Experts and Doctors on gene silencing in Hungary
Topic: gene silencing
Szittya G, Molnar A, Silhavy D, Hornyik C, Burgyan J. Short defective interfering RNAs of tombusviruses are not targeted but trigger post-transcriptional gene silencing against their helper virus. Plant Cell. 2002;14:359-72 pubmed
..Because PTGS operates in a wide variety of different organisms, this model is applicable to DI RNA generation and accumulation in both plant and animal cells. ..
Mérai Z, Kerényi Z, Molnar A, Barta E, Valoczi A, Bisztray G, et al
. Aureusvirus P14 is an efficient RNA silencing suppressor that binds double-stranded RNAs without size specificity. J Virol. 2005;79:7217-26 pubmed
..Finally, sequence analyses suggest that P14 and P19 suppressors diverged from an ancient dsRNA binding suppressor that evolved as a nested protein within the common ancestor of aureusvirus-tombusvirus movement proteins. ..
Molnar A, Csorba T, Lakatos L, Várallyay E, Lacomme C, Burgyan J. Plant virus-derived small interfering RNAs originate predominantly from highly structured single-stranded viral RNAs. J Virol. 2005;79:7812-8 pubmed
..Taken together, these results suggest that virus-derived siRNAs originate predominantly by direct DICER cleavage of imperfect duplexes in the most folded regions of the positive strand of the viral RNA...
Blastyak A, Mishra R, Karch F, Gyurkovics H. Efficient and specific targeting of Polycomb group proteins requires cooperative interaction between Grainyhead and Pleiohomeotic. Mol Cell Biol. 2006;26:1434-44 pubmed
Csorba T, Bovi A, Dalmay T, Burgyan J. The p122 subunit of Tobacco Mosaic Virus replicase is a potent silencing suppressor and compromises both small interfering RNA- and microRNA-mediated pathways. J Virol. 2007;81:11768-80 pubmed
..However, the p122 silencing suppressor does not prevent the methylation of certain miRNAs in hst-15 mutants, in which the nuclear export of miRNAs is compromised. ..
Pal M, Nagy O, Ménesi D, Udvardy A, Deak P. Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster. J Cell Sci. 2007;120:3238-48 pubmed
..Taken together, these data suggest that the structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex. ..
Gomori E, Pal J, Kovács B, Doczi T. Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas. Diagn Pathol. 2012;7:8 pubmed publisher
..However, the DNMT hypermethylation is a late part of glioma progression. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1935054011612460. ..
Masoudi N, Fancsalszky L, Pourkarimi E, Vellai T, Alexa A, RemÃ©nyi A, et al
. The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans. Development. 2013;140:3486-95 pubmed publisher
..Our study reveals that C. elegans NDK-1/Nm23 influences differentiation by enhancing the level of Ras/MAPK signaling. These results might help to better understand how dysregulated Nm23 in humans contributes to tumorigenesis. ..