Experts and Doctors on genotype in New Zealand

Summary

Locale: New Zealand
Topic: genotype

Top Publications

  1. Helsby N, Hui C, Goldthorpe M, Coller J, Soh M, Gow P, et al. The combined impact of CYP2C19 and CYP2B6 pharmacogenetics on cyclophosphamide bioactivation. Br J Clin Pharmacol. 2010;70:844-53 pubmed publisher
    ..The presence of ≥1 LoF allele(s) at either CYP2B6 or CYP2C19 appeared to result in decreased bioactivation of cyclophosphamide both in vitro and in patients. Further clinical studies to confirm this relationship are warranted. ..
  2. Volz R, McGhie T. Genetic variability in apple fruit polyphenol composition in Malus × domestica and Malus sieversii germplasm grown in New Zealand. J Agric Food Chem. 2011;59:11509-21 pubmed publisher
    ..sieversii. In M. × domestica, cultivars and breeding selections originating in NZ had lower average flesh and peel total polyphenols and chlorogenic acid than older cultivars previously imported into NZ from overseas countries. ..
  3. Joyce P, McKenzie J, Mulder R, Luty S, Sullivan P, Miller A, et al. Genetic, developmental and personality correlates of self-mutilation in depressed patients. Aust N Z J Psychiatry. 2006;40:225-9 pubmed
    ..If the association between the T allele of GNbeta3 and self-mutilation can be replicated, this may provide clues to understanding the neurobiology of self-mutilation. ..
  4. Gearry R, Barclay M, Roberts R, Harraway J, Zhang M, Pike L, et al. Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice. Intern Med J. 2005;35:580-5 pubmed
    ..Measurement of TPMT enzyme activity and 6-TGN concentration has been well-integrated into clinical practice. These tests should reduce the risk of toxicity and improve efficacy with thiopurines in patients with IBD. ..
  5. Jones G, Thompson A, van Bockxmeer F, Hafez H, Cooper J, Golledge J, et al. Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arterioscler Thromb Vasc Biol. 2008;28:764-70 pubmed publisher
    ..This study highlights the key role of the RAS in AAA and emphasizes the need for replication and validation of results in suitable independent cohorts. ..
  6. Nowak J, Cruz C, Tempelaars M, Abee T, van Vliet A, Fletcher G, et al. Persistent Listeria monocytogenes strains isolated from mussel production facilities form more biofilm but are not linked to specific genetic markers. Int J Food Microbiol. 2017;256:45-53 pubmed publisher
    ..Our results suggest a link between persistence and biofilm formation, which is most likely multifactorial, combining subtle phenotypic and genotypic differences between isolates. ..
  7. Cundy T, Naot D, Bava U, Musson D, Tong P, Bolland M. Familial Paget disease and SQSTM1 mutations in New Zealand. Calcif Tissue Int. 2011;89:258-64 pubmed publisher
    ..005). SQSTM1 mutations were found in 10.5% of patients with early onset and/or severe disease but no family history. ..
  8. McDonald M, Gehrig S, Meintjes P, Zhang X, Rainey P. Adaptive divergence in experimental populations of Pseudomonas fluorescens. IV. Genetic constraints guide evolutionary trajectories in a parallel adaptive radiation. Genetics. 2009;183:1041-53 pubmed publisher
    ..Together our data provide an explanation for why WS evolution follows a limited number of mutational pathways and show how genetic architecture can bias the molecular variation presented to selection. ..
  9. Barker D, Beck C. Overexpression of the transcription factor Msx1 is insufficient to drive complete regeneration of refractory stage Xenopus laevis hindlimbs. Dev Dyn. 2009;238:1366-78 pubmed publisher
    ..Developmental Dynamics 238:1366-1378, 2009. (c) 2009 Wiley-Liss, Inc. ..

More Information

Publications22

  1. Duchesnes C, Naggert J, Tatnell M, Beckman N, Marnane R, Rodrigues J, et al. New Zealand Ginger mouse: novel model that associates the tyrp1b pigmentation gene locus with regulation of lean body mass. Physiol Genomics. 2009;37:164-74 pubmed publisher
    ..We propose NZG/Kgm mice as a novel model to delineate gene(s) that regulate 1) growth and metabolism, 2) resistance to Type 2 diabetes, and 3) preferential fat deposition in the subcutaneous and gonadal areas. ..
  2. Thorgeirsson T, Geller F, Sulem P, Rafnar T, Wiste A, Magnusson K, et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature. 2008;452:638-642 pubmed publisher
    ..The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases. ..
  3. Dodd A, Rowland S, Hawkes S, Kennedy M, Love D. Mutations in the adrenoleukodystrophy gene. Hum Mutat. 1997;9:500-11 pubmed
    ..While rapid DNA-based diagnoses of ALD is now possible, there appears to be no simple correlation between genotype and phenotype...
  4. McDougall S, Agnew K, Cursons R, Hou X, Compton C. Parenteral treatment of clinical mastitis with tylosin base or penethamate hydriodide in dairy cattle. J Dairy Sci. 2007;90:779-89 pubmed
    ..82.0% of cows treated with penethamate hydriodide or tylosin, respectively), or in SCC or milk production between dairy cows with clinical mastitis and those treated for clinical mastitis with 1 of 2 parenteral antibiotic therapies. ..
  5. Costello M. Ecology of sea lice parasitic on farmed and wild fish. Trends Parasitol. 2006;22:475-83 pubmed
    ..salmonis and Caligus spp. This knowledge could be used to take measures to reduce the risks of lice affecting farmed and wild fish...
  6. Crawford A, Paterson K, Dodds K, Diez Tascon C, Williamson P, Roberts Thomson M, et al. Discovery of quantitative trait loci for resistance to parasitic nematode infection in sheep: I. Analysis of outcross pedigrees. BMC Genomics. 2006;7:178 pubmed
    ..This study was undertaken to identify regions of the genome, quantitative trait loci (QTL) that contain genes affecting resistance to parasitic nematodes...
  7. Pokorny V, McQueen F, Yeoman S, Merriman M, Merriman A, Harrison A, et al. Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis. Ann Rheum Dis. 2005;64:487-90 pubmed
    ..This study provides further evidence for a protective effect of the CCR5 d32 variant on rheumatoid arthritis, consistent with a role for CCR5 and its ligands in disease pathogenesis. ..
  8. Reid S, van Roon Mom W, Wood P, Rees M, Owen M, Faull R, et al. TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease. Brain Res Mol Brain Res. 2004;125:120-8 pubmed
    ..We present this as evidence for the hypothesis that the accumulation or misfolding of this polyQ containing protein may be a contributing factor in Alzheimer's disease. ..
  9. Davis G, Galloway S, Ross I, Gregan S, Ward J, Nimbkar B, et al. DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation. Biol Reprod. 2002;66:1869-74 pubmed
    ..The DNA mutation test for FecB will enable breeding plans to be developed that allow the most effective use of this gene in Garole and Javanese Thin-tailed sheep and their crosses. ..
  10. Martin J, Begg E, Kennedy M, Roberts R, Barclay M. Is cytochrome P450 2C9 genotype associated with NSAID gastric ulceration?. Br J Clin Pharmacol. 2001;51:627-30 pubmed
    ..These results do not support the hypothesis that gastric ulceration resulting from NSAID usage is linked to the poor metabolizing genotypes of CYP2C9. ..
  11. Ferguson L, Browning B, Huebner C, Petermann I, Shelling A, Demmers P, et al. Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population. Dig Liver Dis. 2008;40:723-30 pubmed publisher
    ..Identifying such functional variants will be prioritized in subsequent work. ..
  12. Young R, Hopkins R, Black P, Eddy C, Wu L, Gamble G, et al. Functional variants of antioxidant genes in smokers with COPD and in those with normal lung function. Thorax. 2006;61:394-9 pubmed
    ..The 213Gly variant of the SOD3 gene may, through antioxidant or anti-inflammatory effects, confer a degree of resistance in some smokers to the development of COPD. ..
  13. Hennebry A, Oldham J, Shavlakadze T, Grounds M, Sheard P, Fiorotto M, et al. IGF1 stimulates greater muscle hypertrophy in the absence of myostatin in male mice. J Endocrinol. 2017;234:187-200 pubmed publisher
    ..Finally, we show that myostatin and IGF1 regulate skeletal muscle size, myofibre type and gonadal fat through distinct mechanisms that involve increasing the total abundance and phosphorylation status of AKT and rpS6. ..