Genomes and Genes
Experts and Doctors on gene expression regulation in United States
Locale: United States
Topic: gene expression regulation
Publications1283 found, 100 shown here
- Picca A, Pesce V, Fracasso F, Joseph A, Leeuwenburgh C, Lezza A. A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. Biochim Biophys Acta. 2014;1840:2184-91 pubmed publisher..Aging and CR appear to induce similar mitochondrial molecular mechanisms in the skeletal muscle and liver, different from those elicited in the frontal cortex. ..
- Kirby T, Walton R, Finlin B, Zhu B, Unal R, Rasouli N, et al. Integrative mRNA-microRNA analyses reveal novel interactions related to insulin sensitivity in human adipose tissue. Physiol Genomics. 2016;48:145-53 pubmed publisher..We suggest that use of bioinformatic integration of mRNA and microRNA arrays yields verifiable mRNA-microRNA pairs that are associated with insulin resistance and can be validated in vitro. ..
- Dai J, Kumbhare A, Youssef D, Yao Z, McCall C, El Gazzar M. Expression of C/EBPβ in myeloid progenitors during sepsis promotes immunosuppression. Mol Immunol. 2017;91:165-172 pubmed publisher..Together, these results support that decreasing C/EBPβ expression prevents MDSC generation and decreases immunosuppression in septic mice, providing a target for sepsis treatment. ..
- Miyazaki M, Dobrzyn A, Man W, Chu K, Sampath H, Kim H, et al. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J Biol Chem. 2004;279:25164-71 pubmed
- Zhao Z, Fang L, Chen N, Johnsen R, Stein L, Baillie D. Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans. J Biol Chem. 2005;280:38787-94 pubmed..The results indicate that distinct regulatory elements are able to mediate the similar expression patterns. ..
- Sonntag K, Pruszak J, Yoshizaki T, van Arensbergen J, Sanchez Pernaute R, Isacson O. Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells. 2007;25:411-8 pubmed..After transplantation of differentiated hESCs to a rodent model of PD, some grafts contained human midbrain-like DA neurons. This protocol demonstrates hESC derivation and survival of human DA neurons appropriate for cell therapy in PD. ..
- Menon B, Johnson J, Ross R, Singh M, Singh K. Glycogen synthase kinase-3beta plays a pro-apoptotic role in beta-adrenergic receptor-stimulated apoptosis in adult rat ventricular myocytes: Role of beta1 integrins. J Mol Cell Cardiol. 2007;42:653-61 pubmed..The apoptotic effects of GSK-3beta may be mediated, at least in part, via its nuclear localization and induction of pro-apoptotic genes, such as Gadd153. ..
- Ghanim H, Mohanty P, Deopurkar R, Sia C, Korzeniewski K, Abuaysheh S, et al. Acute modulation of toll-like receptors by insulin. Diabetes Care. 2008;31:1827-31 pubmed publisher..1 following dextrose or saline infusion in the control groups. Insulin suppresses the expression of several TLRs at the transcriptional level, possibly through its suppressive effect on PU.1. ..
- Paulus E, Mintz E. Developmental disruption of the serotonin system alters circadian rhythms. Physiol Behav. 2012;105:257-63 pubmed publisher..These results suggest that developmental loss of serotonergic input to the clock has long-term consequences for both circadian clock parameters and the temporal organization of activity. ..
- Shilatifard A. The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem. 2012;81:65-95 pubmed publisher..The misregulation of histone H2B monoubiquitination and H3K4 methylation result in the pathogenesis of human diseases, including cancer. Recent findings in this regard are also examined. ..
- Haque M, Song J, Fino K, Wang Y, Sandhu P, Song X, et al. C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection. Open Biol. 2016;6:150208 pubmed publisher..These results identify c-Myc as a key controller of memory CD8(+) T cells from costimulatory signals. ..
- Croce C, Calin G. miRNAs, cancer, and stem cell division. Cell. 2005;122:6-7 pubmed..As a cluster of recent Nature papers now show, altered expression of specific miRNA genes contributes to the initiation and progression of cancer. ..
- Slomiany M, Rosenzweig S. Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion. J Pharmacol Exp Ther. 2006;318:666-75 pubmed..In conclusion, IGF-1 regulates VEGF expression and secretion via HIF-1-dependent and -independent pathways. ..
- Carter R, Myers R. Germinal center structure and function: lessons from CD19. Semin Immunol. 2008;20:43-8 pubmed publisher..Loss of these signals leads to surprising changes in germinal center B cells that challenge previous models of GC function. ..
- Vinuela A, Hallett P, Reske Nielsen C, Patterson M, Sotnikova T, Caron M, et al. Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. Brain. 2008;131:3361-79 pubmed publisher..Wild-type dopaminergic neurons appear to be the most effective neuronal type to restore function and reduce L-dopa-induced dyskinesias. ..
- PARK K, Yule D, Bowers W. Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter. J Biol Chem. 2009;284:27557-66 pubmed publisher..Overall, these data delineate a key pathway by which TNF-alpha in a neuronal environment modulates IP(3)R expression and intracellular Ca(2+) homeostasis. ..
- Bates D, Li N, Liang R, Sarojini H, An J, Masternak M, et al. MicroRNA regulation in Ames dwarf mouse liver may contribute to delayed aging. Aging Cell. 2010;9:1-18 pubmed publisher..Furthermore, compared to its normal siblings, the dwarf mouse exhibits a head start in regulating these pathways to control their normality, which may ultimately contribute to its extended health-span and longevity. ..
- Sahay B, Patsey R, Eggers C, Salazar J, Radolf J, Sellati T. CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance. PLoS Pathog. 2009;5:e1000687 pubmed publisher..Perturbation of this CD14/p38-MAPK-dependent immune regulation may underlie development of infectious chronic inflammatory syndromes. ..
- Gong Q, Stump M, Dunn A, Deng V, Zhou Z. Alternative splicing and polyadenylation contribute to the generation of hERG1 C-terminal isoforms. J Biol Chem. 2010;285:32233-41 pubmed publisher..Taken together, these findings suggest that post-transcriptional regulation of hERG1 pre-mRNA may represent a novel mechanism to modulate the expression and function of hERG1 channels. ..
- Huang Y, Xiao Y, Allred D. Unusual chromatin structure associated with monoparalogous transcription of the Babesia bovis ves multigene family. Int J Parasitol. 2013;43:163-72 pubmed publisher..Based upon these results a working model is proposed for the chromatin structural remodeling responsible for the sequential expression of ves multigene family members from divergently-organized loci...
- Jurczyk A, Nowosielska A, Przewozniak N, Aryee K, Diiorio P, Blodgett D, et al. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic Î²-cell function via glycogen synthase kinase-3Î². FASEB J. 2016;30:983-93 pubmed publisher..3 nM) rescued the Î²-cell defects. These results uncover an unexpected role for DISC1 in normal Î²-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition. ..
- Tallafuss A, Kelly M, Gay L, Gibson D, Batzel P, Karfilis K, et al. Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 2015;16:1100 pubmed publisher..This important insight and the lists of enriched genes we have identified will now help pave the way to a better understanding of the mechanisms of embryonic and adult neuronal differentiation and how to manipulate these processes. ..
- Staudinger J, Madan A, Carol K, Parkinson A. Regulation of drug transporter gene expression by nuclear receptors. Drug Metab Dispos. 2003;31:523-7 pubmed
- Pattison J, Conley A, Bird I. Isolation of marmoset P450c17 cDNA and gene regulation in vitro. Endocr Res. 2004;30:737-43 pubmed..Since marmoset adrenocortical cells exhibit similar endocrine function to rhesus, impaired 17,20-lyase activity in the adult marmoset adrenal may in part be due to differences in the primary sequence. ..
- Huh J, Foe I, Muro I, Chen C, Seol J, Yoo S, et al. The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis i. J Biol Chem. 2007;282:2056-68 pubmed..Therefore, diap2 may identify a point of convergence between apoptosis and immune signaling pathways. ..
- Gurung B, Yu L, Yu C. Stigmatellin induces reduction of iron-sulfur protein in the oxidized cytochrome bc1 complex. J Biol Chem. 2008;283:28087-94 pubmed publisher..This results in the reduction of ISP and generation of organic radicals...
- Minhajuddin M, Bijli K, Fazal F, Sassano A, Nakayama K, Hay N, et al. Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. J Biol Chem. 2009;284:4052-61 pubmed publisher..Thus, these data reveal an important role of PKC-delta and PI3K/Akt pathways in activating mTOR as an endogenous modulator to ensure a tight regulation of NF-kappaB signaling of ICAM-1 expression in endothelial cells. ..
- Fu X, Spindel E. Recruitment of GABA(A) receptors in chemoreceptor pulmonary neuroepithelial bodies by prenatal nicotine exposure in monkey lung. Adv Exp Med Biol. 2009;648:439-45 pubmed publisher..The interaction of the intrinsic GABAergic system in the lung with nicotinic receptors in PNEC/NEB may provide a mechanism to explain the link between smoking during pregnancy and SIDS. ..
- Ay F, Xu F, Kahveci T. Scalable steady state analysis of Boolean biological regulatory networks. PLoS ONE. 2009;4:e7992 pubmed publisher..Source code of this work is available at http://bioinformatics.cise.ufl.edu/palSteady.html twocolumnfalse]. ..
- Peluso J, Liu X, Gawkowska A, Lodde V, Wu C. Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression. Mol Cell Endocrinol. 2010;320:153-61 pubmed publisher..Taken together, the present studies suggest a genomic component to PGRMC1's anti-apoptotic mechanism of action, which requires the presence of the PGRMC1 dimer. ..
- Bevan A, Duque S, Foust K, Morales P, Braun L, Schmelzer L, et al. Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders. Mol Ther. 2011;19:1971-80 pubmed publisher..Our findings support the use of AAV9 for gene transfer to the CNS for disorders in pediatric populations. ..
- Nayak L, Goduni L, Takami Y, Sharma N, Kapil P, Jain M, et al. Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation. Am J Pathol. 2013;182:1696-704 pubmed publisher..Collectively, the observations provide biologically relevant insights into KLF2-mediated modulation of these inflammatory processes that could potentially be manipulated for therapeutic gain. ..
- Skeath J, Carroll S. Regulation of proneural gene expression and cell fate during neuroblast segregation in the Drosophila embryo. Development. 1992;114:939-46 pubmed..It appears that one key function of the neurogenic genes is to silence proneural gene expression within the nonsegregating cells of the initial ectodermal clusters, thereby permitting epidermal development. ..
- Belgrader P, Maquat L. Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol Cell Biol. 1994;14:6326-36 pubmed..This suggests that a 5' splice site may extend as far as 12 nucleotides into the upstream exon, which is, to our knowledge, the largest extension. ..
- Asch H, Eliacin E, Fanning T, Connolly J, Bratthauer G, Asch B. Comparative expression of the LINE-1 p40 protein in human breast carcinomas and normal breast tissues. Oncol Res. 1996;8:239-47 pubmed..Our data indicated that expression of the L1Hs p40 protein was often elevated in tumor cells of human breast cancers compared to epithelium of normal mammary gland. ..
- Huang H, Kaku S, Knights C, Park B, Clifford J, Kulesz Martin M. Repression of transcription and interference with DNA binding of TATA-binding protein by C-terminal alternatively spliced p53. Exp Cell Res. 2002;279:248-59 pubmed
- Liu Z, Shi W, Ji X, Sun C, Jee W, Wu Y, et al. Molecules mimicking Smad1 interacting with Hox stimulate bone formation. J Biol Chem. 2004;279:11313-9 pubmed
- Gosselin L, Williams J, Deering M, Brazeau D, Koury S, Martinez D. Localization and early time course of TGF-beta 1 mRNA expression in dystrophic muscle. Muscle Nerve. 2004;30:645-53 pubmed..Therapeutic interventions aimed at neutralizing this cytokine may be beneficial in slowing the development of fibrosis in DMD. ..
- Yuan G, Nanduri J, Bhasker C, Semenza G, Prabhakar N. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 2005;280:4321-8 pubmed..These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase. ..
- Maeda A, Crabb J, Palczewski K. Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry. 2005;44:480-9 pubmed..These results support an important protective function for MGST1 against oxidative insult in the RPE that decreases with age and suggest that this enzyme may play a role in the development of age-related diseases such as AMD. ..
- Pan L, Glenn S, Jones C, Gross K. Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch. J Biol Chem. 2005;280:20860-6 pubmed..PBX1b.PREP1 activate the rat renin promoter cooperatively in COS-7 cells. These results strongly suggest that the renin gene is a downstream target of the Notch signaling pathway. ..
- Huang D, Shi F, Jung S, Pien G, Wang J, Salazar Mather T, et al. The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J. 2006;20:896-905 pubmed..These results are the first to define a chemokine that governs NK cell migration to the CNS, and the findings suggest novel therapeutic manipulation of CX3CR1+ NK cells. ..
- Burke C, Cardenas H, Mussard M, Gasser C, Day M. Steroidogenic changes and steady state amount of messenger RNA encoding steroidogenic enzymes, gonadotropin receptors and cell-death signalling in the dominant ovarian follicle during estradiol-induced atresia in cattle. Anim Reprod Sci. 2007;99:244-57 pubmed..A transient suppression in circulating FSH following administration of EB appears to have initiated these events, and it is suggested that subsequent processes involved in atresia follow this loss in estrogenic function. ..
- Villeneuve D, Blake L, Brodin J, Greene K, Knoebl I, Miracle A, et al. Transcription of key genes regulating gonadal steroidogenesis in control and ketoconazole- or vinclozolin-exposed fathead minnows. Toxicol Sci. 2007;98:395-407 pubmed
- Gruver A, Yard B, McInnes C, Rajesh C, Pittman D. Functional characterization and identification of mouse Rad51d splice variants. BMC Mol Biol. 2009;10:27 pubmed publisher..These results suggest Rad51d alternative splice variants potentially modulate mechanisms of HR by sequestering either RAD51C or XRCC2. ..
- Zhang X, Dowd D, Moore M, Kranenburg T, Meester Smoor M, Zwarthoff E, et al. Meningioma 1 is required for appropriate osteoblast proliferation, motility, differentiation, and function. J Biol Chem. 2009;284:18174-83 pubmed publisher..Cumulatively, these studies indicate an important role for MN1 in maintaining the appropriate maturation and function of calvarial osteoblasts. ..
- Chikina M, Huttenhower C, Murphy C, Troyanskaya O. Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans. PLoS Comput Biol. 2009;5:e1000417 pubmed publisher..To our knowledge, this is the first study producing high-accuracy predictions of tissue-specific expression and interactions for a metazoan organism based on whole-animal data. ..
- Lin H, Cody V, Davis F, Hercbergs A, Luidens M, Mousa S, et al. Identification and functions of the plasma membrane receptor for thyroid hormone analogues. Discov Med. 2011;11:337-47 pubmed..Thus, the receptor described on integrin ?v?3 for T(4) and T(3), the function of which is materially affected by tetrac and nanotetrac, provides insight into tumor cell biology and vascular biology. ..
- Challagundla K, Sun X, Zhang X, Devine T, Zhang Q, Sears R, et al. Ribosomal protein L11 recruits miR-24/miRISC to repress c-Myc expression in response to ribosomal stress. Mol Cell Biol. 2011;31:4007-21 pubmed publisher..Together, our results identify a novel regulatory paradigm wherein L11 plays a critical role in controlling c-myc mRNA turnover via recruiting miRISC in response to ribosomal stress. ..
- Saggu S, Cannon T, Jentsch J, Lavin A. Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice. Schizophr Res. 2013;146:254-63 pubmed publisher..Our results provide new insights into the mechanisms of action of dysbindin-1. ..
- Yockey L, Demehri S, Turkoz M, Turkoz A, Ahern P, Jassim O, et al. The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation. J Invest Dermatol. 2013;133:2714-2721 pubmed publisher..These findings suggest a role for the microbiota in ameliorating stress signals released by keratinocytes in response to perturbation in cutaneous barrier function. ..
- Cheng K, Kiernan E, Eliceiri K, Williams J, Watters J. Blue Light Modulates Murine Microglial Gene Expression in the Absence of Optogenetic Protein Expression. Sci Rep. 2016;6:21172 pubmed publisher..Further studies are needed to elucidate the molecular mechanisms and potential therapeutic utility of blue light modulation of the wild type CNS. ..
- Phelps M, Coss C, Wang H, Cook M. Registered report: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. elife. 2016;5: pubmed publisher..The Reproducibility Project: Cancer Biology is a collaboration between the Center for Open Science and Science Exchange, and the results of the replications will be published by eLife. ..
- Kigerl K, Ankeny D, Garg S, Wei P, Guan Z, Lai W, et al. System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo. Exp Neurol. 2012;233:333-41 pubmed publisher..Together, these data indicate that modulation of redox balance in CNS macrophages, perhaps through regulating system x(c)(-), could be a novel approach for attenuating injurious neuroinflammatory cascades. ..
- Joo J, Correia G, Li J, Lopez M, Baker H, Sugrue S. Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2013;54:697-707 pubmed publisher..Our data suggested that ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in HCET cells to maintain or enhance epithelial characteristics. ..
- Hoog C, Calzone F, Cutting A, Britten R, Davidson E. Gene regulatory factors of the sea urchin embryo. II. Two dissimilar proteins, P3A1 and P3A2, bind to the same target sites that are required for early territorial gene expression. Development. 1991;112:351-64 pubmed..The P3A1 and P3A2 factors could function as regulatory antagonists, having evolved similar target specificities from dissimilar DNA-binding domains. ..
- Pruitt S. Primitive streak mesoderm-like cell lines expressing Pax-3 and Hox gene autoinducing activities. Development. 1994;120:37-47 pubmed..Blumberg, B., Bittner, D. and De Robertis, E. M. (1992) Cell 69, 1097-1106) that signals responsible for anterior-posterior organizer activity are localized to the anterior primitive streak mesoderm of the mouse embryo. ..
- Fletcher F, Carpenter M, Shilling H, Baum P, Ziegler S, Gimpel S, et al. LERK-2, a binding protein for the receptor-tyrosine kinase ELK, is evolutionarily conserved and expressed in a developmentally regulated pattern. Oncogene. 1994;9:3241-7 pubmed..Significant LERK-2 mRNA expression in the young adult rat was restricted to the lung, kidney, heart and testes. ..
- Gaussin V, Tomlinson J, Depre C, Engelhardt S, Antos C, Takagi G, et al. Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy. Circulation. 2003;108:2926-33 pubmed..In addition to preserving cardiac function, betaAR blockade treatment also prevents the genomic regulation that correlates with the onset of heart failure. ..
- Xu J, Han J, Epstein P, Liu Y. Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets. Biochem Biophys Res Commun. 2006;344:827-33 pubmed
- Cassis L, Rateri D, Lu H, Daugherty A. Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms. Arterioscler Thromb Vasc Biol. 2007;27:380-6 pubmed..AT1a receptors expressed on infiltrating cells exert modest regulation of AngII-induced atherosclerosis. However, the presence of this receptor in resident tissue is required for the initiation of AngII-induced atherosclerosis and AAAs. ..
- Higuchi T, Bartel F, Masuya M, Deguchi T, Henderson K, Li R, et al. Thymomegaly, microsplenia, and defective homeostatic proliferation of peripheral lymphocytes in p51-Ets1 isoform-specific null mice. Mol Cell Biol. 2007;27:3353-66 pubmed..Thus, a balance in the differential regulation of Ets1 isoforms represents a potential mechanism in the control of lymphoid maturation and homeostasis. ..
- Liu S, Tang W, Zhou J, Vierthaler L, Quarles L. Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. Am J Physiol Endocrinol Metab. 2007;293:E1636-44 pubmed..In addition, systemic counterregulatory factors that attenuate the upregulation of FGF23 expression in Hyp mouse osteocytes are present in older mice...
- Mahajan S, Aalinkeel R, Sykes D, Reynolds J, Bindukumar B, Adal A, et al. Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res. 2008;1203:133-48 pubmed publisher..An understanding of the mechanisms of BBB breakdown that lead to neurotoxicity is crucial to the development of therapeutic modalities for Meth abusing HAD patients. ..
- Lu T, Ye D, He T, Wang X, Wang H, Lee H. Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Biophys J. 2008;95:5165-77 pubmed publisher..These abnormalities in BK channel gating lead to an increase in the energy barrier for channel activation, and may contribute to the development of vascular dysfunction and complications in type 2 diabetes mellitus. ..
- Su N, Kilberg M. C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem. 2008;283:35106-17 pubmed publisher..Collectively, the results document that CHOP is a member of the transcription factor network that controls the stress-induced regulation of specific C/EBP-ATF-containing genes, such as ASNS. ..
- Khan N, Syed D, Pal H, Mukhtar H, Afaq F. Pomegranate fruit extract inhibits UVB-induced inflammation and proliferation by modulating NF-?B and MAPK signaling pathways in mouse skin. Photochem Photobiol. 2012;88:1126-34 pubmed publisher..Taken together, these data show that PFE consumption afforded protection to mouse skin against the adverse effects of UVB radiation by modulating UVB-induced signaling pathways. ..
- Walker M, LaFerla F, Oddo S, Brewer G. Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr). 2013;35:519-31 pubmed publisher..These data show that the epigenetic states of non-transgenic and 3xTg-AD brain neurons are profoundly different and reversible, beginning at 4 months of age when the first memory deficits are reported. ..
- Myers E. G?o and G?q regulate the expression of daf-7, a TGF?-like gene, in Caenorhabditis elegans. PLoS ONE. 2012;7:e40368 pubmed publisher..This paper provides evidence that while goa-1 and egl-30 are important for normal daf-7 expression, mutations in these genes are not sufficient to disrupt dauer formation. ..
- He W, Xie Q, Wang Y, Chen J, Zhao M, Davis L, et al. Generation of a tenascin-C-CreER2 knockin mouse line for conditional DNA recombination in renal medullary interstitial cells. PLoS ONE. 2013;8:e79839 pubmed publisher..Cre activity was not obvious in other major organs or without tamoxifen treatment. This inducible RMIC specific Cre mouse line should therefore provide a novel tool to manipulate genes of interest in RMICs. ..
- Barger J, Vann J, Cray N, Pugh T, Mastaloudis A, Hester S, et al. Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. Aging Cell. 2017;16:750-760 pubmed publisher..Our findings provide panels of tissue-specific transcriptional markers of CR that can be used to identify novel CRMs, and also represent the first comparative molecular analysis of several potential CRMs in multiple tissues in mammals...
- Rienhoff H, Groudine M. Regulation of amyloid A gene expression in cultured cells. Mol Cell Biol. 1988;8:3710-6 pubmed..These observations suggest that conditioned medium contains a factor(s) that acts directly on hepatocytes to regulate SAA3 mRNA processing. ..
- Herrick D, Ross J. The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3' untranslated regions and role of ribosome translocation. Mol Cell Biol. 1994;14:2119-28 pubmed..These and other data suggest that degradation involving the coding-region determinant occurs most efficiently when ribosomes are translating the determinant. ..
- Hilgarth R, Hong Y, Park Sarge O, Sarge K. Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification. Biochem Biophys Res Commun. 2003;303:196-200 pubmed..Based on these data, we postulate that phosphorylation at serine 307 could stimulate HSF1 sumoylation by causing a conformation change that relieves the inhibitory effect of the C-terminal leucine zipper. ..
- Verlander J, Hassell K, Royaux I, Glapion D, Wang M, Everett L, et al. Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension. Hypertension. 2003;42:356-62 pubmed..We conclude that pendrin is upregulated with aldosterone analogues and is critical in the pathogenesis of mineralocorticoid-induced hypertension and metabolic alkalosis. ..
- Khoshnan A, Ko J, Watkin E, Paige L, Reinhart P, Patterson P. Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. J Neurosci. 2004;24:7999-8008 pubmed..Therefore, aberrant NF-kappaB activation may contribute to the neurodegeneration induced by mutant Htt. ..
- Streb J, Miano J. AKAP12alpha, an atypical serum response factor-dependent target gene. J Biol Chem. 2005;280:4125-34 pubmed..Furthermore, we provide new insight into the role of flanking sequences in determining sensitivity to SRF-myocardin activity. ..
- Rohrer B, Demos C, Frigg R, Grimm C. Classical complement activation and acquired immune response pathways are not essential for retinal degeneration in the rd1 mouse. Exp Eye Res. 2007;84:82-91 pubmed..Our results suggest that both, the classical complement system of innate immunity and a functional acquired immune response are not essential for the degenerative process in the rd1 mouse retina. ..
- Ghaheri B, Kempton J, Pillers D, Trune D. Cochlear cytokine gene expression in murine acute otitis media. Laryngoscope. 2007;117:22-9 pubmed..This study provides a novel site of production of cytokines that may be responsible for the damage seen in sensorineural hearing loss. ..
- Elton T, Martin M. Angiotensin II type 1 receptor gene regulation: transcriptional and posttranscriptional mechanisms. Hypertension. 2007;49:953-61 pubmed
- Sekine H, Ferreira R, Pan Hammarstrom Q, Graham R, Ziemba B, de Vries S, et al. Role for Msh5 in the regulation of Ig class switch recombination. Proc Natl Acad Sci U S A. 2007;104:7193-8 pubmed
- Duric V, McCarson K. Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain. Mol Pain. 2007;3:32 pubmed..modulation of the higher brain structures such as the hippocampus. ..