Genomes and Genes
Experts and Doctors on gene deletion in United States
Locale: United States
Topic: gene deletion
Publications700 found, 100 shown here
- Ward S, Abomoelak B, Hoye E, Steinberg H, Talaat A. CtpV: a putative copper exporter required for full virulence of Mycobacterium tuberculosis. Mol Microbiol. 2010;77:1096-110 pubmed publisher..tuberculosis, supporting the hypothesis that copper response could be important to intracellular pathogens, in general. ..
- Rawls K, Yacovone S, Maupin Furlow J. GlpR represses fructose and glucose metabolic enzymes at the level of transcription in the haloarchaeon Haloferax volcanii. J Bacteriol. 2010;192:6251-60 pubmed publisher..The results presented here provide genetic and biochemical evidence that GlpR controls both fructose and glucose metabolic enzymes through transcriptional repression of the glpR-pfkB operon and kdgK1 during growth on glycerol...
- Zhang Y, Guo G, Klaassen C. Diurnal variations of mouse plasma and hepatic bile acid concentrations as well as expression of biosynthetic enzymes and transporters. PLoS ONE. 2011;6:e16683 pubmed publisher..The diurnal variations of BAs appear to serve as a signal that coordinates daily nutrient metabolism in mammals. ..
- Meyer C, Kerns A, Haberthur K, Dewane J, Walker J, GRAY W, et al. Attenuation of the adaptive immune response in rhesus macaques infected with simian varicella virus lacking open reading frame 61. J Virol. 2013;87:2151-63 pubmed publisher..Taken together, our data suggest that ORF61 plays an important role in orchestrating viral gene expression in vivo and interferes with the host antiviral interferon response. ..
- Boitz J, Ullman B. Adenine and adenosine salvage in Leishmania donovani. Mol Biochem Parasitol. 2013;190:51-5 pubmed publisher..donovani and demonstrate that all of the pathways can function under appropriate conditions of genetic or pharmacologic perturbation. ..
- Kurihara L, Semenova E, Miller W, Ingram R, Guan X, Tilghman S. Candidate genes required for embryonic development: a comparative analysis of distal mouse chromosome 14 and human chromosome 13q22. Genomics. 2002;79:154-61 pubmed..Because we determined that a mutant of Uchl3 was viable, three candidate genes remain within the region. ..
- Casey G, Neville P, Plummer S, Xiang Y, Krumroy L, Klein E, et al. RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. Nat Genet. 2002;32:581-3 pubmed..Men that are heterozygous with respect to the mutated allele have 50% greater risk of prostate cancer than non-carriers, and homozygotes have more than double the risk. ..
- Schwartz M, Chen J, Lee W, Janda M, Ahlquist P. Alternate, virus-induced membrane rearrangements support positive-strand RNA virus genome replication. Proc Natl Acad Sci U S A. 2004;101:11263-8 pubmed
- Whitaker S, Knox B. Conserved transcriptional activators of the Xenopus rhodopsin gene. J Biol Chem. 2004;279:49010-8 pubmed..Furthermore, activation of the endogenous rhodopsin gene was also observed in some animals, showing that XOtx5 and XL-Nrl can activate the promoter in native chromatin environment. ..
- Ruan C, Workman J, Simpson R. The DNA repair protein yKu80 regulates the function of recombination enhancer during yeast mating type switching. Mol Cell Biol. 2005;25:8476-85 pubmed..We also detect directional movement of yKu80p from the RE towards HML during switching. These results indicate a novel function of yeast Ku80p in regulating mating type switching. ..
- Tani S, Judelson H. Activation of zoosporogenesis-specific genes in Phytophthora infestans involves a 7-nucleotide promoter motif and cold-induced membrane rigidity. Eukaryot Cell. 2006;5:745-52 pubmed..The data therefore delineate a pathway in which sporangia perceive cold temperatures through membrane rigidity, which activates signals that drive both zoosporogenesis and cold-box-mediated transcription. ..
- Mefford H, Cooper G, Zerr T, Smith J, Baker C, Shafer N, et al. A method for rapid, targeted CNV genotyping identifies rare variants associated with neurocognitive disease. Genome Res. 2009;19:1579-85 pubmed publisher..More generally, this approach offers a previously unavailable balance between customization, cost, and throughput for analysis of CNVs and should prove valuable for targeted CNV detection in both research and diagnostic settings. ..
- Yadav V, Yanez N, Fenton S, Denning M. Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study. Am J Pathol. 2010;176:1091-6 pubmed publisher..Our results have implications for the development of topical therapeutic strategies to trigger the re-expression of pro-apoptotic PKC-delta to induce apoptosis in SCCs. ..
- Damron F, Owings J, Okkotsu Y, Varga J, Schurr J, Goldberg J, et al. Analysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN. J Bacteriol. 2012;194:1317-30 pubmed publisher..Together, these data strongly suggest that KinB regulates virulence factors important for the development of acute pneumonia and conversion to mucoidy. ..
- Olson D, Giannone R, Hettich R, Lynd L. Role of the CipA scaffoldin protein in cellulose solubilization, as determined by targeted gene deletion and complementation in Clostridium thermocellum. J Bacteriol. 2013;195:733-9 pubmed publisher..thermocellum, and it raises interesting questions about the differential roles of the anchor scaffoldin proteins OlpB, Orf2p, and SdbA. ..
- Forsberg L, Rasi C, Malmqvist N, Davies H, Pasupulati S, Pakalapati G, et al. Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet. 2014;46:624-8 pubmed publisher..LOY in blood could become a predictive biomarker of male carcinogenesis...
- Kokoye Y, Ivanov I, Cheng Q, Matafonov A, Dickeson S, Mason S, et al. A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation. Thromb Res. 2016;140:118-124 pubmed publisher..The findings suggest that inhibitors of FXIIa will have more potent anti-thrombotic effects than inhibitors of Î±-kallikrein. ..
- Zanotti S, Yu J, Sanjay A, Schilling L, Schoenherr C, Economides A, et al. Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome. J Biol Chem. 2017;292:12232-12244 pubmed publisher..In conclusion, introduction of the HCS mutation in osteoblasts, but not in osteoclasts, causes osteopenia. ..
- Santiago González D, Cheli V, Zamora N, Lama T, Spreuer V, Murphy G, et al. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice. J Neurosci. 2017;37:10038-10051 pubmed publisher..These findings could lead to novel approaches for obtaining a better understanding of the factors that control OPC maturation in order to stimulate this pool of progenitors to replace myelin in demyelinating diseases. ..
- Johnson J, Craig E. An essential role for the substrate-binding region of Hsp40s in Saccharomyces cerevisiae. J Cell Biol. 2001;152:851-6 pubmed..Furthermore, the substrate-binding domain must function in cis with a functional Hsp70-interacting domain. We conclude that the ability of cytosolic Hsp40s to bind unfolded protein substrates is an essential function in vivo. ..
- Olney R, Mougey E, Wang J, Shulman D, Sylvester J. Using real-time, quantitative PCR for rapid genotyping of the steroid 21-hydroxylase gene in a north Florida population. J Clin Endocrinol Metab. 2002;87:735-41 pubmed..Faster results will allow for more timely initiation of appropriate therapy and limit the exposure of potentially unnecessary therapy. ..
- Raisz L. The hunting of the snark: the elusive calcium receptor(s). J Clin Invest. 2003;111:945-7 pubmed
- Puolakkainen P, Brekken R, Muneer S, Sage E. Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis. Mol Cancer Res. 2004;2:215-24 pubmed..These data reflect the importance of ECM deposition in regulating tumor growth and demonstrate that host-derived SPARC is a critical factor in the response of host tissue to tumorigenesis. ..
- Wei X, Hao L, Ni S, Liu Q, Xu J, Correll P. Altered exon usage in the juxtamembrane domain of mouse and human RON regulates receptor activity and signaling specificity. J Biol Chem. 2005;280:40241-51 pubmed..These data provide direct evidence that the divergence of exon usage among different species can generate a protein with novel activity and subsequently add to the complexity of cellular signaling regulation. ..
- Bennett K, Karpenko M, Lin M, Claus R, Arab K, Dyckhoff G, et al. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. Cancer Res. 2008;68:4494-9 pubmed publisher..Interestingly, all of the candidates identified may be involved in the transforming growth factor beta signaling pathway, which is often disrupted in HNSCC. ..
- Zhuang D, Mannava S, Grachtchouk V, Tang W, Patil S, Wawrzyniak J, et al. C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells. Oncogene. 2008;27:6623-34 pubmed publisher..Our data suggest that one of the major functions of C-MYC overexpression in melanoma progression is to continuous suppress BRAF(V600E)- or NRAS(Q61R)-dependent senescence programs. ..
- Wang E, Dimova N, Sperle K, Huang Z, Lock L, McCulloch M, et al. Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. Exp Neurol. 2008;214:322-30 pubmed publisher..This knockin mouse represents a useful model to investigate the mechanisms of disease in human disorders in which PLP1 expression is reduced. ..
- Griggs B, Ladd S, Decker A, DuPont B, Asamoah A, Srivastava A. Identification of ectodysplasin-A receptor gene deletion at 2q12.2 and a potential autosomal MR locus. Eur J Hum Genet. 2009;17:30-6 pubmed publisher..It is plausible that a potential autosomal MR gene deleted at 2q12.2 or 6q22.3 is likely the cause of the neurodevelopmental defects in the patient...
- Juhan N, LeRoith T, Opriessnig T, Meng X. The open reading frame 3 (ORF3) of porcine circovirus type 2 (PCV2) is dispensable for virus infection but evidence of reduced pathogenicity is limited in pigs infected by an ORF3-null PCV2 mutant. Virus Res. 2010;147:60-6 pubmed publisher..Thus, the data from this study do not fully support the conclusion of a previous report regarding PCV2 attenuation by abrogation of ORF3 although the results did show that ORF3 is dispensable for PCV2 replication in pigs...
- Kovacikova G, Lin W, Skorupski K. The LysR-type virulence activator AphB regulates the expression of genes in Vibrio cholerae in response to low pH and anaerobiosis. J Bacteriol. 2010;192:4181-91 pubmed publisher..These results raise the possibility that the activity of AphB is influenced by the pH and oxygen tension of the environment. ..
- Cugini C, Morales D, Hogan D. Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains. Microbiology. 2010;156:3096-107 pubmed publisher..aeruginosa. The finding that C. albicans, farnesol or ROS stimulate virulence factor production in lasR strains provides new insight into the virulence potential of these strains...
- Mbantenkhu M, Wang X, Nardozzi J, Wilkens S, Hoffman E, Patel A, et al. Mgm101 is a Rad52-related protein required for mitochondrial DNA recombination. J Biol Chem. 2011;286:42360-70 pubmed publisher..These studies reveal a recombination protein of likely bacteriophage origin in mitochondria and support the notion that recombination is indispensable for mtDNA integrity. ..
- Burall L, Laksanalamai P, Datta A. Listeria monocytogenes mutants with altered growth phenotypes at refrigeration temperature and high salt concentrations. Appl Environ Microbiol. 2012;78:1265-72 pubmed publisher..These studies indicate the potential for an intricate relationship between environmental stress regulation and virulence in L. monocytogenes. ..
- Brennan C, DeLoney Marino C, Mandel M. Chemoreceptor VfcA mediates amino acid chemotaxis in Vibrio fischeri. Appl Environ Microbiol. 2013;79:1889-96 pubmed publisher..fischeri and that the attraction is also mediated by VfcA. This study thus provides the first insights into how V. fischeri integrates information from one of its 43 MCPs to respond to environmental stimuli. ..
- Shippy D, Eakley N, Lauhon C, Bochsler P, Fadl A. Virulence characteristics of Salmonella following deletion of genes encoding the tRNA modification enzymes GidA and MnmE. Microb Pathog. 2013;57:1-9 pubmed publisher..Overall, the data suggest MnmE and GidA bind together and use a post-transcriptional mechanism to modify tRNA to regulate Salmonella pathogenesis. ..
- Mai B, Breeden L. CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast. Mol Cell Biol. 2000;20:478-87 pubmed..Thus, CLN1 may be Xbp1's primary target in meiotic cells. We hypothesize that CLN1 plays a role early in the meiotic program but must be repressed, by Xbp1, at later stages to promote efficient sporulation. ..
- Steinebrunner I, Wu J, Sun Y, Corbett A, Roux S. Disruption of apyrases inhibits pollen germination in Arabidopsis. Plant Physiol. 2003;131:1638-47 pubmed..The male-specific double KO mutation is fully penetrant and shows that apyrases play a crucial role in pollen germination. ..
- Gao W, Liu Y, Giometti C, Tollaksen S, Khare T, Wu L, et al. Knock-out of SO1377 gene, which encodes the member of a conserved hypothetical bacterial protein family COG2268, results in alteration of iron metabolism, increased spontaneous mutation and hydrogen peroxide sensitivity in Shewanella oneidensis MR-1. BMC Genomics. 2006;7:76 pubmed..Our results showed that the knock-out of SO1377 gene had pleiotropic effects and suggested that SO1377 may play a role in iron homeostasis and oxidative damage protection in S. oneidensis MR-1. ..
- Murphy R, Boyd E. Three pathogenicity islands of Vibrio cholerae can excise from the chromosome and form circular intermediates. J Bacteriol. 2008;190:636-47 pubmed..These results show that all three pathogenicity islands can excise from the chromosome, which is likely a first step in their horizontal transfer. ..
- Pajaniappan M, Hall J, Cawthraw S, Newell D, Gaynor E, Fields J, et al. A temperature-regulated Campylobacter jejuni gluconate dehydrogenase is involved in respiration-dependent energy conservation and chicken colonization. Mol Microbiol. 2008;68:474-91 pubmed publisher..These results suggest that the ability of C. jejuni to use gluconate as an electron donor via GADH activity is an important metabolic characteristic that is required for full colonization of avian but not mammalian hosts. ..
- Zhou G, Kowalczyk D, Humbard M, Rohatgi S, Maupin Furlow J. Proteasomal components required for cell growth and stress responses in the haloarchaeon Haloferax volcanii. J Bacteriol. 2008;190:8096-105 pubmed publisher..This contrasted with what was seen for panA knockouts, which displayed enhanced thermotolerance. Together, these results provide new and important insight into the biological role of proteasomes in archaea...
- Manhiani M, Quigley J, Knight S, Tasoobshirazi S, Moore T, Brands M, et al. Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension. Am J Physiol Renal Physiol. 2009;297:F740-8 pubmed publisher..These data demonstrate that Ephx2 gene deletion decreases blood pressure, attenuates renal inflammation, and ameliorates glomerular injury in DOCA-salt hypertension. ..
- Whitaker W, Parent M, Naughton L, Richards G, Blumerman S, Boyd E. Modulation of responses of Vibrio parahaemolyticus O3:K6 to pH and temperature stresses by growth at different salt concentrations. Appl Environ Microbiol. 2010;76:4720-9 pubmed publisher..The effect of V. parahaemolyticus growth in 1% or 3% NaCl was examined using a cytotoxicity assay, and we found that V. parahaemolyticus grown in 1% NaCl was significantly more toxic than that grown in 3% NaCl. ..
- Murphy T, Brauer A. Expression of urease by Haemophilus influenzae during human respiratory tract infection and role in survival in an acid environment. BMC Microbiol. 2011;11:183 pubmed publisher..Expression of urease enhances viability in an acid environment. Taken together, these observations suggest that urease is important for survival and replication of H. influenzae in the human respiratory tract. ..
- Vassilopoulos G, Wang P, Russell D. Transplanted bone marrow regenerates liver by cell fusion. Nature. 2003;422:901-4 pubmed..We also show that the haematopoietic donor genome adopts a more hepatocyte-specific expression profile after cell fusion, as the wild-type Fah gene was activated and the pan-haematopoietic CD45 marker was no longer expressed...
- Al Mubarak A, Chowdhury S. In the absence of glycoprotein I (gI), gE determines bovine herpesvirus type 5 neuroinvasiveness and neurovirulence. J Neurovirol. 2004;10:233-43 pubmed..The authors believe that in the absence of gI, BHV-5 gE is sufficient for BHV-5 neurovirulence...
- VanWert A, Srimaroeng C, Sweet D. Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin. Mol Pharmacol. 2008;74:122-31 pubmed publisher..The present findings indicate that polymorphisms of and drug interactions on hOAT3 may influence carboxyfluoroquinolone efficacy, especially in urinary tract infections. ..
- Chen Y, Wendt Pienkowski E, Shen B. Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts. J Bacteriol. 2008;190:5587-96 pubmed publisher..griseus and heterologous hosts, such as S. albus and S. lividans. The approach taken capitalizes on FdmR1, a key activator of the FDM biosynthetic machinery. ..
- Pastor R, McKinnon C, Scibelli A, Burkhart Kasch S, Reed C, Ryabinin A, et al. Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism. Proc Natl Acad Sci U S A. 2008;105:9070-5 pubmed publisher..A CRF/CRF1-mediated mechanism involving the HPA axis is proposed for acquisition, whereas an extrahypothalamic CRF/CRF1 participation is suggested for expression of sensitization to EtOH. ..
- Kumari S, Tishel R, Eisenbach M, Wolfe A. Cloning, characterization, and functional expression of acs, the gene which encodes acetyl coenzyme A synthetase in Escherichia coli. J Bacteriol. 1995;177:2878-86 pubmed..coli enzyme activated acetate across a wide range of concentrations in a coenzyme A-dependent manner. On the basis of these and other observations, we conclude that this open reading frame encodes the acetate-activating enzyme, Acs. ..
- Huang G, Zhang M, Erdman S. Posttranslational modifications required for cell surface localization and function of the fungal adhesin Aga1p. Eukaryot Cell. 2003;2:1099-114 pubmed..Our studies also suggest that in addition to GPI-glucan linkages, other cell surface anchorage mechanisms, such as transmembrane domains or disulfides, may be employed by fungal species to localize adhesins. ..
- Lemos J, Nascimento M, Lin V, Abranches J, Burne R. Global regulation by (p)ppGpp and CodY in Streptococcus mutans. J Bacteriol. 2008;190:5291-9 pubmed publisher..Notably, the identification of putative CodY-binding boxes upstream of genes that were downregulated in the codY mutant indicates that CodY may also function as a transcriptional activator in S. mutans...
- Witola W, El Bissati K, Pessi G, Xie C, Roepe P, Mamoun C. Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects. J Biol Chem. 2008;283:27636-43 pubmed publisher..Interestingly, loss of PfPMT resulted in significant defects in parasite growth, multiplication, and viability, suggesting that this gene plays an important role in the pathogenesis of intraerythrocytic Plasmodium parasites...
- Shan J, Chobot Rodd J, Castellanos R, Babcock M, Shanske A, Parikh S, et al. GJB2 mutation spectrum in 209 hearing impaired individuals of predominantly Caribbean Hispanic and African descent. Int J Pediatr Otorhinolaryngol. 2010;74:611-8 pubmed publisher..These results demonstrate that GJB2 is not the major contributor to the genetic basis of NSHI for the Bronx minority admixture populations. ..
- Hossain M, Biswas I. Mutacins from Streptococcus mutans UA159 are active against multiple streptococcal species. Appl Environ Microbiol. 2011;77:2428-34 pubmed publisher..In contrast, mutacin V displayed a narrower inhibitory range than mutacin IV. Our results suggest that mutacin IV and mutacin V may act synergistically to inhibit various organisms...
- Narayanan S, Suwanpradid J, Saul A, Xu Z, Still A, Caldwell R, et al. Arginase 2 deletion reduces neuro-glial injury and improves retinal function in a model of retinopathy of prematurity. PLoS ONE. 2011;6:e22460 pubmed publisher..This study was undertaken to determine the role of the mitochondrial arginine/ornithine regulating enzyme arginase 2 (A2) in retinal neuro-glial cell injury in the mouse model of ROP...
- Yin Z, Pringle D, Jones G, Kelly K, Kirschner L. Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the Carney complex gene Prkar1a. Mol Endocrinol. 2011;25:1786-93 pubmed publisher..These data suggest that both developmental and tumor phenotypes caused by Prkar1a mutation result from excess PKA activity due to PKA-Ca. ..
- Varahan S, Iyer V, Moore W, Hancock L. Eep confers lysozyme resistance to enterococcus faecalis via the activation of the extracytoplasmic function sigma factor SigV. J Bacteriol. 2013;195:3125-34 pubmed publisher..We also demonstrate that, in the absence of eep or sigV, enterococci bind significantly more lysozyme, providing a plausible explanation for the increased sensitivity of these mutants toward lysozyme. ..
- Wille P, Wisner T, RYCKMAN B, Johnson D. Human cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in trans acting as the viral fusion protein rather than as a receptor-binding protein. MBio. 2013;4:e00332-13 pubmed publisher..In contrast, virus particles lacking gH/gL could not enter cells expressing gH/gL. Our study supports the hypothesis that gB is the fusion protein and gH/gL acts upstream of gB to bind receptors and then activate gB for fusion...
- Baxter B, James P, Evans T, Craig E. SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum. Mol Cell Biol. 1996;16:6444-56 pubmed..Interestingly, SSI1 deletion strains show a partial block in translocation of multiple proteins into the ER, suggesting that Ssi1p plays a direct role in the translocation process. ..
- Lin Y, Waldman A. Promiscuous patching of broken chromosomes in mammalian cells with extrachromosomal DNA. Nucleic Acids Res. 2001;29:3975-81 pubmed..Microhomology existed at most junctions between φX174 DNA and genomic sequences. Our work suggests that virtually any extrachromosomal DNA molecule may be recruited for the patching of DSBs in a mammalian genome. ..
- Krings G, Bastia D. swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 2004;101:14085-90 pubmed..The results support the notion that Swi1p and Swi3p act at several different protein-DNA complexes in the rDNA spacer regions to arrest replication but that not all fork barriers required their activity to arrest forks. ..
- Picking W, Nishioka H, Hearn P, Baxter M, Harrington A, Blocker A, et al. IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infect Immun. 2005;73:1432-40 pubmed publisher..While efficient insertion of IpaB/IpaC pores is needed for optimal invasion efficiency, it may be especially important for Ipa-dependent membrane disruption and thus for efficient vacuolar escape and intercellular spread...
- Ahn S, Lemos J, Burne R. Role of HtrA in growth and competence of Streptococcus mutans UA159. J Bacteriol. 2005;187:3028-38 pubmed
- Goldberg J, Wolpin E, Bosgraaf L, Clarkson B, Van Haastert P, Smith J. Myosin light chain kinase A is activated by cGMP-dependent and cGMP-independent pathways. FEBS Lett. 2006;580:2059-64 pubmed publisher..Thus MLCK-A is activated by a cGMP/GbpC-independent mechanism activated during cytokinesis or by conA, and a cGMP/GbpC-dependent pathway during chemotaxis...
- Falkner K, Prough R. Regulation of the rat glutathione S-transferase A2 gene by glucocorticoids: crosstalk through C/EBPs. Drug Metab Rev. 2007;39:401-18 pubmed..We conclude that C/EBP alpha and beta are involved in GC-dependent repression of GSTA2 gene expression and ARE sequences that bind C/EBPs appears to be critical for these responses. ..
- Yoder K, Espeseth A, Wang X, Fang Q, Russo M, Lloyd R, et al. The base excision repair pathway is required for efficient lentivirus integration. PLoS ONE. 2011;6:e17862 pubmed publisher..Integration activity is restored by addition of recombinant BER protein POLß. Lentiviral infection and integration efficiency appears to depend on the presence of BER proteins. ..
- Wang W, Pan Y, Wietecha T, Zou J, Abel G, Kuo C, et al. Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb. J Biol Chem. 2013;288:2623-31 pubmed publisher..These results identify ERK5 as a novel and critical signaling mechanism underlying prolactin-induced adult neurogenesis. ..
- Al Hinai M, Jones S, Papoutsakis E. ?K of Clostridium acetobutylicum is the first known sporulation-specific sigma factor with two developmentally separated roles, one early and one late in sporulation. J Bacteriol. 2014;196:287-99 pubmed publisher..This is the first sporulation-specific sigma factor shown to have two developmentally separated roles...
- Ye L, Mishina Y, Chen D, Huang H, Dallas S, Dallas M, et al. Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem. 2005;280:6197-203 pubmed..In addition, blood vessel invasion is impaired in the epiphyses of Dmp1(-/-) mice. These findings show that DMP1 is essential for normal postnatal chondrogenesis and subsequent osteogenesis. ..
- Dmitrieva N, Yu L, Viapiano M, Cripe T, Chiocca E, Glorioso J, et al. Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. 2011;17:1362-72 pubmed publisher..018). Glioma cell migration and invasion were not increased by OV-Chase treatment. We conclude that degradation of glioma extracellular matrix with OV-expressing bacterial Chase-ABC enhanced OV spread and antitumor efficacy. ..
- Wellington M, Koselny K, Krysan D. Candida albicans morphogenesis is not required for macrophage interleukin 1? production. MBio. 2012;4:e00433-12 pubmed publisher..Since these observations are inconsistent with some current models, alternative mechanisms for the interaction of C. albicans with macrophages must be considered. ..
- Bonner J, Carlson T, Fackenthal D, Paddock D, Storey K, Lea K. Complex regulation of the yeast heat shock transcription factor. Mol Biol Cell. 2000;11:1739-51 pubmed
- Simirskii V, Lee R, Wawrousek E, Duncan M. Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens. Invest Ophthalmol Vis Sci. 2006;47:4931-4 pubmed..The demonstration that FVB/N mice lack CP49 protein in the lens suggests that it may be necessary to reevaluate the mechanisms underlying lens phenotypes obtained as a result of transgenic manipulation of this strain. ..
- Kim S, Bultman S, Jing H, Blobel G, Bresnick E. Dissecting molecular steps in chromatin domain activation during hematopoietic differentiation. Mol Cell Biol. 2007;27:4551-65 pubmed..These studies defined a hierarchical order of GATA-1-triggered events at a complex locus and establish a novel mechanism of long-range gene regulation. ..
- Blader I, Cope M, Jackson T, Profit A, Greenwood A, Drubin D, et al. GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. Mol Biol Cell. 1999;10:581-96 pubmed..These data provide in vivo and in vitro evidence that Gcs1p interacts directly with the actin cytoskeleton in S. cerevisiae. ..
- Cushman J, Lo J, Huang Z, Wasserfall C, Petitto J. Neurobehavioral changes resulting from recombinase activation gene 1 deletion. Clin Diagn Lab Immunol. 2003;10:13-8 pubmed..Study of the neurobiological actions of RAG-1 in the brain may provide new insights into important processes involved in normal brain function and disease. ..
- Inscho E, Cook A, Imig J, Vial C, Evans R. Physiological role for P2X1 receptors in renal microvascular autoregulatory behavior. J Clin Invest. 2003;112:1895-905 pubmed..These data provide compelling new evidence indicating that tubuloglomerular feedback signals are coupled to autoregulatory preglomerular vasoconstriction through ATP-mediated activation of P2X1 receptors. ..
- Facher J, Regier E, Jacobs G, Siwik E, Delaunoy J, Robin N. Cardiomyopathy in Coffin-Lowry syndrome. Am J Med Genet A. 2004;128A:176-8 pubmed..This is the first description of the histology and electron microscopy of cardiomyopathy in CLS...
- Kee Y, Bronner Fraser M. To proliferate or to die: role of Id3 in cell cycle progression and survival of neural crest progenitors. Genes Dev. 2005;19:744-55 pubmed..Our data suggest that Id3 functions by a novel mechanism, independent of cell fate determination, to mediate the decision of neural crest precursors to proliferate or die. ..
- Kohno M, Momoi M, Oo M, Paik J, Lee Y, Venkataraman K, et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. 2006;26:7211-23 pubmed..Our findings suggest that Sphk1 plays a critical role in intestinal tumor cell proliferation and that inhibitors of Sphk1 may be useful in the control of intestinal cancer. ..
- Tan Y, Keum J, Wang B, McHenry M, Lipsitz S, Jaffa A. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy. Am J Physiol Renal Physiol. 2007;293:F1026-35 pubmed..These findings provide the first evidence that targeted deletion of B2KR protects against the development of DN. ..
- Ahn S, Burne R. Effects of oxygen on biofilm formation and the AtlA autolysin of Streptococcus mutans. J Bacteriol. 2007;189:6293-302 pubmed..This study illustrates the central role of AtlA and VicK in orchestrating growth on surfaces and envelope biogenesis in response to redox conditions. ..
- Kuramitsu H, Chi B, Ikegami A. Genetic manipulation of Treponema denticola. Curr Protoc Microbiol. 2005;Chapter 12:Unit 12B.2 pubmed publisher..denticola. The transformation of other spirochetes such as T. phagedenis with these plasmids further suggests that it should be possible to develop similar gene transfer systems in other cultivable treponemes. ..