Experts and Doctors on golgi apparatus in United States


Locale: United States
Topic: golgi apparatus

Top Publications

  1. Wan L, Molloy S, Thomas L, Liu G, Xiang Y, Rybak S, et al. PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization. Cell. 1998;94:205-16 pubmed
    ..Cell-free assays indicate TGN localization of furin is directed by a PACS-1-mediated retrieval step. Together, these findings explain a mechanism by which membrane proteins in mammalian cells are localized to the TGN. ..
  2. Merianda T, Lin A, Lam J, Vuppalanchi D, Willis D, Karin N, et al. A functional equivalent of endoplasmic reticulum and Golgi in axons for secretion of locally synthesized proteins. Mol Cell Neurosci. 2009;40:128-42 pubmed publisher
    ..Finally, the capacity for secreting locally synthesized proteins in axons appears to be increased by injury. ..
  3. Selyunin A, Iles L, Bartholomeusz G, Mukhopadhyay S. Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking. J Cell Biol. 2017;216:3249-3262 pubmed publisher
    ..These results provide new information about STx2 trafficking mechanisms and may advance efforts to generate therapeutically viable toxin-trafficking inhibitors. ..
  4. Patel S, Brkljacic J, Gindullis F, Rose A, Meier I. The plant nuclear envelope protein MAF1 has an additional location at the Golgi and binds to a novel Golgi-associated coiled-coil protein. Planta. 2005;222:1028-40 pubmed
    ..Like LeMAF1, LeWAP is localized at the Golgi. Moreover, we present data showing that Arabidopsis WAP is necessary for the existence of a multi-protein complex containing WPP2. ..
  5. Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, et al. Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem. 2006;281:22289-98 pubmed
    ..This result is consistent with the recessive pattern of inheritance of this mutation. Thus, our study reveals a novel molecular mechanism for retinal degeneration that results from deficient export of opsin from the Golgi apparatus. ..
  6. Faulhammer F, Kanjilal Kolar S, Knödler A, Lo J, Lee Y, Konrad G, et al. Growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase. Traffic. 2007;8:1554-67 pubmed
    ..Sac1p and Pik1p/Frq1p are therefore elements of a unique machinery that synchronizes ER and Golgi function in response to different growth conditions. ..
  7. Suzuki H, Moldoveanu Z, Hall S, Brown R, Vu H, Novak L, et al. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. J Clin Invest. 2008;118:629-39 pubmed publisher
    ..Thus, our data suggest that premature sialylation likely contributes to the aberrant IgA1 glycosylation in IgA nephropathy and may represent a new therapeutic target. ..
  8. Lee C, Teng Q, Huang W, Zhong R, Ye Z. The Arabidopsis family GT43 glycosyltransferases form two functionally nonredundant groups essential for the elongation of glucuronoxylan backbone. Plant Physiol. 2010;153:526-41 pubmed publisher
  9. Gault C, Obeid L, Hannun Y. An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol. 2010;688:1-23 pubmed
    ..With this thought in mind, this chapter will pay tribute to the complex sphingolipids, but focus on the regulation of simple sphingolipid metabolism. ..

More Information

Publications189 found, 100 shown here

  1. Vaidyanathan R, Vega A, Song C, Zhou Q, Tan B, Tan B, et al. The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J Biol Chem. 2013;288:17472-80 pubmed publisher
    ..1. Kir2.1 loss of function is additive to the increase described previously in late INa, prolonging repolarization and leading to arrhythmia generation in Cav3-mediated LQT9. ..
  2. Gimelbrant A, Haley S, McClintock T. Olfactory receptor trafficking involves conserved regulatory steps. J Biol Chem. 2001;276:7285-90 pubmed
    ..These results also indicate that some components of the regulatory mechanism are conserved. ..
  3. Tripathi A, Ren Y, Jeffrey P, Hughson F. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Nat Struct Mol Biol. 2009;16:114-23 pubmed publisher
    ..Our results map out two alternative protein-interaction networks capable of tethering COPI-coated vesicles, via the Dsl1p complex, to ER membranes. ..
  4. Nelson D, Alvarez C, Gao Y, Garcia Mata R, Fialkowski E, Sztul E. The membrane transport factor TAP/p115 cycles between the Golgi and earlier secretory compartments and contains distinct domains required for its localization and function. J Cell Biol. 1998;143:319-31 pubmed
  5. Reiness C, Seppa M, Dion D, Sweeney S, Foster D, Nishi R. Chick ciliary neurotrophic factor is secreted via a nonclassical pathway. Mol Cell Neurosci. 2001;17:931-44 pubmed
    ..When synthesized in vitro, chick CNTF did not translocate into microsomes. We conclude that chick CNTF is secreted via a nonclassical pathway...
  6. Schillace R, Andrews S, Liberty G, Davey M, Carr D. Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. J Immunol. 2002;168:1590-9 pubmed
    ..These experiments represent the first report of AKAPs in T cells and suggest that MTG16b is a novel AKAP that targets PKA to the Golgi of T lymphocytes. ..
  7. Choudhury A, Dominguez M, Puri V, Sharma D, Narita K, Wheatley C, et al. Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells. J Clin Invest. 2002;109:1541-50 pubmed
    ..Our results demonstrate a role for Rab7 and Rab9 in the Golgi targeting of glycosphingolipids and suggest a new therapeutic approach for restoring normal lipid trafficking in NP-C cells...
  8. Wang J, Chen J, Enns C, Mayinger P. The first transmembrane domain of lipid phosphatase SAC1 promotes Golgi localization. PLoS ONE. 2013;8:e71112 pubmed publisher
    ..We conclude that the distribution of SAC1 within the Golgi is controlled via both passive membrane thickness-dependent partitioning of TM1 and a retention mechanism that requires the N-terminal cytoplasmic region. ..
  9. Wang N, Lee I, Rask G, Wu J. Roles of the TRAPP-II Complex and the Exocyst in Membrane Deposition during Fission Yeast Cytokinesis. PLoS Biol. 2016;14:e1002437 pubmed publisher
    ..We conclude that the exocyst and TRAPP-II complex have distinct localizations at the division site, but both are important for membrane expansion and exocytosis during cytokinesis. ..
  10. Broome A, Eckert R. Microtubule-dependent redistribution of a cytoplasmic cornified envelope precursor. J Invest Dermatol. 2004;122:29-38 pubmed
    ..Staining of epidermal tissue sections from uninvolved and psoriatic epidermis reveals strong staining at the cell periphery in the majority of suprabasal cells, confirming a peripheral distribution of S100A11 in vivo. ..
  11. Sevova E, Bangs J. Streamlined architecture and glycosylphosphatidylinositol-dependent trafficking in the early secretory pathway of African trypanosomes. Mol Biol Cell. 2009;20:4739-50 pubmed publisher
    ..This unusual architecture probably maximizes efficiency of VSG transport and fidelity in organellar segregation during cytokinesis. ..
  12. Yang W, Sperry A. C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport. Biol Reprod. 2003;69:1719-29 pubmed
    ..This article represents the first demonstration of a direct association of a molecular motor with the spermatid acrosome, the formation of which is essential for fertilization. ..
  13. Lorente Rodríguez A, Heidtman M, Barlowe C. Multicopy suppressor analysis of thermosensitive YIP1 alleles implicates GOT1 in transport from the ER. J Cell Sci. 2009;122:1540-50 pubmed publisher
    ..Based on the findings we propose that Got1p has an unexpected role in vesicle formation from the ER by influencing membrane properties. ..
  14. Lester H, Miwa J, Srinivasan R. Psychiatric drugs bind to classical targets within early exocytotic pathways: therapeutic effects. Biol Psychiatry. 2012;72:907-15 pubmed publisher
    ..We propose experimental tests and note pathophysiological correlates. ..
  15. Lecuit T, Wieschaus E. Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo. J Cell Biol. 2000;150:849-60 pubmed
    ..We thus identify a tightly regulated scheme of polarized membrane insertion during cellularization. We propose that such a mechanism could participate in the progressive emergence of apical-basal polarity. ..
  16. Nothwehr S, Ha S, Bruinsma P. Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p. J Cell Biol. 2000;151:297-310 pubmed
    ..These data strongly support a model in which Vps35p acts as a "receptor" protein for recognition of the retrieval signal domains of cargo proteins during their recruitment into retrograde vesicles. ..
  17. Ginkel L, Wordeman L. Expression and partial characterization of kinesin-related proteins in differentiating and adult skeletal muscle. Mol Biol Cell. 2000;11:4143-58 pubmed
    ..We propose that these membranes, consisting of the transverse-tubules and sarcoplasmic reticulum, are dynamic structures in which kinesin-II may function to actively assemble and maintain in myogenic cells. ..
  18. Blagoveshchenskaya A, Cheong F, Rohde H, Glover G, Knödler A, Nicolson T, et al. Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J Cell Biol. 2008;180:803-12 pubmed publisher
    ..Inhibition of p38 MAPK abolishes growth factor-induced Golgi-to-ER shuttling of SAC1 and slows secretion. These results suggest direct roles for p38 MAPK and SAC1 in transmitting growth signals to the secretory machinery. ..
  19. Bresnahan P, Leduc R, Thomas L, Thorner J, Gibson H, Brake A, et al. Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol. 1990;111:2851-9 pubmed
    ..Thus, the sequence homology shared by furin and the yeast KEX2 prohormone processing enzyme is reflected by significant functional homology both in vitro and in vivo. ..
  20. Belden W, Barlowe C. Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles. Science. 2001;294:1528-31 pubmed
    ..In vivo, export of gpalphaf from the ER was saturable and depended on the expression level of Erv29p. These results indicate that membrane receptors can link soluble cargo proteins to the COPII coat. ..
  21. Tandler B, Phillips C. Ultrastructure of the submandibular gland of the rare white-winged vampire bat, Diaemus youngi. Eur J Morphol. 2002;40:253-6 pubmed
  22. Rennolds J, Boyaka P, Bellis S, Cormet Boyaka E. Low temperature induces the delivery of mature and immature CFTR to the plasma membrane. Biochem Biophys Res Commun. 2008;366:1025-9 pubmed
    ..These results suggest that low temperature induces the appearance of a mix population of mature and immature CFTR molecules at the plasma membrane through distinct pathways. ..
  23. de Paulo Martins V, Okura M, Maric D, Engman D, Vieira M, Docampo R, et al. Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J Biol Chem. 2010;285:30906-17 pubmed publisher
    ..Taken together, these results indicate that N-terminal acyl modifications serve as a molecular addressing system for sending TcPI-PLC to the outer surface of the cell. ..
  24. Li C, Fan Y, Lan T, Lambert N, Wu G. Rab26 modulates the cell surface transport of ?2-adrenergic receptors from the Golgi. J Biol Chem. 2012;287:42784-94 pubmed publisher
    ..These data also provide the first evidence implicating an important function of Rab26 in coordinating plasma membrane protein transport. ..
  25. Hayden J, Williams M, Granich A, Ahn H, Tenay B, Lukehart J, et al. Vps1 in the late endosome-to-vacuole traffic. J Biosci. 2013;38:73-83 pubmed
    ..Together, we propose that Vps1 is required for correct and efficient trafficking from the late endosomal compartments to the vacuole. ..
  26. Huang K, D hondt K, Riezman H, Lemmon S. Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast. EMBO J. 1999;18:3897-908 pubmed
    ..Therefore, alternative mechanisms for clathrin assembly and coated vesicle formation, as well as the role of AP complexes and AP180-related proteins in these processes, must be considered. ..
  27. Thévenin A, Monillas E, Winget J, Czymmek K, Bahnson B. Trafficking of platelet-activating factor acetylhydrolase type II in response to oxidative stress. Biochemistry. 2011;50:8417-26 pubmed publisher
    ..Additionally, colocalization studies using organelle-specific proteins demonstrate that PAFAH-II is transported to the membranes of both the endoplasmic reticulum and Golgi apparatus. ..
  28. Jiang L, Phillips T, Rogers S, Rogers J. Biogenesis of the protein storage vacuole crystalloid. J Cell Biol. 2000;150:755-70 pubmed
    ..The uptake and preservation of the contents of these organelles in vacuoles represents a unique mechanism for compartmentalization of protein and lipid for storage. ..
  29. Ding W, Albrecht B, Luo R, Zhang W, Stanley J, Newbound G, et al. Endoplasmic reticulum and cis-Golgi localization of human T-lymphotropic virus type 1 p12(I): association with calreticulin and calnexin. J Virol. 2001;75:7672-82 pubmed
    ..Our results indicate that p12(I) directly binds key regulatory proteins involved in calcium-mediated cell signaling and suggest a role of p12(I) in the establishment of HTLV-1 infection by activation of host cells. ..
  30. Hait N, Fujita K, Lester R, Dickson R. Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes. FEBS Lett. 2002;532:97-102 pubmed
    ..These results indicate that LCBs made in the endoplasmic reticulum must transit to the Golgi to be converted into LCBPs, which must then return to the endoplasmic reticulum to be degraded. ..
  31. Wang Y, Boudreaux D, Estrada D, Egan C, St Jeor S, De Guzman R. NMR structure of the N-terminal coiled coil domain of the Andes hantavirus nucleocapsid protein. J Biol Chem. 2008;283:28297-304 pubmed publisher
    ..Thus, Arg22 and Lys26 are likely involved in a conformational change or molecular recognition when the N protein is trafficked from the cytoplasm to the Golgi, the site of viral assembly and maturation. ..
  32. Chen M, Thelen J. ACYL-LIPID DESATURASE2 is required for chilling and freezing tolerance in Arabidopsis. Plant Cell. 2013;25:1430-44 pubmed publisher
  33. Nothwehr S, Hindes A. The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi. J Cell Sci. 1997;110 ( Pt 9):1063-72 pubmed
    ..These results support a model in which Vps5p is required for retrieval of membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus. ..
  34. Cheong F, Sharma V, Blagoveshchenskaya A, Oorschot V, Brankatschk B, Klumperman J, et al. Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity. Traffic. 2010;11:1180-90 pubmed publisher
    ..These results indicate that SAC1 organizes PI(4)P distribution between the Golgi complex and the TGN, which is instrumental for resident enzyme partitioning and Golgi morphology. ..
  35. Tarsio M, Zheng H, Smardon A, Martínez Muñoz G, Kane P. Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasis. J Biol Chem. 2011;286:28089-96 pubmed publisher
    ..These results emphasize that loss of a single subunit isoform may have effects far beyond the organelle where it resides. ..
  36. Gao Y, Sztul E. A novel interaction of the Golgi complex with the vimentin intermediate filament cytoskeleton. J Cell Biol. 2001;152:877-94 pubmed
  37. Dunn W. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol. 1990;110:1923-33 pubmed
    ..The results were consistent with the formation of autophagic vacuoles from ribosome-free regions of the RER. ..
  38. Hasan N, Corbin D, Hu C. Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception. PLoS ONE. 2010;5:e14238 pubmed publisher
    ..These data indicate that VAMPs have differential membrane fusion capacities, and imply that with the exception of VAMP5, VAMPs are essentially redundant in mediating fusion with plasma membrane t-SNAREs. ..
  39. Kwon S, Christian J. Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation. J Biol Chem. 2011;286:21876-85 pubmed publisher
    ..Our results suggest that sortilin negatively regulates TGF-? signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway...
  40. Li Q, Muma N. Estradiol potentiates 8-OH-DPAT-induced sumoylation of 5-HT?A receptor: characterization and subcellular distribution of sumoylated 5-HT?A receptors. Psychoneuroendocrinology. 2013;38:2542-53 pubmed publisher
    ..Since 5-HT1A-Rs play an important role in mood regulation, the present results significantly impact on the understanding of the pathogenesis of affective disorders and development of better therapeutic approaches for these diseases...
  41. Robinson J, Graham T, Emr S. A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Mol Cell Biol. 1991;11:5813-24 pubmed
  42. Paris N, Rogers S, Jiang L, Kirsch T, Beevers L, Phillips T, et al. Molecular cloning and further characterization of a probable plant vacuolar sorting receptor. Plant Physiol. 1997;115:29-39 pubmed
  43. Sharma D, Choudhury A, Singh R, Wheatley C, Marks D, Pagano R. Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for recycling. J Biol Chem. 2003;278:7564-72 pubmed
  44. Novick R, Mitzey A, Brownfield M, Elfarra A. Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes. J Pharmacol Exp Ther. 2009;329:1148-55 pubmed publisher
  45. Collins J, Hua P, Lu Y, Ranganathan P. Alternative splicing of the Menkes copper Atpase (Atp7a) transcript in the rat intestinal epithelium. Am J Physiol Gastrointest Liver Physiol. 2009;297:G695-707 pubmed publisher
    ..We conclude that novel Atp7a protein variants may exist in rat and human intestinal epithelial cells, with different intracellular locations and potentially distinct physiological functions. ..
  46. Subathra M, Qureshi A, Luberto C. Sphingomyelin synthases regulate protein trafficking and secretion. PLoS ONE. 2011;6:e23644 pubmed publisher
  47. Piao H, Mayinger P. Growth and metabolic control of lipid signalling at the Golgi. Biochem Soc Trans. 2012;40:205-9 pubmed publisher
    ..These results suggest that temporal and spatial integration of metabolic and lipid signalling networks at the Golgi is required for controlling the secretory pathway. ..
  48. Nothwehr S, Bruinsma P, Strawn L. Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment. Mol Biol Cell. 1999;10:875-90 pubmed
    ..These data suggest a model in which distinct structural features within Vps35p are required for associating with the cytosolic domains of each cargo protein during the retrieval process. ..
  49. Xiang Y, Molloy S, Thomas L, Thomas G. The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments. Mol Biol Cell. 2000;11:1257-73 pubmed
    ..Our results demonstrate that AC motifs can target proteins to distinct TGN/endosomal compartments and indicate that the AC-mediated localization of PC6B and furin contribute to their distinct roles in vivo. ..
  50. Workman J, Manny N, Walton J, Nelson R. Short day lengths alter stress and depressive-like responses, and hippocampal morphology in Siberian hamsters. Horm Behav. 2011;60:520-8 pubmed publisher
    ..This study is the first to investigate hippocampal changes in the context of short-day induced immobility and may be relevant for understanding psychological disorders with a seasonal component. ..
  51. Barlowe C. COPII and selective export from the endoplasmic reticulum. Biochim Biophys Acta. 1998;1404:67-76 pubmed
    ..This review will focus on the molecular constituents of the COPII coat and emerging interactions of the coat subunits with proteins involved in selective export from the ER...
  52. Terasaki M, Loew L, Lippincott Schwartz J, Zaal K. Fluorescent staining of subcellular organelles: ER, Golgi complex, and mitochondria. Curr Protoc Cell Biol. 2001;Chapter 4:Unit 4.4 pubmed publisher
    ..Fluorescent dyes and/or fluorescently labeled lipid derivatives can be used to identify ER, Golgi complex, and mitochondria. Specific conditions for labeling each of these compartments are described. ..
  53. El Meskini R, Culotta V, Mains R, Eipper B. Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 2003;278:12278-84 pubmed
    ..Similarly, production of active PHM in mouse fibroblasts is impaired in the presence of a mutant ATP7A gene. Although delivery of copper to lumenal cuproproteins like PAM involves ATP7A, lumenal chaperones may not be required. ..
  54. Liu Y, Barlowe C. Analysis of Sec22p in endoplasmic reticulum/Golgi transport reveals cellular redundancy in SNARE protein function. Mol Biol Cell. 2002;13:3314-24 pubmed
  55. Herrick Davis K, Weaver B, Grinde E, Mazurkiewicz J. Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum: real-time visualization with confocal fluorescence resonance energy transfer. J Biol Chem. 2006;281:27109-16 pubmed
  56. Sosa R, Weber M, Wen Y, O Halloran T. A single ? adaptin contributes to AP1 and AP2 complexes and clathrin function in Dictyostelium. Traffic. 2012;13:305-16 pubmed publisher
    ..Our results support the essential contribution of a single ? subunit to the stability and function of AP1 and AP2 in a simple eukaryote. ..
  57. Garcia Mata R, Sztul E. The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor. EMBO Rep. 2003;4:320-5 pubmed
    ..Expression of the p115-binding (pro-rich) region of GBF1 leads to Golgi disruption, indicating that the interaction between p115 and GBF1 is functionally relevant. ..
  58. Heidtman M, Chen C, Collins R, Barlowe C. A role for Yip1p in COPII vesicle biogenesis. J Cell Biol. 2003;163:57-69 pubmed
    ..We propose that Yip1p has a previously unappreciated role in COPII vesicle biogenesis. ..
  59. Ko M, Puglielli L. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J Biol Chem. 2009;284:2482-92 pubmed publisher
    ..The biochemical characterization of the above events could lead to the identification of novel pharmacological strategies for the prevention of this form of dementia. ..
  60. Conibear E, Cleck J, Stevens T. Vps51p mediates the association of the GARP (Vps52/53/54) complex with the late Golgi t-SNARE Tlg1p. Mol Biol Cell. 2003;14:1610-23 pubmed
    ..The binding of this small, coiled-coil protein to the conserved N-terminal domain of the t-SNARE therefore provides a crucial link between components of the tethering and the fusion machinery. ..
  61. Liu Y, Flanagan J, Barlowe C. Sec22p export from the endoplasmic reticulum is independent of SNARE pairing. J Biol Chem. 2004;279:27225-32 pubmed
    ..We propose that the COPII budding machinery has a preference for unassembled ER/Golgi SNARE proteins. ..
  62. Enns C, Ahmed R, Zhang A. Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage. J Biol Chem. 2012;287:35104-17 pubmed publisher
    ..The complex facilitates HJV cleavage by MT2, and release of the cleaved HJV from the cell occurs after a retrograde trafficking through the TGN/Golgi compartments. ..
  63. Fischer von Mollard G, Stevens T. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways. J Biol Chem. 1998;273:2624-30 pubmed
    ..Amino acid exchanges in vti1 mutant alleles defective either in one or both trafficking steps cluster in this domain, suggesting that this structure is probably the binding site for effector proteins. ..
  64. Rezaie T, Child A, Hitchings R, Brice G, Miller L, Coca Prados M, et al. Adult-onset primary open-angle glaucoma caused by mutations in optineurin. Science. 2002;295:1077-9 pubmed publisher
    ..Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role...
  65. Vashist S, Frank C, Jakob C, Ng D. Two distinctly localized p-type ATPases collaborate to maintain organelle homeostasis required for glycoprotein processing and quality control. Mol Biol Cell. 2002;13:3955-66 pubmed
    ..Taken together, our results reveal an interdependent relationship between two P-type ATPases to maintain homeostasis of the organelles where they reside...
  66. Sun W, Hu W, Xu R, Jin J, Szulc Z, Zhang G, et al. Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion. FASEB J. 2009;23:656-66 pubmed publisher
    ..These results suggest that the ACER2/sphingosine pathway plays an important role in regulating beta1 maturation and cell adhesion mediated by beta1 integrins. ..
  67. Otte S, Belden W, Heidtman M, Liu J, Jensen O, Barlowe C. Erv41p and Erv46p: new components of COPII vesicles involved in transport between the ER and Golgi complex. J Cell Biol. 2001;152:503-18 pubmed
    ..A cell-free assay that reproduces transport between the ER and Golgi indicates that deletion of the Erv41p-Erv46p complex influences the membrane fusion stage of transport. ..
  68. MATTISON H, Hayashi T, Barria A. Palmitoylation at two cysteine clusters on the C-terminus of GluN2A and GluN2B differentially control synaptic targeting of NMDA receptors. PLoS ONE. 2012;7:e49089 pubmed publisher
  69. Jaskiewicz E, Zhu G, Bassi R, Darling D, Young W. Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease. J Biol Chem. 1996;271:26395-403 pubmed
    ..Biol. Chem. 264, 14159-14164). These findings suggest that GalNAcT is converted from a membrane-bound to a soluble form as a result of cleavage by a cathepsin D-like protease in a compartment late in the Golgi secretory pathway. ..
  70. Redmann V, Lamb C, Hwang S, Orchard R, Kim S, Razi M, et al. Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Sci Rep. 2016;6:23326 pubmed publisher
    ..Therefore Clec16a, an autophagy protein that is critical for autolysosome function and clearance, is required for Purkinje cell survival. ..
  71. VanRheenen S, Cao X, Sapperstein S, Chiang E, Lupashin V, Barlowe C, et al. Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p. J Cell Biol. 1999;147:729-42 pubmed
    ..Finally, we describe RUD3, a novel gene identified through a genetic screen for multicopy suppressors of a mutation in USO1, which suppresses the sec34-2 mutation as well. ..
  72. Fu L, Miseta A, Hunton D, Marchase R, Bedwell D. Loss of the major isoform of phosphoglucomutase results in altered calcium homeostasis in Saccharomyces cerevisiae. J Biol Chem. 2000;275:5431-40 pubmed
    ..These results suggest that Glc-1-P (or a related metabolite) may participate in the control of Ca(2+) uptake from the environment. ..
  73. Tempel W, Karaveg K, Liu Z, Rose J, Wang B, Moremen K. Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases. J Biol Chem. 2004;279:29774-86 pubmed
  74. Faulhammer F, Konrad G, Brankatschk B, Tahirovic S, Knödler A, Mayinger P. Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p. J Cell Biol. 2005;168:185-91 pubmed
    ..Thus, the lipid phosphatase Sac1p may be a key regulator, coordinating the secretory capacity of ER and Golgi membranes in response to growth conditions. ..
  75. Peremyslov V, Prokhnevsky A, Dolja V. Class XI myosins are required for development, cell expansion, and F-Actin organization in Arabidopsis. Plant Cell. 2010;22:1883-97 pubmed publisher
    ..These results establish critical roles of myosin-driven transport and F-actin organization during polarized and diffuse cell growth and indicate that myosins are key factors in plant growth and development. ..
  76. Gharakhanian E, Chima Okereke O, Olson D, Frost C, Kathleen Takahashi M. env1 Mutant of VPS35 gene exhibits unique protein localization and processing phenotype at Golgi and lysosomal vacuole in Saccharomyces cerevisiae. Mol Cell Biochem. 2011;346:187-95 pubmed publisher
  77. Ling I, Bhongsatiern J, Simpson J, Fardo D, Estus S. Genetics of clusterin isoform expression and Alzheimer's disease risk. PLoS ONE. 2012;7:e33923 pubmed publisher
    ..Since CLU1 and CLU2 appear to produce similar proteins and are increased in AD, the AD-protection afforded by the rs11136000T allele may reflect increased soluble clusterin throughout life. ..
  78. Kawar Z, Karaveg K, Moremen K, Jarvis D. Insect cells encode a class II alpha-mannosidase with unique properties. J Biol Chem. 2001;276:16335-40 pubmed
    ..Based on these properties, we designated this enzyme Sf9 alpha-mannosidase III and concluded that it probably provides an alternate N-glycan processing pathway in Sf9 cells. ..
  79. Ungar D, Oka T, Vasile E, Krieger M, Hughson F. Subunit architecture of the conserved oligomeric Golgi complex. J Biol Chem. 2005;280:32729-35 pubmed
    ..Vasile, E., Penman, M., Novina, C. D., Dykxhoorn, D. M., Ungar, D., Hughson, F. M., and Krieger, M. (2005) J. Biol. Chem. 280, 32736-32745). ..
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