Experts and Doctors on glutamate decarboxylase in Japan


Locale: Japan
Topic: glutamate decarboxylase

Top Publications

  1. Kami K, Taguchi Ms S, Tajima F, Senba E. Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic pain. Mol Pain. 2016;12: pubmed publisher
    ..Therefore, improvements in impaired GABAergic inhibition may be involved in exercise-induced hypoalgesia. ..
  2. Maemura K, Yanagawa Y, Obata K, Dohi T, Egashira Y, Shibayama Y, et al. Antigen-presenting cells expressing glutamate decarboxylase 67 were identified as epithelial cells in glutamate decarboxylase 67-GFP knock-in mouse thymus. Tissue Antigens. 2006;67:198-206 pubmed
  3. Kahara T, Takamura T, Ando H, Sakurai M, Ota T, Misaki T, et al. Fulminating onset type 1 diabetes with positivity for anti-GAD antibody and elevated pancreatic exocrine enzyme concentrations. Intern Med. 2003;42:517-20 pubmed
    ..After 10 months, anti-GAD antibody had become negative, but insulin therapy was still needed for glycemic control. This report concerns a case of autoimmune fulminating onset type 1 diabetes. ..
  4. Naritsuka H, Sakai K, Hashikawa T, Mori K, Yamaguchi M. Perisomatic-targeting granule cells in the mouse olfactory bulb. J Comp Neurol. 2009;515:409-26 pubmed publisher
    ..These findings indicate the morphological differentiation of GCs into dendritic-targeting and perisomatic-targeting subsets, and suggest the functional differentiation of the GC subsets in the processing of odor information in the OB. ..
  5. Nishikawa K, Kubo K, Obata H, Yanagawa Y, Saito S. The influence of manipulations to alter ambient GABA concentrations on the hypnotic and immobilizing actions produced by sevoflurane, propofol, and midazolam. Neuropharmacology. 2011;61:172-80 pubmed publisher
  6. Kubo K, Nishikawa K, Ishizeki J, Hardy Yamada M, Yanagawa Y, Saito S. Thermal hyperalgesia via supraspinal mechanisms in mice lacking glutamate decarboxylase 65. J Pharmacol Exp Ther. 2009;331:162-9 pubmed publisher
    ..These results support the hypothesis that GAD65-mediated GABA synthesis plays relatively small but significant roles in nociceptive processing via supraspinal mechanisms. ..
  7. Kaneko T, Mizuno N. Glutamate-synthesizing enzymes in GABAergic neurons of the neocortex: a double immunofluorescence study in the rat. Neuroscience. 1994;61:839-49 pubmed
    ..Mitochondrial aspartate aminotransferase was located in perikarya, rather than in axon terminals of GABAergic neurons, suggesting a transmitter-irrelevant role of this enzyme in neurons. ..
  8. Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed publisher
    ..Monoaminergic modulation of the neural connections between globular cells and PCs could play a role in cerebellar motor coordination. ..
  9. Win Shwe T, Fujimaki H, Fujitani Y, Hirano S. Novel object recognition ability in female mice following exposure to nanoparticle-rich diesel exhaust. Toxicol Appl Pharmacol. 2012;262:355-62 pubmed publisher
    ..The present study suggests that genes related to glutamate metabolism may be involved in the NRDE-induced neurotoxicity observed in the present mouse model. ..

More Information


  1. Mieda M, Hasegawa E, Kisanuki Y, Sinton C, Yanagisawa M, Sakurai T. Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci. 2011;31:6518-26 pubmed publisher
    ..Thus, each orexin receptor subtype plays differential roles in gating NREM and REM sleep through distinct neuronal pathways. ..
  2. Akihiro T, Koike S, Tani R, Tominaga T, Watanabe S, Iijima Y, et al. Biochemical mechanism on GABA accumulation during fruit development in tomato. Plant Cell Physiol. 2008;49:1378-89 pubmed publisher
    ..Taken together, our results suggest that GAD and GABA-TK play crucial roles in GABA accumulation and catabolism, respectively, in tomato fruits. ..
  3. Oikawa Y, Shimada A, Kasuga A, Morimoto J, Osaki T, Tahara H, et al. Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic mice. J Immunol. 2003;171:5865-75 pubmed
  4. Hayashi A, Nakamagoe K, Ohkoshi N, Hoshino S, Shoji S. Double filtration plasma exchange and immunoadsorption therapy in a case of stiff-man syndrome with negative anti-GAD antibody. J Med. 1999;30:321-7 pubmed
    ..The patient's improvement continued, but his condition declined again about ten months after plasma exchange. Immunoadsorption therapy was then performed, and this treatment was also effective...
  5. Nomura M, Nakajima I, Fujita Y, Kobayashi M, Kimoto H, Suzuki I, et al. Lactococcus lactis contains only one glutamate decarboxylase gene. Microbiology. 1999;145 ( Pt 6):1375-80 pubmed publisher
    ..A single band corresponding to the glutamate decarboxylase gene was detected on Southern blot analysis. These data suggest that there is one glutamate decarboxylase gene in L. lactis...
  6. Kawasaki E, Moriuchi R, Watanabe M, Saitoh K, Brunicardi F, Watt P, et al. Cloning and expression of large isoform of glutamic acid decarboxylase from human pancreatic islet. Biochem Biophys Res Commun. 1993;192:1353-9 pubmed
    ..The bacterially expressed human islet GAD67 protein was enzymatically active and immunoreactive. The isolation of cDNA for this additional islet GAD isoforms will be important in studying the etiology and pathogenesis of IDDM. ..
  7. Yoshida T, Yamashino T, Ueguchi C, Mizuno T. Expression of the Escherichia coli dimorphic glutamic acid decarboxylases is regulated by the nucleoid protein H-NS. Biosci Biotechnol Biochem. 1993;57:1568-9 pubmed
  8. Ota T, Takamura T, Nagai Y, Bando Y, Usuda R. Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody. Diabetes Res Clin Pract. 2005;67:63-9 pubmed
    ..Measuring IA-2A in combination with GADA is useful for the diagnosis and prognosis of type 1 diabetes in Japanese. ..
  9. Misaki K, Kikkawa S, Terashima T. Reelin-expressing neurons in the anterior commissure and corpus callosum of the rat. Brain Res Dev Brain Res. 2004;148:89-96 pubmed
    ..These results suggest that Reelin may participate in the regulatory mechanism of neuronal activities through the commissure structure during the postnatal periods. ..
  10. Kikuoka N, Sugihara S, Yanagawa T, Ikezaki A, Kim H, Matsuoka H, et al. Cytotoxic T lymphocyte antigen 4 gene polymorphism confers susceptibility to type 1 diabetes in Japanese children: analysis of association with HLA genotypes and autoantibodies. Clin Endocrinol (Oxf). 2001;55:597-603 pubmed
    ..The association between this CTLA4 polymorphism and the HLA genotype was similar for both major groups with HLA high-risk alleles. CTLA4 might contribute to the humoral immune response to GAD in newly diagnosed subjects. ..