Experts and Doctors on genetic predisposition to disease in China

Summary

Locale: China
Topic: genetic predisposition to disease

Top Publications

  1. Li L, Kang X, Ran X, Wang Y, Wang C, Huang L, et al. Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol. 2007;34:1287-90 pubmed
    ..05). 4. Adiponectin SNP 45 is positively correlated with the prevalence of T2DM in Uygurs of Xinjiang. The G allele carriers who have reduced plasma concentrations of adiponectin may have associated insulin resistance. ..
  2. Zhang Y, Yang L, Shao H, Li K, Sun C, Shi L. ABCB1 polymorphisms may have a minor effect on ciclosporin blood concentrations in myasthenia gravis patients. Br J Clin Pharmacol. 2008;66:240-6 pubmed publisher
    ..007). ABCB1 polymorphisms in both genotype and haplotype may have a minor effect on the CsA blood concentrations. ..
  3. Lu P, Tang Y, Li C, Shen W, Ji L, Guo Y, et al. [Meta-analysis of association of tumor necrosis factor alpha-308 gene promoter polymorphism with gastric cancer]. Zhonghua Yu Fang Yi Xue Za Zhi. 2010;44:209-14 pubmed
    ..90 (95%CI: 0.79 - 1.02, P = 0.10) and 1.08 (95%CI: 0.62 - 1.88, P = 0.79). TNF-alpha-308 A allele and AA genotype were associated with a statistically significant increased risk of gastric cancer in western people. ..
  4. Song W, Chen Y, Huang R, Chen K, Pan P, Li J, et al. Analysis of the genotype of diacylglycerol kinase delta single-nucleotide polymorphisms in Parkinson disease in the Han Chinese population. Neurol India. 2012;60:82-5 pubmed publisher
    ..The present study is the first to report on the lack of association of DGKD SNPs with PD in the Han Chinese population. More related studies involving larger numbers of participants are necessary to confirm the present finding. ..
  5. Chen X, Xue A, Chen W, Ding Y, Yan D, Peng J, et al. Assessment of exonic single nucleotide polymorphisms in the adenosine A2A receptor gene to high myopia susceptibility in Chinese subjects. Mol Vis. 2011;17:486-91 pubmed
    ..The reduced frequency of the heterozygote rs5751876 genotype in subjects suggests a possible association of A(2A)R with high myopia in a Chinese population. ..
  6. Yang Y, Guo S, Yang Z, Zhang T, Cao H, Wang R. [Association between 1019C/T polymorphism of Connexin 37 gene and restenosis after coronary stenting]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013;30:456-60 pubmed publisher
    ..655). The C allele of 1019C/T polymorphism in the CX37 gene is associated with susceptibility to CAD as well as restenosis after coronary stenting in male patients from Wuxi. ..
  7. Wang B, Li G, Sun F, Dong N, Sun Z, Jiang D. Association Between WRN Cys1367Arg (T>C) and Cancer Risk: A Meta-analysis. Technol Cancer Res Treat. 2016;15:20-7 pubmed publisher
    ..Our study suggests that WRN Cys1367Arg (T>C) polymorphism is not associated with overall cancer risk, although subgroup analyses suggested an association with breast cancer and overall cancer specifically in European populations. ..
  8. Song Y, Li B, Wang C, Wang P, Gao X, Liu G. Association between 5,10-Methylenetetrahydrofolate Reductase C677T Gene Polymorphism and Risk of Ischemic Stroke: A Meta-analysis. J Stroke Cerebrovasc Dis. 2016;25:679-87 pubmed publisher
    ..29, 95% CI: 1.18-1.42). The meta-analysis suggests that MTHFR C677T genetic polymorphism is significantly associated with susceptibility to IS, which provides evidence supporting hyperhomocysteinemia as a risk factor for stroke. ..
  9. Tian D, Wei W, Dong Y. Influence of COL1A2 gene variants on the incidence of hypertensive intracerebral hemorrhage in a Chinese population. Genet Mol Res. 2016;15: pubmed publisher
    ..In conclusion, our study suggests that the COL1A2 rs42524 polymorphism is associated with the development of hypertensive intracerebral hemorrhage, particularly in conjunction with tobacco use and alcohol consumption. ..

More Information

Publications370 found, 100 shown here

  1. Liu D, Liu Q, Guan L, Jiang X, Zhou D, Beghetti M, et al. BMPR2 mutation is a potential predisposing genetic risk factor for congenital heart disease associated pulmonary vascular disease. Int J Cardiol. 2016;211:132-6 pubmed publisher
    ..Genetic predisposing factor may be an important component in the process of development of PVD in CHD patients. Female, repaired patients are more likely to be detected with genetic mutations. ..
  2. Liu S, Xiong Y, Li T, Li Y, Gu S, Wang Y, et al. Interleukin-17A and -17F Gene Polymorphisms in Chinese Population with Chronic Immune Thrombocytopenia. Ann Clin Lab Sci. 2016;46:291-7 pubmed
    ..33, 95% CI 1.11-4.89; AG: OR=2.03, 95% CI 1.14-3.61). Our results suggest that SNPs in IL-17F A7488G but not IL-17A are associated with the development of chronic ITP in China. ..
  3. Wang Z, Liu P, Liu X, Manfredsson F, Sandoval I, Yu S, et al. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Mol Cell. 2017;67:812-825.e5 pubmed publisher
    ..Our findings support that delta-secretase phosphorylation by SRPK2 plays a critical role in aggravating AD pathogenesis. ..
  4. Wang A, Sun C, Li L, Huang J, Chen Q, Xu D. Genetic susceptibility and environmental factors of esophageal cancer in Xi'an. World J Gastroenterol. 2004;10:940-4 pubmed
    ..CYP1A1 Val/Val and GSTM1 deletion genotypes are genetic susceptibility biomarkers for EC. There are synergic interactions between genetic susceptibility and environmental factors. ..
  5. Fei B, Xia B, Deng C, Xia X, Xie M, Crusius J, et al. Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population. World J Gastroenterol. 2004;10:1256-61 pubmed
    ..TNF-beta Ncol*1/2 and d2/d6 genotypes are associated with the susceptibility to gastric adenocarcinoma, whereas TNFa6b5c1 haplotype homozygote may contribute to the resistance against gastric adenocarcinoma. ..
  6. Leung K, Yip S, Wong W, Yiu L, Chan K, Lai W, et al. Sex- and age-dependent association of SLC11A1 polymorphisms with tuberculosis in Chinese: a case control study. BMC Infect Dis. 2007;7:19 pubmed
    ..This study confirmed the association between SLC11A1 and TB susceptibility and demonstrated for the first time that the association was restricted to females and the young age group. ..
  7. Shao J, Gu M, Xu Z, Hu Q, Qian L. Polymorphisms of the DNA gene XPD and risk of bladder cancer in a Southeastern Chinese population. Cancer Genet Cytogenet. 2007;177:30-6 pubmed
    ..These two XPD polymorphisms may play an important role in the etiology of bladder cancer in the southeastern Chinese population. ..
  8. Xu H, Cheng J, Andreotti G, Gao Y, Rashid A, Wang B, et al. Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. Carcinogenesis. 2011;32:58-62 pubmed publisher
    ..Our findings suggest that ABCG8 rs11887534, identified as a gallstone risk single-nucleotide polymorphism by whole genome scan, is also associated with an increased risk of biliary tract cancer...
  9. Chen H, Zheng Z, Yuan B, Liu Z, Jing J, Wang S. The effect of galectin-3 genetic variants on the susceptibility and prognosis of gliomas in a Chinese population. Neurosci Lett. 2012;518:1-4 pubmed publisher
    ..The results of this study suggest the SNPs at +292 A>C, not SNPs at +191 A>C, of galectin-3 gene were associated with the tumor grade and prognosis of gliomas. ..
  10. Bao L, Niu J, Song H, Wang Y, Ma R, Ren X, et al. Association between the GSTP1 codon 105 polymorphism and gastric cancer risk: an updated meta-analysis. Asian Pac J Cancer Prev. 2012;13:3687-93 pubmed
    ..Since potential confounders could not be ruled out completely, further studies are needed to confirm these results. ..
  11. Li S, Li W, Wang J, Zhang H, Li W, Zhang P, et al. Association of the genes for tumor necrosis factor-? and myelin basic protein with delayed encephalopathy after acute carbon monoxide poisoning. Genet Mol Res. 2012;11:4479-86 pubmed publisher
    ..DEACMP may be the result of interaction of environmental and genetic factors...
  12. Li X, Li X, Hu F, Shen H, Cao J, Li Z, et al. Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population. J Occup Health. 2013;55:56-65 pubmed
    ..36, 95% CI, 1.07-1.71) and rs7786401 GT + TT genotype (OR=1.33, 95% CI, 1.05-1.68) were risk factors for NIHL. PON2 gene polymorphisms may be associated with susceptibility to NIHL in the Chinese population ..
  13. Jiang H, Hu Y, Shang L, Li Y, Yang L, Chen Y. Association between MUC5B polymorphism and susceptibility and severity of idiopathic pulmonary fibrosis. Int J Clin Exp Pathol. 2015;8:14953-8 pubmed
    ..0294). This study demonstrated that the MUC5B polymorphism rs35705950 is associated with increased risk of idiopathic pulmonary fibrosis susceptibility, severity, and the decreased overall survival. ..
  14. Dang R, Guo Y, Cai H, Yang R, Liang D, Lv C, et al. Effects of prolonged antipsychotic administration on neuregulin-1/ErbB signaling in rat prefrontal cortex and myocardium: implications for the therapeutic action and cardiac adverse effect. J Toxicol Sci. 2016;41:303-9 pubmed publisher
  15. Mak J, Leung H, Ho S, Law B, Ho A, Lam W, et al. Analysis of TGF-beta(1) gene polymorphisms in Hong Kong Chinese patients with asthma. J Allergy Clin Immunol. 2006;117:92-6 pubmed
  16. Hu Z, Xu L, Shao M, Yuan J, Wang Y, Wang F, et al. Polymorphisms in the two helicases ERCC2/XPD and ERCC3/XPB of the transcription factor IIH complex and risk of lung cancer: a case-control analysis in a Chinese population. Cancer Epidemiol Biomarkers Prev. 2006;15:1336-40 pubmed
  17. Jia H, Wang B, Yu L, Jiang Z. Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis. J Renin Angiotensin Aldosterone Syst. 2013;14:255-62 pubmed publisher
    ..However, considering that the conclusions were based on a relatively small sample size, larger studies involving various ethnic populations should be warranted in future studies to validate our findings. ..
  18. Ma Y, Yuan B, Yi J, Zhuang R, Wang J, Zhang Y, et al. The genetic polymorphisms of HLA are strongly correlated with the disease severity after Hantaan virus infection in the Chinese Han population. Clin Dev Immunol. 2012;2012:308237 pubmed publisher
  19. Wei B, Zhou Y, Xu Z, Ruan J, Cheng H, Zhu M, et al. GSTP1 Ile105Val polymorphism and prostate cancer risk: evidence from a meta-analysis. PLoS ONE. 2013;8:e71640 pubmed publisher
    ..This meta-analysis showed that GSTP1 Ile105Val polymorphism might not be significantly associated with overall prostate cancer risk. Further stratified analyses showed a significant association with low-stage prostate cancer. ..
  20. Wang J, Li H, Wang J, Gao X. Association between ERAP1 gene polymorphisms and ankylosing spondylitis susceptibility in Han population. Int J Clin Exp Pathol. 2015;8:11641-6 pubmed
    ..005), which indicated that A-C might be the susceptible haplotype to AS. ERAP1 gene rs27434 and rs7711564 polymorphisms may increase the risk of AS. ..
  21. Wan X, Li X, Yang J, Lv W, Wang Q, Chen Y, et al. Genetic association between PIK3CA gene and oral squamous cell carcinoma: a case control study conducted in Chongqing, China. Int J Clin Exp Pathol. 2015;8:13360-6 pubmed
    ..The expression of PIK3CA was increased in OSCC tumors; however, none of the nine tested SNPs of PIK3CA was associated with susceptibility to OSCC in the studied population. ..
  22. Meng L, Gu Y, Du X, Shao M, Zhang L, Zhang G, et al. Two novel ATP2C1 mutations in patients with Hailey-Hailey disease and a literature review of sequence variants reported in the Chinese population. Genet Mol Res. 2015;14:19349-59 pubmed publisher
    ..It is of note that some reported "novel" mutations were in fact found to be recurrent. Our findings expand the range of known ATP2C1 sequence variants in this disease. ..
  23. Cai F, Cui N, Ma H, Wang X, Qiao G, Liu D. Interleukin-10 -1082A/G polymorphism is associated with the development of acute pancreatitis in a Chinese population. Int J Clin Exp Pathol. 2015;8:15170-6 pubmed
    ..In conclusion, we suggest that IL-10-1082A/G gene polymorphisms contribute to the development of acute pancreatitis in codominant, dominant and recessive models. ..
  24. Ma S, Tang N, Lam L. Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population. J Psychiatr Res. 2016;76:143-7 pubmed publisher
    ..Our study further suggested the role of methylation in gene regulation and the role in AD. ..
  25. Han C, Huang X, Hua R, Song S, Lyu L, Ta N, et al. The association between XPG polymorphisms and cancer susceptibility: Evidence from observational studies. Medicine (Baltimore). 2017;96:e7467 pubmed publisher
    ..Large studies are needed to validate our findings, especially in Caucasian and African population. ..
  26. Bian L, Yang J, Guo T, Sun Y, Duan S, Chen W, et al. Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese. Neurology. 2004;63:241-5 pubmed
    ..These results suggest a possible synergic interaction between IDE and APOE epsilon4 in the risk to develop late-onset sporadic AD. IDE might modify the effect of the APOE epsilon4 risk factor in the Han Chinese population. ..
  27. Ip W, Chan K, Law H, Tso G, Kong E, Wong W, et al. Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. J Infect Dis. 2005;191:1697-704 pubmed
    ..These results suggest that MBL contributes to the first-line host defense against SARS-CoV and that MBL deficiency is a susceptibility factor for acquisition of SARS. ..
  28. Zhang H, Zhong B, Zhu W, Xie S, Qiu L, Zhu L, et al. CD14 C-260T gene polymorphism and ischemic heart disease susceptibility: a HuGE review and meta-analysis. Genet Med. 2009;11:403-8 pubmed publisher
    ..Further studies are warranted to assess these associations in greater details, especially in East Asian and Indian populations. ..
  29. Zheng J, Jiang L, Zhang L, Yang L, Deng J, You Y, et al. Functional genetic variations in the IL-23 receptor gene are associated with risk of breast, lung and nasopharyngeal cancer in Chinese populations. Carcinogenesis. 2012;33:2409-16 pubmed publisher
    ..Our findings indicate that the IL-23R rs10889677A>C polymorphism may influence T-cell proliferation, resulting in changes in the levels of Tregs in vivo and modifying cancer susceptibility. ..
  30. Wang S, Ma F, Zhao J. Expressions of nuclear factor-kappa B p50 and p65 and their significance in the up-regulation of intercellular cell adhesion molecule-1 mRNA in the nasal mucosa of allergic rhinitis patients. Eur Arch Otorhinolaryngol. 2013;270:1329-34 pubmed publisher
    ..8995, P < 0.01; r = 0.7601, P < 0.01). In conclusion, NF-?B plays a key role in AR. Excessively activated NF-?B promotes the transcription of ICAM-1 mRNA. ICAM-1 is related to the pathogenesis and development of AR...
  31. Liu J, Zhang H. A comprehensive study indicates PRSS1 gene is significantly associated with pancreatitis. Int J Med Sci. 2013;10:981-7 pubmed publisher
    ..In conclusion, PRSS1 gene was significantly associated with total pancreatitis disease, both totally and separately. ..
  32. Wu Y, Liu X, Hu L, Tao H, Guan X, Zhang K, et al. Copy number loss of variation_91720 in PIK3CA predicts risk of esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2015;8:14479-85 pubmed
    ..0003) and increased with the copy number gain of Variation_91720. Our findings suggest that copy number loss of Variation_91720 in PIK3CA predicts risk of ESCC, which might serve as a biomarker that for early diagnosis of ESCC. ..
  33. Chen S, Wang Z, Zhang L, Lu G, Zhou C, Wang D, et al. CAMK4 gene variation is associated with hypertension in a Uygur population. Genet Mol Res. 2016;15: pubmed publisher
    ..200; 95% confidence interval = 1.473-3.285, P < 0.001). However, no significant correlation was found in the Han and Kazak groups. The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group. ..
  34. Qian J, Song Z, Lv Y, Huang X, Mao B. Glutathione S-Transferase T1 Null Genotype is Associated with Susceptibility to Inflammatory Bowel Disease. Cell Physiol Biochem. 2017;41:2545-2552 pubmed publisher
    ..023) after adjusting for study heterogeneity. The GSTT1 null genotype is significantly associated with an increased susceptibility to inflammatory bowel disease and is a risk factor for both ulcerative colitis and Crohn's disease. ..
  35. He X, Su J, Zhang Y, Huang X, Liu Y, Ding D, et al. Association between the p53 polymorphisms and breast cancer risk: meta-analysis based on case-control study. Breast Cancer Res Treat. 2011;130:517-29 pubmed publisher
  36. Zhang Y, Wang B, Wan H, Zhou Q, Li T. Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease. Neurosci Lett. 2013;541:132-7 pubmed publisher
    ..However, larger scale association studies are necessary to further validate the association of IDE polymorphisms with sporadic AD risk and to define potential gene-gene interactions. ..
  37. Tang N, Yeung H, Hung V, Di Liao C, Lam T, Yeung H, et al. Genetic epidemiology and heritability of AIS: A study of 415 Chinese female patients. J Orthop Res. 2012;30:1464-9 pubmed publisher
    ..Here we provided a large-scale study for the genetic aggregation estimates in an Asian population for the first time. The finding also positioned AIS among other common disease or complex traits with a high heritability. ..
  38. Zhou F, Zhu H, Luo D, Wang M, Dong X, Hong Y, et al. A functional polymorphism in Pre-miR-146a is associated with susceptibility to gastric cancer in a Chinese population. DNA Cell Biol. 2012;31:1290-5 pubmed publisher
    ..51, 95% CI = 1.25-1.81) rather than in older subjects. Our results suggest that the rs2910164 polymorphism in the sequence of miR-146a precursor may influence the susceptibility to gastric cancer in our Chinese population. ..
  39. Jin C, Zhang F, Zhu J, Yuan J, Xia M, Xu Q, et al. Association of CYP46 gene polymorphism with sporadic Alzheimer's disease in Chinese Han populations: a meta-analysis. Int J Neurosci. 2013;123:226-32 pubmed publisher
    ..05 for each model). In conclusion, despite several limitations, this meta-analysis indicates that the CYP46 gene SNP rs754203 is not significantly associated with SAD susceptibility in Chinese Han populations. ..
  40. Wen J, Song C, Liu J, Chen J, Zhai X, Hu Z. Expression quantitative trait loci for TNFRSF10 influence both HBV infection and hepatocellular carcinoma development. J Med Virol. 2016;88:474-80 pubmed publisher
    ..These findings suggest that eQTL SNPs for TNFRSF10 may be susceptibility markers for HCC and chronic HBV infection. ..
  41. Pang J, Xiong H, Yang H, Ou Y, Xu Y, Huang Q, et al. Circulating miR-34a levels correlate with age-related hearing loss in mice and humans. Exp Gerontol. 2016;76:58-67 pubmed publisher
    ..However, SIRT1, Bcl-2, and E2F3 showed no correlation with AHL in humans. In summary, circulating miR-34a level may potentially serve as a useful biomarker for early detection of AHL. ..
  42. Nong L, Luo B, Zhang L, Nong H. Interleukin-18 gene promoter polymorphism and the risk of nasopharyngeal carcinoma in a Chinese population. DNA Cell Biol. 2009;28:507-13 pubmed publisher
    ..Consistent with the results of the genotyping analyses, the -137 C/-607 A haplotype was associated with a significantly increased risk of NPC as compared with the -137 G/-607 C haplotype (OR = 1.721; 95% CI, 1.262-2.349; p = 0.001). ..
  43. Huang Q, Shao F, Wang C, Qiu L, Hu Y, Yu J. Association between CTLA-4 exon-1 +49A>G polymorphism and primary biliary cirrhosis risk: a meta-analysis. Arch Med Res. 2011;42:235-8 pubmed publisher
    ..AA OR=1.432; 95% CI=1.078-1.902). This meta-analysis suggests that the CTLA-4 +49G>A polymorphism may be a risk factor for primary biliary cirrhosis in Asians. ..
  44. Zhang P, Wang J, Lu T, Wang X, Zheng Y, Guo S, et al. miR-449b rs10061133 and miR-4293 rs12220909 polymorphisms are associated with decreased esophageal squamous cell carcinoma in a Chinese population. Tumour Biol. 2015;36:8789-95 pubmed publisher
    ..77, 95% CI 0.61-0.96). This study provides the first evidence that miR-449b rs10061133 and miR-4293 rs12220909 are associated with ESCC risk in Chinese population. ..
  45. Ye N, Rao S, Du T, Hu H, Liu Z, Shen Y, et al. Intergenic variants may predispose to major depression disorder through regulation of long non-coding RNA expression. Gene. 2017;601:21-26 pubmed publisher
    ..001), so that its tag SNPs were genotyped and rs2272260 in LINC00998 was found to be associated with MDD (?2=26.39, P=2.8E-07). This work suggests that non-coding variants may play an important role in conferring risk of MDD. ..
  46. Zhu Y, Zhuang Y, Yang G, Qiang X, Yang L, Shen Y. [Polymorphisms of Fc?RIIA, Fc?RIIIA and Fc?RIIB in patients with immune thrombocytopenia and their clinical significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013;21:135-9 pubmed publisher
    ..It is concluded that the polymorphism of Fc?RIIIA-158V/F, but not Fc?RIIA-131H/R or Fc?RIIB-232T/I, correlates with the patient susceptibility and therapeutic response of ITP. ..
  47. Qian Y, Li D, Ma L, Zhang H, Gong M, Li S, et al. TPM1 polymorphisms and nonsyndromic orofacial clefts susceptibility in a Chinese Han population. Am J Med Genet A. 2016;170A:1208-15 pubmed publisher
    ..TPM1 polymorphisms might contribute to the etiology of NSOC, and more emphasis should be placed on TPM1 during craniofacial development. ..
  48. Min Pan -, Jiang M, Wei M, Liu Z, Jiang W, Geng H, et al. Association of angiotensin-converting enzyme gene 2350G>A polymorphism with myocardial infarction in a Chinese population. Clin Appl Thromb Hemost. 2009;15:435-42 pubmed publisher
    ..05). These results suggest that ACE2350G>A polymorphism is associated with acute MI, and A allele carrier is an independent risk factor for acute MI in the Chinese Han population. ..
  49. Si F, Feng Y, Han M. Association between interleukin-17 gene polymorphisms and the risk of laryngeal cancer in a Chinese population. Genet Mol Res. 2017;16: pubmed publisher
    ..08-3.39, respectively). In conclusion, the rs2275913 IL-17A (197 G/A) is associated with the incidence and development of laryngeal cancer in the Chinese population, and the AA and GA+AA genotypes harbor a high laryngeal cancer risk. ..
  50. Yuan J, Jin C, Qin H, Wang J, Sha W, Wang M, et al. Replication study confirms link between TSPAN18 mutation and schizophrenia in Han Chinese. PLoS ONE. 2013;8:e58785 pubmed publisher
    ..047-1.369) between risk for SCZ and this 'A' allele. These results confirm the significant association, in Han Chinese populations, of increased SCZ risk and the variant of the TSPAN18 gene containing the 'A' allele of SNP rs835784. ..
  51. Wang C, Lai Q, Zhang S, Hu J. Senile cataract and genetic polymorphisms of APE1, XRCC1 and OGG1. Int J Clin Exp Pathol. 2015;8:16036-45 pubmed
    ..In OGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms, there were no significant differences in frequencies of the variant homozygous in patients compared with controls. ..
  52. Xie G, Guo D, Li Y, Liang S, Wu Y. The impact of severity of hypertension on association of PGC-1alpha gene with blood pressure and risk of hypertension. BMC Cardiovasc Disord. 2007;7:33 pubmed
    ..This finding suggested severe hypertension rather than regular hypertension should be used as the outcome in studies on association of genes with blood pressure or hypertension, in order to have a better power. ..
  53. Sun F, Sun Y, Zhang D, Zhang J, Song B, Zheng H. Association of interleukin-10 gene polymorphism with cachexia in Chinese patients with gastric cancer. Ann Clin Lab Sci. 2010;40:149-55 pubmed
    ..21; 95% CI, 1.14 - 4.30; p = 0.02). Our results suggest that genetic polymorphisms of IL-10 contribute to the susceptibility to cachexia in patients with gastric cancer in the Chinese population. ..
  54. Mayinu -, Chen X. Evaluation of LOXL1 polymorphisms in exfoliation syndrome in the Uygur population. Mol Vis. 2011;17:1734-44 pubmed
    ..The genotypic and allelic distributions of these SNPs are similar between XFS and XFG. ..
  55. Mao C, Pan H, Chen Q, Wang X, Ye D, Qiu L. Association between Fc receptor-like 3 C169T polymorphism and risk of systemic lupus erythematosus: a meta-analysis. Mol Biol Rep. 2010;37:191-6 pubmed publisher
    ..In summary, this meta-analysis demonstrates that the FCRL3 169CC genotype (recessive effect) may confer susceptibility to SLE, especially in Asian-derived population. ..
  56. Ma X, Cai G, Zou W, Huang Y, Zhang J, Wang D, et al. First evidence for the contribution of the genetic variations of BRCA1-interacting protein 1 (BRIP1) to the genetic susceptibility of cervical cancer. Gene. 2013;524:208-13 pubmed publisher
    ..These findings point to a role for the BRIP1 gene polymorphisms in cervical cancer in a Chinese Han population, and may be informative for future genetic or biological studies on cervical cancer. ..
  57. Hu W, Ren H. A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus. Int J Immunogenet. 2011;38:411-7 pubmed publisher
    ..This meta-analysis suggested that IRF5 gene polymorphism was associated with SLE in multiple ethnic populations. ..
  58. Hu M, Zheng J, Zhang L, Jiang L, You Y, Jiang M, et al. The association between -1304T>G polymorphism in the promoter of mitogen-activated protein kinase kinase 4 gene and the risk of cervical cancer in Chinese population. DNA Cell Biol. 2012;31:1167-73 pubmed publisher
  59. Zhang Y, Wang Z, Ma T. Associations of Genetic Polymorphisms Relevant to Metabolic Pathway of Vitamin D3 with Development and Prognosis of Childhood Bronchial Asthma. DNA Cell Biol. 2017;36:682-692 pubmed publisher
  60. Zhang M, Yuan G, Yao J, Qian Y, Zhang X, Huang Y, et al. [Associations between six functional genes and schizophrenia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20:69-71 pubmed
    ..441, 95% CI:0.202-0.963, Z=2.05, P<0.05). The 480 bp allele of DAT1 gene is negatively associated with schizophrenia in Chinese Han population, which stands for the dopamine hypothesis of schizophrenia. ..
  61. Wang L, Zhou J, Zhang B, Wang H, Li M, Niu Q, et al. Association of echocardiographic left ventricular structure and -344C/T aldosterone synthase gene variant: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 2015;16:858-71 pubmed publisher
    ..The present findings support the hypothesis that CC homozygous individuals may have greater left ventricular diameters (LVEDD and LVESD) regardless of their ethnicities or physical conditions. ..
  62. Zhou J, Ding J, Fung W, Lin S. Detection of parent-of-origin effects using general pedigree data. Genet Epidemiol. 2010;34:151-8 pubmed publisher
    ..Application of the proposed methods to a rheumatoid arthritis dataset further demonstrates the advantage of MCPPAT. ..
  63. Sun T, Zhou Y, Li H, Han X, Shi Y, Wang L, et al. FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer. J Exp Med. 2005;202:967-74 pubmed
  64. Tam K, Leung J, Chan L, Lam M, Tang S, Lai K. In vitro enhanced chemotaxis of CD25+ mononuclear cells in patients with familial IgAN through glomerulotubular interactions. Am J Physiol Renal Physiol. 2010;299:F359-68 pubmed publisher
    ..A long-term follow-up is needed to better define the prognostic course for familial IgAN and to clarify the risk of developing IgAN in initially asymptomatic relatives from a multiplex IgAN family. ..
  65. Li D, Wu C, Cai Y, Liu B. Association of NFKB1 and NFKBIA gene polymorphisms with susceptibility of gastric cancer. Tumour Biol. 2017;39:1010428317717107 pubmed publisher
  66. Tang W, Wang L, Li C, Hu Z, Chen R, Zhu Y, et al. Identification and functional characterization of JWA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. J Toxicol Environ Health A. 2007;70:885-94 pubmed
    ..Further studies are needed to substantiate the biological significance and related mechanisms underlying the associations. ..
  67. So H, Gui A, Cherny S, Sham P. Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases. Genet Epidemiol. 2011;35:310-7 pubmed publisher
    ..Programs to implement the methodologies described in this paper are available at http://sites.google.com/site/honcheongso/software/varexp. ..
  68. Wei B, Xu Z, Zhou Y, Ruan J, Cheng H, Xi B, et al. Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies. PLoS ONE. 2012;7:e46982 pubmed publisher
    ..12, 95% CI: 0.96-1.31, P?=?0.16). In addition, we did not find that smoking modified the genotype effect on the risk of PCa. The present meta-analysis suggested that GSTM1 null allele was a low-penetrant risk factor for PCa among Asians. ..
  69. Li M, Wu D, Yao Y, Huo Y, Liu J, Su B, et al. Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans. Schizophr Bull. 2016;42:178-90 pubmed publisher
  70. Shan Y, Shen N, Han L, Chen Q, Zhang J, Long X, et al. MicroRNA-499 Rs3746444 polymorphism and biliary atresia. Dig Liver Dis. 2016;48:423-8 pubmed publisher
    ..37; 95% CI, 1.08-1.83). MiR-499 (rs3746444) gene polymorphisms may be genetic determinants for increased risk of BA and prolonged recovery of BA patients after liver transplantation in Han Chinese. ..
  71. Li H, Liu F, Zhu H, Zhou X, Lu J, Chang H, et al. PIK3CA polymorphisms associated with susceptibility to hepatocellular carcinoma. Int J Clin Exp Pathol. 2015;8:15255-9 pubmed
    ..030), which suggested that G-T might be a susceptible haplotype to HCC. The PIK3CA rs17849071 and rs17849079 polymorphisms may increase the risk of HCC either independently or synergistically. ..
  72. Wang L, Shen C, Yang S, Chen Y, Guo D, Jin Y, et al. Association study of NOS3 gene polymorphisms and hypertension in the Han Chinese population. Nitric Oxide. 2015;51:1-6 pubmed publisher
    ..Age and gender might modify the genetic effect of NOS3 on HT, and drinking significantly interacts with rs3918186. ..
  73. Wang L, Duan C, Gao Y, Xu W, Ding J, Liu V, et al. Lack of association between TOR1A and THAP1 mutations and sporadic adult-onset primary focal dystonia in a Chinese population. Clin Neurol Neurosurg. 2016;142:26-30 pubmed publisher
    ..05). This result was confirmed by pooled analysis of multi-ethnic groups. Our study suggested that there might not be an association between TOR1A or THAP1 and patients with AOPFD. ..
  74. Zhang H, Li X, Zhou L, Zhang K, Zhang Q, Li J, et al. A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension. Medicine (Baltimore). 2017;96:e8150 pubmed publisher
    ..000495). All |D'| values of the seven SNPs were >0.9, and r values for rs28659182- rs10087214-rs28491316-rs7463212 SNPs were >0.8 and showed strong linkage intensity. Haplotype T-G-T may therefore be a useful genetic marker for EH. ..
  75. Yau W, Lung H, Zabarovsky E, Lerman M, Sham J, Chua D, et al. Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma. Int J Cancer. 2006;119:2821-6 pubmed
    ..This study provides the first significant evidence to demonstrate BLU/ZMYND10 can functionally suppress tumor formation in vivo and is, therefore, likely to be one of the candidate tumor suppressor genes involved in NPC. ..
  76. Wang Q, Hu X, Li S, Wang X, Wang J, Zhang R, et al. Association of the angiotensinogen M235T polymorphism with recurrence after catheter ablation of acquired atrial fibrillation. J Renin Angiotensin Aldosterone Syst. 2015;16:888-97 pubmed publisher
    ..These strategies may differ and should be individualized according to patients' genotype. Future studies are warranted to validate the potential effect of AGT M235T on AF recurrence post CA. ..
  77. Deng Y, Hou D, Tian M, Li W, Feng X, Yu Z. Relationship between the gene polymorphisms of kallikrein-kinin system and Alzheimer's disease in a Hunan Han Chinese population. Int J Clin Exp Pathol. 2015;8:15550-62 pubmed
    ..The polymorphisms of rs4309 may be related to LOAD, as well as ATA, ACA, and TCA haplotype composed of rs4291/rs4309/rs4343. ..
  78. Wang R, Zhou D, Xi B, Ge X, Zhu P, Wang B, et al. ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects. Biomed Environ Sci. 2011;24:200-6 pubmed publisher
  79. Liu C, Wang G, Liu H, Li Y, Li J, Dai Y, et al. CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese. Can J Neurol Sci. 2012;39:488-90 pubmed
    ..The results strongly support that the TT genotypes are associated with NMO but are not significantly correlated with susceptibility for MS. CD226 Gly307Ser may correlate with risk of NMO in Southern Han Chinese. ..
  80. Yuan Y, Qi C, Maling G, Xiang W, Yanhui L, Ruofei L, et al. TERT mutation in glioma: Frequency, prognosis and risk. J Clin Neurosci. 2016;26:57-62 pubmed publisher
    ..28, 95% CI 1.23-1.33). Our study shows that the TERT gene is a valuable prognostic and predictive biomarker of glioma, and TERT gene polymorphisms are significantly associated with an increased risk of glioma. ..
  81. Jiang Z, Tang X, Zhao Y, Zheng L. A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population. Tumour Biol. 2014;35:12345-52 pubmed publisher
    ..miR-34a/TLR4 axis may play an important role in the development of hepatocellular carcinoma. ..
  82. Luo J, Li S, Qin X, Peng Q, Liu Y, Yang S, et al. Association of the NQO1 C609T polymorphism with Alzheimer's disease in Chinese populations: a meta-analysis. Int J Neurosci. 2016;126:199-204 pubmed publisher
    ..In conclusion, our results showed that NQO1 C609T polymorphism increases the risk of AD in Chinese populations. Larger studies with different ethnic populations are required to validate our findings. ..
  83. Ma L, Liu H, Ruan L, Feng Y. CYP3A5 ∗ 3 genetic polymorphism is associated with childhood acute lymphoblastic leukemia risk: A meta-analysis. Biomed J. 2015;38:428-32 pubmed publisher
    ..No significant publication bias was detected by funnel plot. The current meta-analysis showed that there was association between CYP3A5 FNx01 3 polymorphism and the altered risk of ALL in children, especially in Caucasian populations. ..
  84. Li Y, Li S, Zhai Q, Hai J, Wang D, Cao M, et al. Association of GSTs polymorphisms with risk of gestational diabetes mellitus. Int J Clin Exp Pathol. 2015;8:15191-7 pubmed
    ..In conclusion, we suggest that the GSTM1 null genotype and GSTT1 null genotype are correlated with an increased risk of gestational diabetes mellitus in a Chinese population. ..
  85. Wang Z, Xu Y, Zhu S. Interleukin-16 rs4778889 polymorphism contributes to the development of renal cell cancer in a Chinese population. Int J Clin Exp Pathol. 2015;8:15228-33 pubmed
    ..44, 95% CI = 1.01-6.00) and diabetes (OR = 6.91, 95% CI = 1.44-37.05) in the risk of RCC. In conclusion, the results of our study suggested an association between the IL-16 rs4778889 polymorphism and an elevated risk of RCC. ..
  86. Wang K, Zhao X, Du Y, He F, Peng G, Luo B. Phenotypic overlap among paroxysmal dyskinesia subtypes: Lesson from a family with PRRT2 gene mutation. Brain Dev. 2013;35:664-6 pubmed publisher
    ..In addition, an unusual exercise trigger observed in the proband, likely representing an underestimated occurrence, together with the current clinical PD classification is also elucidated. ..
  87. Chen Y, Song W, Huang R, Chen K, Zhao B, Li J, et al. GAK rs1564282 and DGKQ rs11248060 increase the risk for Parkinson's disease in a Chinese population. J Clin Neurosci. 2013;20:880-3 pubmed publisher
    ..GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients. More related studies with a larger number of participants are needed to confirm these findings. ..
  88. Zhang L, Yuan B, Li H, Tao S, Yan H, Chang L, et al. Associations of genetic polymorphisms of SAA1 with cerebral infarction. Lipids Health Dis. 2013;12:130 pubmed publisher
    ..01, OR = 2.106, 95% CI: 1.811-7.121). Genetic polymorphism of SAA1 may be a genetic maker of cerebral infarction in Chinese. ..
  89. Hou Y, Chen J, Gao M, Zhou F, Du W, Shen Y, et al. Five novel mutations of RNA-specific adenosine deaminase gene with dyschromatosis symmetrica hereditaria. Acta Derm Venereol. 2007;87:18-21 pubmed
    ..The tRNA-specific and double-stranded RNA adenosine deaminase domain is essential for the deaminase activity of the ADAR encoded protein. ..
  90. Yang H, Zhou Q, Chen Z, Chen W, Wang M, Chen J. Polymorphisms in STAT4 increase the risk of acute renal allograft rejection in the Chinese population. Transpl Immunol. 2011;24:216-9 pubmed publisher
    ..049, two-tailed ?(2); OR=0.466, 95% CI=0.216-1.003). Thus, our data suggest that the rs7574865 STAT4 SNP is a genetic susceptibility variant for acute renal allograft rejection in the Chinese population. ..
  91. Zhang C, Li J, Lv G, Yu X, Gu Y, Zhou P. Lack of association of SULT1A1 R213H polymorphism with colorectal cancer: a meta-analysis. PLoS ONE. 2011;6:e19127 pubmed publisher
    ..78-1.56, P?=?0.57; HH versus RR: OR?=?1.09, 95%CI?=?0.83-1.44, P?=?0.53; HR versus RR: OR?=?1.02, 95%CI?=?0.92-1.13, P?=?0.75). This meta-analysis demonstrates that there is no association between the SULT1A1 R213H polymorphism and CRC. ..
  92. Han X, Xing Q, Li Y, Sun J, Ji H, Huazheng P, et al. Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Hepatogastroenterology. 2012;59:2285-9 pubmed
    ..98, 95% CI=1.77-7.54). In conclusion, we observed that XRCC1-Arg399Gln and XRCC3-Thr241Met polymorphism is associated with susceptibility to HCC and XRCC1 Gin allele and XRCC3 Met allele genotype showed significant poor prognosis of HCC. ..