Genomes and Genes
Experts and Doctors on gene silencing in France
Topic: gene silencing
- Remy E, Meyer M, Blaise F, Simon U, Kuhn D, Chabirand M, et al. The Lmgpi15 gene, encoding a component of the glycosylphosphatidylinositol anchor biosynthesis pathway, is required for morphogenesis and pathogenicity in Leptosphaeria maculans. New Phytol. 2008;179:1105-20 pubmed publisher..It is concluded that the GPI anchor biosynthetic pathway is required for morphogenesis, cell wall integrity and pathogenicity in Leptosphaeria maculans. ..
- Chamboredon S, Ciais D, Desroches Castan A, Savi P, Bono F, Feige J, et al. Hypoxia-inducible factor-1? mRNA: a new target for destabilization by tristetraprolin in endothelial cells. Mol Biol Cell. 2011;22:3366-78 pubmed publisher..Altogether, these data reveal a new role for TTP in the control of gene expression during the response of endothelial cell to hypoxia. ..
- Rusconi F, Durand Dubief M, Bastin P. Functional complementation of RNA interference mutants in trypanosomes. BMC Biotechnol. 2005;5:6 pubmed..In addition, our strategy should constitute a firm basis to elaborate functional-dissection studies of genes from other organisms. ..
- Dalmais B, Schumacher J, Moraga J, Le Pêcheur P, Tudzynski B, Collado I, et al. The Botrytis cinerea phytotoxin botcinic acid requires two polyketide synthases for production and has a redundant role in virulence with botrydial. Mol Plant Pathol. 2011;12:564-79 pubmed publisher..However, double mutants that do not produce botcinic acid or botrydial (bcpks6?bcbot2?) exhibit markedly reduced virulence. Hence, a redundant role of botrydial and botcinic acid in the virulence of B. cinerea has been demonstrated...
- Kumar S, Aninat C, Michaux G, Morel F. Anticancer drug 5-fluorouracil induces reproductive and developmental defects in Caenorhabditis elegans. Reprod Toxicol. 2010;29:415-20 pubmed publisher..Thus, we proposed that C. elegans could be a useful model system for studying the mechanisms by which 5-FU might affect either embryo, adult or organ development...
- Girard A, Mounet F, Lemaire Chamley M, Gaillard C, Elmorjani K, Vivancos J, et al. Tomato GDSL1 is required for cutin deposition in the fruit cuticle. Plant Cell. 2012;24:3119-34 pubmed publisher..These results suggest that GDSL1 is specifically involved in the extracellular deposition of the cutin polyester in the tomato fruit cuticle...
- Soares H, Castro R, TomÃ¡s H, Rodrigues A, Gomes Alves P, Bellier B, et al. Tetraspanins displayed in retrovirus-derived virus-like particles and their immunogenicity. Vaccine. 2016;34:1634-1641 pubmed publisher..These results highlight the dynamic nature of host-derived proteins incorporation in retroVLPs membrane, which should be considered when retrovirus-based biopharmaceuticals are produced in xenogeneic cells. ..
- Gouédard C, Barouki R, Morel Y. Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol Cell Biol. 2004;24:5209-22 pubmed..They suggest also that AhR ligands may differentially regulate gene expression depending on the DNA target sequence. ..
- Schang A, Granger A, Querat B, Bleux C, Cohen Tannoudji J, Laverrière J. GATA2-induced silencing and LIM-homeodomain protein-induced activation are mediated by a bi-functional response element in the rat GnRH receptor gene. Mol Endocrinol. 2013;27:74-91 pubmed publisher..Such a hierarchical interplay may contribute to finely adjust Gnrhr gene expression in gonadotrope cell lineage during pituitary development as well as in the adult animal. ..
- Delest A, Sexton T, Cavalli G. Polycomb: a paradigm for genome organization from one to three dimensions. Curr Opin Cell Biol. 2012;24:405-14 pubmed publisher..Recent studies suggest that the linear epigenetic domains and chromosome architecture are intimately linked and the developmental plasticity of these scales of chromosome organization is beginning to be explored. ..
- Hesling C, Fattet L, Teyre G, Jury D, Gonzalo P, Lopez J, et al. Antagonistic regulation of EMT by TIF1? and Smad4 in mammary epithelial cells. EMBO Rep. 2011;12:665-72 pubmed publisher..This study shows the molecular relationship between TIF1? and Smad4 in TGF-? signalling and EMT. ..
- Hube F, Reverdiau P, Iochmann S, Rollin J, Cherpi Antar C, Gruel Y. Transcriptional silencing of the TFPI-2 gene by promoter hypermethylation in choriocarcinoma cells. Biol Chem. 2003;384:1029-34 pubmed..We conclude that hypermethylation of the TFPI-2 gene is correlated with transcriptional silencing and that the TFPI-2 gene may be a candidate tumor suppressor gene. ..
- Nowak J, Archange C, Tardivel Lacombe J, Pontarotti P, Pébusque M, Vaccaro M, et al. The TP53INP2 protein is required for autophagy in mammalian cells. Mol Biol Cell. 2009;20:870-81 pubmed publisher..It is concluded that TP53INP2 is a novel gene involved in the autophagy of mammalian cells. ..
- Sirour C, Hidalgo M, Bello V, Buisson N, Darribère T, Moreau N. Dystroglycan is involved in skin morphogenesis downstream of the Notch signaling pathway. Mol Biol Cell. 2011;22:2957-69 pubmed publisher..Our study showed for the first time in vivo that Dg, in addition to organizing laminin in the ECM, also acts as a key signaling component in the Notch pathway. ..
- Grimaud C, Bantignies F, Pal Bhadra M, Ghana P, Bhadra U, Cavalli G. RNAi components are required for nuclear clustering of Polycomb group response elements. Cell. 2006;124:957-71 pubmed..This suggests a novel role for the RNAi machinery in regulating the nuclear organization of PcG chromatin targets. ..
- Rageul J, Frémin C, Ezan F, Baffet G, Langouet S. The knock-down of ERCC1 but not of XPF causes multinucleation. DNA Repair (Amst). 2011;10:978-90 pubmed publisher..This work reveals a new role for ERCC1 distinct from its known function in DNA repair, which may be independent of XPF. The role for ERCC1 in mitotic progression may be critical during development, particularly in humans. ..
- Morgan M, Woltering J, In der Rieden P, Durston A, Thiery J. YY1 regulates the neural crest-associated slug gene in Xenopus laevis. J Biol Chem. 2004;279:46826-34 pubmed
- Abdel Lateif K, Vaissayre V, Gherbi H, Verries C, Meudec E, Perrine Walker F, et al. Silencing of the chalcone synthase gene in Casuarina glauca highlights the important role of flavonoids during nodulation. New Phytol. 2013;199:1012-21 pubmed publisher..Our results provide, for the first time, direct evidence of an important role for flavonoids during the early stages of actinorhizal nodulation. ..
- Cai Q, Dierich A, Oulad Abdelghani M, Chan S, Kastner P. Helios deficiency has minimal impact on T cell development and function. J Immunol. 2009;183:2303-11 pubmed publisher..These results suggest that Helios is not essential for T cells, and that its function can be compensated for by other members of the Ikaros family. ..
- Jousse C, Deval C, Maurin A, Parry L, Cherasse Y, Chaveroux C, et al. TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway. J Biol Chem. 2007;282:15851-61 pubmed..Collectively, our data identify TRB3 as a negative feedback regulator of the ATF4-dependent transcription and participates to the fine regulation of the ISR. ..
- Soares H, Henriques R, Sachse M, Ventimiglia L, Alonso M, Zimmer C, et al. Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse. J Exp Med. 2013;210:2415-33 pubmed publisher..This mechanism is required for priming IL-2 and IFN-? production and may contribute to fine-tuning T cell activation breadth in response to different stimulatory conditions. ..
- Vayssie L, Garreau de Loubresse N, Sperling L. Growth and form of secretory granules involves stepwise assembly but not differential sorting of a family of secretory proteins in Paramecium. J Cell Sci. 2001;114:875-86 pubmed..We present a model for trichocyst biogenesis in which TMP assembly is controlled by protein processing...
- Wydau S, van der Rest G, Aubard C, Plateau P, Blanquet S. Widespread distribution of cell defense against D-aminoacyl-tRNAs. J Biol Chem. 2009;284:14096-104 pubmed publisher..Moreover, one or several dtd3-like genes can be recognized in all cellular types, arguing in favor of the nearubiquity of an enzymatic function involved in the defense of translational systems against invasion by d-amino acids. ..
- Gaulin E, Haget N, Khatib M, Herbert C, Rickauer M, Bottin A. Transgenic sequences are frequently lost in Phytophthora parasitica transformants without reversion of the transgene-induced silenced state. Can J Microbiol. 2007;53:152-7 pubmed..This suggests that instability of P. parasitica transformants is not an obstacle for loss-of-function studies in this organism. ..
- Garel S, Marin F, Grosschedl R, Charnay P. Ebf1 controls early cell differentiation in the embryonic striatum. Development. 1999;126:5285-94 pubmed
- Pujol A, Hindelang C, Callizot N, Bartsch U, Schachner M, Mandel J. Late onset neurological phenotype of the X-ALD gene inactivation in mice: a mouse model for adrenomyeloneuropathy. Hum Mol Genet. 2002;11:499-505 pubmed..The phenotype of ALD-deficient mice mimics features of human AMN, thus providing a model for investigating the pathogenesis of this disease...
- Lawrence M, Daujat S, Schneider R. Lateral Thinking: How Histone Modifications Regulate Gene Expression. Trends Genet. 2016;32:42-56 pubmed publisher..We suggest that these lateral surface modifications represent a key insight into chromatin regulation in the cell. Therefore, lateral surface modifications form a key area of interest and a focal point of ongoing study in epigenetics. ..
- Guizetti J, Scherf A. Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum. Cell Microbiol. 2013;15:718-26 pubmed publisher..Integrating findings about all clonally variant gene families and other mutually exclusive expression systems will hopefully drive mechanistic understanding of antigenic variation. ..
- Alhagdow M, Mounet F, Gilbert L, Nunes Nesi A, Garcia V, Just D, et al. Silencing of the mitochondrial ascorbate synthesizing enzyme L-galactono-1,4-lactone dehydrogenase affects plant and fruit development in tomato. Plant Physiol. 2007;145:1408-22 pubmed..Moreover, it strongly suggests that, in addition to ascorbate synthesis, GalLDH could play an important role in the regulation of cell growth-related processes in plants. ..
- Cases O, Perea Gomez A, Aguiar D, Nykjaer A, Amsellem S, Chandellier J, et al. Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head. J Biol Chem. 2013;288:16655-70 pubmed publisher..We propose that plasma membrane binding of Fgf8, and most likely of the Fgf8 family members Fgf17 and Fgf18, to Cubn improves Fgf ligand endocytosis and availability to FgfRs, thus modulating Fgf signaling activity. ..
- Blein T, Pulido A, Vialette Guiraud A, Nikovics K, Morin H, Hay A, et al. A conserved molecular framework for compound leaf development. Science. 2008;322:1835-9 pubmed publisher..This domain has a dual role promoting leaflet separation locally and leaflet formation at distance. In this manner, boundaries of compound leaves resemble boundaries functioning during animal development...
- Scherf A, Lopez Rubio J, Rivière L. Antigenic variation in Plasmodium falciparum. Annu Rev Microbiol. 2008;62:445-70 pubmed publisher..In addition, controversies surrounding var genetic elements in antigenic variation are discussed. ..
- Malinsky S, Bucheton A, Busseau I. New insights on homology-dependent silencing of I factor activity by transgenes containing ORF1 in Drosophila melanogaster. Genetics. 2000;156:1147-55 pubmed..No effect of ORF1 is detected when it is controlled by the I factor promoter. We discuss the relevance of the described regulation to the repression of I factors in I strains. ..
- Fourel G, Boscheron C, Revardel E, Lebrun E, Hu Y, Simmen K, et al. An activation-independent role of transcription factors in insulator function. EMBO Rep. 2001;2:124-32 pubmed..These findings predict that certain promoters behave as insulators and partition genomes in functionally independent domains. ..
- Maynadier M, Ramirez J, Cathiard A, Platet N, Gras D, Gleizes M, et al. Unliganded estrogen receptor alpha inhibits breast cancer cell growth through interaction with a cyclin-dependent kinase inhibitor (p21(WAF1)). FASEB J. 2008;22:671-81 pubmed..Taken together, our results point to an antiproliferative function of the unliganded ER alpha through its physical interactions with p21(WAF1) that may also explain the favorable prognosis of ER alpha-positive breast cancers. ..
- Pham B, Ramelet S, Wibaut B, Juszczak G, Loukil C, Dubeaux I, et al. Molecular background of novel silent RHCE alleles. Transfusion. 2013;53:2990-9 pubmed publisher..Regarding the RH system, silent alleles may not be investigated among D-?- or Rhnull individuals only. Rh phenotype and/or serologic data unexplained by inheritance of conventional RH alleles should lead to molecular investigations. ..
- El Wakil A, Bandulik S, Guy N, Bendahhou S, Zennaro M, Niehrs C, et al. Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex. Hum Mol Genet. 2012;21:4922-9 pubmed publisher..Our data show that Dkk3 can act as a modifier gene in a mouse model for altered potassium channel function and suggest its potential involvement in human PA syndromes. ..
- Desroches Castan A, Cherradi N, Feige J, Ciais D. A novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3'-end processing. Mol Biol Cell. 2011;22:3625-33 pubmed publisher..This work constitutes the first description of a new function for Tis11b in mammalian cell mRNA 3'-end maturation. ..
- Corbel C, Diabangouaya P, Gendrel A, Chow J, Heard E. Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells. Development. 2013;140:861-72 pubmed publisher..This unusual combination of silent and active features is likely to reflect, and might underlie, the partial activity of the X chromosome in TGCs...
- Vandamme J, Volkel P, Rosnoblet C, Le Faou P, Angrand P. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Mol Cell Proteomics. 2011;10:M110.002642 pubmed publisher..Finally, we suggest that differences in CBX protein interactions would account, at least in part, for distinct subnuclear localization of the CBX family members. ..
- ..Finally, novel studies were undertaken to elucidate mechanisms leading to selection in virus population, according to the host or its environment, opening a new research area in plant-virus coevolution. ..
- Brodersen P, Sakvarelidze Achard L, Schaller H, Khafif M, Schott G, Bendahmane A, et al. Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis. Proc Natl Acad Sci U S A. 2012;109:1778-83 pubmed publisher..These results suggest a possible basis for the requirement of isoprenoid biosynthesis for the activity of plant miRNAs, and unravel mechanistic features shared with their metazoan counterparts. ..
- Deltour S, Guerardel C, Leprince D. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proc Natl Acad Sci U S A. 1999;96:14831-6 pubmed..Taken together, our studies show that the recruitment onto target promoters of an HDAC complex is not a general property of transcriptional repressors containing a conserved BTB/POZ domain. ..
- D Autréaux F, Coppola E, Hirsch M, Birchmeier C, Brunet J. Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways. Proc Natl Acad Sci U S A. 2011;108:20018-23 pubmed publisher..Thus, the cranial sensory pathways, somatic and visceral, are related, and Phox2b serves as a developmental switch from the former to the latter...
- Xu L, Shen W. Polycomb silencing of KNOX genes confines shoot stem cell niches in Arabidopsis. Curr Biol. 2008;18:1966-71 pubmed publisher..We propose a model in which AtRING1a, AtRING1b, and LHP1 form a PRC1-like complex, which binds trimethyl-H3K27 marked by the CLF-containing PRC2, resulting in transcriptional suppression of KNOX. ..
- Trian T, Girodet P, Ousova O, Marthan R, Tunon de Lara J, Berger P. RNA interference decreases PAR-2 expression and function in human airway smooth muscle cells. Am J Respir Cell Mol Biol. 2006;34:49-55 pubmed..Transfection efficiency was maximal after 24 h and disappeared after 48 h. Gene silencing using siRNA can thus be used in vitro to assess the function of PAR-2 in HASMC. ..
- Roudier N, Lefebvre C, Legouis R. CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans. Traffic. 2005;6:695-705 pubmed..These results indicate that CeVPS-27 is required for endosomal and autophagic pathways in C. elegans and plays a crucial role in the control of molting through LRP-1 internalization and cholesterol traffic. ..
- Wassmer T, Froissard M, Plattner H, Kissmehl R, Cohen J. The vacuolar proton-ATPase plays a major role in several membrane-bounded organelles in Paramecium. J Cell Sci. 2005;118:2813-25 pubmed..The V-ATPase was found to be crucial for osmoregulation, the phagocytotic pathway and the biogenesis of dense core secretory granules. No evidence was found supporting participation of V0 in membrane fusion. ..
- Bezy O, Elabd C, Cochet O, Petersen R, Kristiansen K, Dani C, et al. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. J Biol Chem. 2005;280:11432-8 pubmed..Thus, DIPA is a novel partner of C/EBP beta that down-regulates early events of adipogenesis. ..
- Rahier A, Darnet S, Bouvier F, Camara B, Bard M. Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana. J Biol Chem. 2006;281:27264-77 pubmed..These two novel oxidative decarboxylases constitute the first molecularly and functionally characterized HSDs from a short chain dehydrogenase/reductase family in plants. ..
- Chaumeil J, Le Baccon P, Wutz A, Heard E. A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes Dev. 2006;20:2223-37 pubmed
- Vazquez F, Gasciolli V, Crété P, Vaucheret H. The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing. Curr Biol. 2004;14:346-51 pubmed..elegans and Drosophila, respectively. ..
- Boutet S, Vazquez F, Liu J, Beclin C, Fagard M, Gratias A, et al. Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance. Curr Biol. 2003;13:843-8 pubmed
- Barbot W, Dupressoir A, Lazar V, Heidmann T. Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction. Nucleic Acids Res. 2002;30:2365-73 pubmed..This phenomenon, which develops on a timescale of months to years in the aging mouse, might reveal a general epigenetic--and stochastic--process, which could account for a large series of events associated with cell and animal aging. ..
- Grienenberger A, Miotto B, Sagnier T, Cavalli G, Schramke V, Geli V, et al. The MYST domain acetyltransferase Chameau functions in epigenetic mechanisms of transcriptional repression. Curr Biol. 2002;12:762-6 pubmed
- Ogata H, Audic S, Renesto Audiffren P, Fournier P, Barbe V, Samson D, et al. Mechanisms of evolution in Rickettsia conorii and R. prowazekii. Science. 2001;293:2093-8 pubmed..A 38-kilobase sequence inversion was dated shortly after the divergence of the genus...
- Vial L, Gomez P, Panvert M, Schmitt E, Blanquet S, Mechulam Y. Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: gene disruption and tRNA substrate specificity. Biochemistry. 2003;42:932-9 pubmed..Each mechanism appears well suited to an efficient selection of the substrate within the pool of all tRNAs. ..
- Mascrez B, Ghyselinck N, Watanabe M, Annicotte J, Chambon P, Auwerx J, et al. Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep. 2004;5:285-90 pubmed..Our results also indicate that RXRbeta may be activated by a ligand distinct from 9-cis retinoic acid...
- Bouhouche K, Zickler D, Debuchy R, Arnaise S. Altering a gene involved in nuclear distribution increases the repeat-induced point mutation process in the fungus Podospora anserina. Genetics. 2004;167:151-9 pubmed..Our results suggest that the developmental slowdown of the ami1 mutant during the period of RIP and PR increases time exposure to the duplication detection system and thus increases the frequency of RIP and PR...
- Garcon L, Lacout C, Svinartchouk F, Le Couedic J, Villeval J, Vainchenker W, et al. Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells. Blood. 2005;105:1448-55 pubmed..Deletion of the SNAG repressor domain abolished Gfi-1B-induced erythroid maturation, strongly suggesting that Gfi-1B acts in the late stage of erythroid differentiation as a transcriptional repressor. ..
- Prévost G, Arabo A, Jian L, Quelennec E, Cartier D, Hassan S, et al. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human ?-cells and its targeted inactivation impairs glucose tolerance. Endocrinology. 2013;154:3796-806 pubmed publisher..Our findings are the first to show that the PACAP-regulated SelT is localized in pancreatic ?- and ?-cells and is involved in the control of glucose homeostasis. ..
- Lauritzen I, Chemin J, Honore E, Jodar M, Guy N, Lazdunski M, et al. Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton. EMBO Rep. 2005;6:642-8 pubmed..Conversely, the actin cytoskeleton tonically represses TREK-1 mechano-sensitivity. Thus, the dialogue between TREK-1 and the actin cytoskeleton might influence both synaptogenesis and neuronal electrogenesis. ..
- Fagard M, Boutet S, Morel J, Bellini C, Vaucheret H. AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals. Proc Natl Acad Sci U S A. 2000;97:11650-4 pubmed..These results raise the possibility that PTGS, or at least some of its elements, could participate in the regulation of gene expression during development in plants. ..
- Wozny A, Lauret A, Battiston Montagne P, Guy J, Beuve M, Cunha M, et al. Differential pattern of HIF-1Î± expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect. Br J Cancer. 2017;116:1340-1349 pubmed publisher..Hypoxia-inducible factor-1Î± plays a main role in the response of CSCs and non-CSCs to carbon ion and photon irradiations, which makes the HIF-1Î± targeting an attractive therapeutic challenge. ..
- Krejbich Trotot P, Gay B, Li Pat Yuen G, Hoarau J, Jaffar Bandjee M, Briant L, et al. Chikungunya triggers an autophagic process which promotes viral replication. Virol J. 2011;8:432 pubmed publisher..Here we provide the first evidence that hallmarks of autophagy are specifically found in HEK.293 infected cells and are involved in ChikV replication...
- Ragni L, Belles Boix E, Günl M, Pautot V. Interaction of KNAT6 and KNAT2 with BREVIPEDICELLUS and PENNYWISE in Arabidopsis inflorescences. Plant Cell. 2008;20:888-900 pubmed publisher..Hence, our data showed that BP and PNY restrict KNAT6 and KNAT2 expression to promote correct inflorescence development. This interaction was also revealed in the carpel. ..
- Diop S, Bertaux K, Vasanthi D, Sarkeshik A, Goirand B, Aragnol D, et al. Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control. EMBO Rep. 2008;9:260-6 pubmed publisher..Furthermore, the enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output. ..
- Hofmann C, Sambade A, Heinlein M. Plasmodesmata and intercellular transport of viral RNA. Biochem Soc Trans. 2007;35:142-5 pubmed..Studies using tobacco mosaic virus have led to the identification of host components that participate in plasmodesmal targeting of viral RNA and movement protein...
- Marteau J, Rigaud O, Brugat T, Gault N, Vallat L, Kruhoffer M, et al. Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of RELB in an aggressive subset of chronic lymphocytic leukemia in males. BMC Med Genomics. 2010;3:53 pubmed publisher..Together, these results highlighted the epigenetic RELB silencing as a new marker of the progressive disease in males. ..
- Zhu Y, Dong A, Meyer D, Pichon O, Renou J, Cao K, et al. Arabidopsis NRP1 and NRP2 encode histone chaperones and are required for maintaining postembryonic root growth. Plant Cell. 2006;18:2879-92 pubmed..Both proteins specifically bind histones H2A and H2B and associate with chromatin in vivo. We propose that NRP1 and NRP2 act as H2A/H2B chaperones in the maintenance of dynamic chromatin in epigenetic inheritance. ..
- Bouvier F, Linka N, Isner J, Mutterer J, Weber A, Camara B. Arabidopsis SAMT1 defines a plastid transporter regulating plastid biogenesis and plant development. Plant Cell. 2006;18:3088-105 pubmed publisher..Biochemical analysis suggests that the latter effect represents one prominent example of the multiple events triggered by undermethylation, when there is decreased SAM flux into plastids...
- Bertero T, Gastaldi C, Bourget Ponzio I, Imbert V, Loubat A, Selva E, et al. miR-483-3p controls proliferation in wounded epithelial cells. FASEB J. 2011;25:3092-105 pubmed publisher..miR-483-3p-mediated down-regulation of MK2, MKI67, and YAP1 thus represents a novel mechanism controlling keratinocyte growth arrest at the final steps of reepithelialization. ..
- Wassmer T, Kissmehl R, Cohen J, Plattner H. Seventeen a-subunit isoforms of paramecium V-ATPase provide high specialization in localization and function. Mol Biol Cell. 2006;17:917-30 pubmed..Interestingly, some chimeras provoked deleterious effects, locally in their target compartment, or remotely, in the compartment whose specific a-subunit N terminus was used in the chimera...
- Elmayan T, Proux F, Vaucheret H. Arabidopsis RPA2: a genetic link among transcriptional gene silencing, DNA repair, and DNA replication. Curr Biol. 2005;15:1919-25 pubmed..These results suggest a coordination of the TGS machinery with DNA replication, repair, or recombination machinery at some loci, and they emphasize the diversification of the TGS pathway. ..
- Dupuis Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits Iacovoni F, et al. The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness. J Biol Chem. 2011;286:32105-14 pubmed publisher..Accordingly, immunofluorescence studies confirm a perturbation of matrix metalloproteinase 9 localization at the cell surface and defect in maturation. Altogether, these results suggest a role for PIKfyve in NPM-ALK-mediated invasion. ..
- Bellot G, Cartron P, Er E, Oliver L, Juin P, Armstrong L, et al. TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax. Cell Death Differ. 2007;14:785-94 pubmed..Our data provide a new perspective on the mechanism of association of Bax with mitochondria as it involves a classical import pathway. ..
- Burger C, Rondet S, Benveniste P, Schaller H. Virus-induced silencing of sterol biosynthetic genes: identification of a Nicotiana tabacum L. obtusifoliol-14alpha-demethylase (CYP51) by genetic manipulation of the sterol biosynthetic pathway in Nicotiana benthamiana L. J Exp Bot. 2003;54:1675-83 pubmed
- Therizols P, Fairhead C, Cabal G, Genovesio A, Olivo Marin J, Dujon B, et al. Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric region. J Cell Biol. 2006;172:189-99 pubmed..They also indicate that anchoring of telomeres is essential for efficient repair of DSBs occurring therein and is important for preserving genome integrity. ..
- Liu C, Tonini L, Malaga W, Beau M, Stella A, Bouyssie D, et al. Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2013;110:6560-5 pubmed publisher..These data are unique in providing evidence of the biological significance of protein O-mannosylation in mycobacteria and demonstrate the crucial contribution of this protein posttranslational modification to Mtb virulence in the host. ..
- Déjardin J, Rappailles A, Cuvier O, Grimaud C, Decoville M, Locker D, et al. Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1. Nature. 2005;434:533-8 pubmed..The binding of DSP1 to PREs is therefore important for the recruitment of PcG proteins. ..
- Foveau B, Boulay G, Pinte S, Van Rechem C, Rood B, Leprince D. The receptor tyrosine kinase EphA2 is a direct target gene of hypermethylated in cancer 1 (HIC1). J Biol Chem. 2012;287:5366-78 pubmed publisher..Thus, loss of the regulation of this Eph pathway through HIC1 epigenetic silencing could be an important mechanism in the pathogenesis of epithelial cancers. ..
- Galvani A, Sperling L. Transgene-mediated post-transcriptional gene silencing is inhibited by 3' non-coding sequences in Paramecium. Nucleic Acids Res. 2001;29:4387-94 pubmed
- Fuentes L, Wouters K, Hannou S, Cudejko C, Rigamonti E, Mayi T, et al. Downregulation of the tumour suppressor p16INK4A contributes to the polarisation of human macrophages toward an adipose tissue macrophage (ATM)-like phenotype. Diabetologia. 2011;54:3150-6 pubmed publisher..These results show that p16(INK4A) inhibits the acquisition of the ATM phenotype. The age-related increase in p16(INK4A) level may thus influence normal ATM function and contribute to type 2 diabetes risk. ..
- Cherrier T, Suzanne S, Redel L, Calao M, Marban C, Samah B, et al. p21(WAF1) gene promoter is epigenetically silenced by CTIP2 and SUV39H1. Oncogene. 2009;28:3380-9 pubmed publisher..Altogether, our results suggest that CTIP2 is a constitutive p21 gene suppressor that cooperates with SUV39H1 and histone methylation to silence the p21 gene transcription...
- Marin L, Lehmann M, Nouaud D, Izaabel H, Anxolabehere D, Ronsseray S. P-Element repression in Drosophila melanogaster by a naturally occurring defective telomeric P copy. Genetics. 2000;155:1841-54 pubmed..Conversely, a second P-lacZ construct, in which the fusion with lacZ takes place in exon 3 of P, was successfully repressed by NA-P(1A). This suggests that NA-P(1A) repression involves a homology-dependent component. ..
- Abekhoukh S, Sahin H, Grossi M, Zongaro S, Maurin T, Madrigal I, et al. New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes. Dis Model Mech. 2017;10:463-474 pubmed publisher..Collectively, our results illustrate a new model to explain the cellular roles of FMRP and CYFIP1 and the molecular significance of their interaction. ..
- Bergamaschi A, Ayinde D, David A, Le Rouzic E, Morel M, Collin G, et al. The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection. J Virol. 2009;83:4854-60 pubmed publisher..Altogether, our data point to a mechanism in which Vpx diverts the Cul4A-DDB1(DCAF1) ligase to inactivate an evolutionarily conserved factor, which restricts macrophage infection by HIV-2 and closely related simian viruses. ..