Experts and Doctors on genomic instability in Denmark


Locale: Denmark
Topic: genomic instability

Top Publications

  1. Scholz C, Bruggemann H, Lomholt H, Tettelin H, Kilian M. Genome stability of Propionibacterium acnes: a comprehensive study of indels and homopolymeric tracts. Sci Rep. 2016;6:20662 pubmed publisher
    ..The catalogued data and the public P. acnes Sybil database provide a solid foundation for generating hypotheses and facilitate comparative genetic analyses in future P. acnes research. ..
  2. Li J, Gao F, Li N, Li S, Yin G, Tian G, et al. An improved method for genome wide DNA methylation profiling correlated to transcription and genomic instability in two breast cancer cell lines. BMC Genomics. 2009;10:223 pubmed publisher
    ..The MMSDK method will be a valuable tool to increase the current knowledge of genome wide DNA methylation profiles. ..
  3. Beck H, Nähse V, Larsen M, Groth P, Clancy T, Lees M, et al. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol. 2010;188:629-38 pubmed publisher
    ..We conclude that the mitotic kinase WEE1 and CHK1 jointly maintain balanced cellular control of Cdk activity during normal DNA replication, which is crucial to prevent the generation of harmful DNA lesions during replication. ..
  4. Mankouri H, Huttner D, Hickson I. How unfinished business from S-phase affects mitosis and beyond. EMBO J. 2013;32:2661-71 pubmed publisher
    ..Furthermore, we discuss the potential ways in which cells might not only tolerate this inevitable aspect of chromosome biology, but also exploit it to assist in the maintenance of genome stability. ..
  5. Bekker Jensen S, Mailand N. Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amst). 2010;9:1219-28 pubmed publisher
    ..In this review, we focus on recent discoveries on the mechanisms that govern the formation of IRIF, and discuss the implications of such findings in light of our understanding of the physiological importance of these structures. ..
  6. Birkbak N, Eklund A, Li Q, McClelland S, Endesfelder D, Tan P, et al. Paradoxical relationship between chromosomal instability and survival outcome in cancer. Cancer Res. 2011;71:3447-52 pubmed publisher
    ..Inclusion of a surrogate measurement of CIN may improve cancer risk stratification and future therapeutic approaches. ..
  7. Alabert C, Groth A. Chromatin replication and epigenome maintenance. Nat Rev Mol Cell Biol. 2012;13:153-67 pubmed publisher
    ..If DNA synthesis is perturbed, cells can suffer loss of both genome and epigenome integrity with severe consequences for the organism. ..
  8. Barua H, Lindblom I, Bisgaard M, Christensen J, Olsen R, Christensen H. In vitro and in vivo investigation on genomic stability of Salmonella enterica Typhimurium DT41 obtained from broiler breeders in Denmark. Vet Microbiol. 2013;166:607-16 pubmed publisher
    ..Minor genetic changes were observed in isolates from the in vitro experiment as revealed by MLVA. The epidemiological impact of these findings is briefly discussed. ..
  9. Holmberg C, Fleck O, Hansen H, Liu C, Slaaby R, Carr A, et al. Ddb1 controls genome stability and meiosis in fission yeast. Genes Dev. 2005;19:853-62 pubmed
    ..These results suggest that Ddb1, along with Cullin 4 and the signalosome, constitute a major pathway controlling genome stability, repair, and differentiation via RNR regulation. ..

More Information


  1. Germann S, Schramke V, Pedersen R, Gallina I, Eckert Boulet N, Oestergaard V, et al. TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability. J Cell Biol. 2014;204:45-59 pubmed publisher
    ..In conclusion, we propose that TopBP1/Dpb11 prevents accumulation of anaphase bridges via stimulation of the Mec1/ATR kinase and suppression of homologous recombination...
  2. Patro B, Frøhlich R, Bohr V, Stevnsner T. WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes. J Cell Sci. 2011;124:3967-79 pubmed publisher
    ..Together, our results strongly suggest an essential regulatory role for WRN in controlling the ATR-CHK1-mediated S-phase checkpoint in CPT-treated cells. ..
  3. Jørgensen S, Schotta G, Sørensen C. Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity. Nucleic Acids Res. 2013;41:2797-806 pubmed publisher
    ..In this review, we explain molecular mechanisms underlying these defects and discuss novel ideas for furthering our understanding of genome maintenance in higher eukaryotes. ..
  4. Mailand N, Gibbs Seymour I, Bekker Jensen S. Regulation of PCNA-protein interactions for genome stability. Nat Rev Mol Cell Biol. 2013;14:269-82 pubmed publisher
    ..This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage. ..
  5. Saredi G, Huang H, Hammond C, Alabert C, Bekker Jensen S, Forne I, et al. H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Nature. 2016;534:714-718 pubmed publisher
    ..Together, these data reveal a histone-reader-based mechanism for recognizing the post-replicative state, offering a new angle to understand DNA repair with the potential for targeted cancer therapy. ..
  6. Fleck O, Vejrup Hansen R, Watson A, Carr A, Nielsen O, Holmberg C. Spd1 accumulation causes genome instability independently of ribonucleotide reductase activity but functions to protect the genome when deoxynucleotide pools are elevated. J Cell Sci. 2013;126:4985-94 pubmed publisher
    ..Our results provide evidence that excess Spd1 interferes with other functions in addition to its inhibitory effect on ribonucleotide reduction to generate replication stress and genome instability. ..
  7. Qvist P, Huertas P, Jimeno S, Nyegaard M, Hassan M, Jackson S, et al. CtIP Mutations Cause Seckel and Jawad Syndromes. PLoS Genet. 2011;7:e1002310 pubmed publisher
    ..This work thus identifies CtIP as a disease gene for Seckel and Jawad syndromes and defines a new type of genetic disease mechanism in which a dominant negative mutation yields a recessively inherited disorder...
  8. Hasemann M, Damgaard I, Schuster M, Theilgaard Monch K, Sørensen A, Mrsic A, et al. Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen. Blood. 2008;111:4309-21 pubmed publisher
  9. Jørgensen S, Elvers I, Trelle M, Menzel T, Eskildsen M, Jensen O, et al. The histone methyltransferase SET8 is required for S-phase progression. J Cell Biol. 2007;179:1337-45 pubmed publisher
    ..Overall, we show that SET8 is essential for genomic stability in mammalian cells and that decreased expression of SET8 results in DNA damage and Chk1-dependent S-phase arrest. ..
  10. Bekker Jensen S, Fugger K, Danielsen J, Gromova I, Sehested M, Celis J, et al. Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks. J Biol Chem. 2007;282:19638-43 pubmed
    ..Collectively, these findings implicate Xip1 as a new regulator of genome maintenance pathways, which may function to organize DNA strand break repair complexes at sites of DNA damage. ..
  11. Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol. 2007;19:238-45 pubmed
    ..Such studies highlight the dynamic nature of these processes and help us to better understand the molecular basis, spatiotemporal orchestration and biological significance of the DNA damage response in normal and cancerous cells. ..