Genomes and Genes
Experts and Doctors on gtp binding proteins in United States
Locale: United States
Topic: gtp binding proteins
Publications172 found, 100 shown here
- Albert P, Zhou Q, Van Tol H, Bunzow J, Civelli O. Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene. J Biol Chem. 1990;265:5825-32 pubmed..9, 3.6, and 3.3 kilobases). These studies represent the first characterization of receptor function and brain distribution of the cloned rat 5-HT1A receptor. ..
- Wiley E, Zakian V. Extra telomeres, but not internal tracts of telomeric DNA, reduce transcriptional repression at Saccharomyces telomeres. Genetics. 1995;139:67-79 pubmed..These results also provide evidence for a terminus-specific binding factor that is a factor with a higher affinity for DNA termini than for nonterminal tracts of telomeric DNA and indicate that this factor is important for TPE. ..
- Krapivinsky G, Gordon E, Wickman K, Velimirovic B, Krapivinsky L, Clapham D. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature. 1995;374:135-41 pubmed..It is now shown that IKACh is a heteromultimer of two distinct inwardly rectifying K(+)-channel subunits, GIRK1 and a newly cloned member of the family, CIR. ..
- Symons M, Derry J, Karlak B, Jiang S, Lemahieu V, McCormick F, et al. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell. 1996;84:723-34 pubmed..The WASP sequence contains two novel domains that are homologous to other proteins involved in action organization. ..
- Loijens J, Boronenkov I, Parker G, Anderson R. The phosphatidylinositol 4-phosphate 5-kinase family. Adv Enzyme Regul. 1996;36:115-40 pubmed..The concept of localized complexes containing particular PIP5K isoforms that control the composition of different polyphosphoinositide pools will likely be important as the family of PIP5K isoforms grows. ..
- Takeishi Y, Jalili T, Hoit B, Kirkpatrick D, Wagoner L, Abraham W, et al. Alterations in Ca2+ cycling proteins and G alpha q signaling after left ventricular assist device support in failing human hearts. Cardiovasc Res. 2000;45:883-8 pubmed
- MacLennan A, Devlin B, Marks L, Gaskin A, Neitzel K, Lee N. Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. Dev Neurosci. 2000;22:283-95 pubmed..Finally, and in agreement with a S1P receptor role for H218, we find that the antisense-H218 cells display less S1P-induced neurite retraction than control cells. ..
- Mourton T, Hellberg C, Burden Gulley S, Hinman J, Rhee A, Brady Kalnay S. The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts. J Biol Chem. 2001;276:14896-901 pubmed..Therefore, PTPmu may be one of the proteins that recruits RACK1 to points of cell-cell contact, which may be important for PTPmu-dependent signaling in response to cell-cell adhesion. ..
- Stitham J, Stojanovic A, Hwa J. Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism. J Biol Chem. 2002;277:15439-44 pubmed..This study provides the mechanistic basis for further research into genetic risk factors and pharmacogenetics of cardiovascular disease associated with hIP. ..
- O Brien T. Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease. Gene. 2002;286:73-9 pubmed..Interest is growing in the structure, organization, chromosomal location and expression of genes for human MRPs. Proteins which are essential for mitoribosome function are candidates for involvement in human genetic disease. ..
- Zheng Z, Nafisi M, Tam A, Li H, Crowell D, Chary S, et al. Plasma membrane-associated ROP10 small GTPase is a specific negative regulator of abscisic acid responses in Arabidopsis. Plant Cell. 2002;14:2787-97 pubmed..These results suggest that ROP10 is a PM-localized signaling molecule that is involved specifically in the negative regulation of ABA signaling. ..
- Reynolds J, Ignatowski T, Spengler R. Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor. J Neurosci Res. 2005;79:779-87 pubmed..Therefore, TNF directs the coupling of the alpha2-adrenergic receptor, ultimately affecting NE release. ..
- West M, Hedges J, Chen A, Johnson A. Defining the order in which Nmd3p and Rpl10p load onto nascent 60S ribosomal subunits. Mol Cell Biol. 2005;25:3802-13 pubmed..These results support the idea that Sqt1p loads Rpl10p onto the Nmd3p-bound subunit after export to the cytoplasm and that Rpl10p loading involves the GTPase Lsg1p. ..
- D Souza D, Wei J, Shao Q, Hebert M, Subramony S, Vig P. Tissue transglutaminase crosslinks ataxin-1: possible role in SCA1 pathogenesis. Neurosci Lett. 2006;409:5-9 pubmed..These data indicate that ataxin-1 is a substrate of TG2. Further, in SCA1 TG2 may translocate to the nucleus in response to nuclear accumulation of mutant ataxin-1 at early stages of the disease. ..
- Mayer A, Wickner W. Docking of yeast vacuoles is catalyzed by the Ras-like GTPase Ypt7p after symmetric priming by Sec18p (NSF). J Cell Biol. 1997;136:307-17 pubmed..In addition to Sec17p/Sec18p, docking requires the activity of the Ras-like GTPase Ypt7p. Unlike Sec17p/Sec18p, which must act before docking, Ypt7p is directly involved in the docking process itself. ..
- Lee M, Van Brocklyn J, Thangada S, Liu C, Hand A, Menzeleev R, et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science. 1998;279:1552-5 pubmed..Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho. ..
- Gatti A, Huang Z, Tuazon P, Traugh J. Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation. J Biol Chem. 1999;274:8022-8 pubmed..Further, the phosphorylation of Ser-141, Ser-165, and Thr-402 was found to correlate with gamma-PAK activation. ..
- Turner C, Brown M, Perrotta J, Riedy M, Nikolopoulos S, McDonald A, et al. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol. 1999;145:851-63 pubmed..These data implicate paxillin as a mediator of p21 GTPase-regulated actin cytoskeletal reorganization through the recruitment to nascent focal adhesion structures of an active PAK/PIX complex potentially via interactions with p95PKL. ..
- Petty W, Li N, Biddle A, Bounds R, Nitkin C, Ma Y, et al. A novel retinoic acid receptor beta isoform and retinoid resistance in lung carcinogenesis. J Natl Cancer Inst. 2005;97:1645-51 pubmed..35 to 0.67, P = .003; 8 microM: treated mean = 0.50 versus untreated mean = 1.0, difference = 0.50, 95% CI = 0.26 to 0.74, P = .015). Restoration of RARbeta1' expression may overcome retinoid resistance in lung carcinogenesis. ..
- Baker H. GCR1 of Saccharomyces cerevisiae encodes a DNA binding protein whose binding is abolished by mutations in the CTTCC sequence motif. Proc Natl Acad Sci U S A. 1991;88:9443-7 pubmed..This finding, in addition to the work of others, suggests that the GCR1 gene product and the RAP1/GRF1/TUF gene product act in concert to mediate high-level glycolytic gene expression. ..
- Metz S, Rabaglia M, Stock J, Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. Biochem J. 1993;295 ( Pt 1):31-40 pubmed
- Chen C, Wieland T, Simon M. RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling. Proc Natl Acad Sci U S A. 1996;93:12885-9 pubmed..This specific interaction further rationalizes the kinetics of the phototransduction cascade and provides a general hypothesis to explain the mechanism of interaction of RGS proteins with other G proteins. ..
- Davis C, Richman T, Deliduka S, Blaisdell J, Collins C, Johnson D. Analysis of the mechanisms of action of the Saccharomyces cerevisiae dominant lethal cdc42G12V and dominant negative cdc42D118A mutations. J Biol Chem. 1998;273:849-58 pubmed
- Diviani D, Soderling J, Scott J. AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. J Biol Chem. 2001;276:44247-57 pubmed..Furthermore, biochemical studies indicate that AKAP-Lbc functions as an adaptor protein to selectively couple Galpha(12) to Rho. Thus, AKAP-Lbc anchors PKA and nucleates the assembly of a Rho-mediated signaling pathway. ..
- Vogt L, Sim Selley L, Childers S, Wiley R, Vogt B. Colocalization of mu-opioid receptors and activated G-proteins in rat cingulate cortex. J Pharmacol Exp Ther. 2001;299:840-8 pubmed..Finally, perigenual and midcingulate cortices have different opioid architectures due to a higher proportion of mu-opioid receptors expressed by afferent axons in areas 24 and 32. ..
- Lee C, Ji I, Ryu K, Song Y, Conn P, Ji T. Two defective heterozygous luteinizing hormone receptors can rescue hormone action. J Biol Chem. 2002;277:15795-800 pubmed..Our observations provide new insights into the mechanisms of the functional and structural relationship of the exo- and endodomain, signal transduction, and receptor genetics, in particular for defective heterozygotes. ..
- Bhatia N, Herter J, Slaga T, Fuchs S, Spiegelman V. Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. Oncogene. 2002;21:1501-9 pubmed..The role of mHOS in the constitutive activation of NF-kappaB in skin carcinogenesis is discussed. ..
- Prober D, Edgar B. Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing. Genes Dev. 2002;16:2286-99 pubmed
- Seifert R, Wenzel Seifert K. The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors. Life Sci. 2003;73:2263-80 pubmed..Moreover, N-glycosylation of the N-terminus seems to be important for constitutive FPR activity. Finally, we discuss some future directions of research. ..
- Taha T, Argraves K, Obeid L. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim Biophys Acta. 2004;1682:48-55 pubmed
- Coppola D, Waguespack A, Reems M, Butman M, Cherry J. Naris occlusion alters transductory protein immunoreactivity in olfactory epithelium. Histol Histopathol. 2006;21:487-501 pubmed publisher..Taken together, our findings provide support for the previously unknown phenomenon of compensatory responses by OSNs to odor environment. ..
- Angelova K, Fanelli F, Puett D. Contributions of intracellular loops 2 and 3 of the lutropin receptor in Gs coupling. Mol Endocrinol. 2008;22:126-38 pubmed..A novel way to consider constitutively active mutants was inferred from this study, i.e. receptor states with improved complementarity for the G protein compared to the wild-type receptor. ..
- Ai L, Kim W, Demircan B, Dyer L, Bray K, Skehan R, et al. The transglutaminase 2 gene (TGM2), a potential molecular marker for chemotherapeutic drug sensitivity, is epigenetically silenced in breast cancer. Carcinogenesis. 2008;29:510-8 pubmed publisher..This work indicates that the TGM2 gene is a target for epigenetic silencing in breast cancer and suggests that this aberrant molecular event is a potential marker for chemotherapeutic drug sensitivity. ..
- Skoura A, Hla T. Regulation of vascular physiology and pathology by the S1P2 receptor subtype. Cardiovasc Res. 2009;82:221-8 pubmed publisher..These studies suggest that selective modulation of S1P2 receptor function by pharmacological tools may be useful in a variety of pathological conditions. ..
- Bennett K, Lee W, Lamarre E, Zhang X, Seth R, Scharpf J, et al. HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. Genes Chromosomes Cancer. 2010;49:319-26 pubmed publisher
- Dai K, Mukherjee A, Xu Y, Lutkenhaus J. Mutations in ftsZ that confer resistance to SulA affect the interaction of FtsZ with GTP. J Bacteriol. 1994;176:130-6 pubmed..It is likely that mutations in ftsZ that confer sulA resistance alter the conformation of the protein such that it assumes the active form. ..
- Ghosh M, Schaefer T, Fahey J, Wright J, Wira C. Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C). Fertil Steril. 2008;89:1497-506 pubmed
- Spiegelman V, Tang W, Katoh M, Slaga T, Fuchs S. Inhibition of HOS expression and activities by Wnt pathway. Oncogene. 2002;21:856-60 pubmed..These results indicate that expression and activities of HOS are negatively regulated by Wnt/beta-catenin pathway. ..
- Larkin J, Oswald B, McNiven M. Ethanol-induced retention of nascent proteins in rat hepatocytes is accompanied by altered distribution of the small GTP-binding protein rab2. J Clin Invest. 1996;98:2146-57 pubmed..The effects of ethanol exposure on rab proteins and Golgi function are discussed. ..
- Silverman S, Lester H, Dougherty D. Subunit stoichiometry of a heteromultimeric G protein-coupled inward-rectifier K+ channel. J Biol Chem. 1996;271:30524-8 pubmed..Efforts to establish a preferred arrangement of subunits around the channel pore suggest that more than one arrangement may be viable. ..
- Huang T, Feinberg S, Suryanarayanan S, Miyamoto S. The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors. Mol Cell Biol. 2002;22:5813-25 pubmed..Thus, we suggest that the zinc finger domain of NEMO likely represents a point of convergence for signaling pathways initiated by slow and weak NF-kappa B-activating conditions. ..
- Fu Y, Gu Y, Zheng Z, Wasteneys G, Yang Z. Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. Cell. 2005;120:687-700 pubmed..We propose that the counteractivity of these two pathways demarcates outgrowing and indenting cortical domains, coordinating a process that gives rise to interdigitations between adjacent pavement cells. ..
- Ray K, Robishaw J. Cloning and sequencing of a rat heart cDNA encoding a G-protein beta subunit related to the human retinal beta 3 subunit. Gene. 1994;149:337-40 pubmed..Northern blot analysis revealed that the major mRNA corresponding to the rat pJ5 cDNA is 2.0 kb in length. It is expressed at a high level in the heart and at a much lower level in the brain. ..
- Bustelo X, Crespo P, López Barahona M, Gutkind J, Barbacid M. Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene. 1997;15:2511-20 pubmed
- Surprenant A, Horstman D, Akbarali H, Limbird L. A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents. Science. 1992;257:977-80 pubmed
- Varshavsky A. The N-end rule pathway of protein degradation. Genes Cells. 1997;2:13-28 pubmed..Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of the N-end rule pathway. ..
- Cho S, Rogers K, Fay D. The C. elegans glycopeptide hormone receptor ortholog, FSHR-1, regulates germline differentiation and survival. Curr Biol. 2007;17:203-12 pubmed..Our data suggest a model whereby FSHR-1 signaling acts in parallel to the known sex-determination pathway to control multiple aspects of germline development. ..
- Pedram A, Razandi M, Kehrl J, Levin E. Natriuretic peptides inhibit G protein activation. Mediation through cross-talk between cyclic GMP-dependent protein kinase and regulators of G protein-signaling proteins. J Biol Chem. 2000;275:7365-72 pubmed..The rapid inactivation of G proteins provides a mechanism by which ANP inhibits downstream signaling to the cell proliferation program. ..
- Cheng Z, Miller L. Agonist-dependent dissociation of oligomeric complexes of G protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer. J Biol Chem. 2001;276:48040-7 pubmed..This provides the first evidence for CCK receptor oligomerization in living cells, with insights that the active conformation of this receptor dissociates these complexes in a phosphorylation-independent manner. ..
- Futey L, Medley Q, Cote G, Egelhoff T. Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins. J Biol Chem. 1995;270:523-9 pubmed..Southern blot analysis indicates that MHCK A is encoded by a single gene that has no detectable introns. ..
- Hsiao P, Lin D, Nakao R, Chang C. The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator. J Biol Chem. 1999;274:20229-34 pubmed..The consequence of poor interaction and weak coactivation may eventually lead to the partial androgen insensitivity during the development of Kennedy's disease. ..
- Anitei M, Cowan A, Pfeiffer S, Bansal R. Role for Rab3a in oligodendrocyte morphological differentiation. J Neurosci Res. 2009;87:342-52 pubmed publisher..Together, these findings indicate that Rab3a specifically stimulates morphological differentiation of mature oligodendrocytes and thus may be part of the necessary machinery for myelin membrane biogenesis. ..
- Shuey D, Betty M, Jones P, Khawaja X, Cockett M. RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells. J Neurochem. 1998;70:1964-72 pubmed..Our findings provide further evidence to support a functional role for RGS4 and RGS7 in G(alpha q)-mediated signaling in the CNS. ..
- Saugstad J, Kinzie J, Shinohara M, Segerson T, Westbrook G. Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile. Mol Pharmacol. 1997;51:119-25 pubmed..Thus, cellular responses mediated by both group II and III agonists may in some cases reflect activation of mGluR8 rather than multiple mGluR subtypes. ..
- Quan F, Wolfgang W, Forte M. The Drosophila gene coding for the alpha subunit of a stimulatory G protein is preferentially expressed in the nervous system. Proc Natl Acad Sci U S A. 1989;86:4321-5 pubmed..In situ hybridization studies indicate that the Drosophila Gs alpha transcript is localized primarily in the cells of the central nervous system and in the eyes. ..
- Brown M, Andrade J, Radhakrishna H, Donaldson J, Cooper J, Randazzo P. ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol. 1998;18:7038-51 pubmed..By directly interacting with both Arfs and tyrosine kinases involved in regulating cell growth and cytoskeletal organization, ASAP1 could coordinate membrane remodeling events with these processes. ..
- Vomaske J, Melnychuk R, Smith P, Powell J, Hall L, DeFilippis V, et al. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. PLoS Pathog. 2009;5:e1000304 pubmed publisher..Additionally, the demonstration that US28-mediated chemotaxis is both ligand-specific and cell type-specific has important implications in the role of US28 in HCMV pathogenesis. ..
- Oien D, Ortiz A, Rittel A, Dobrowsky R, Johnson M, Levant B, et al. Dopamine D(2) receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse. J Neurochem. 2010;114:51-61 pubmed publisher..We conclude that ablation of methionine sulfoxide reductase can affect dopamine signaling through altering dopamine D(2)-receptor physiology and may be related to symptoms associated with neurological disorders and diseases. ..
- Zainelli G, Ross C, Troncoso J, Muma N. Transglutaminase cross-links in intranuclear inclusions in Huntington disease. J Neuropathol Exp Neurol. 2003;62:14-24 pubmed..Based on these and other studies, modulation of transglutaminase activity could be explored as a treatment for HD. ..
- Gu Y, Fu Y, Dowd P, Li S, Vernoud V, Gilroy S, et al. A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. J Cell Biol. 2005;169:127-38 pubmed..The dual and antagonistic roles of this GTPase may provide a unifying mechanism by which Rho modulates various processes dependent on actin dynamics in eukaryotic cells. ..
- Yuen C, Sedbrook J, Perrin R, Carroll K, Masson P. Loss-of-function mutations of ROOT HAIR DEFECTIVE3 suppress root waving, skewing, and epidermal cell file rotation in Arabidopsis. Plant Physiol. 2005;138:701-14 pubmed..We hypothesize that RHD3 may control epidermal CFR, root skewing, and waving on hard-agar surfaces by regulating the traffic of wall- or plasma membrane-associated determinants of anisotropic cell expansion. ..
- Eckel Mahan K, Phan T, Han S, Wang H, Chan G, Scheiner Z, et al. Circadian oscillation of hippocampal MAPK activity and cAmp: implications for memory persistence. Nat Neurosci. 2008;11:1074-82 pubmed..These data suggest that the persistence of long-term memories may depend on reactivation of the cAMP/MAPK/CREB transcriptional pathway in the hippocampus during the circadian cycle. ..
- Yan A, Xu G, Yang Z. Calcium participates in feedback regulation of the oscillating ROP1 Rho GTPase in pollen tubes. Proc Natl Acad Sci U S A. 2009;106:22002-7 pubmed publisher..Our experimental data strongly support this role of calcium in tip growth. Thus, our findings provide insight into the mechanism of pollen tube growth and the oscillation of cellular signaling. ..
- Kim M, Javed N, Yu J, Christofi F, Cooke H. Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells. J Clin Invest. 2001;108:1051-9 pubmed..The results suggest that mechanical stimulation of enterochromaffin-derived BON cells directly or indirectly stimulates a G protein-coupled receptor that activates Galphaq, mobilizes intracellular calcium, and causes 5-HT release. ..
- Gao X, Du Z, Patel T. Copper and zinc inhibit Galphas function: a nucleotide-free state of Galphas induced by Cu2+ and Zn2+. J Biol Chem. 2005;280:2579-86 pubmed
- Barbosa M, Johnson S, Achey K, Gutierrez M, Wakeland E, Zerial M, et al. The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995;30:439-44 pubmed
- Madison D, Krüger W, Kim T, Pfeiffer S. Differential expression of rab3 isoforms in oligodendrocytes and astrocytes. J Neurosci Res. 1996;45:258-68 pubmed..No novel rab3 isoform was detected in glia. These results indicate that glial cells in the brain express specific isoforms of the vesicular trafficking Rab3 protein family. ..
- Fowler T, DeSimone S, Mitton M, Kurjan J, Raper C. Multiple sex pheromones and receptors of a mushroom-producing fungus elicit mating in yeast. Mol Biol Cell. 1999;10:2559-72 pubmed
- Hale C, de Boer P. Direct binding of FtsZ to ZipA, an essential component of the septal ring structure that mediates cell division in E. coli. Cell. 1997;88:175-85 pubmed..ZipA is an essential component of the division machinery, and, by binding to both FtsZ and the cytoplasmic membrane, is likely to be directly involved in the assembly and/or function of the FtsZ ring. ..
- Liu C, Hla T. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997;43:15-24 pubmed..However, the activity of the 5'-flanking region was suppressed by the repressor activity within the first intron. These data provide the basis for the further characterization of the regulation of the orphan GPR edg-1. ..
- Weldon S, Rando A, Matathias A, Hod Y, Kalonick P, Savon S, et al. Mitochondrial phosphoenolpyruvate carboxykinase from the chicken. Comparison of the cDNA and protein sequences with the cytosolic isozyme. J Biol Chem. 1990;265:7308-17 pubmed..Thus, PEPCK-M and PEPCK-C, clearly represented the products of two distinct genes, which were distinguished by altered protein sequences and non-cross-hybridizing, differentially regulated mRNAs. ..
- Overmeyer J, Wilson A, Erdman R, Maltese W. The putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort protein. Mol Biol Cell. 1998;9:223-35 pubmed
- Kajkowski E, Lo C, Ning X, Walker S, Sofia H, Wang W, et al. beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. J Biol Chem. 2001;276:18748-56 pubmed..These findings suggest that BBP is a target of neurotoxic beta-amyloid peptide and provide new insight into the molecular pathophysiology of Alzheimer's disease. ..
- Xu Y. Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochim Biophys Acta. 2002;1582:81-8 pubmed..The signaling and ligand-binding properties of these receptors are reviewed here. These discoveries provide an intriguing opportunity and a novel approach in studying the pathophysiological roles of SPC and LPC and their receptors. ..
- Dedeoglu A, Kubilus J, Jeitner T, Matson S, Bogdanov M, Kowall N, et al. Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci. 2002;22:8942-50 pubmed..These findings are consistent with the hypothesis that transglutaminase activity may play a role in the pathogenesis of HD, and they identify cystamine as a potential therapeutic strategy for treating HD patients...
- Xi Z, Ramamoorthy S, Baker D, Shen H, Samuvel D, Kalivas P. Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine. J Pharmacol Exp Ther. 2002;303:608-15 pubmed..Together, these data demonstrate that repeated cocaine produces an enduring reduction in mGluR2/3 function in the nucleus accumbens. ..
- Liang Y, Fotiadis D, Filipek S, Saperstein D, Palczewski K, Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem. 2003;278:21655-21662 pubmed publisher..This is the first semi-empirical model of a higher order structure of a GPCR in native membranes, and it has profound implications for the understanding of how this receptor interacts with partner proteins. ..
- Bandyopadhyay S, Pai S, Hirota S, Hosobe S, Takano Y, Saito K, et al. Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression. Oncogene. 2004;23:5675-81 pubmed..Together, our results strongly suggest functional involvement of the Drg-1 gene in suppressing the metastatic advancement of human breast cancer. ..
- Li Y, Lee P, Kellner E, Paulus M, Switanek J, Xu Y, et al. Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus. Arthritis Res Ther. 2010;12:R90 pubmed publisher..Flow-cytometry analysis of CD64 expression on circulating monocytes is a convenient and rapid approach for estimating IFN-I levels in SLE patients. ..
- Peterson J, Zheng Y, Bender L, Myers A, Cerione R, Bender A. Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast. J Cell Biol. 1994;127:1395-406 pubmed..Also, these findings raise the possibility that Bem1p may regulate or be a target of action of one or more of these GTPases. ..
- Cheon C, Lee N, Siddique A, Bal A, Verma D. Roles of plant homologs of Rab1p and Rab7p in the biogenesis of the peribacteroid membrane, a subcellular compartment formed de novo during root nodule symbiosis. EMBO J. 1993;12:4125-35 pubmed..These data suggest that both Rab1p and Rab7p are essential for the development of the PBM compartment in effective symbiosis...
- Erickson J, Wu J, Goddard J, Tigyi G, Kawanishi K, Tomei L, et al. Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J Biol Chem. 1998;273:1506-10 pubmed..These results indicate that Edg-2 encodes a highly specific LPA receptor. ..
- York R, Yao H, Dillon T, Ellig C, Eckert S, McCleskey E, et al. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature. 1998;392:622-6 pubmed..We propose that the activation of Rap1 by C3G represents a common mechanism to induce sustained activation of the MAP kinase cascade in cells that express B-Raf. ..
- Nguyen T, Sawa H, Okano H, White J. The C. elegans septin genes, unc-59 and unc-61, are required for normal postembryonic cytokineses and morphogenesis but have no essential function in embryogenesis. J Cell Sci. 2000;113 Pt 21:3825-37 pubmed..unc-59 and unc-61 double mutants show similar defects to each of the single mutants. ..
- Mah A, Jang J, Deshaies R. Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proc Natl Acad Sci U S A. 2001;98:7325-30 pubmed..We propose that Mob1 promotes this activation process by enabling Cdc15 to phosphorylate the critical Ser-374 and Thr-544 phosphoacceptor sites of Dbf2. ..
- Finlin B, Gau C, Murphy G, Shao H, Kimel T, Seitz R, et al. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. J Biol Chem. 2001;276:42259-67 pubmed..These features of RERG are strikingly different from most Ras superfamily GTP-binding pro-teins and suggest that the loss of RERG expression may contribute to breast tumorigenesis. ..
- Gorbacheva V, Lindner D, Sen G, Vestal D. The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation. J Biol Chem. 2002;277:6080-7 pubmed
- Kallstrom G, Hedges J, Johnson A. The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol Cell Biol. 2003;23:4344-55 pubmed..Since Lsg1p is cytoplasmic, its role in nuclear export is likely to be indirect. We suggest that Lsg1p is needed to recycle an export factor(s) that shuttles from the nucleus associated with the nascent 60S subunit. ..
- Herrick Davis K, Grinde E, Harrigan T, Mazurkiewicz J. Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein. J Biol Chem. 2005;280:40144-51 pubmed..These results are consistent with a model in which one GPCR dimer binds two molecules of ligand and one G-protein and indicate that dimerization is essential for 5-HT receptor function. ..