Genomes and Genes
Experts and Doctors on genetic complementation test in United States
Locale: United States
Topic: genetic complementation test
Publications494 found, 100 shown here
- Heinrich M, Silvey K, Stone S, Zigler A, Griffith D, Montalto M, et al. Posttranscriptional cell cycle-dependent regulation of human FANCC expression. Blood. 2000;95:3970-7 pubmed..Our observation of dynamic control of FANCC expression by the proteasome has important implications for understanding the molecular regulation of the multiprotein complex. (Blood. 2000;95:3970-3977) ..
- Liu Cm C, McElver J, Tzafrir I, Joosen R, Wittich P, Patton D, et al. Condensin and cohesin knockouts in Arabidopsis exhibit a titan seed phenotype. Plant J. 2002;29:405-15 pubmed..Further analysis of titan mutants and the SMC gene family in Arabidopsis should provide clues to chromosome mechanics in plants and insights into the regulation of nuclear activity during endosperm development. ..
- Tamada Y, Yun J, Woo S, Amasino R. ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C. Plant Cell. 2009;21:3257-69 pubmed publisher..We show that the flowering phenotype of atx1 atxr7 double mutants is additive relative to those of single mutants. Therefore, both classes of H3K4 methylases appear to be required for proper regulation of FLC expression. ..
- De Veaux L, Hoagland N, Smith G. Seventeen complementation groups of mutations decreasing meiotic recombination in Schizosaccharomyces pombe. Genetics. 1992;130:251-62 pubmed..These results indicate that these multiple rec gene products are required for high level meiotic recombination throughout the S. pombe genome. ..
- Degelmann A, Hardy P, Mahowald A. Genetic analysis of two female-sterile loci affecting eggshell integrity and embryonic pattern formation in Drosophila melanogaster. Genetics. 1990;126:427-34 pubmed..Possible mechanisms to account for the association of these two functions are discussed. ..
- Malakooti J, Ely B. Principal sigma subunit of the Caulobacter crescentus RNA polymerase. J Bacteriol. 1995;177:6854-60 pubmed..coli RNA polymerase, allowing the expression of C. crescentus promoters in E. coli. Thus, the C. crescentus sigma 73 appears to have a broader specificity than does the sigma 70 of the enteric bacteria...
- Chen Y, McPhie D, Hirschberg J, Neve R. The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J Biol Chem. 2000;275:8929-35 pubmed..A specific caspase-6 inhibitor blocks this apoptosis. These findings are discussed in the context of abnormalities in the cell cycle that have been observed in Alzheimer's disease. ..
- Hasona A, Crowley P, Levesque C, Mair R, Cvitkovitch D, Bleiweis A, et al. Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2. Proc Natl Acad Sci U S A. 2005;102:17466-71 pubmed..In S. mutans, this pathway contributes to protection against rapid environmental challenge and may overlap functionally with YidC2. ..
- Eun S, Lea K, Overstreet E, Stevens S, Lee J, Fischer J. Identification of genes that interact with Drosophila liquid facets. Genetics. 2007;175:1163-74 pubmed..We describe the mutant alleles and mutant phenotypes of Rala and aux. We discuss the relevance of all of these genetic interactions to the function of Liquid facets in Notch signaling. ..
- Hall B, Owens K, Singh K. Distinct functions of evolutionary conserved MSF1 and late embryogenesis abundant (LEA)-like domains in mitochondria. J Biol Chem. 2011;286:39141-52 pubmed publisher..Together our studies suggest distinct roles of MSF1 and LEA-like domains in mitochondrial function and resistance to oxidative stress. ..
- Brickman T, Armstrong S. Bordetella pertussis fur gene restores iron repressibility of siderophore and protein expression to deregulated Bordetella bronchiseptica mutants. J Bacteriol. 1995;177:268-70 pubmed..The fur gene of Bordetella pertussis was cloned by genetic complementation of this deregulated phenotype and confirmed as fur by nucleotide sequence analysis. ..
- Wayne L, Wallis J, Kumar R, Markham J, Browse J. Cytochrome b5 reductase encoded by CBR1 is essential for a functional male gametophyte in Arabidopsis. Plant Cell. 2013;25:3052-66 pubmed publisher..These results indicate that cytochrome b5 reductase is not essential during vegetative growth but is required for correct pollen function and seed maturation. ..
- Gulig P, Chiodo V. Genetic and DNA sequence analysis of the Salmonella typhimurium virulence plasmid gene encoding the 28,000-molecular-weight protein. Infect Immun. 1990;58:2651-8 pubmed..2-kilobase BamHI-EcoRI fragment encoding the 28K protein and identified the structural gene, virA. A 723-base-pair open reading frame which encodes a peptide with a molecular weight of 27,572 was found. ..
- Keith L, Bender C. AlgT (sigma22) controls alginate production and tolerance to environmental stress in Pseudomonas syringae. J Bacteriol. 1999;181:7176-84 pubmed..The latter two compounds are frequently encountered during colonization of plant tissue and may be unique signals for algT activation in P. syringae...
- Rogers E, Guerinot M. FRD3, a member of the multidrug and toxin efflux family, controls iron deficiency responses in Arabidopsis. Plant Cell. 2002;14:1787-99 pubmed..The phenotypes of frd3 mutant plants, which are consistent with a defect in either iron deficiency signaling or iron distribution, indicate that FRD3 is an important component of iron homeostasis in Arabidopsis. ..
- Yan N, Doelling J, Falbel T, Durski A, Vierstra R. The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine. Plant Physiol. 2000;124:1828-43 pubmed..This phenotype suggests that the AtUBP1 and 2 enzymes are needed for abnormal protein turnover in Arabidopsis. ..
- Rodriguez Contreras D, Feng X, Keeney K, Bouwer H, Landfear S. Phenotypic characterization of a glucose transporter null mutant in Leishmania mexicana. Mol Biochem Parasitol. 2007;153:9-18 pubmed..These results underscore the importance of glucose transporters in the parasite life cycle and suggest reasons for their non-viability in the disease-causing amastigote stage...
- Muralla R, Chen E, Sweeney C, Gray J, Dickerman A, Nikolau B, et al. A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis. Plant Physiol. 2008;146:60-73 pubmed..This complex locus exhibits several unusual features that distinguish it from biotin operons in bacteria and from other genes known to encode bifunctional enzymes in plants. ..
- Albright B, Nellissery J, Szczepaniak R, Weller S. Disulfide bond formation in the herpes simplex virus 1 UL6 protein is required for portal ring formation and genome encapsidation. J Virol. 2011;85:8616-24 pubmed publisher..Taken together, these results indicate that disulfide bond formation is required for portal ring formation and/or stability and for the production of procapsids that are capable of encapsidation. ..
- Payne T, Lund P, Knoll L. A transmembrane domain containing pellicle protein of Toxoplasma gondii enhances virulence and invasion after extracellular stress. Mol Biochem Parasitol. 2011;179:107-10 pubmed publisher..Overall, TgTPP1 may function during acute infection by enhancing the parasites ability to invade after extracellular stress. ..
- Harding C, Tracy E, Carruthers M, Rather P, Actis L, Munson R. Acinetobacter baumannii strain M2 produces type IV pili which play a role in natural transformation and twitching motility but not surface-associated motility. MBio. 2013;4: pubmed publisher..Using this strategy, we demonstrated that strain M2 produces TFP and that TFP are not required for surface-associated motility exhibited by strain M2. ..
- Gast C, Basso L, Bruzual I, Wong B. Azole resistance in Cryptococcus gattii from the Pacific Northwest: Investigation of the role of ERG11. Antimicrob Agents Chemother. 2013;57:5478-85 pubmed publisher..neoformans strains H99 or JEC21. We conclude that neither ERG11 overexpression nor variations in ERG11 coding sequences was responsible for the high azole MICs observed for the Pacific Northwest C. gattii strains we studied. ..
- Yildiz F, Gest H, Bauer C. Conservation of the photosynthesis gene cluster in Rhodospirillum centenum. Mol Microbiol. 1992;6:2683-91 pubmed
- Robinson J, Graham T, Emr S. A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation. Mol Cell Biol. 1991;11:5813-24 pubmed
- Presgraves D, Balagopalan L, Abmayr S, Orr H. Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila. Nature. 2003;423:715-9 pubmed publisher..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...
- Honma K, Mishima E, Inagaki S, Sharma A. The OxyR homologue in Tannerella forsythia regulates expression of oxidative stress responses and biofilm formation. Microbiology. 2009;155:1912-22 pubmed publisher..forsythia constitutively activates antioxidant genes involved in resistance to peroxides as well as oxygen stress (aerotolerance). In addition, the oxyR deletion attenuates biofilm formation in T. forsythia. ..
- He Y, Mawhinney T, Preuss M, Schroeder A, Chen B, Abraham L, et al. A redox-active isopropylmalate dehydrogenase functions in the biosynthesis of glucosinolates and leucine in Arabidopsis. Plant J. 2009;60:679-90 pubmed publisher..It provides evidence for the hypothesis that the two pathways share a common origin, and suggests a role for redox regulation of glucosinolate and leucine synthesis in plants. ..
- Kustusch R, Kuehl C, Crosa J. The ttpC gene is contained in two of three TonB systems in the human pathogen Vibrio vulnificus, but only one is active in iron transport and virulence. J Bacteriol. 2012;194:3250-9 pubmed publisher..Furthermore, in the absence of TonB1, TtpC2 is essential for a fully virulent phenotype as demonstrated using 50% lethal dose (LD(50)) experiments in mice. ..
- Brennan C, DeLoney Marino C, Mandel M. Chemoreceptor VfcA mediates amino acid chemotaxis in Vibrio fischeri. Appl Environ Microbiol. 2013;79:1889-96 pubmed publisher..fischeri and that the attraction is also mediated by VfcA. This study thus provides the first insights into how V. fischeri integrates information from one of its 43 MCPs to respond to environmental stimuli. ..
- Fillingame R, Oldenburg M, Fraga D. Mutation of alanine 24 to serine in subunit c of the Escherichia coli F1F0-ATP synthase reduces reactivity of aspartyl 61 with dicyclohexylcarbodiimide. J Biol Chem. 1991;266:20934-9 pubmed..These results support a model in which subunit c folds in the membrane like a hairpin, where the region of residues 24-28 in transmembrane helix-1 is close to that of aspartyl 61 in transmembrane helix-2. ..
- Lycan D, Mikesell G, Bunger M, Breeden L. Differential effects of Cdc68 on cell cycle-regulated promoters in Saccharomyces cerevisiae. Mol Cell Biol. 1994;14:7455-65 pubmed..We suggest that Cdc68 functions both in the assembly of repressive complexes that form on many intact promoters in vivo and in the relief of this repression during gene activation. ..
- Vande Weghe J, Ow D. A fission yeast gene for mitochondrial sulfide oxidation. J Biol Chem. 1999;274:13250-7 pubmed
- Lekven A, Helde K, Thorpe C, Rooke R, Moon R. Reverse genetics in zebrafish. Physiol Genomics. 2000;2:37-48 pubmed
- Gilliland L, Kandasamy M, Pawloski L, Meagher R. Both vegetative and reproductive actin isovariants complement the stunted root hair phenotype of the Arabidopsis act2-1 mutation. Plant Physiol. 2002;130:2199-209 pubmed..Impairment of root hair functions such as nutrient mining, water uptake, and physical anchoring are the likely cause of the reduced fitness seen for act2-1 mutants in multigenerational studies. ..
- Simm R, Fetherston J, Kader A, Romling U, Perry R. Phenotypic convergence mediated by GGDEF-domain-containing proteins. J Bacteriol. 2005;187:6816-23 pubmed..pestis cells carrying adrA under the control of an arabinose-inducible promoter produced substantial biofilms in the presence of arabinose. Finally, we demonstrate that HmsT is involved in the synthesis of cyclic di-GMP. ..
- Vidali L, Augustine R, Kleinman K, Bezanilla M. Profilin is essential for tip growth in the moss Physcomitrella patens. Plant Cell. 2007;19:3705-22 pubmed..Additionally, profilin is not needed for formation of F-actin, but profilin and its interactions with actin and poly-l-proline ligands are required to properly organize F-actin...
- He Y, Chen B, Pang Q, Strul J, Chen S. Functional specification of Arabidopsis isopropylmalate isomerases in glucosinolate and leucine biosynthesis. Plant Cell Physiol. 2010;51:1480-7 pubmed publisher..A defect in female gametophyte development was found to contribute to the mutant lethality, suggesting the important role of AtLeuD3 in female gametophyte development. ..
- Carter M, Louie J, Fagerquist C, Sultan O, Miller W, Mandrell R. Evolutionary silence of the acid chaperone protein HdeB in enterohemorrhagic Escherichia coli O157:H7. Appl Environ Microbiol. 2012;78:1004-14 pubmed publisher..These results suggest a divergent evolution of acid resistance mechanisms within E. coli. ..
- Singh P, Brooks J, Ray V, Mandel M, Visick K. CysK Plays a Role in Biofilm Formation and Colonization by Vibrio fischeri. Appl Environ Microbiol. 2015;81:5223-34 pubmed publisher..Finally, our data reveal a role for cysK in symbiotic colonization by V. fischeri. Although many questions remain, this work provides insights into additional factors required for biofilm formation and colonization by V. fischeri. ..
- Oliver B, Perrimon N, Mahowald A. Genetic evidence that the sans fille locus is involved in Drosophila sex determination. Genetics. 1988;120:159-71 pubmed
- Geraghty R, Talbot K, Callahan M, Harper W, Panganiban A. Cell type-dependence for Vpu function. J Med Primatol. 1994;23:146-50 pubmed..A yeast GAL4 transcriptional activation system was used to screen for cellular proteins that may interact with Vpu. One such protein was identified which we provisionally designate "Vpu interactive protein" or VIP. ..
- Aumiller J, Jarvis D. Expression and functional characterization of a nucleotide sugar transporter from Drosophila melanogaster: relevance to protein glycosylation in insect cell expression systems. Protein Expr Purif. 2002;26:438-48 pubmed..These findings are relevant to insect cell biology and to an informed consideration of insect cell expression systems as tools for recombinant glycoprotein production. ..
- Lu B, Liu T, Crosby J, Thomas Wohlever J, Lee I, Suzuki C. The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals. Gene. 2003;306:45-55 pubmed..In addition, the evolutionary conservation of mitochondrial Lon function is demonstrated by the ability of mouse Lon to substitute for the yeast protein in vivo. ..
- Yao J, Allen C. The plant pathogen Ralstonia solanacearum needs aerotaxis for normal biofilm formation and interactions with its tomato host. J Bacteriol. 2007;189:6415-24 pubmed..These results indicate that energy taxis contributes significantly to the ability of R. solanacearum to locate and effectively interact with its host plants...
- Butchko R, Brown D, Busman M, Tudzynski B, Wiemann P. Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides. Fungal Genet Biol. 2012;49:602-12 pubmed publisher..Fumonisin production is unchanged in the F. verticillioides lae1 mutant. Complementation of the F. verticillioides mutant resulted in increased fumonisin production. ..
- Holdorf M, Owen H, Lieber S, Yuan L, Adams N, Dabney Smith C, et al. Arabidopsis ETHE1 encodes a sulfur dioxygenase that is essential for embryo and endosperm development. Plant Physiol. 2012;160:226-36 pubmed publisher..Strong ETHE1 labeling was observed in the peripheral and chalazal endosperm of wild-type seeds prior to cellularization. Therefore, ETHE1 appears to play an essential role in regulating sulfide levels in seeds. ..
- Withers J, Shipp M, Rupasinghe S, Sukumar P, Schuler M, Muday G, et al. Gravity Persistent Signal 1 (GPS1) reveals novel cytochrome P450s involved in gravitropism. Am J Bot. 2013;100:183-93 pubmed publisher..The characterization of two novel P450s (CYP705A22 and CYP705A5) and their role in the gravity response has offered new insights into the regulation of the genetic and physiological controls of plant gravitropism. ..
- Tang F, Yang S, Liu J, Zhu H. Rj4, a Gene Controlling Nodulation Specificity in Soybeans, Encodes a Thaumatin-Like Protein But Not the One Previously Reported. Plant Physiol. 2016;170:26-32 pubmed publisher..Instead, we provide convincing evidence that Rj4 is Glyma.01g165800-D, a duplicated and unique version of Glyma.01g165800, that has evolved the ability to control symbiotic specificity. ..
- Li S, Fu B, Wang L, Dorf M. ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity. DNA Cell Biol. 2017;36:513-517 pubmed publisher..In vivo studies with zmpste24-deficient mice demonstrate the importance of ZMPSTE24 for antiviral defense. ..
- Yang Y, Polisky B. Suppression of ColE1 high-copy-number mutants by mutations in the polA gene of Escherichia coli. J Bacteriol. 1993;175:428-37 pubmed..The third suppressor alters a residue in the 3'-5' exonuclease domain of the enzyme. Implications for the interaction of DNA polymerase I with the ColE1 primer RNA are discussed. ..
- Mansky L. The mutation rate of human immunodeficiency virus type 1 is influenced by the vpr gene. Virology. 1996;222:391-400 pubmed..Immunoprecipitation analysis indicated that Vpr virion incorporation coincided with the influence of vpr on the mutation rate. ..
- Dick F, Trumpower B. Heterologous complementation reveals that mutant alleles of QSR1 render 60S ribosomal subunits unstable and translationally inactive. Nucleic Acids Res. 1998;26:2442-8 pubmed..Velocity gradient analyses of the hybrid ribosomes after exposure to high concentrations of salt indicate that the decreased activity is due to lability of the hybrid 60S subunits. ..
- Hiscock S, McInnis S, Tabah D, Henderson C, Brennan A. Sporophytic self-incompatibility in Senecio squalidus L (Asteraceae)--the search for S. J Exp Bot. 2003;54:169-74 pubmed..Together these data suggest that SSP is a strong candidate for a Senecio S-gene...
- Li W, Li M, Zhang W, Welti R, Wang X. The plasma membrane-bound phospholipase Ddelta enhances freezing tolerance in Arabidopsis thaliana. Nat Biotechnol. 2004;22:427-33 pubmed
- Du L, Poovaiah B. Ca2+/calmodulin is critical for brassinosteroid biosynthesis and plant growth. Nature. 2005;437:741-5 pubmed..These results raise the possibility of producing size-engineered crops by altering the Ca2+/calmodulin-binding property of their DWF1 orthologues. ..
- González E, Brown D, Swanson J, Allen C. Using the Ralstonia solanacearum Tat secretome to identify bacterial wilt virulence factors. Appl Environ Microbiol. 2007;73:3779-86 pubmed..Additional bacterial wilt virulence factors may be found in the Tat secretome. ..
- Spitzer C, Reyes F, Buono R, Sliwinski M, Haas T, Otegui M. The ESCRT-related CHMP1A and B proteins mediate multivesicular body sorting of auxin carriers in Arabidopsis and are required for plant development. Plant Cell. 2009;21:749-66 pubmed publisher..Thus, Arabidopsis CHMP1A and B are ESCRT-related proteins with conserved endosomal functions, and the auxin carriers PIN1, PIN2, and AUX1 are ESCRT cargo proteins in the MVB sorting pathway. ..
- Wang Y, Langer N, Shaw G, Yang G, Li L, Kaplan J, et al. Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Exp Hematol. 2011;39:784-94 pubmed publisher..Abnormal MFRN1 expression can contribute to erythropoietic protoporphyria phenotype in some patients, probably by causing a reduction in FECH activity. ..
- Hasnain G, Frelin O, Roje S, Ellens K, Ali K, Guan J, et al. Identification and characterization of the missing pyrimidine reductase in the plant riboflavin biosynthesis pathway. Plant Physiol. 2013;161:48-56 pubmed publisher..The role of the COG3236 domain remains mysterious; no evidence was obtained for the possibility that it catalyzes the dephosphorylation that follows pyrimidine reduction. ..
- Li Y, Jin K, Ghosh S, Devarakonda P, Carlson K, Davis A, et al. Structural and functional analysis of the GerD spore germination protein of Bacillus species. J Mol Biol. 2014;426:1995-2008 pubmed publisher..subtilis. These results and those of others lead us to propose that GerD mediates clustering of germination proteins in the inner membrane of dormant spores and thus promotes the rapid and cooperative germination response to nutrients. ..
- Jiang H, Kendrick K. Characterization of ssfR and ssgA, two genes involved in sporulation of Streptomyces griseus. J Bacteriol. 2000;182:5521-9 pubmed..The ssfR and ssgA disruption mutants were constructed and showed the "white" mutant phenotype, with some growth medium dependence. In addition, the ssfR null mutant sporulated ectopically in phosphate starvation medium...
- Sun S, Scheffler N, Gibson B, Wang J, Munson R. Identification and characterization of the N-acetylglucosamine glycosyltransferase gene of Haemophilus ducreyi. Infect Immun. 2002;70:5887-92 pubmed..This strain produced the lipooligosaccharide glycoforms produced by the parental strain, confirming that the lgtA gene encodes the N-acetylglucosamine glycosyltransferase. ..
- Haynes W, Kung C, Saimi Y, Preston R. An exchanger-like protein underlies the large Mg2+ current in Paramecium. Proc Natl Acad Sci U S A. 2002;99:15717-22 pubmed..The significance of finding the molecular basis of a Mg(2+)-specific pathway is also discussed. ..
- Rontein D, Wu W, Voelker D, Hanson A. Mitochondrial phosphatidylserine decarboxylase from higher plants. Functional complementation in yeast, localization in plants, and overexpression in Arabidopsis. Plant Physiol. 2003;132:1678-87 pubmed..They also indicate that mitochondrial PSD is an important housekeeping enzyme whose expression is strongly regulated at the transcriptional level. ..
- Li C, Xu H, Zhang K, Liang F. Inactivation of a putative flagellar motor switch protein FliG1 prevents Borrelia burgdorferi from swimming in highly viscous media and blocks its infectivity. Mol Microbiol. 2010;75:1563-76 pubmed publisher..burgdorferi and probably other pathogenic spirochetes. ..
- Wirth M, Walton W, Federici B. Inheritance patterns, dominance, stability, and allelism of insecticide resistance and cross-resistance in two colonies of Culex quinquefasciatus (Diptera: Culicidae) selected with cry toxins from Bacillus thuringiensis subsp, israelensis. J Med Entomol. 2010;47:814-22 pubmed..thuringiensis subsp. israelensis de Barjac. ..
- Mulangi V, Chibucos M, Phuntumart V, Morris P. Kinetic and phylogenetic analysis of plant polyamine uptake transporters. Planta. 2012;236:1261-73 pubmed..We surmise that the genes in Entamoeba species were acquired by phagotrophy of Discicristates. In summary, phylogenetic and functional analysis has identified two clades of genes that are predictive of polyamine transport activity. ..
- Zallot R, Agrimi G, Lerma Ortiz C, Teresinski H, Frelin O, Ellens K, et al. Identification of mitochondrial coenzyme a transporters from maize and Arabidopsis. Plant Physiol. 2013;162:581-8 pubmed publisher..The highly conserved nature of these carriers makes possible their reliable annotation in other angiosperm genomes. ..
- Hu Z, Patel I, Mukherjee A. Genetic analysis of the roles of agaA, agaI, and agaS genes in the N-acetyl-D-galactosamine and D-galactosamine catabolic pathways in Escherichia coli strains O157:H7 and C. BMC Microbiol. 2013;13:94 pubmed publisher..We propose that agaS codes for Gam-6-P deaminase/isomerase in the Aga/Gam pathway. ..
- Zhou J, Wang L, Zuo M, Wang X, Ahmed A, Chen Q, et al. Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm. Sci Rep. 2016;6:21538 pubmed publisher..5, gata4 and hand2 involved in cardiac morphogenesis. These data for the first time revealed a novel role that MOG1, a nucleocytoplasmic transport protein, plays in cardiac physiology and development. ..
- Matusick Kumar L, Hurlburt W, Weinheimer S, Newcomb W, Brown J, Gao M. Phenotype of the herpes simplex virus type 1 protease substrate ICP35 mutant virus. J Virol. 1994;68:5384-94 pubmed
- Sau S, Sun J, Lee C. Molecular characterization and transcriptional analysis of type 8 capsule genes in Staphylococcus aureus. J Bacteriol. 1997;179:1614-21 pubmed..In addition, Southern hybridization analyses showed that cap8H, cap8I, cap8J, and cap8K, located in the central region of the cap8 gene cluster, were CP8 specific. ..
- Hasona A, Ray R, Shanmugam K. Physiological and genetic analyses leading to identification of a biochemical role for the moeA (molybdate metabolism) gene product in Escherichia coli. J Bacteriol. 1998;180:1466-72 pubmed
- Sedbrook J, Chen R, Masson P. ARG1 (altered response to gravity) encodes a DnaJ-like protein that potentially interacts with the cytoskeleton. Proc Natl Acad Sci U S A. 1999;96:1140-5 pubmed..Ubiquitous ARG1 expression in Arabidopsis and the identification of an ortholog in Caenorhabditis elegans suggest that ARG1 is involved in other essential processes. ..
- Smalle J, Kurepa J, Yang P, Babiychuk E, Kushnir S, Durski A, et al. Cytokinin growth responses in Arabidopsis involve the 26S proteasome subunit RPN12. Plant Cell. 2002;14:17-32 pubmed..We propose that RPN12a is part of the Arabidopsis 26S proteasome that controls the stability of one or more of the factors involved in cytokinin regulation. ..
- Dajkovic A, Mukherjee A, Lutkenhaus J. Investigation of regulation of FtsZ assembly by SulA and development of a model for FtsZ polymerization. J Bacteriol. 2008;190:2513-26 pubmed publisher..In vivo stoichiometry of the disruption of Z rings by SulA suggests that FtsZ may undergo two cooperative transitions in forming the Z ring. ..
- Maloney G, Kochevenko A, Tieman D, Tohge T, Krieger U, Zamir D, et al. Characterization of the branched-chain amino acid aminotransferase enzyme family in tomato. Plant Physiol. 2010;153:925-36 pubmed publisher..Together, these results support a model in which the mitochondrial SlBCAT1 and -2 function in BCAA catabolism while the chloroplastic SlBCAT3 and -4 function in BCAA synthesis. ..
- Danelishvili L, Yamazaki Y, Selker J, Bermudez L. Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis. PLoS ONE. 2010;5:e10474 pubmed publisher..While M. tuberculosis inhibits the extrinsic pathway of apoptosis, it appears to activate the intrinsic pathway leading to macrophage necrosis as a potential exit strategy. ..
- Chartron J, Suloway C, Zaslaver M, Clemons W. Structural characterization of the Get4/Get5 complex and its interaction with Get3. Proc Natl Acad Sci U S A. 2010;107:12127-32 pubmed publisher..This work provides further evidence for a model in which Get4/5 operates upstream of Get3 and mediates the specific delivery of a TA substrate. ..
- Boitz J, Strasser R, Yates P, Jardim A, Ullman B. Adenylosuccinate synthetase and adenylosuccinate lyase deficiencies trigger growth and infectivity deficits in Leishmania donovani. J Biol Chem. 2013;288:8977-90 pubmed publisher..donovani, both ASL and ADSS are cytosolic enzymes. Overall, these data underscore the paramount importance of ASL to purine salvage by both life cycle stages of L. donovani and authenticate ASL as a potential drug target in Leishmania...
- Carruthers M, Nicholson P, Tracy E, Munson R. Acinetobacter baumannii utilizes a type VI secretion system for bacterial competition. PLoS ONE. 2013;8:e59388 pubmed publisher..Collectively, our data have provided the first evidence demonstrating function in inter-bacterial competition, for a T6SS produced by A. baumannii...
- Cullen P, Schultz J, Horecka J, Stevenson B, Jigami Y, Sprague G. Defects in protein glycosylation cause SHO1-dependent activation of a STE12 signaling pathway in yeast. Genetics. 2000;155:1005-18 pubmed
- van Waasbergen L, Dolganov N, Grossman A. nblS, a gene involved in controlling photosynthesis-related gene expression during high light and nutrient stress in Synechococcus elongatus PCC 7942. J Bacteriol. 2002;184:2481-90 pubmed..Thus, the NblS protein is involved in the control of a number of processes critical for altering the photosynthetic apparatus in response to both HL and nutrient stress conditions. ..
- Danhorn T, Hentzer M, Givskov M, Parsek M, Fuqua C. Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system. J Bacteriol. 2004;186:4492-501 pubmed..tumefaciens surface interactions. ..
- Kim S, Smith J, Claude A, Lin R. The purified yeast pre-mRNA splicing factor PRP2 is an RNA-dependent NTPase. EMBO J. 1992;11:2319-26 pubmed..The fact that an RNA-dependent NTPase activity is intrinsic to PRP2 may account for the ATP requirement in the first catalytic reaction of pre-mRNA splicing. ..
- Valentine G, Wallace Y, Turner F, Zolan M. Pathway analysis of radiation-sensitive meiotic mutants of Coprinus cinereus. Mol Gen Genet. 1995;247:169-79 pubmed..Therefore, these four genes are in the same pathway for the repair of gamma radiation damage, and this pathway also represents one or more functions essential for meiosis. ..
- Khalfan W, Ivanovska I, Rose M. Functional interaction between the PKC1 pathway and CDC31 network of SPB duplication genes. Genetics. 2000;155:1543-59 pubmed..In support of the model that the PKC1 pathway regulates SPB duplication, one of the phosphorylated forms of Spc110p was absent in pkc1 and mpk1Delta mutants. ..
- Mohr G, Del Campo M, Mohr S, Yang Q, Jia H, Jankowsky E, et al. Function of the C-terminal domain of the DEAD-box protein Mss116p analyzed in vivo and in vitro. J Mol Biol. 2008;375:1344-64 pubmed