Experts and Doctors on galectin 3 in Sweden

Summary

Locale: Sweden
Topic: galectin 3

Top Publications

  1. Diehl C, Engström O, Delaine T, Håkansson M, Genheden S, Modig K, et al. Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3. J Am Chem Soc. 2010;132:14577-89 pubmed publisher
  2. Sörme P, Arnoux P, Kahl Knutsson B, Leffler H, Rini J, Nilsson U. Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction. J Am Chem Soc. 2005;127:1737-43 pubmed
    ..The results demonstrate that protein-ligand interactions can be significantly enhanced by the fine-tuning of arginine-arene interactions. ..
  3. Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, et al. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury. Neurobiol Dis. 2010;38:36-46 pubmed publisher
    ..In conclusion, galectin-3 contributes to neonatal HI injury particularly in male mice. Our results indicate that galectin-3 exerts its effect by modulating the inflammatory response. ..
  4. Li H, Li Q, Du X, Sun Y, Wang X, Kroemer G, et al. Lithium-mediated long-term neuroprotection in neonatal rat hypoxia-ischemia is associated with antiinflammatory effects and enhanced proliferation and survival of neural stem/progenitor cells. J Cereb Blood Flow Metab. 2011;31:2106-15 pubmed publisher
    ..In summary, lithium conferred impressive, morphological long-term protection against neonatal HI, at least partly by inhibiting inflammation and promoting NSPC proliferation and survival. ..
  5. Genheden S, Mikulskis P, Hu L, Kongsted J, Söderhjelm P, Ryde U. Accurate predictions of nonpolar solvation free energies require explicit consideration of binding-site hydration. J Am Chem Soc. 2011;133:13081-92 pubmed publisher
    ..We have tried to improve the continuum solvation methods by adding information about the solvent exposure of the binding site or the hydration of the binding site, and the results are promising at least for this small set of complexes. ..
  6. Karlsson A, Christenson K, Matlak M, Björstad A, Brown K, Telemo E, et al. Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology. 2009;19:16-20 pubmed publisher
  7. Feuk Lagerstedt E, Jordan E, Leffler H, Dahlgren C, Karlsson A. Identification of CD66a and CD66b as the major galectin-3 receptor candidates in human neutrophils. J Immunol. 1999;163:5592-8 pubmed
    ..This conclusion was supported by the subcellular localization of the CD66 proteins to the gelatinase and specific granules in resting neutrophils. ..
  8. Oberg C, Blanchard H, Leffler H, Nilsson U. Protein subtype-targeting through ligand epimerization: talose-selectivity of galectin-4 and galectin-8. Bioorg Med Chem Lett. 2008;18:3691-4 pubmed publisher
    ..Galectin-4C and 8N were found to prefer the d-talopyranose configuration to the natural ligand d-galactopyranose configuration. Derivatization at talose O2 and/or O3 provided selective submillimolar inhibitors for these two galectins. ..
  9. Karlsson H, Lindbom J, Ghafouri B, Lindahl M, Tagesson C, Gustafsson M, et al. Wear particles from studded tires and granite pavement induce pro-inflammatory alterations in human monocyte-derived macrophages: a proteomic study. Chem Res Toxicol. 2011;24:45-53 pubmed publisher
    ..Investigating the effects of characterized wear particles on human macrophages with a toxicoproteomic approach has shown to be useful in the search for more detailed information about specific pathways and possible biological markers. ..

More Information

Publications14

  1. Forsman H, Islander U, Andréasson E, Andersson A, Onnheim K, Karlström A, et al. Galectin 3 aggravates joint inflammation and destruction in antigen-induced arthritis. Arthritis Rheum. 2011;63:445-54 pubmed publisher
    ..To our knowledge, this is the first report of in vivo evidence that galectin 3 plays a crucial role in the development of arthritis. ..
  2. Saraboji K, Håkansson M, Genheden S, Diehl C, Qvist J, Weininger U, et al. The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics. Biochemistry. 2012;51:296-306 pubmed publisher
    ..These observations make a case for protein cryo-crystallography as a valuable screening method in fragment-based drug discovery and further suggest that identification of water sites might inform inhibitor design. ..
  3. Cederfur C, Malmstrom J, Nihlberg K, Block M, Breimer M, Bjermer L, et al. Glycoproteomic identification of galectin-3 and -8 ligands in bronchoalveolar lavage of mild asthmatics and healthy subjects. Biochim Biophys Acta. 2012;1820:1429-36 pubmed publisher
    ..This article is part of a Special Issue entitled Glycoproteomics. ..
  4. Block M, Mölne J, Leffler H, Börjesson L, Breimer M. Immunohistochemical Studies on Galectin Expression in Colectomised Patients with Ulcerative Colitis. Biomed Res Int. 2016;2016:5989128 pubmed publisher
    ..Galectin expression in patients with UC seems to be more dependent on disease focality and individual variation than on degree of tissue inflammation. ..
  5. Elmwall J, Kwieciński J, Na M, Ali A, Osla V, Shaw L, et al. Galectin-3 Is a Target for Proteases Involved in the Virulence of Staphylococcus aureus. Infect Immun. 2017;85: pubmed publisher
    ..In conclusion, the staphylococcal protease SspB inactivates galectin-3, abrogating its stimulation of oxygen radical production in human neutrophils and increasing tissue damage during skin infection. ..