Experts and Doctors on haemophilus somnus in United States

Summary

Locale: United States
Topic: haemophilus somnus

Top Publications

  1. Sylte M, Inzana T, Czuprynski C. Reactive oxygen and nitrogen intermediates contribute to Haemophilus somnus lipooligosaccharide-mediated apoptosis of bovine endothelial cells. Vet Immunol Immunopathol. 2004;97:207-17 pubmed
    ..These data suggest H. somnus LOS triggers endogenous ROS and RNI production by endothelial cells, which contributes to apoptosis...
  2. Howard M, Willis L, Wakarchuk W, St Michael F, Cox A, Horne W, et al. Genetics and molecular specificity of sialylation of Histophilus somni lipooligosaccharide (LOS) and the effect of LOS sialylation on Toll-like receptor-4 signaling. Vet Microbiol. 2011;153:163-72 pubmed publisher
    ..Therefore, sialylation inhibited LOS signaling through TLR-4. In conclusion, H. somni utilizes linkage-specific sialyltransferases to sialylate its LOS to avoid innate host defense mechanisms despite simultaneous epitope phase variation...
  3. Kuckleburg C, McClenahan D, Czuprynski C. Platelet activation by Histophilus somni and its lipooligosaccharide induces endothelial cell proinflammatory responses and platelet internalization. Shock. 2008;29:189-96 pubmed
    ..These findings suggest that activated platelets might play a role in promoting vascular inflammation during H. somni infection...
  4. Behling Kelly E, Kim K, Czuprynski C. Haemophilus somnus activation of brain endothelial cells: potential role for local cytokine production and thrombosis in central nervous system (CNS) infection. Thromb Haemost. 2007;98:823-30 pubmed
    ..These changes would be expected to promote thrombus formation in vessels of the CNS, and potentially contribute to the pathogenesis of TME...
  5. Behling Kelly E, McClenahan D, Kim K, Czuprynski C. Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance. Infect Immun. 2007;75:4572-81 pubmed
    ..The data from this study support the hypothesis that viable H. somnus alters integrity of the blood-brain barrier by promoting contraction of BBEC and increasing paracellular permeability of the CNS vasculature...
  6. Behling Kelly E, Vonderheid H, Kim K, Corbeil L, Czuprynski C. Roles of cellular activation and sulfated glycans in Haemophilus somnus adherence to bovine brain microvascular endothelial cells. Infect Immun. 2006;74:5311-8 pubmed
    ..These data suggest that heparin-binding proteins on H. somnus could serve as initial adhesins to sulfated proteoglycans on the endothelial cell surface, thus contributing to the ability of H. somnus to infect the bovine CNS...
  7. Sylte M, Kuckleburg C, Leite F, Inzana T, Czuprynski C. Tumor necrosis factor-alpha enhances Haemophilus somnus lipooligosaccharide-induced apoptosis of bovine endothelial cells. Vet Immunol Immunopathol. 2006;110:303-9 pubmed
    ..Conversely, addition of soluble recombinant human (sTNF-R1) diminished LOS-induced apoptosis. Overall, these data suggest that LOS-mediated apoptosis may be due, in part, to activation of a TNR-R1-dependent death pathway...
  8. Godinho K, Wolf R, Sherington J, Rowan T, Sunderland S, Evans N. Efficacy of tulathromycin in the treatment and prevention of natural outbreaks of bovine respiratory disease in European cattle. Vet Ther. 2005;6:122-35 pubmed
    ..7%) or saline-treated (63.7%) cattle, and this was maintained through day 60 (tulathromycin 85.4% versus tilmicosin 75.1% and saline 56.2%). Tulathromycin was highly effective in the treatment and prevention of BRD...
  9. Godinho K, Keane S, Nanjiani I, Benchaoui H, Sunderland S, Jones M, et al. Minimum inhibitory concentrations of tulathromycin against respiratory bacterial pathogens isolated from clinical cases in European cattle and swine and variability arising from changes in in vitro methodology. Vet Ther. 2005;6:113-21 pubmed
    ..Isolates were retested in the presence of serum. The activity of tulathromycin against fastidious organisms was affected by culture conditions, and MICs were reduced in the presence of serum...

More Information

Publications17

  1. Czuprynski C, Leite F, Sylte M, Kuckleburg C, Schultz R, Inzana T, et al. Complexities of the pathogenesis of Mannheimia haemolytica and Haemophilus somnus infections: challenges and potential opportunities for prevention?. Anim Health Res Rev. 2004;5:277-82 pubmed
    ..A more thorough understanding of M. haemolytica and H. somnus virulence factors and their interactions with the host might identify new targets for prevention of bovine respiratory disease...
  2. Sylte M, Kuckleburg C, Inzana T, Bertics P, Czuprynski C. Stimulation of P2X receptors enhances lipooligosaccharide-mediated apoptosis of endothelial cells. J Leukoc Biol. 2005;77:958-65 pubmed
    ..Together, these data indicate that stimulation of P2X receptors enhances LOS-induced apoptosis of endothelial cells, possibly as a result of endogenous release of ATP, which results in caspase-8 activation...
  3. Kuckleburg C, Sylte M, Inzana T, Corbeil L, Darien B, Czuprynski C. Bovine platelets activated by Haemophilus somnus and its LOS induce apoptosis in bovine endothelial cells. Microb Pathog. 2005;38:23-32 pubmed
    ..If these events occur in vivo, they might promote vascular damage and endothelial cell apoptosis, leading to the development of vasculitis and thrombosis that characterize bovine H. somnus infection...
  4. Berry B, Krehbiel C, Confer A, Gill D, Smith R, Montelongo M. Effects of dietary energy and starch concentrations for newly received feedlot calves: I. Growth performance and health. J Anim Sci. 2004;82:837-44 pubmed
    ..Although animal performance was not influenced, the present data suggest that feeding the high-energy diet decreased the percentage of P. multocida and H. somnus pathogens in calves that received one or more antimicrobial treatments...
  5. Sylte M, Kuckleburg C, Atapattu D, Leite F, McClenahan D, Inzana T, et al. Signaling through interleukin-1 type 1 receptor diminishes Haemophilus somnus lipooligosaccharide-mediated apoptosis of endothelial cells. Microb Pathog. 2005;39:121-30 pubmed
    ..Exposure of endothelial cells to IL-1beta or LOS increased pAkt protein as assessed by western blot. Overall, these results suggest that signaling through the IL-1 type 1 receptor diminishes H. somnus LOS-mediated apoptosis...
  6. Godinho K. Susceptibility testing of tulathromycin: interpretative breakpoints and susceptibility of field isolates. Vet Microbiol. 2008;129:426-32 pubmed publisher
    ..The use of recently established interpretative breakpoints would indicate that to date there has been no apparent decrease in susceptibility to tulathromycin since it became widely used across Europe...
  7. Kuckleburg C, Tiwari R, Czuprynski C. Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species. Thromb Haemost. 2008;99:363-72 pubmed publisher
    ..These findings suggest that bacterial activation of platelets may contribute to endothelial cell dysfunction observed during sepsis, specifically by inducing endothelial cell apoptosis...
  8. Sylte M, Leite F, Kuckleburg C, Inzana T, Czuprynski C. Caspase activation during Haemophilus somnus lipooligosaccharide-mediated apoptosis of bovine endothelial cells. Microb Pathog. 2003;35:285-91 pubmed
    ..These data suggest that LOS-mediated activation of caspase-3 and apoptosis of endothelial cells is caspase-8 dependent...