dta show that azapropazone limits infarct size in a canine model of coronary thrombosis and long-term reperfusion and that this cardioprotection is independent of cardiovascular parameters. ..
- Zile M, Richardson K, Cowles M, Buckley J, Koide M, Cowles B, et al. Constitutive properties of adult mammalian cardiac muscle cells. Circulation. 1998;98:567-79 pubmed..Changes in viscous damping and myofilament activation in combination may cause pressure-hypertrophied cardiocytes to resist changes in shape during diastole and contribute to diastolic dysfunction. ..
- Spinner B, Zajdel R, McLean M, Denz C, Dube S, Mehta S, et al. Characterization of a TM-4 type tropomyosin that is essential for myofibrillogenesis and contractile activity in embryonic hearts of the Mexican axolotl. J Cell Biochem. 2002;85:747-61 pubmed..These results demonstrated that a striated muscle isoform of the TM-4 gene was expressed embryonically and was necessary for normal structure and function of the ventricle...
- Hua D, Zhuang X, Ye J, Wilson D, Chiang B, Chien S. Using fructose-1,6-diphosphate during hypothermic rabbit-heart preservation: a high-energy phosphate study. J Heart Lung Transplant. 2003;22:574-82 pubmed..This difference was especially prominent in the left and right ventricles. The protective effect of FDP during hypothermic heart preservation deserves further study. ..
- Hua F, Ricketts B, Reifsteck A, Ardell J, Williams C. Myocardial ischemia induces the release of substance P from cardiac afferent neurons in rat thoracic spinal cord. Am J Physiol Heart Circ Physiol. 2004;286:H1654-64 pubmed
- Yatani A, Kim S, Kudej R, Wang Q, Depre C, Irie K, et al. Insights into cardioprotection obtained from study of cellular Ca2+ handling in myocardium of true hibernating mammals. Am J Physiol Heart Circ Physiol. 2004;286:H2219-28 pubmed..These changes may account for natural resistance to Ca2+ overload-related ventricular dysfunction and point to an important cardioprotective mechanism during true hibernation. ..
- Chen G, Sun Z. Effects of chronic cold exposure on the endothelin system. J Appl Physiol (1985). 2006;100:1719-26 pubmed..Therefore, cold exposure increased ET-1 production, upregulated ETA receptors, and downregulated ETB receptors. ..
- Chen Y, Daosukho C, Opii W, Turner D, Pierce W, Klein J, et al. Redox proteomic identification of oxidized cardiac proteins in adriamycin-treated mice. Free Radic Biol Med. 2006;41:1470-7 pubmed..The observation that these cardiac enzymes involved in energy production are more oxidized resulting from ADR treatment indicates that the bioenergetic pathway is an important target in ADR-initiated oxidative stress. ..
- Korzick D, Kostyak J, Hunter J, Saupe K. Local delivery of PKCepsilon-activating peptide mimics ischemic preconditioning in aged hearts through GSK-3beta but not F1-ATPase inactivation. Am J Physiol Heart Circ Physiol. 2007;293:H2056-63 pubmed
- Gibbons R, Miller T, Hodge D, Urban L, Araoz P, Pellikka P, et al. Application of appropriateness criteria to stress single-photon emission computed tomography sestamibi studies and stress echocardiograms in an academic medical center. J Am Coll Cardiol. 2008;51:1283-9 pubmed publisher..Quality improvement efforts directed at reducing the number of these inappropriate studies may improve efficiency in the health care system. ..
- Vellaichamy E, Das S, Subramanian U, Maeda N, Pandey K. Genetically altered mutant mouse models of guanylyl cyclase/natriuretic peptide receptor-A exhibit the cardiac expression of proinflammatory mediators in a gene-dose-dependent manner. Endocrinology. 2014;155:1045-56 pubmed publisher..The present findings suggest that Npr1 represses the expression of cardiac proinflammatory mediators, hypertrophic markers, and NF-?B/AP-1-mediated mechanisms, which seem to be associated in an Npr1 gene-dose-dependent manner. ..
- Baker S, Buss D, Epstein M, Posner P. Effect of chronic hypoxia on cardiac beta-adrenergic and muscarinic receptors during maturation. Res Commun Chem Pathol Pharmacol. 1989;63:307-15 pubmed..The data suggest that hypoxia during the first 3 weeks of postnatal development in the rabbit induces alterations in the cardiac beta-adrenergic receptor with no effect on the development of the cholinergic muscarinic receptor. ..
- Norris R, Kern C, Wessels A, Wirrig E, Markwald R, Mjaatvedt C. Detection of betaig-H3, a TGFbeta induced gene, during cardiac development and its complementary pattern with periostin. Anat Embryol (Berl). 2005;210:13-23 pubmed..The mRNA expression domains of betaig-H3 show a complementary pattern compared to that of its highly homologous relative, periostin. ..
- Thomas N, Dubey J, Lindsay D, Cole R, Meteyer C. Protozoal meningoencephalitis in sea otters (Enhydra lutris): a histopathological and immunohistochemical study of naturally occurring cases. J Comp Pathol. 2007;137:102-21 pubmed..neurona encephalitis, supporting the conclusion that S. neurona is the most significant protozoal pathogen in the central nervous system of sea otters...
- Rufer E, Hacker T, Flentke G, Drake V, Brody M, Lough J, et al. Altered cardiac function and ventricular septal defect in avian embryos exposed to low-dose trichloroethylene. Toxicol Sci. 2010;113:444-52 pubmed publisher..These data demonstrate that TCE is a cardiac teratogen for chick. ..
- Lenhart K, Holtzman N, Williams J, Burdine R. Integration of nodal and BMP signals in the heart requires FoxH1 to create left-right differences in cell migration rates that direct cardiac asymmetry. PLoS Genet. 2013;9:e1003109 pubmed publisher..These findings have implications for understanding the complex genetic interactions that lead to congenital heart disease in humans. ..
- Chetty K, Light R, Stansbury D, Milne N. Exercise performance of polycythemic chronic obstructive pulmonary disease patients. Effect of phlebotomies. Chest. 1990;98:1073-7 pubmed..There was no relationship between the increases in the upright exercise capacity and changes in the supine ejection fractions of the right or left ventricular either at rest or during exercise. ..
- Grover G, Sleph P. The cardioprotective effects of R 75231 and lidoflazine are not caused by adenosine A1 receptor activation. J Pharmacol Exp Ther. 1994;268:90-6 pubmed..It may be acting as a calcium antagonist in this model. ..
- Zhang N, Mustin D, Reardon W, Almeida A, Mozdziak P, Mrug M, et al. Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development. Stem Cells Dev. 2006;15:17-28 pubmed..Moreover, the demonstration that blood-borne cells contribute to the development of various organs lends credence to claims that hematopoietic stem cells have utility for treating diseased or damaged tissues in the adult. ..
- Jones C, Quinn M, Minisi A. Reflex control of sympathetic outflow and depressed baroreflex sensitivity following myocardial infarction. Auton Neurosci. 2008;141:46-53 pubmed publisher..These results provide additional support for the hypothesis that depressed reflex control of heart rate following myocardial infarction is related to augmented afferent input from the left ventricle. ..
- Geng Q, Romero J, Saini V, Baker T, Picken M, Gamelli R, et al. A subset of 26S proteasomes is activated at critically low ATP concentrations and contributes to myocardial injury during cold ischemia. Biochem Biophys Res Commun. 2009;390:1136-41 pubmed publisher..A subset of 26S proteasomes appears to be a cell-destructive protease that is activated as ATP levels decline. Proteasome inhibition during cold ischemia preserves the ultrastructural integrity of the cardiomyocyte. ..
- Serrano M, Han M, Brinez P, Linask K. Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. Am J Obstet Gynecol. 2010;203:75.e7-75.e15 pubmed publisher..Folic acid supplementation alone or with myoinositol prevented alcohol potentiation of Wnt/beta-catenin signaling that allowed normal gene activation and cardiogenesis. ..
- Chen Y, Somji A, Yu X, Stelzer J. Altered in vivo left ventricular torsion and principal strains in hypothyroid rats. Am J Physiol Heart Circ Physiol. 2010;299:H1577-87 pubmed publisher..Thus, increased expression of β-MHC alters the pattern and decreases the magnitude of LV rotation, contributing to reduced mechanical performance during systole, especially in conditions of increased workload. ..
- Johnson M, Demarco V, Heesch C, Whaley Connell A, Schneider R, Rehmer N, et al. Sex differences in baroreflex sensitivity, heart rate variability, and end organ damage in the TGR(mRen2)27 rat. Am J Physiol Heart Circ Physiol. 2011;301:H1540-50 pubmed publisher..These data demonstrated relative protection in females from autonomic dysfunction and end-organ damage associated with elevated blood pressure in the Ren2 model of hypertension. ..
- FOSTER C, Zha Q, Daniel L, Singh M, Singh K. Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in ?-adrenergic receptor-stimulated apoptosis. Exp Physiol. 2012;97:506-15 pubmed publisher..Adrenergic receptor-stimulated apoptosis in WT hearts is associated with a p53- and JNKs-dependent mechanism, while decreased Akt activity may play a role in increased myocyte apoptosis in the absence of ATM. ..
- Cheng Y, Wan X, McElfresh T, Chen X, Gresham K, Rosenbaum D, et al. Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere. Am J Physiol Heart Circ Physiol. 2013;305:H52-65 pubmed publisher..Perturbations in mechanical and electrical activity in MyBP-C+/- mice could increase their susceptibility to cardiac dysfunction and arrhythmia. ..
- McCully B, Hasan W, Streiff C, Houle J, Woodward W, Giraud G, et al. Sympathetic cardiac hyperinnervation and atrial autonomic imbalance in diet-induced obesity promote cardiac arrhythmias. Am J Physiol Heart Circ Physiol. 2013;305:H1530-7 pubmed publisher..However, normalized cardiac parasympathetic nervous system control may protect the heart from arrhythmic events. ..
- Denslow S. Constraints on cardiac hypertrophy imposed by myocardial viscosity. J Appl Physiol (1985). 2000;89:1022-32 pubmed..It is concluded that load-independent viscous resistance to contraction is an important factor in cardiac mechanics, especially of the thickened ventricles of concentric hypertrophy...
- Hoover L, Burton E, Brooks B, Kubalak S. The expanding role for retinoid signaling in heart development. ScientificWorldJournal. 2008;8:194-211 pubmed publisher..It is our hope that this review of the role of retinoid signaling during formation, remodeling, and maturation of the developing heart will serve as a tool for future discoveries. ..
- Miller T, Christian T, Hodge D, Mullan B, Gibbons R. Prognostic value of exercise thallium-201 imaging performed within 2 years of coronary artery bypass graft surgery. J Am Coll Cardiol. 1998;31:848-54 pubmed..Exercise Tl-201 imaging performed within 2 years of CABG can stratify patients into low and high risk subgroups. ..
- Gaussin V, Morley G, Cox L, Zwijsen A, Vance K, Emile L, et al. Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus. Circ Res. 2005;97:219-26 pubmed..In conclusion, our mouse model demonstrated critical roles for Alk3 signaling in the AV myocardium during the development of AV valves and the annulus fibrosus. ..
- Zhai P, Galeotti J, Liu J, Holle E, Yu X, Wagner T, et al. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circ Res. 2006;99:528-36 pubmed..The YIPP motif in the AT(1)R plays an important role in mediating cardiac hypertrophy in vivo. ..
- Hu C, Chandra R, Ge H, Pain J, Yan L, Babu G, et al. Adenylyl cyclase type 5 protein expression during cardiac development and stress. Am J Physiol Heart Circ Physiol. 2009;297:H1776-82 pubmed publisher..Thus this new AC5 antibody demonstrated that this AC isoform behaves similarly to fetal type genes, such as atrial natriuretic peptide; i.e., it declines with development and increases with pressure-overload hypertrophy...
- Qipshidze N, Tyagi N, Sen U, Givvimani S, Metreveli N, Lominadze D, et al. Folic acid mitigated cardiac dysfunction by normalizing the levels of tissue inhibitor of metalloproteinase and homocysteine-metabolizing enzymes postmyocardial infarction in mice. Am J Physiol Heart Circ Physiol. 2010;299:H1484-93 pubmed publisher..We showed that FA supplementation resulted in significant improvement of myocardial function after MI. The study eluted the importance of homocysteine (Hcy) metabolism and FA supplementation in cardiovascular disease. ..
- Lee Y, Song A, Baker R, Micales B, Conway S, Lyons G. Jumonji, a nuclear protein that is necessary for normal heart development. Circ Res. 2000;86:932-8 pubmed..These data demonstrate that JMJ is a nuclear protein, which is essential for normal heart development and function. ..
- Banerjee I, Fuseler J, Price R, Borg T, Baudino T. Determination of cell types and numbers during cardiac development in the neonatal and adult rat and mouse. Am J Physiol Heart Circ Physiol. 2007;293:H1883-91 pubmed..Taken together, these data enabled us to establish a homeostatic model for the myocardium that can be compared with genetic and cardiac disease models. ..
- Tirziu D, Chorianopoulos E, Moodie K, Palac R, Zhuang Z, Tjwa M, et al. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. J Clin Invest. 2007;117:3188-97 pubmed..Thus stimulation of vascular growth in normal adult mouse hearts leads to an increase in cardiac mass. ..
- Jacobson A, Senior R, Cerqueira M, Wong N, Thomas G, Lopez V, et al. Myocardial iodine-123 meta-iodobenzylguanidine imaging and cardiac events in heart failure. Results of the prospective ADMIRE-HF (AdreView Myocardial Imaging for Risk Evaluation in Heart Failure) study. J Am Coll Cardiol. 2010;55:2212-21 pubmed publisher
- Billinger S, Vidoni E, Honea R, Burns J. Cardiorespiratory response to exercise testing in individuals with Alzheimer's disease. Arch Phys Med Rehabil. 2011;92:2000-5 pubmed publisher..003). Individuals with AD demonstrate physiologic responses to submaximal exercise effort that are not significantly different than individuals without dementia. However, differences are apparent at the extreme of effort. ..
- Woodhull McNeal A. Project labs in physiology. Am J Physiol. 1992;263:S29-32 pubmed..Project-based laboratories, even more than standard laboratories, can serve the technical, motivational, and conceptual purposes for our laboratory teaching. ..
- Pappano A. Development of cholinergic neuroeffector transmission in the avian heart. Implications for regulatory mechanisms. Ann N Y Acad Sci. 1990;588:131-6 pubmed..This suppressed response can be revealed later in life, even in adults, when provision is made to exclude Gi/Go and or K channel activity. ..
- Rajasekaran S, Morey T, Martynyuk A, Dennis D. Free radicals potentiate the negative dromotropic effect of adenosine in guinea pig isolated heart. Acta Cardiol. 2003;58:191-7 pubmed..Superoxides and adenosine delay AV nodal conduction in a synergistic manner via a NO-dependent mechanism involving an I(K,ADO)-independent component. This phenomenon may contribute to the genesis of reperfusion arrhythmias. ..
- Janssen P, Hiranandani N, Mays T, Rafael Fortney J. Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice. Am J Physiol Heart Circ Physiol. 2005;289:H2373-8 pubmed..7 +/- 5.1 compared with 30.9 +/- 8.9 in mdx and 41.0 +/- 4.9 in WT mice. These data show that cardiac contractile dysfunction of mdx mice is generally worsened in mice also lacking utrophin. ..
- Okere I, Young M, McElfresh T, Chess D, Sharov V, Sabbah H, et al. Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Hypertension. 2006;48:1116-23 pubmed..In conclusion, increased dietary lipid intake can reduce cardiac growth, left ventricular remodeling, contractile dysfunction, and alterations in gene expression in response to hypertension. ..
- Zou L, Yang S, Hu S, Chaudry I, Marchase R, Chatham J. The protective effects of PUGNAc on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels. Shock. 2007;27:402-8 pubmed..The similar effects of glucosamine and PUGNAc support the notion that the protection associated with both interventions is mediated via increased protein O-GlcNAc levels. ..
- Murray D, Gardner J, Brower G, Janicki J. Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats. Am J Physiol Heart Circ Physiol. 2008;294:H1251-7 pubmed publisher..Another novel finding from this study is that chronic nonspecific endothelin antagonism may inadvertently potentiate ET-1-mediated signaling. ..
- Shen J, Yu W, Brotto M, Scherman J, Guo C, Stoddard C, et al. Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis. Nat Cell Biol. 2009;11:769-76 pubmed publisher..These studies provide the first evidence that finely controlled PtdInsP levels in muscle cells are essential for maintaining Ca(2+) homeostasis and muscle performance. ..
- Rodgers K, Papinska A, Mordwinkin N. Regulatory aspects of small molecule drugs for heart regeneration. Adv Drug Deliv Rev. 2016;96:245-52 pubmed publisher..This review will focus on regulatory aspects as well as preclinical hurdles of development of new treatments for heart regeneration. ..
- Isaacson D, Mueller J, Newell J, Siltanen S. Imaging cardiac activity by the D-bar method for electrical impedance tomography. Physiol Meas. 2006;27:S43-50 pubmed..Results are shown for reconstructions from data collected on electrodes placed around the circumference of a human chest to reconstruct a 2D cross-section of the torso. The images show changes in conductivity during a cardiac cycle. ..
- Powers S, Quindry J, Kavazis A. Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radic Biol Med. 2008;44:193-201 pubmed publisher..Understanding the molecular basis for exercise-induced cardioprotection will provide the required knowledge base to develop therapeutic approaches to protect the heart during an IR insult. ..
- Gonzalez Stawinski G, Tan C, Smedira N, Starling R, Rodriguez E. Decay-accelerating factor expression may provide immunoprotection against antibody-mediated cardiac allograft rejection. J Heart Lung Transplant. 2008;27:357-61 pubmed publisher..Expression of DAF on cardiac allografts may provide an immunoprotective mechanism against the deleterious effects of complement deposition in patients with antibody-mediated cardiac allograft rejection. ..
- Gale A, Jain A, Vallow L, Serago C, Buskirk S, Heckman M. Cardiac dose evaluation for 3-dimensional conformal partial breast irradiation compared with whole breast irradiation. J Appl Clin Med Phys. 2009;10:2868 pubmed..Patients with left-sided lesions and lateralized tumor beds warrant special consideration for PBI, given the significant cardiac dose sparing. ..
- Gage A, Baust J, Baust J. Experimental cryosurgery investigations in vivo. Cryobiology. 2009;59:229-43 pubmed publisher..In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described. ..
- Hicks C, Sweeney D, Danner R, Eichacker P, Suffredini A, Feng J, et al. Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock. Crit Care Med. 2012;40:199-207 pubmed publisher..Prophylactic mineralocorticoids should be further investigated in patients at high risk to develop sepsis, whereas glucocorticoids should only be administered therapeutically to prevent adrenal suppression and worse outcomes. ..
- Demirel H, Powers S, Zergeroglu M, Shanely R, Hamilton K, Coombes J, et al. Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. J Appl Physiol (1985). 2001;91:2205-12 pubmed
- Grimes A, Stadt H, Shepherd I, Kirby M. Solving an enigma: arterial pole development in the zebrafish heart. Dev Biol. 2006;290:265-76 pubmed
- Bissonnette J, Knopp S, Maylie J, Thong T. Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Auton Neurosci. 2007;136:82-9 pubmed..Maximum gain was not different. These results do reveal any disturbance of autonomic cardiovascular regulation in the Mecp2 deficient mouse genotype. ..
- Saraceni C, Broderick T. Cardiac and metabolic consequences of aerobic exercise training in experimental diabetes. Curr Diabetes Rev. 2007;3:75-84 pubmed..Notably, the cardio-protective and metabolic benefits of aerobic exercise are seemingly more pronounced in those individuals most susceptible to diabetes progression. ..
- Smith R, Matiukas A, Zemlin C, Pertsov A. Nondestructive optical determination of fiber organization in intact myocardial wall. Microsc Res Tech. 2008;71:510-6 pubmed publisher..These results show that optical clearing, in combination with a fluorescent dye and confocal microscopy, is a practical and accurate method for determining myocardial fiber organization. ..
- Nakamura T, Kawabe K, Sapru H. Cardiovascular responses to microinjections of urocortin 3 into the nucleus tractus solitarius of the rat. Am J Physiol Heart Circ Physiol. 2009;296:H325-32 pubmed publisher..These results indicate that Ucn3 microinjections into the mNTS exerted excitatory effects on the mNTS neurons via CRF2Rs, leading to depressor and bradycardic responses. ..
- Givvimani S, Munjal C, Tyagi N, Sen U, Metreveli N, Tyagi S. Mitochondrial division/mitophagy inhibitor (Mdivi) ameliorates pressure overload induced heart failure. PLoS ONE. 2012;7:e32388 pubmed publisher..Above results suggest that Mdivi inhibits the abnormal cardiac mitophagy response during sustained pressure overload stress and propose the novel therapeutic role of Mdivi in ameliorating heart failure. ..
- Kocan R, LaPatra S, Hershberger P. Evidence for an amoeba-like infectious stage of Ichthyophonus sp. and description of a circulating blood stage: a probable mechanism for dispersal within the fish host. J Parasitol. 2013;99:235-40 pubmed publisher..From 20 to 60 days PE, schizont diameter increased from ? 25 ?m to ? 82 ?m. Based on the data presented herein, we are confident that we have resolved the life cycle of Ichthyophonus sp. within the piscivorous host. ..
- Williams A, Kwiatkowski M, Mortimer A, Marder E, Zeeman M, Dickinson P. Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis. J Neurophysiol. 2013;109:2451-65 pubmed publisher..Overall, we suggest that the phasing of the CG may vary without compromising appropriate motor output and that this variability may critically determine how the network behaves in response to manipulations. ..
- Gershlak J, Resnikoff J, Sullivan K, Williams C, Wang R, Black L. Mesenchymal stem cells ability to generate traction stress in response to substrate stiffness is modulated by the changing extracellular matrix composition of the heart during development. Biochem Biophys Res Commun. 2013;439:161-6 pubmed publisher..In summary, this study found that complex ECM composition plays an important role in modulating a cell's ability to generate traction stress against a substrate, which is a significant component of mechanotransductive signaling. ..
- Zeng H, He X, Hou X, Li L, Chen J. Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3. Am J Physiol Heart Circ Physiol. 2014;306:H585-97 pubmed publisher..We conclude that apelin gene therapy increases vascular density and alleviates diabetic cardiomyopathy by a mechanism involving activation of Sirt3 and upregulation of VEGF/VEGFR2 and Ang-1/Tie-2 expression. ..
- Finlin B, Andres D. Rem is a new member of the Rad- and Gem/Kir Ras-related GTP-binding protein family repressed by lipopolysaccharide stimulation. J Biol Chem. 1997;272:21982-8 pubmed..Thus, Rem is the first Ras-related gene whose mRNA levels have been shown to be regulated by repression. ..
- Chesterman E, Gainey G, Varn A, Peterson R, Kern M. Investigation of Prx1 protein expression provides evidence for conservation of cardiac-specific posttranscriptional regulation in vertebrates. Dev Dyn. 2001;222:459-70 pubmed..This observation provides a new explanation of why the Prx null mice lack cardiac malformations. ..
- Kubalak S, Hutson D, Scott K, Shannon R. Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Development. 2002;129:733-46 pubmed
- Stelzer J, Larsson L, Fitzsimons D, Moss R. Activation dependence of stretch activation in mouse skinned myocardium: implications for ventricular function. J Gen Physiol. 2006;127:95-107 pubmed..Such a mechanism would contribute to increased systolic ejection in response to increased delivery of activator Ca2+ during excitation-contraction coupling. ..
- Takagi H, Matsui Y, Sadoshima J. The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal. 2007;9:1373-81 pubmed..In this review, the signaling mechanism and the functional significance of autophagy during myocardial ischemia and reperfusion are discussed. ..
- Baden K, Murray J, Capaldi R, Guillemin K. Early developmental pathology due to cytochrome c oxidase deficiency is revealed by a new zebrafish model. J Biol Chem. 2007;282:34839-49 pubmed..The zebrafish model has revealed tissue-specific responses to COX deficiency and holds promise for discovery of new therapies to treat mitochondrial diseases in humans. ..
- Terenzi F, Ladd A. Conserved developmental alternative splicing of muscleblind-like (MBNL) transcripts regulates MBNL localization and activity. RNA Biol. 2010;7:43-55 pubmed..Thus, we propose that conserved developmental stage- and tissue-specific alternative splicing of MBNL transcripts is an important mechanism by which MBNL activity is regulated during embryonic development. ..
- Mabe A, Hoover D. Remodeling of cardiac cholinergic innervation and control of heart rate in mice with streptozotocin-induced diabetes. Auton Neurosci. 2011;162:24-31 pubmed publisher..The increased density of cholinergic nerves observed at the sinoatrial node of diabetic mice might be a compensatory response. ..
- FOSTER C, Singh M, Subramanian V, Singh K. Ataxia telangiectasia mutated kinase plays a protective role in ?-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling. Mol Cell Biochem. 2011;353:13-22 pubmed publisher..MMP-9 protein levels were increased in WT-ISO, not in hKO hearts. In conclusion, ATM plays a protective role in cardiac remodeling in response to ?-AR stimulation. ..
- Gao M, Ha T, Zhang X, Liu L, Wang X, Kelley J, et al. Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med. 2012;40:2390-9 pubmed publisher..These data indicate that TLR3 plays a deleterious role in mediating cardiac dysfunction in sepsis. Thus, modulation of the TLR3 activity may be useful in preventing cardiac dysfunction in sepsis. ..