Experts and Doctors on glucuronidase in Japan


Locale: Japan
Topic: glucuronidase

Top Publications

  1. Nakamura J, Kubota Y, Miyaoka M, Saitoh T, Mizuno F, Benno Y. Comparison of four microbial enzymes in Clostridia and Bacteroides isolated from human feces. Microbiol Immunol. 2002;46:487-90 pubmed
    ..05) higher than that in the clostridia isolated from healthy subjects and the subjects given high beef diets. However, the activities of some microorganisms tested showed marked differences in each strain. ..
  2. Tang W, Nakamura Y, Tsujimoto M, Sato M, Wang X, Kurozumi K, et al. Heparanase: a key enzyme in invasion and metastasis of gastric carcinoma. Mod Pathol. 2002;15:593-8 pubmed
    ..It was indicated that patients with heparanase-positive gastric carcinoma would have a greater chance of metastasis with a poor prognosis. ..
  3. Tanaka T, Sugiura H, Inaba R, Nishikawa A, Murakami A, Koshimizu K, et al. Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice. Carcinogenesis. 1999;20:1471-6 pubmed
    ..These findings might suggest that oral administration of citrus auraptene effectively enhanced macrophage and lymphocyte functions in mice. ..
  4. Nakagawa T, Takane K, Sugimoto T, Izui K, Kouchi H, Hata S. Regulatory regions and nuclear factors involved in nodule-enhanced expression of a soybean phosphoenolpyruvate carboxylase gene: implications for molecular evolution. Mol Genet Genomics. 2003;269:163-72 pubmed
    ..This study suggests that the acquisition of two interdependent cis-acting elements resulted in molecular evolution of the nodule-enhanced GmPEPC7gene. ..
  5. Hiwasa Tanase K, Kuroda H, Hirai T, Aoki K, Takane K, Ezura H. Novel promoters that induce specific transgene expression during the green to ripening stages of tomato fruit development. Plant Cell Rep. 2012;31:1415-24 pubmed publisher
    ..Novel fruit-specific promoters have been identified and are suitable for transgene expression during green to ripening stages of tomato fruit development. ..
  6. Kapoor M, Tsuda S, Tanaka Y, Mayama T, Okuyama Y, Tsuchimoto S, et al. Role of petunia pMADS3 in determination of floral organ and meristem identity, as revealed by its loss of function. Plant J. 2002;32:115-27 pubmed
    ..The evidence presented here suggest that a complex involving PMADS3 and FBP2 is responsible for specification of organ identity in the third whorl. ..
  7. Toda T, Sano M, Honda M, Rimoldi O, Yang Y, Yamamoto M, et al. Deletion analysis of the enolase gene (enoA) promoter from the filamentous fungus Aspegillus oryzae. Curr Genet. 2001;40:260-7 pubmed
    ..oryzae cellular factors specifically bind. These results suggest that the 15-bp element between -195 nt and -181 nt includes the sequence essential for the transcription regulation of the A. oryzae enoA gene. ..
  8. Kanegae T, Kajiya H, Amano Y, Hashimoto T, Yamada Y. Species-dependent expression of the hyoscyamine 6 beta-hydroxylase gene in the pericycle. Plant Physiol. 1994;105:483-90 pubmed
    ..These studies indicate that the cell-specific expression of the H6H gene is controlled by some genetic regulation specific to scopolamine-producing plants. ..
  9. Tran L, Nakashima K, Shinozaki K, Yamaguchi Shinozaki K. Plant gene networks in osmotic stress response: from genes to regulatory networks. Methods Enzymol. 2007;428:109-28 pubmed
    ..This chapter summarizes the methodology used to dissect gene regulatory networks involved in the response to osmotic stresses, such as drought and high salinity. ..

More Information


  1. Shimoi K, Nakayama T. Glucuronidase deconjugation in inflammation. Methods Enzymol. 2005;400:263-72 pubmed
    ..These results suggest that beta-glucuronidase released from neutrophils or certain injured cells may hydrolyze glucuronide conjugates to free aglycones at the site of inflammation. ..
  2. Maeo K, Tomiya T, Hayashi K, Akaike M, Morikami A, Ishiguro S, et al. Sugar-responsible elements in the promoter of a gene for beta-amylase of sweet potato. Plant Mol Biol. 2001;46:627-37 pubmed
  3. Masaki H, Miki T. [Bone and calcium metabolism in elderly women]. Clin Calcium. 2011;21:1361-7 pubmed publisher
    ..These factors may influence on the elevated bone metabolism resulting in the discrepancy with morphometric evaluation. ..
  4. Nishimura M, Nikawa T, Kawano Y, Nakayama M, Ikeda M. Effects of dimethyl sulfoxide and dexamethasone on mRNA expression of housekeeping genes in cultures of C2C12 myotubes. Biochem Biophys Res Commun. 2008;367:603-8 pubmed publisher
    ..The GUSB, PPIA, and TFRC mRNA levels were unaffected by exposure to Dex. GUSB, HPRT1, and PPIA are thus suitable internal controls for evaluating mRNA expression levels in cultures of C2C12 cells. ..
  5. Suzuki Y, Kitagawa M, Knox J, Yamaguchi I. A role for arabinogalactan proteins in gibberellin-induced alpha-amylase production in barley aleurone cells. Plant J. 2002;29:733-41 pubmed
    ..The possible mechanism of AGP function in gibberellin-induced alpha-amylase production is discussed. ..
  6. Taniguchi M, Izawa K, Ku M, Lin J, Saito H, Ishida Y, et al. The promoter for the maize C4 pyruvate, orthophosphate dikinase gene directs cell- and tissue-specific transcription in transgenic maize plants. Plant Cell Physiol. 2000;41:42-8 pubmed
    ..Furthermore, the 0.9 kb maize C4Pdk promoter sequences appear to contain the necessary cis-acting elements for its cell- and organ-specific expression. ..
  7. Kobae Y, Sekino T, Yoshioka H, Nakagawa T, Martinoia E, Maeshima M. Loss of AtPDR8, a plasma membrane ABC transporter of Arabidopsis thaliana, causes hypersensitive cell death upon pathogen infection. Plant Cell Physiol. 2006;47:309-18 pubmed
    ..Our results indicate that AtPDR8 is a key factor controlling the extent of cell death in the defense response and suggest that AtPDR8 transports some substance(s) which is closely related to the response of plants to pathogens...
  8. Tomatsu S, Fukuda S, Sukegawa K, Ikedo Y, Yamada S, Yamada Y, et al. Mucopolysaccharidosis type VII: characterization of mutations and molecular heterogeneity. Am J Hum Genet. 1991;48:89-96 pubmed
    ..Each of these two amino acid changes reduced the beta G1 activity of the corresponding mutant beta G1 expressed following transfection of COS cells with expression vectors harboring the mutated cDNAs. ..
  9. Tajima H, Koizumi N. Induction of BiP by sugar independent of a cis-element for the unfolded protein response in Arabidopsis thaliana. Biochem Biophys Res Commun. 2006;346:926-30 pubmed
    ..thaliana harboring luciferase (LUC) gene regulated by P-UPRE was analyzed. Sugar depletion also increased LUC activity. It is concluded that BiP is induced by sugar independent of the cis-element responsible for the UPR. ..
  10. Takeda T, Amano K, Ohto M, Nakamura K, Sato S, Kato T, et al. RNA interference of the Arabidopsis putative transcription factor TCP16 gene results in abortion of early pollen development. Plant Mol Biol. 2006;61:165-77 pubmed
    ..Our results therefore suggest that TCP16, a putative transcription factor, plays a crucial role in early processes in pollen development. ..
  11. Sasaki M, Ito T, Kashima M, Fukui S, Izumiyama N, Watanabe A, et al. Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro. Mediators Inflamm. 2001;10:259-67 pubmed
    ..The suppressive effect of heparanase mRNA expression by EM and CAM may have interestingtherapeutic applications in the prevention of metastasis. ..
  12. Uno Y, Furihata T, Abe H, Yoshida R, Shinozaki K, Yamaguchi Shinozaki K. Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions. Proc Natl Acad Sci U S A. 2000;97:11632-7 pubmed
    ..Using cultured Arabidopsis cells, we demonstrated that a specific ABA-activated protein kinase of 42-kDa phosphorylated conserved N-terminal regions in the AREB proteins. ..
  13. Dong J, Kukula A, Toyoshima M, Nakajima M. Genomic organization and chromosome localization of the newly identified human heparanase gene. Gene. 2000;253:171-8 pubmed
    ..A possible involvement of heparanase in neuronal degeneration is discussed. ..
  14. Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, Kagawa T, et al. Serum levels of soluble secreted ?-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol. 2012;16:722-9 pubmed publisher
    ..Soluble ?-Klotho may thus represent a new biomarker for the diagnosis of CKD, especially in the early stage. ..
  15. Nakashima K, Shinwari Z, Sakuma Y, Seki M, Miura S, Shinozaki K, et al. Organization and expression of two Arabidopsis DREB2 genes encoding DRE-binding proteins involved in dehydration- and high-salinity-responsive gene expression. Plant Mol Biol. 2000;42:657-65 pubmed
    ..Several conserved sequences were found in the promoter regions of both genes. The beta-glucuronidase (GUS) reporter gene driven by the DREB2 promoters was induced by dehydration and high-salt stress in transgenic Arabidopsis plants. ..
  16. Satoh T, Suzuki S, Kawai N, Nakamura T, Hosokawa M. Toxicological significance in the cleavage of esterase-beta-glucuronidase complex in liver microsomes by organophosphorus compounds. Chem Biol Interact. 1999;119-120:471-8 pubmed
    ..From these in vivo and in vitro data, it is concluded that increase of the plasma beta-G level after OP administration is much more sensitive biomarker than cholinesterase inhibition to acute intoxication of OPs and carbamates...
  17. Abe H, Yamaguchi Shinozaki K, Urao T, Iwasaki T, Hosokawa D, Shinozaki K. Role of arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression. Plant Cell. 1997;9:1859-68 pubmed
    ..These results indicate that both the rd22BP1 (MYC) and ATMYB2 (MYB) proteins function as transcriptional activators in the dehydration- and ABA-inducible expression of the rd22 gene. ..
  18. Yamaguchi Shinozaki K, Shinozaki K. Characterization of the expression of a desiccation-responsive rd29 gene of Arabidopsis thaliana and analysis of its promoter in transgenic plants. Mol Gen Genet. 1993;236:331-40 pubmed
    ..Histochemical analysis of GUS activity revealed that the rd29A promoter functions in almost all the organs and tissues of vegetative plants during water deficiency. ..
  19. Nishimura R, Ohmori M, Fujita H, Kawaguchi M. A Lotus basic leucine zipper protein with a RING-finger motif negatively regulates the developmental program of nodulation. Proc Natl Acad Sci U S A. 2002;99:15206-10 pubmed publisher
    ..Legume-characteristic combination of motifs of ASTRAY may play specific roles in the regulation of nodule development...
  20. Suzuki H, Amizuka N, Noda M, Amano O, Maeda T. Histological and immunohistochemical changes in the submandibular gland in klotho-deficient mice. Arch Histol Cytol. 2006;69:119-28 pubmed
    ..Our findings suggest that the klotho gene inhibited the differentiation of the granular duct from the striated duct due to the repression and/or down-regulation of sexual and growth hormones. ..
  21. Ando A, Sakuradani E, Horinaka K, Ogawa J, Shimizu S. Transformation of an oleaginous zygomycete Mortierella alpina 1S-4 with the carboxin resistance gene conferred by mutation of the iron-sulfur subunit of succinate dehydrogenase. Curr Genet. 2009;55:349-56 pubmed publisher
    ..alpina 1S-4, is considered to be widely useful for the wild strain, M. alpina 1S-4, and various derivative mutants without laborious preparation of auxotrophic mutants as a host strain...
  22. Nagatsuka H, Siar C, Tsujigiwa H, Naomoto Y, Han P, Gunduz M, et al. Heparanase and cyclooxygenase-2 gene and protein expressions during progression of oral epithelial dysplasia to carcinoma. Ann Diagn Pathol. 2012;16:354-61 pubmed publisher
    ..These results, taken together, suggest that heparanase and COX-2 might play complementary roles in the stepwise progression of OED to carcinoma. ..
  23. Haque M, Kotake T, Tsumuraya Y. Mode of action of beta-glucuronidase from Aspergillus niger on the sugar chains of arabinogalactan-protein. Biosci Biotechnol Biochem. 2005;69:2170-7 pubmed
    ..These results indicate that beta-glucuronidase acts upon 4-Me-beta-GlcA residues in long (1-->6)-linked beta-galactosyl side chains of the AGP, whereas short acidic side chains survive the attack of the enzyme. ..
  24. Muñoz Castañeda J, Herencia C, Pendón Ruiz de Mier M, Rodriguez Ortiz M, Díaz Tocados J, Vergara N, et al. Differential regulation of renal Klotho and FGFR1 in normal and uremic rats. FASEB J. 2017;31:3858-3867 pubmed publisher
    ..Diaz-Tocados, J. M., Vergara, N., Martínez-Moreno, J. M., Salmerón, M. D., Richards, W. G., Felsenfeld, A., Kuro-O, M., Almadén, Y., Rodríguez, M. Differential regulation of renal Klotho and FGFR1 in normal and uremic rats. ..
  25. Tohyama O, Imura A, Iwano A, Freund J, Henrissat B, Fujimori T, et al. Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem. 2004;279:9777-84 pubmed
    ..Collectively, these data suggest that Klotho functions as a novel beta-glucuronidase and that steroid beta-glucuronides are potential candidates for the natural substrate(s) of Klotho. ..
  26. Yoshioka Y, Kurei S, Machida Y. Identification of a monofunctional aspartate kinase gene of Arabidopsis thaliana with spatially and temporally regulated expression. Genes Genet Syst. 2001;76:189-98 pubmed
    ..These results indicated that this aspartate kinase gene was not expressed uniformly but in a spatially specific manner. ..
  27. Yabe N, Takahashi T, Komeda Y. Analysis of tissue-specific expression of Arabidopsis thaliana HSP90-family gene HSP81. Plant Cell Physiol. 1994;35:1207-19 pubmed
    ..Only a slight response to IAA was observed in HSP81-1 mRNA accumulation at 22 degrees C; the increase was possibly caused by a novel pathway other than heat-shock-response pathway. ..
  28. Kawaguchi H, Manabe N, Chikuda H, Nakamura K, Kuroo M. Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse. Cell Mol Life Sci. 2000;57:731-7 pubmed
    ..We conclude that a defect in klotho gene expression leads to the independent impairment of osteoblast and osteoclast differentiation, which can be a cause of low-turnover osteoporosis. ..
  29. Nagai R, Saito Y, Ohyama Y, Aizawa H, Suga T, Nakamura T, et al. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci. 2000;57:738-46 pubmed
    ..The Klotho protein itself, or its metabolites, promotes endothelial NO production in aorta as well as arterioles, and klotho mRNA in kidney is downregulated under sustained circulatory stress. ..
  30. Yahata K, Mori K, Arai H, Koide S, Ogawa Y, Mukoyama M, et al. Molecular cloning and expression of a novel klotho-related protein. J Mol Med (Berl). 2000;78:389-94 pubmed
    ..In conclusion, we describe the primary structure and gene expression of a novel protein related to klotho protein. ..
  31. Oda A, Sakuta C, Masuda S, Mizoguchi T, Kamada H, Satoh S. Possible involvement of leaf gibberellins in the clock-controlled expression of XSP30, a gene encoding a xylem sap lectin, in cucumber roots. Plant Physiol. 2003;133:1779-90 pubmed
    ..This is the first demonstration of the regulation of the expression of a clock-controlled gene by GA. ..
  32. Morishita K, Shirai A, Kubota M, Katakura Y, Nabeshima Y, Takeshige K, et al. The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. J Nutr. 2001;131:3182-8 pubmed
    ..05). These results indicate that dietary phosphorus and zinc modulate the phenotypes of klotho mice, and that klotho expression in the kidneys is regulated not only in klotho mutant mice, but also in wild-type mice...
  33. Kosugi S, Ohashi Y. DNA binding and dimerization specificity and potential targets for the TCP protein family. Plant J. 2002;30:337-48 pubmed
    ..These results suggest that the two classes of TCP protein are distinct in DNA binding specificity and transcriptional regulation. ..
  34. Nakamura T, Saito Y, Ohyama Y, Masuda H, Sumino H, Kuro O M, et al. Production of nitric oxide, but not prostacyclin, is reduced in klotho mice. Jpn J Pharmacol. 2002;89:149-56 pubmed
    ..No immunostaining for NO synthase was noted in the aorta of kl/kl mice. The expression of the klotho gene product may have a role in the regulation of VEGF expression and is tightly linked to endothelial release of NO. ..
  35. Ohtake S, Kimata K, Habuchi O. A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase. J Biol Chem. 2003;278:38443-52 pubmed
    ..Oligo III behaved identically with the sulfated Oligos I and II. These results suggest that GalNAc4S-6ST may be involved in the terminal modification of CS-A, through which a highly sulfated nonreducing terminal sequence is generated. ..
  36. Shimomura K, Nomura M, Tajima S, Kouchi H. LjnsRING, a novel RING finger protein, is required for symbiotic interactions between Mesorhizobium loti and Lotus japonicus. Plant Cell Physiol. 2006;47:1572-81 pubmed publisher
    ..These results suggest the requirement for LjnsRING in rhizobial infection and the subsequent nodule formation process...
  37. Endo M, Ishikawa Y, Osakabe K, Nakayama S, Kaya H, Araki T, et al. Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants. EMBO J. 2006;25:5579-90 pubmed
  38. Ikeda K, Nakayashiki H, Takagi M, Tosa Y, Mayama S. Heat shock, copper sulfate and oxidative stress activate the retrotransposon MAGGY resident in the plant pathogenic fungus Magnaporthe grisea. Mol Genet Genomics. 2001;266:318-25 pubmed
    ..The relationship between the activation of MAGGY by stress and phenotypic diversification in M. grisea, including variations in pathogenicity, is discussed...
  39. Hayashi K, Yamazoe A, Ishibashi Y, Kusaka N, Oono Y, Nozaki H. Active core structure of terfestatin A, a new specific inhibitor of auxin signaling. Bioorg Med Chem. 2008;16:5331-44 pubmed publisher
    ..The structure-activity relationships revealed the essential active core structure of TrfA, 3-butoxy-4-methylbiphenyl-2,6-diol, which will lead to the design of biotin-tagged active TrfA. ..
  40. Kizaki K, Nakano H, Takahashi T, Imai K, Hashizume K. Expression of heparanase mRNA in bovine placenta during gestation. Reproduction. 2001;121:573-80 pubmed
    ..These results demonstrate that heparanase mRNA is expressed in the placentome, indicating that heparanase may play a role in implantation, and in placental development and function. ..
  41. Fukuda A, Nakamura A, Hara N, Toki S, Tanaka Y. Molecular and functional analyses of rice NHX-type Na+/H+ antiporter genes. Planta. 2011;233:175-88 pubmed publisher
  42. Kosakai A, Ito D, Nihei Y, Yamashita S, Okada Y, Takahashi K, et al. Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure. Brain Res. 2011;1382:109-17 pubmed publisher
    ..The present study provides new insights into the pathology of age-related degeneration of dopaminergic neurons possibly related to Klotho-mediated regulation of vitamin D. ..
  43. Sompornpailin K, Makita Y, Yamazaki M, Saito K. A WD-repeat-containing putative regulatory protein in anthocyanin biosynthesis in Perilla frutescens. Plant Mol Biol. 2002;50:485-95 pubmed
    ..We propose a model of genetic regulation in which the PFWD protein acts in signal transduction process in a variety of pathways through protein interaction with MYC proteins...
  44. Kawano K, Ogata N, Chiano M, Molloy H, Kleyn P, Spector T, et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res. 2002;17:1744-51 pubmed
    ..These results indicate that the klotho gene may be involved in the pathophysiology of bone loss with aging in humans. ..
  45. Aizawa H, Saito Y, Nakamura T, Inoue M, Imanari T, Ohyama Y, et al. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochem Biophys Res Commun. 1998;249:865-71 pubmed
    ..This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure. ..
  46. Tanaka H, Fukagawa M. [Hormonal regulation of phosphate balance]. Clin Calcium. 2012;22:1477-85 pubmed
    ..However, the precise feedback system in the phosphate metabolism remains to be determined and further research is required to provide a greater understanding of the phosphate metabolism system. ..
  47. Sotta N, Shantikumar L, Sakamoto T, Matsunaga S, Fujiwara T. TPR5 is involved in directional cell division and is essential for the maintenance of meristem cell organization in Arabidopsis thaliana. J Exp Bot. 2016;67:2401-11 pubmed publisher
    ..From this study, we concluded that TPR5 is involved in preventing the formation of micronuclei and is necessary for both the activity and directionality of cell division in root meristems. ..
  48. Kumagai Y, Watanabe W, Kobayashi A, Sato K, Onuma S, Sakamoto H. Inhibitory effect of low density lipoprotein on the inflammation-inducing activity of calcium pyrophosphate dihydrate crystals. J Rheumatol. 2001;28:2674-80 pubmed
    ..We examined whether LDL binds to calcium pyrophosphate dihydrate (CPPD) crystals as a possible mechanism for reduction of inflammation...