Experts and Doctors on gata transcription factors in United States


Locale: United States
Topic: gata transcription factors

Top Publications

  1. Park J, Attardo G, Hansen I, Raikhel A. GATA factor translation is the final downstream step in the amino acid/target-of-rapamycin-mediated vitellogenin gene expression in the anautogenous mosquito Aedes aegypti. J Biol Chem. 2006;281:11167-76 pubmed
    ..These experiments have revealed that the TOR signaling pathway induced by nutritional signaling regulates the translation of a GATA factor, which is the specific transcriptional activator of the Vg gene. ..
  2. Bertolino E, Reinitz J, Manu -. The analysis of novel distal Cebpa enhancers and silencers using a transcriptional model reveals the complex regulatory logic of hematopoietic lineage specification. Dev Biol. 2016;413:128-44 pubmed publisher
    ..Current address: Department of Biology, University of North Dakota, 10 Cornell Street, Stop 9019, Grand Forks, ND 58202-9019, USA. ..
  3. Chikina M, Huttenhower C, Murphy C, Troyanskaya O. Global prediction of tissue-specific gene expression and context-dependent gene networks in Caenorhabditis elegans. PLoS Comput Biol. 2009;5:e1000417 pubmed publisher
    ..To our knowledge, this is the first study producing high-accuracy predictions of tissue-specific expression and interactions for a metazoan organism based on whole-animal data. ..
  4. Zaytouni T, Efimenko E, Tevosian S. GATA transcription factors in the developing reproductive system. Adv Genet. 2011;76:93-134 pubmed publisher
    ..We also discuss the molecular mechanisms involved in this regulation through the control of Dmrt1 gene expression in the testis and the canonical Wnt/ß-catenin pathway in the ovary. ..
  5. Gauthier G, Sullivan T, Gallardo S, Brandhorst T, Vanden Wymelenberg A, Cuomo C, et al. SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog. 2010;6:e1000846 pubmed publisher
    ..To our knowledge, this is the first gene identified that promotes the conversion from yeast to mold in the dimorphic fungi, and may shed light on environmental persistence of these pathogens. ..
  6. Hewitt K, Katsumura K, Matson D, Devadas P, Tanimura N, Hebert A, et al. GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Dev Cell. 2017;42:213-225.e4 pubmed publisher
  7. Choi H, Broitman Maduro G, Maduro M. Partially compromised specification causes stochastic effects on gut development in C. elegans. Dev Biol. 2017;427:49-60 pubmed publisher
    ..Hence, upstream perturbation of specification dramatically affects the E lineage, but as long as sufficient descendants adopt a gut fate, organogenesis overcomes these effects to form a relatively normal intestine. ..
  8. Zhou J, Wang L, Zuo M, Wang X, Ahmed A, Chen Q, et al. Cardiac sodium channel regulator MOG1 regulates cardiac morphogenesis and rhythm. Sci Rep. 2016;6:21538 pubmed publisher
    ..5, gata4 and hand2 involved in cardiac morphogenesis. These data for the first time revealed a novel role that MOG1, a nucleocytoplasmic transport protein, plays in cardiac physiology and development. ..
  9. Wiesenfahrt T, Berg J, Osborne Nishimura E, Robinson A, Goszczynski B, Lieb J, et al. The function and regulation of the GATA factor ELT-2 in the C. elegans endoderm. Development. 2016;143:483-91 pubmed publisher
    ..Thus, in addition to controlling gene expression during differentiation, ELT-2 is capable of specifying the entire C. elegans endoderm. ..

More Information


  1. Materna S, Ransick A, Li E, Davidson E. Diversification of oral and aboral mesodermal regulatory states in pregastrular sea urchin embryos. Dev Biol. 2013;375:92-104 pubmed publisher
    ..We have analyzed the regulatory linkages within the aboral NSM gene regulatory network. A linchpin of this network is gataE which as we show is a direct Gcm target and part of a feedback loop locking down the aboral regulatory state. ..
  2. Chiang Y, Zubo Y, Tapken W, Kim H, Lavanway A, Howard L, et al. Functional characterization of the GATA transcription factors GNC and CGA1 reveals their key role in chloroplast development, growth, and division in Arabidopsis. Plant Physiol. 2012;160:332-48 pubmed publisher
  3. Lan X, Witt H, Katsumura K, Ye Z, Wang Q, Bresnick E, et al. Integration of Hi-C and ChIP-seq data reveals distinct types of chromatin linkages. Nucleic Acids Res. 2012;40:7690-704 pubmed
    ..Our work, in combination with previous studies linking regulation by GATA factors with c-Jun and BRG1, provides genome-wide evidence that Hi-C data identify sets of biologically relevant interacting loci...
  4. Bresnick E, Katsumura K, Lee H, Johnson K, Perkins A. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res. 2012;40:5819-31 pubmed publisher
    ..This article highlights GATA factor mechanistic principles, with a heavy emphasis on GATA-1 and GATA-2 functions in the hematopoietic system, and new links between GATA-2 dysregulation and human pathophysiologies. ..
  5. Svenson J, Chike Harris K, Amria M, Nowling T. The mouse and human Fli1 genes are similarly regulated by Ets factors in T cells. Genes Immun. 2010;11:161-72 pubmed publisher
    ..This report lays the groundwork for identifying targets for manipulating Fli1 expression as a possible therapeutic approach. ..
  6. Krueger K, Deneris E. Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors. J Neurosci. 2008;28:12748-58 pubmed publisher
    ..Our findings identify a direct transcriptional interaction between Gata-2 and FEV and a unique marker for new insight into FEV/Pet-1 function in 5-HT neuron development. ..
  7. Harju Baker S, Costa F, Fedosyuk H, Neades R, Peterson K. Silencing of Agamma-globin gene expression during adult definitive erythropoiesis mediated by GATA-1-FOG-1-Mi2 complex binding at the -566 GATA site. Mol Cell Biol. 2008;28:3101-13 pubmed publisher
  8. Nowling T, Fulton J, Chike Harris K, Gilkeson G. Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes. Mol Immunol. 2008;45:1-12 pubmed
    ..Furthermore, the presence of a polymorphic microsatellite in the Fli1 promoter may contribute to increased Fli1 expression in T cells during lupus disease progression. ..
  9. Lee P, Nam J, Davidson E. Exclusive developmental functions of gatae cis-regulatory modules in the Strongylocentrorus purpuratus embryo. Dev Biol. 2007;307:434-45 pubmed publisher
    ..In addition, they imply a functional cis-regulatory module exclusion, whereby only a single module can associate with the basal promoter and drive gene expression at any given time...
  10. Broitman Maduro G, Lin K, Hung W, Maduro M. Specification of the C. elegans MS blastomere by the T-box factor TBX-35. Development. 2006;133:3097-106 pubmed
    ..Our results show that this role has been evolutionarily conserved in the early C. elegans embryo, and that a progenitor of multiple tissue types can be specified by a surprisingly simple gene cascade. ..
  11. Harrison K, Marzluf G. Characterization of DNA binding and the cysteine rich region of SRE, a GATA factor in Neurospora crassa involved in siderophore synthesis. Biochemistry. 2002;41:15288-95 pubmed
    ..The combined results of mobility shift assays, siderophore synthesis assays, and ornithine oxygenase enzyme activity determinations demonstrate that these mutants with cysteine substitutions have a dominant repressor phenotype. ..
  12. Page B, Zhang W, Steward K, Blumenthal T, Priess J. ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos. Genes Dev. 1997;11:1651-61 pubmed
    ..The ELT-1 protein is expressed in epidermal cells and in their precursors. We propose that elt-1 functions at an early step in the specification of epidermal cell fates. ..
  13. Mimoto M, Christian J. Friend of GATA (FOG) interacts with the nucleosome remodeling and deacetylase complex (NuRD) to support primitive erythropoiesis in Xenopus laevis. PLoS ONE. 2012;7:e29882 pubmed publisher
    ..Together, our data suggest that a requirement for FOG and its interaction with NuRD during primitive erythropoiesis are conserved in Xenopus and that loss of blood upon FOG overexpression is due to a dominant-interfering effect. ..
  14. Maduro M, Broitman Maduro G, Mengarelli I, Rothman J. Maternal deployment of the embryonic SKN-1-->MED-1,2 cell specification pathway in C. elegans. Dev Biol. 2007;301:590-601 pubmed
  15. Coroian C, Broitman Maduro G, Maduro M. Med-type GATA factors and the evolution of mesendoderm specification in nematodes. Dev Biol. 2006;289:444-55 pubmed publisher
    ..elegans med-1,2(-) strain. We conclude that Med function and expression have been conserved over tens of millions of years of evolution, and that there may be a mechanism that selects against the acquisition of introns in these genes...
  16. Oskouian B, Mendel J, Shocron E, Lee M, Fyrst H, Saba J. Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors. J Biol Chem. 2005;280:18403-10 pubmed
    ..Overexpression of GATA-4 led to both an increase in activity of a reporter gene as well as an increase in endogenous sphingosine-1-phosphate lyase protein. ..
  17. Zhao Y, Medrano L, Ohashi K, Fletcher J, Yu H, Sakai H, et al. HANABA TARANU is a GATA transcription factor that regulates shoot apical meristem and flower development in Arabidopsis. Plant Cell. 2004;16:2586-600 pubmed
    ..Ectopic HAN expression causes growth retardation, aberrant cell division patterns, and loss of meristem activity, suggesting that HAN is involved in controlling cell proliferation and differentiation. ..
  18. Shim Y, Bonner J, Blumenthal T. Activity of a C. elegans GATA transcription factor, ELT-1, expressed in yeast. J Mol Biol. 1995;253:665-76 pubmed
    ..We conclude that, although ELT-1 having only its C-terminal finger is capable of activation in response to the WGATAR site, the presence of the upstream finger supplies additional base specificity. ..