Genomes and Genes
Experts and Doctors on genetic transcription in United Kingdom
Locale: United Kingdom
Topic: genetic transcription
Publications182 found, 100 shown here
- Parham K, Zervou S, Karteris E, Catalano R, Old R, Hillhouse E. Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin. Endocrinology. 2004;145:3971-83 pubmed..Collectively, our data suggest that the CRFR1 gene is under the influence of both CRF and UCN, acting via distinct signaling pathways to create a positive feedback loop and regulate further the transcription of the receptor. ..
- Klenova E, Scott A, Roberts J, Shamsuddin S, Lovejoy E, Bergmann S, et al. YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. J Neurosci. 2004;24:5966-73 pubmed..Our data suggest a novel mechanism that explains, in part, the ability of the distinct VNTR copy numbers to support differential reporter gene expression based on YB-1 binding sites. ..
- Singhatanadgit W, Salih V, Olsen I. Shedding of a soluble form of BMP receptor-IB controls bone cell responses to BMP. Bone. 2006;39:1008-1017 pubmed publisher..In conclusion, our study has provided evidence, for the first time, that BMPR can be modulated at the cell surface by the shedding of a soluble form of the antigen, resulting in a markedly diminished response to BMP-2 in vitro. ..
- Noon L, Clark A, O Shaughnessy P, King P. A CCAAT/enhancer-binding protein site at -87 is required for the activation of a novel murine melanocortin 2-receptor promoter at late stages during adipogenesis. Endocrinology. 2006;147:6019-26 pubmed..Real-time PCR analysis of mRNA initiating from the two start sites shows that there is a switch in promoter usage from the 5' to the 3' promoter around d 5, indicating the complex regulation of the murine MC2-R during adipogenesis. ..
- Bayele H, Peyssonnaux C, Giatromanolaki A, Arrais Silva W, Mohamed H, Collins H, et al. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood. 2007;110:3039-48 pubmed..This report also suggests that microsatellites may play critical roles in the directional evolution of complex heritable traits by regulating gene expression phenotypes. ..
- Sellick C, Jowitt T, Reece R. The effect of ligand binding on the galactokinase activity of yeast Gal1p and its ability to activate transcription. J Biol Chem. 2009;284:229-36 pubmed publisher..These data give significant insights into the mechanism of action of both a galactokinase and a transcriptional inducer. ..
- Bailey S, Hayes F. Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex. J Bacteriol. 2009;191:762-72 pubmed publisher..Deciphering the molecular basis of toxin-antitoxin transcriptional control will provide key insights into toxin-antitoxin activation and function. ..
- Ward A, Bates P, Fisher R, Richardson L, Graham C. Disproportionate growth in mice with Igf-2 transgenes. Proc Natl Acad Sci U S A. 1994;91:10365-9 pubmed..Adult total live weight was slightly increased and there was no macroscopic evidence of tumor formation. The characteristics of these transgenic mice indicate distinct local and systemic actions for insulin-like growth factor II. ..
- Otero G, Fellows J, Li Y, de Bizemont T, Dirac A, Gustafsson C, et al. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol Cell. 1999;3:109-18 pubmed..Our data indicate that the transition from transcriptional initiation to elongation involves an exchange of the multiprotein mediator complex for elongator in a reaction coupled to CTD hyperphosphorylation. ..
- Boudonck K, Dolan L, Shaw P. The movement of coiled bodies visualized in living plant cells by the green fluorescent protein. Mol Biol Cell. 1999;10:2297-307 pubmed..Deletion analysis of the U2B" gene construct has shown that the first RNP-80 motif is sufficient for localization to the coiled body. ..
- Morillon A, Karabetsou N, O Sullivan J, Kent N, Proudfoot N, Mellor J. Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. Cell. 2003;115:425-35 pubmed..Overall these studies establish the central role played by Isw1p in the coordination of transcription. ..
- Gottgens B, Broccardo C, Sanchez M, Deveaux S, Murphy G, Gothert J, et al. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol. 2004;24:1870-83 pubmed
- Kistner C, Winzer T, Pitzschke A, Mulder L, Sato S, Kaneko T, et al. Seven Lotus japonicus genes required for transcriptional reprogramming of the root during fungal and bacterial symbiosis. Plant Cell. 2005;17:2217-29 pubmed publisher..By contrast, AM fungus-induced gene repression appeared to be unaffected in mutant backgrounds, which indicates the presence of additional independent signaling pathways...
- Jones M, Fusi L, Higham J, Abdel Hafiz H, Horwitz K, Lam E, et al. Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone. Proc Natl Acad Sci U S A. 2006;103:16272-7 pubmed..Our findings demonstrate how dynamic changes in the SUMO pathway mediated by cAMP signaling determine the endometrial response to progesterone. ..
- Roberts R, Lienhard C, Gaines C, Smith J, Guest J. Genetic and molecular characterization of the guaC-nadC-aroP region of Escherichia coli K-12. J Bacteriol. 1988;170:463-7 pubmed..The guaC locus expressed a product of Mr 37,000 with a clockwise transcriptional polarity, and the GMP reductase activities of guaC+ plasmid-containing strains were amplified 15- to 20-fold. ..
- Whitehouse A, Cooper M, Meredith D. The immediate-early gene product encoded by open reading frame 57 of herpesvirus saimiri modulates gene expression at a posttranscriptional level. J Virol. 1998;72:857-61 pubmed..This suggests that it regulates gene expression through a posttranscriptional mechanism. ..
- Park S, Purdy D, Leach S. Localized reversible frameshift mutation in the flhA gene confers phase variability to flagellin gene expression in Campylobacter coli. J Bacteriol. 2000;182:207-10 pubmed..Mutation-based phase variation in flhA may generate functional diversity in the host and environment. ..
- Kingsnorth C, Eastwood D, Burton K. Cloning and postharvest expression of serine proteinase transcripts in the cultivated mushroom Agaricus bisporus. Fungal Genet Biol. 2001;32:135-44 pubmed..In three of the cloned cDNAs, sequence analysis showed that the poly(A) tail starts at different positions. Expression of Spr1 in Escherichia coli caused restricted colony growth. ..
- Ito K, Jazrawi E, Cosio B, Barnes P, Adcock I. p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex. J Biol Chem. 2001;276:30208-15 pubmed..These data also suggest that pharmacological manipulation of specific histone acetylation status is a potentially useful approach for the treatment of inflammatory diseases. ..
- Mahy N, Perry P, Gilchrist S, Baldock R, Bickmore W. Spatial organization of active and inactive genes and noncoding DNA within chromosome territories. J Cell Biol. 2002;157:579-89 pubmed
- Clarke S, Harris L, Richards R, Foster S. Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus. Infect Immun. 2002;70:6680-7 pubmed..aureus infections were found to contain anti-Ebh antibodies. Localization studies revealed Ebh to be cell envelope associated and is proposed to form a specialized surface structure involved in cellular adhesion...
- Coulthard V, Matsuda S, Heery D. An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220. J Biol Chem. 2003;278:10942-51 pubmed..Finally, we show that the NR binding specificity of full-length TRAP220 can be altered by swapping extended LXM sequences. ..
- Jones R, Britt Compton B, Williams P. The naphthalene catabolic (nag) genes of Ralstonia sp. strain U2 are an operon that is regulated by NagR, a LysR-type transcriptional regulator. J Bacteriol. 2003;185:5847-53 pubmed..However, other mutations in the region increased the effectiveness of salicylate as an inducer. ..
- Nie M, Pang L, Inoue H, Knox A. Transcriptional regulation of cyclooxygenase 2 by bradykinin and interleukin-1beta in human airway smooth muscle cells: involvement of different promoter elements, transcription factors, and histone h4 acetylation. Mol Cell Biol. 2003;23:9233-44 pubmed
- Borodina E, McDonald I, Murrell J. Chloromethane-dependent expression of the cmu gene cluster of Hyphomicrobium chloromethanicum. Appl Environ Microbiol. 2004;70:4177-86 pubmed..chloromethanicum. Mutational and transcriptional analysis data indicated that, in H. chloromethanicum, CH(3)Cl is metabolized via a corrinoid-specific (cmuA) and tetrahydrofolate-dependent (metF, purU, folD) methyltransfer system...
- Rodriguez A, Griffiths Jones S, Ashurst J, Bradley A. Identification of mammalian microRNA host genes and transcription units. Genome Res. 2004;14:1902-10 pubmed
- Gupta M, Trott D, Porter A. Rescue of a human cell line from endogenous Cdk1 depletion by Cdk1 lacking inhibitory phosphorylation sites. J Biol Chem. 2007;282:4301-9 pubmed..They also indicate that inhibitory phosphorylation is indispensable for only a fraction of the total cellular complement of Cdk1. ..
- Spencer M, Casson S, Lindsey K. Transcriptional profiling of the Arabidopsis embryo. Plant Physiol. 2007;143:924-40 pubmed..We show how identified genes can be used to generate cell type-specific markers and promoter activities for future application in cell biology. ..
- Koch C, Andrews R, Flicek P, Dillon S, Karaoz U, Clelland G, et al. The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res. 2007;17:691-707 pubmed..These results provide an overview of the functional relationship among histone modifications and gene expression in human cells. ..
- Gallagher D, Gutierrez H, Gavalda N, O Keeffe G, Hay R, Davies A. Nuclear factor-kappaB activation via tyrosine phosphorylation of inhibitor kappaB-alpha is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons. J Neurosci. 2007;27:9664-9 pubmed..These findings demonstrate that NF-kappaB signaling by an unusual activation mechanism is essential for the ability of CNTF to promote the growth of neural processes in the developing nervous system. ..
- McStay B, Grummt I. The epigenetics of rRNA genes: from molecular to chromosome biology. Annu Rev Cell Dev Biol. 2008;24:131-57 pubmed publisher..We also review the critical role of the RNA polymerase I transcription factor UBF in the formation of active nucleolar organizer regions (NORs) and maintenance of the euchromatic state of rRNA genes...
- Scibetta A, Santangelo S, Coleman J, Hall D, Chaplin T, Copier J, et al. Functional analysis of the transcription repressor PLU-1/JARID1B. Mol Cell Biol. 2007;27:7220-35 pubmed..As expected from the microarray data, cells overexpressing PLU-1/JARID1B have an impaired G(2)/M checkpoint. Our study provides insight into the molecular function of the breast cancer-associated transcriptional repressor PLU-1/JARID1B...
- Gadhavi P, Greenwood M, Strom M, King I, Buxton R. The regulatory region of the human desmocollin 3 promoter forms a DNA four-way junction. Biochem Biophys Res Commun. 2001;281:520-8 pubmed
- Daniels J, Schultz G, Blalock T, Garrett Q, Grotendorst G, Dean N, et al. Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring. Am J Pathol. 2003;163:2043-52 pubmed..Inhibition of CTGF activity or gene transcription could be a suitable target for anti-scarring therapies. ..
- Welsh G, Miyamoto S, Price N, Safer B, Proud C. T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. J Biol Chem. 1996;271:11410-3 pubmed..Since phosphorylation of eIF2B by GSK-3 appears to inhibit nucleotide exchange in vitro, this provides a potential mechanism by which eIF2B may be activated. ..
- Hernando Y, Carter A, Parr A, Hove Jensen B, Schweizer M. Genetic analysis and enzyme activity suggest the existence of more than one minimal functional unit capable of synthesizing phosphoribosyl pyrophosphate in Saccharomyces cerevisiae. J Biol Chem. 1999;274:12480-7 pubmed..These data suggest that yeast phosphoribosyl pyrophosphate synthetase exists in vivo as multimeric complex(es). ..
- Navarro L, Zipfel C, Rowland O, Keller I, Robatzek S, Boller T, et al. The transcriptional innate immune response to flg22. Interplay and overlap with Avr gene-dependent defense responses and bacterial pathogenesis. Plant Physiol. 2004;135:1113-28 pubmed publisher..We also compared FLARE gene sets and genes induced in basal or gene-for-gene interactions upon different Pseudomonas syringae treatments, and infer that Pseudomonas syringae pv tomato represses the flagellin-initiated defense response...
- Sanson B, Alexandre C, Fascetti N, Vincent J. Engrailed and hedgehog make the range of Wingless asymmetric in Drosophila embryos. Cell. 1999;98:207-16 pubmed..We demonstrate the role of hedgehog in the formation of this barrier. ..
- Carter A, Sachchithananthan M, Stasinopoulos S, Maurer F, Medcalf R. Prothrombin G20210A is a bifunctional gene polymorphism. Thromb Haemost. 2002;87:846-53 pubmed..Our results indicate that the G20210A is a bifunctional polymorphism, as it not only alters the efficiency of mRNA processing, but also the decay rate of prothrombin mRNA. ..
- Gilbert C, Kristjuhan A, Winkler G, Svejstrup J. Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation. Mol Cell. 2004;14:457-64 pubmed..These results strongly support a role for Elongator in transcript elongation. ..
- Thompson S, Croft N, Sotiriou A, Piggins H, Crosthwaite S. Neurospora crassa heat shock factor 1 Is an essential gene; a second heat shock factor-like gene, hsf2, is required for asexual spore formation. Eukaryot Cell. 2008;7:1573-81 pubmed publisher..Altered expression profiles of hsp90 and a putative hsp90-associated protein in the hsf2(KO) strain after exposure to heat shock may in part account for its reduced ability to cope with heat stress...
- Cabart P, Murphy S. BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein. J Biol Chem. 2001;276:43056-64 pubmed..Therefore, the polymerase recruitment is not simply determined by the sequence of the TATA-box and immediate flanking sequences. ..
- Barley N, Howard A, O CALLAGHAN D, Legon S, Walters J. Epithelial calcium transporter expression in human duodenum. Am J Physiol Gastrointest Liver Physiol. 2001;280:G285-90 pubmed..This may account for some of the unexplained variability in calcium absorption...
- Wickremasinghe M, Thomas L, O Kane C, Uddin J, Friedland J. Transcriptional mechanisms regulating alveolar epithelial cell-specific CCL5 secretion in pulmonary tuberculosis. J Biol Chem. 2004;279:27199-210 pubmed..IL-1beta is the critical regulator of tuberculosis-stimulated CCL5 secretion in the lung. ..
- Morton N, Emilsson V, Liu Y, Cawthorne M. Leptin action in intestinal cells. J Biol Chem. 1998;273:26194-201 pubmed..Lack of leptin or resistance to leptin action in this site may contribute to obesity and its related syndromes by directly affecting lipid handling. ..
- Morton N, Holmes M, Fievet C, Staels B, Tailleux A, Mullins J, et al. Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. J Biol Chem. 2001;276:41293-300 pubmed..Further, 11beta-HSD-1(-/-) mice have improved glucose tolerance. These data suggest that 11beta-HSD-1 deficiency produces an improved lipid profile, hepatic insulin sensitization, and a potentially atheroprotective phenotype. ..
- Géranton S, Morenilla Palao C, Hunt S. A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. J Neurosci. 2007;27:6163-73 pubmed..Our results uncover an unexpected complexity in the regulation of gene expression, including the modulation of transcriptional repression, that accompanies development and maintenance of an inflammatory pain state. ..
- Kirton J, Crofts N, George S, Brennan K, Canfield A. Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?. Circ Res. 2007;101:581-9 pubmed..This effect was negated by transduction of pericytes with RAd/dnTCF. Together, these results demonstrate that Wnt/beta-catenin signaling inhibits adipogenic and enhances chondrogenic differentiation of pericytes. ..
- Dornan A, Gailey D, Goodwin S. GAL4 enhancer trap targeting of the Drosophila sex determination gene fruitless. Genesis. 2005;42:236-46 pubmed..These novel fru alleles provide the tools for manipulation of fru-expressing cells, allowing the consequent effects to be related back to specific fru functions and the regulatory units controlling these activities. ..
- Greenall A, Williams E, Martin K, Palmer J, Gray J, Liu C, et al. Hip3 interacts with the HIRA proteins Hip1 and Slm9 and is required for transcriptional silencing and accurate chromosome segregation. J Biol Chem. 2006;281:8732-9 pubmed..Importantly, the function of Hip1, Slm9, and Hip3 is not restricted to constitutive heterochromatic loci, since these proteins also repress the expression of a number of genes, including the Tf2 retrotransposons. ..
- Leverentz M, Campbell R, Connolly Y, Whetton A, Reece R. Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner. J Biol Chem. 2009;284:24115-22 pubmed publisher..Combined, our findings suggest that this may represent a mechanism through which yeast cells rapidly adapt to use proline as a nitrogen source under nitrogen limiting conditions. ..
- Feldman B, Concha M, Saude L, Parsons M, Adams R, Wilson S, et al. Lefty antagonism of Squint is essential for normal gastrulation. Curr Biol. 2002;12:2129-35 pubmed..Furthermore, we find that Cyclops is specifically required for the maintenance of lefty1 and lefty2 transcription. ..
- Mead J, Hughes T, Irvine S, Singh N, Ramji D. Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription. J Biol Chem. 2003;278:17741-51 pubmed
- Delpuech O, Griffiths B, East P, Essafi A, Lam E, Burgering B, et al. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol. 2007;27:4917-30 pubmed..Our results provide evidence of direct regulation of Mxi1 by FOXO3a and imply an additional mechanism through which the PI3-kinase/Akt/FOXO pathway can modulate Myc function. ..
- Jackson K, Helston R, McKay J, O Neill E, Mathers J, Ford D. Splice variants of the human zinc transporter ZnT5 (SLC30A5) are differentially localized and regulated by zinc through transcription and mRNA stability. J Biol Chem. 2007;282:10423-31 pubmed..To our knowledge, this is the first report that zinc affects the stability of a transcript with a direct role in cellular zinc homeostasis. ..
- Membrillo Hernandez J, Coopamah M, Anjum M, Stevanin T, Kelly A, Hughes M, et al. The flavohemoglobin of Escherichia coli confers resistance to a nitrosating agent, a "Nitric oxide Releaser," and paraquat and is essential for transcriptional responses to oxidative stress. J Biol Chem. 1999;274:748-54 pubmed..This protective role probably involves direct detoxification of those species and sensing of NO-related and oxidative stress. ..
- Yang S, Vickers E, Brehm A, Kouzarides T, Sharrocks A. Temporal recruitment of the mSin3A-histone deacetylase corepressor complex to the ETS domain transcription factor Elk-1. Mol Cell Biol. 2001;21:2802-14 pubmed..Elk-1 therefore undergoes temporal activator-repressor switching and contributes to both the activation and repression of target genes following growth factor stimulation. ..
- Silverdale M, McGuire S, McInnes A, Crossman A, Brotchie J. Striatal cannabinoid CB1 receptor mRNA expression is decreased in the reserpine-treated rat model of Parkinson's disease. Exp Neurol. 2001;169:400-6 pubmed..The data support the idea that cannabinoid receptor antagonists may provide a useful treatment for the symptoms of Parkinson's disease. ..
- Xie S, Martin S, Guillot P, Bentley D, Pombo A. Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C-terminal domain. Mol Biol Cell. 2006;17:1723-33 pubmed..We find that paraspeckles are transcriptionally inactive but contain polymerase II, which remains stably associated upon transcriptional inhibition, when paraspeckles reorganize around nucleoli in the form of caps...
- Sutcliffe J, Cairns C, McLees A, Allison S, Tosh K, White R. RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130. Mol Cell Biol. 1999;19:4255-61 pubmed..Pol III activity is also deregulated in fibroblasts derived from p107 p130 double knockout mice. We conclude that TFIIIB is targeted for repression not only by RB but also by its relatives p107 and p130. ..
- Sherriff J, Kent N, Mellor J. The Isw2 chromatin-remodeling ATPase cooperates with the Fkh2 transcription factor to repress transcription of the B-type cyclin gene CLB2. Mol Cell Biol. 2007;27:2848-60 pubmed..We propose that chromatin-mediated repression by Isw1 and Isw2 may serve to limit activation of CLB2 expression by the Clb2/Cdk1 kinase during G(2)/M and to fully repress expression during G(1). ..
- Ellis J, Luzio J. Identification and characterization of a novel protein (p137) which transcytoses bidirectionally in Caco-2 cells. J Biol Chem. 1995;270:20717-23 pubmed
- Wicks S, Lui S, Abdel Wahab N, Mason R, Chantry A. Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol Cell Biol. 2000;20:8103-11 pubmed..These findings provide a novel cross-talk mechanism by which Ca(2+)-dependent kinases activated downstream of multiple growth factor receptors antagonize cell responses to TGF-beta. ..
- Pragai Z, Eschevins C, Bron S, Harwood C. Bacillus subtilis NhaC, an Na+/H+ antiporter, influences expression of the phoPR operon and production of alkaline phosphatases. J Bacteriol. 2001;183:2505-15 pubmed..This suggests that NhaC effects APase production via phoPR. ..
- Bonifer C, Hume D. The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 2008;13:549-60 pubmed..Aside from the direct relevance to hematopoiesis, studies of csf1r transcriptional regulation provide a model for understanding the molecular mechanisms that control mammalian cell fate. ..
- Sanna B, Kramer D, Genazzani A. The expression of the PDZ protein MALS-1/velis is regulated by calcium and calcineurin in cerebellar granule cells. J Biol Chem. 2002;277:49585-90 pubmed..These data suggest that Ca(2+) entry by means of calcineurin is capable of controlling the structure of the post-synaptic density by controlling the expression of key components at the transcriptional level. ..
- Rigas A, Ozanne D, Neal D, Robson C. The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway. J Biol Chem. 2003;278:46087-93 pubmed..Our data suggest that RACK1 may function as a scaffold for the association and modification of AR by PKC enabling translocation of AR to the nucleus but rendering AR unable to activate transcription of its target genes. ..
- Schulze A, Nicke B, Warne P, Tomlinson S, Downward J. The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Mol Biol Cell. 2004;15:3450-63 pubmed..The use of transcriptional profiling in this way allows detailed analysis of the architecture of signaling pathways to be undertaken. ..
- Sharp T, Munoz F, Bourboulia D, Presneau N, Darai E, Wang H, et al. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. Proc Natl Acad Sci U S A. 2004;101:16531-6 pubmed..Our data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis. ..
- Green C, Thompson P, Johnston P, El Tanani M. Interaction between transcription factor, basal transcription factor 3, and the NH2-terminal domain of human estrogen receptor alpha. Mol Cancer Res. 2007;5:1191-200 pubmed..The effects of BTF3 on the reporter genes requires the presence of ERalpha containing an active AF-1 function. BTF3 may be a component of the mechanism by which the AF-1 function of ERalpha stimulates gene transcription. ..
- Stapleton G, Steel M, Richardson M, Mason J, Rose K, Morris R, et al. A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995;270:29739-45 pubmed
- Chen D, Davies M, Rudland P, Barraclough R. Transcriptional down-regulation of the metastasis-inducing S100A4 (p9Ka) in benign but not in malignant rat mammary epithelial cells by GC-factor. J Biol Chem. 1997;272:20283-90 pubmed..The results suggest a novel mechanism for regulating the expression of the mRNA encoding an S100 protein. ..
- Peters J, Wroe S, Wells C, Miller H, Bodle D, Beechey C, et al. A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2. Proc Natl Acad Sci U S A. 1999;96:3830-5 pubmed..This demonstrates an imprinting mechanism in which two oppositely imprinted genes share the same downstream exons. ..
- Babik J, Adams E, Tone Y, Fairchild P, Tone M, Waldmann H. Expression of murine IL-12 is regulated by translational control of the p35 subunit. J Immunol. 1999;162:4069-78 pubmed..Furthermore, p35 mRNA levels were substantially up-regulated after LPS stimulation in both cell types. Thus, our results show that p35 gene expression is highly regulated by both transcriptional and translational mechanisms. ..
- Pratt T, Conway C, Tian N, Price D, Mason J. Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm. J Neurosci. 2006;26:6911-23 pubmed
- El Hage A, French S, Beyer A, Tollervey D. Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis. Genes Dev. 2010;24:1546-58 pubmed publisher..We conclude that the loss of Top1 enhances inherent R-loop formation, particularly over the 5' region of the rDNA, imposing persistent transcription blocks when RNase H is limiting. ..
- Jones A, Logan R, Foynes S, Cockayne A, Wren B, Penn C. A flagellar sheath protein of Helicobacter pylori is identical to HpaA, a putative N-acetylneuraminyllactose-binding hemagglutinin, but is not an adhesin for AGS cells. J Bacteriol. 1997;179:5643-7 pubmed..J. Trust, J. Bacteriol. 177:6049-6057, 1995) locale. Agglutination of erythrocytes and adherence to AGS cells by a delta hpaA mutant were no different from those of the parent strain, confirming a recent finding of O'Toole et al...
- Davies S, Golby P, Omrani D, Broad S, Harrington V, Guest J, et al. Inactivation and regulation of the aerobic C(4)-dicarboxylate transport (dctA) gene of Escherichia coli. J Bacteriol. 1999;181:5624-35 pubmed..Reverse transcriptase-mediated primer extension indicated a single transcriptional start site centered 81 bp downstream of a strongly predicted CRP-binding site. ..
- Alao J, Lam E, Ali S, Buluwela L, Bordogna W, Lockey P, et al. Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. Clin Cancer Res. 2004;10:8094-104 pubmed..Taken together, our data show that TSA effectively induces cyclin D1 down-regulation through both ERalpha-dependent and ERalpha-independent mechanisms, providing an important new strategy for combating resistance to antiestrogens. ..
- Madureira P, Varshochi R, Constantinidou D, Francis R, Coombes R, Yao K, et al. The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells. J Biol Chem. 2006;281:25167-76 pubmed..Together with the chromatin immunoprecipitation and biotinylated oligonucleotide pulldown data, the co-immunoprecipitation results also suggest the possibility that FoxM1 and FoxO3a cooperate to regulate ERalpha gene transcription. ..
- Nichol D, Christian M, Steel J, White R, Parker M. RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis. J Biol Chem. 2006;281:32140-7 pubmed..Thus, the up-regulation of RIP140 by ERRalpha during adipogenesis may provide an inhibitory feedback mechanism to control the expression of many nuclear receptor target genes. ..
- Kelly G, Milner A, Baldwin G, Bell A, Rickinson A. Three restricted forms of Epstein-Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 2006;103:14935-40 pubmed
- Grohmann D, Klose D, Klare J, Kay C, Steinhoff H, Werner F. RNA-binding to archaeal RNA polymerase subunits F/E: a DEER and FRET study. J Am Chem Soc. 2010;132:5954-5 pubmed publisher..Our results demonstrate that, upon binding of RNA, F/E remains in a stable conformation, which suggests that it serves as a structurally rigid guiding rail for the growing RNA chain during transcription. ..
- Zoidl G, Blanchard A, Zoidl C, Dong Z, Brennan A, Parmantier E, et al. Identification of transcriptionally regulated mRNAs from mouse Schwann cell precursors using modified RNA fingerprinting methods. J Neurosci Res. 1997;49:32-42 pubmed
- Stover C, Thiel S, Thelen M, Lynch N, Vorup Jensen T, Jensenius J, et al. Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. J Immunol. 1999;162:3481-90 pubmed
- Belandia B, Parker M. Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors. J Biol Chem. 2000;275:30801-5 pubmed..These results suggest that the p160 proteins could be bona fide coactivators of the TEF family of transcription factors. ..
- O Reilly D, Quinn C, El Shanawany T, Gordon S, Greaves D. Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner. J Biol Chem. 2003;278:21909-19 pubmed..We propose that expression of CD68 in myeloid cells requires the Ets transcription factors Elf-1 and PU.1 and CD68 expression is down-regulated in lymphoid cells by combinatorial interactions between PU.1 and IRF-4. ..
- Sunters A, Fernandez De Mattos S, Stahl M, Brosens J, Zoumpoulidou G, Saunders C, et al. FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem. 2003;278:49795-805 pubmed..This is the first demonstration that up-regulation of FoxO3a by paclitaxel can result in increased levels of Bim mRNA and protein, which can be a direct cause of apoptosis in breast cancer cells. ..