Experts and Doctors on glutathione peroxidase in Japan


Locale: Japan
Topic: glutathione peroxidase

Top Publications

  1. Toyokuni S, Itani T, Morimitsu Y, Okada K, Ozeki M, Kondo S, et al. Protective effect of colored rice over white rice on Fenton reaction-based renal lipid peroxidation in rats. Free Radic Res. 2002;36:583-92 pubmed
    ..These may partly explain the antioxidative effect. Furthermore, colored strains of rice are rich in proteins. Thus, our data warrants further investigation of the antioxidative effect of colored rice. ..
  2. Kashiwagi K, Shinkai T, Kajii E, Kashiwagi A. The effects of reactive oxygen species on amphibian aging. Comp Biochem Physiol C Toxicol Pharmacol. 2005;140:197-205 pubmed
    ..These findings suggest that a decrease in the activity of antioxidant enzymes over time results in increased levels of ROS damage in the livers of older frogs. ..
  3. Soetikno V, Sari F, Sukumaran V, Lakshmanan A, Mito S, Harima M, et al. Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway. Eur J Pharm Sci. 2012;47:604-14 pubmed publisher
    ..Taken together, it is suggested that curcumin by inhibiting PKC-? and -??-MAPK pathway may be useful as an adjuvant therapy for the prevention of diabetic cardiomyopathy. ..
  4. Yokozawa T, Nakagawa T, Lee K, Cho E, Terasawa K, Takeuchi S. Effects of green tea tannin on cisplatin-induced nephropathy in LLC-PK1 cells and rats. J Pharm Pharmacol. 1999;51:1325-31 pubmed
    ..Based on the evidence available it appeared that green tea tannin eliminated oxidative stress and was beneficial to renal function. ..
  5. Murakami C, Hirakawa Y, Inui H, Nakano Y, Yoshida H. Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells. Biosci Biotechnol Biochem. 2002;66:1559-62 pubmed
    ..Moreover, all four catechins suppressed the formation of glutathione disulfide and the activation of glutathione peroxidase induced by tert-butylated hydroperoxide. ..
  6. Shiobara Y, Yoshida T, Suzuki K. Effects of dietary selenium species on Se concentrations in hair, blood, and urine. Toxicol Appl Pharmacol. 1998;152:309-14 pubmed
    ..The results could be explained by regulated metabolism of selenite, and both nonregulated and regulated aspects of the metabolism of SeMet. ..
  7. Murakoshi M, Ikeda R, Fukui N, Tagawa M. Histopathological and immunocytochemical studies of chlormadinone acetate on the rat prostate. Tokai J Exp Clin Med. 2002;27:91-5 pubmed
  8. Yamaoka K, Kojima S, Nomura T. Inhibitory effects of post low dose gamma-ray irradiation on ferric-nitrilotriacetate-induced mice liver damage. Free Radic Res. 2000;32:213-21 pubmed
    ..These findings suggest that low-dose irradiation relieved functional disorders at least in the livers of mice with active oxygen species related diseases. ..
  9. Yokozawa T, Liu Z, Chen C. Protective effects of Glycyrrhizae radix extract and its compounds in a renal hypoxia (ischemia)-reoxygenation (reperfusion) model. Phytomedicine. 2000;6:439-45 pubmed

More Information


  1. Tsuji T, Watanabe Y, Katoh H, Sato K, Kunieda T. Cloning and mapping of the mouse Gpx2 gene encoding gastrointestinal glutathione peroxidase. J Vet Med Sci. 1998;60:651-4 pubmed
    ..Linkage analysis using backcross mouse progeny indicated the mouse Cpx2 gene and its pseudogene to be located on mouse chromosomes 12 and 7, respectively. ..
  2. Nishida H, Kushida M, Nakajima Y, Ogawa Y, Tatewaki N, Sato S, et al. Amyloid-beta-induced cytotoxicity of PC-12 cell was attenuated by Shengmai-san through redox regulation and outgrowth induction. J Pharmacol Sci. 2007;104:73-81 pubmed
    ..It may also be beneficial not only for the treatment of brain disorders but also for other diseases caused by oxidative stress. ..
  3. Sugimoto M, Sakamoto W. Putative phospholipid hydroperoxide glutathione peroxidase gene from Arabidopsis thaliana induced by oxidative stress. Genes Genet Syst. 1997;72:311-6 pubmed
    ..5 times after exposure to NaCl and Al/Fe, respectively. These results suggest that the putative PHGPX gene is induced by oxidative stress in Arabidopsis. ..
  4. Komatsu H, Okayasu I, Mitomi H, Imai H, Nakagawa Y, Obata F. Immunohistochemical detection of human gastrointestinal glutathione peroxidase in normal tissues and cultured cells with novel mouse monoclonal antibodies. J Histochem Cytochem. 2001;49:759-66 pubmed
  5. Osame S, Ohtani T, Ichijo S. Studies on serum tocopherol and selenium levels and blood glutathione peroxidase activities in lambs with white muscle disease. Nihon Juigaku Zasshi. 1990;52:705-10 pubmed
    ..It was concluded that WMD of lambs in Hokkaido was nutritional muscular dystrophy resulted from deficiencies of Toc and Se to their ewes...
  6. Hammad H, Higashi T, Tateishi N, Hanatani M, Sakamoto Y. Lipid peroxidation in the liver of carcinogen-resistant rats. Biochim Biophys Acta. 1990;1045:99-106 pubmed
    ..The higher ADH activity may explain the decreased lipid peroxidation in R rats at least partly, if this enzyme is involved in lipid peroxidation...
  7. Akasaka M, Mizoguchi J, Takahashi K. A human cDNA sequence of a novel glutathione peroxidase-related protein. Nucleic Acids Res. 1990;18:4619 pubmed
  8. Kabuto H, Nishizawa M, Tada M, Higashio C, Shishibori T, Kohno M. Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum. Neurochem Res. 2005;30:325-32 pubmed
    ..Effects of zingerone treatment in this model suggest possible value in treatment of Parkinson's disease. ..
  9. Matsuzawa D, Hashimoto K, Hashimoto T, Shimizu E, Watanabe H, Fujita Y, et al. Association study between the genetic polymorphisms of glutathione-related enzymes and schizophrenia in a Japanese population. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:86-94 pubmed publisher
  10. Ohta Y, Kobayashi T, Inui K, Yoshino J, Nakazawa S. Repeated recurrence of gastric mucosal lesions in rats after a single treatment with compound 48/80, a mast cell degranulator. J Physiol Pharmacol. 2009;60 Suppl 7:139-48 pubmed
  11. Ohta Y, Kongo M, Kishikawa T. Preventive effect of melatonin on the progression of alpha-naphthylisothiocyanate-induced acute liver injury in rats. J Pineal Res. 2003;34:185-93 pubmed
  12. Lu G, Shimizu I, Cui X, Itonaga M, Tamaki K, Fukuno H, et al. Interferon-alpha enhances biological defense activities against oxidative stress in cultured rat hepatocytes and hepatic stellate cells. J Med Invest. 2002;49:172-81 pubmed
    ..These findings suggest that IFN-alpha may enhance biological defense activities against oxidative stress and function as a potent fibrosuppressant by protecting hepatocytes and hepatic stellate cells from lipid peroxidation in vivo. ..
  13. Nam S, Nakamuta N, Kurohmaru M, Hayashi Y. Cloning and sequencing of the mouse cDNA encoding a phospholipid hydroperoxide glutathione peroxidase. Gene. 1997;198:245-9 pubmed
    ..4%), human (92.9%), and rat (98%) PHGPxs. However, the PHGPx mRNA particularly showed a high degree of expression in testis. This suggests that the PHGPx in testis may have more than just an antioxidant function. ..
  14. Akasaka M, Mizoguch J, Yoshimura S, Watanabe K. Nucleotide sequence of cDNA for rabbit glutathione peroxidase. Nucleic Acids Res. 1989;17:2136 pubmed
  15. Suzuki K, Ishiwata K, Ogra Y. Incorporation of selenium into selenoprotein P and extracellular glutathione peroxidase: HPLC-ICPMS data with enriched selenite. Analyst. 1999;124:1749-53 pubmed
  16. Nam S, Fujisawa M, Kim J, Kurohmaru M, Hayashi Y. Expression pattern of phospholipid hydroperoxide glutathione peroxidase messenger ribonucleic acid in mouse testis. Biol Reprod. 1998;58:1272-6 pubmed
    ..These findings suggest that PHGPx in testes may be closely involved in spermatogenesis as well as having a general antioxidant function. ..
  17. Murawaki Y, Tsuchiya H, Kanbe T, Harada K, Yashima K, Nozaka K, et al. Aberrant expression of selenoproteins in the progression of colorectal cancer. Cancer Lett. 2008;259:218-30 pubmed
    ..These data suggest that contrasting expression pattern of the antioxidant selenoproteins plays an important role in the progression of colorectal cancer. ..
  18. Okamura N, Iwaki Y, Hiramoto S, Tamba M, Bannai S, Sugita Y, et al. Molecular cloning and characterization of the epididymis-specific glutathione peroxidase-like protein secreted in the porcine epididymal fluid. Biochim Biophys Acta. 1997;1336:99-109 pubmed
    ..The possibilities have been discussed that it protects sperm from the premature acrosome reaction and maintains sperm fertilizing ability in the epididymis. ..
  19. Ohnuma A, Yoshida T, Horiuchi H, Fukumori J, Tomita M, Kojima S, et al. Altered pulmonary defense system in lung injury induced by didecyldimethylammonium chloride in mice. Inhal Toxicol. 2011;23:476-85 pubmed publisher
    ..The results suggest that DDAC alters pulmonary defense system, which may contribute to susceptibility to an exogenous infectious agent. ..
  20. Ohdate T, Inoue Y. Involvement of glutathione peroxidase 1 in growth and peroxisome formation in Saccharomyces cerevisiae in oleic acid medium. Biochim Biophys Acta. 2012;1821:1295-305 pubmed publisher