Experts and Doctors on glycine hydroxymethyltransferase in Germany
Topic: glycine hydroxymethyltransferase
Schwertz G, Witschel M, Rottmann M, Bonnert R, Leartsakulpanich U, Chitnumsub P, et al
. Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures. J Med Chem. 2017;60:4840-4860 pubmed publisher
..3-2.6 Å resolution, revealing a unique water-mediated interaction with Tyr63 at the end of the para-aminobenzoate channel. They also displayed the high degree of conformational flexibility of the Cys364-loop lining this channel. ..
Monschau N, Stahmann K, Sahm H, McNeil J, Bognar A. Identification of Saccharomyces cerevisiae GLY1 as a threonine aldolase: a key enzyme in glycine biosynthesis. FEMS Microbiol Lett. 1997;150:55-60 pubmed
..On ethanol as carbon source simultaneous disruption of GLY1, SHM1 and SHM2 did not lead to glycine auxotrophy because glycine biosynthesis proceeds via alanine glyoxylate aminotransferase. ..
Eisenhut M, Kahlon S, Hasse D, Ewald R, Lieman Hurwitz J, Ogawa T, et al
. The plant-like C2 glycolate cycle and the bacterial-like glycerate pathway cooperate in phosphoglycolate metabolism in cyanobacteria. Plant Physiol. 2006;142:333-42 pubmed
..This finding and the growth data imply a dominant, although not exclusive, role of the C2 route in cyanobacterial phosphoglycolate metabolism. ..
Beckmann K, Dzuibany C, Biehler K, Fock H, Hell R, Migge A, et al
. Photosynthesis and fluorescence quenching, and the mRNA levels of plastidic glutamine synthetase or of mitochondrial serine hydroxymethyltransferase (SHMT) in the leaves of the wild-type and of the SHMT-deficient stm mutant of Arabidopsis thaliana in. Planta. 1997;202:379-86 pubmed
Simic P, Willuhn J, Sahm H, Eggeling L. Identification of glyA (encoding serine hydroxymethyltransferase) and its use together with the exporter ThrE to increase L-threonine accumulation by Corynebacterium glutamicum. Appl Environ Microbiol. 2002;68:3321-7 pubmed
..This shows that the potential for amino acid formation can be considerably improved by reducing its intracellular degradation and increasing its export...
Buchenau B, Thauer R. Tetrahydrofolate-specific enzymes in Methanosarcina barkeri and growth dependence of this methanogenic archaeon on folic acid or p-aminobenzoic acid. Arch Microbiol. 2004;182:313-25 pubmed publisher
..The presence of both H4SPT and H4F in M. barkeri is in agreement with earlier isotope labeling studies indicating that there are two separate C1 pools in these methanogens...
Engel N, Ewald R, Gupta K, Zrenner R, Hagemann M, Bauwe H. The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria. Plant Physiol. 2011;157:1711-20 pubmed publisher
..We hypothesize that yet unknown kinetic properties of SHM2 might render this enzyme unsuitable for the high-folate conditions of photorespiring mesophyll mitochondria. ..
Schorsch C, Köhler T, Andrea H, Boles E. High-level production of tetraacetyl phytosphingosine (TAPS) by combined genetic engineering of sphingoid base biosynthesis and L-serine availability in the non-conventional yeast Pichia ciferrii. Metab Eng. 2012;14:172-84 pubmed publisher
..The final recombinant P. ciferrii strain produced up to 199 mg((TAPS))g(-1)((cdw)) with a maximal production rate of 8.42 mg×OD(600nm)(-1)h(-1) and a titer of about 2 g L(-1), and should be applicable for industrial TAPS production. ..
Kuhn A, Engqvist M, Jansen E, Weber A, Jakobs C, Maurino V. D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant. Plant Biol (Stuttg). 2013;15:776-84 pubmed publisher
..Thus, a novel interaction of the photorespiratory pathway with cellular processes involving D-2HG has been identified. ..