Experts and Doctors on g protein coupled receptors in United States

Summary

Locale: United States
Topic: g protein coupled receptors

Top Publications

  1. Hla T, Lee M, Ancellin N, Liu C, Thangada S, Thompson B, et al. Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger?. Biochem Pharmacol. 1999;58:201-7 pubmed
    ..Better knowledge of the molecular basis of SPP action is needed to assess the physiological and pathophysiological significance of this bioactive lipid mediator. ..
  2. Ancellin N, Colmont C, Su J, Li Q, Mittereder N, Chae S, et al. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem. 2002;277:6667-75 pubmed
    ..These findings suggest that S1P is made in the extracellular milieu and that extracellular export of SK contributes to the action of S1P in the vascular system. ..
  3. Fazal N, Al Ghoul W, Schmidt M, Choudhry M, Sayeed M. Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury. Am J Physiol Cell Physiol. 2002;283:C1469-79 pubmed
    ..Overall, our studies show that enhanced neutrophil O production after thermal injury is a result of potentiation of Ca2+ -linked and -independent signaling triggered by inflammatory agents such as PAF. ..
  4. Lu S, Zhao F, Herness S. Physiological phenotyping of cholecystokinin-responsive rat taste receptor cells. Neurosci Lett. 2003;351:157-60 pubmed
    ..They further support the notion of a putative modulatory role of CCK with convergence of multiple inputs occurring at the level of intracellular calcium. ..
  5. Breitwieser G. G protein-coupled receptor oligomerization: implications for G protein activation and cell signaling. Circ Res. 2004;94:17-27 pubmed
    ..Our evolving understanding of the structural and functional consequences of GPCR oligomerization may provide novel and more selective sites for pharmacological tuning of cardiovascular function. ..
  6. Pi M, Quarles L. Osteoblast calcium-sensing receptor has characteristics of ANF/7TM receptors. J Cell Biochem. 2005;95:1081-92 pubmed
  7. Cismowski M. Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins). Semin Cell Dev Biol. 2006;17:334-44 pubmed
    ..AGS proteins provide a basis for understanding the function of heterotrimeric G-proteins in both GPCR-driven and GPCR independent cellular signaling pathways. ..
  8. Kusakabe M, Nakamura I, Evans J, Swanson P, Young G. Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes. J Endocrinol. 2006;189:541-54 pubmed
  9. Hettinger T, Formaker B, Frank M. Cycloheximide: no ordinary bitter stimulus. Behav Brain Res. 2007;180:4-17 pubmed
    ..The combination of T2R multiplicity, species divergence and gene duplication results in diverse ligands for multiple species-specific T2R receptors, which confounds definition of 'bitter' stimuli across species. ..

More Information

Publications140 found, 100 shown here

  1. Wang Y, Danilova V, Cragin T, Roberts T, Koposov A, Hellekant G. The sweet taste quality is linked to a cluster of taste fibers in primates: lactisole diminishes preference and responses to sweet in S fibers (sweet best) chorda tympani fibers of M. fascicularis monkey. BMC Physiol. 2009;9:1 pubmed publisher
    ..The absence of the effect of lactisole on the faint responses in some S fibers to other stimuli as well as the responses to sweet and non-sweet stimuli in non-S fibers suggest that these responses originate from other taste receptors. ..
  2. Camilleri M, Carlson P, Zinsmeister A, McKinzie S, Busciglio I, Burton D, et al. Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders. Gastroenterology. 2010;138:98-107.e4 pubmed publisher
    ..Expression of several neuropeptides is induced upon NPS-NPSR1 signaling; NPSR1 variants are associated with colonic transit in FGID. The role of the NPS system in FGID deserves further study. ..
  3. Asioli S, Erickson L, Sebo T, Zhang J, Jin L, Thompson G, et al. Papillary thyroid carcinoma with prominent hobnail features: a new aggressive variant of moderately differentiated papillary carcinoma. A clinicopathologic, immunohistochemical, and molecular study of eight cases. Am J Surg Pathol. 2010;34:44-52 pubmed publisher
    ..Two patients are alive without disease after 120 and 236 months. PTC with a prominent hobnail pattern is a moderately differentiated PTC variant with aggressive clinical behavior and significant mortality...
  4. Williams J, Oh S, Jorgensen M, Steiger N, Darwiche H, Shupe T, et al. The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation. Am J Pathol. 2010;176:2732-42 pubmed publisher
    ..Furthermore, changes in Wnt1 levels are required for the efficient regeneration of the liver by oval cells during massive hepatic injury...
  5. Tholanikunnel B, Joseph K, Kandasamy K, Baldys A, Raymond J, Luttrell L, et al. Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane. J Biol Chem. 2010;285:33816-25 pubmed publisher
  6. Blackwell K, Raisz L, Pilbeam C. Prostaglandins in bone: bad cop, good cop?. Trends Endocrinol Metab. 2010;21:294-301 pubmed publisher
    ..Further analysis of COX-2 and PG receptors and their downstream G-protein signaling in bone could provide important clues to the regulation of skeletal cell growth in both health and disease. ..
  7. Reeves S, Gozal D. Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. Am J Physiol Regul Integr Comp Physiol. 2004;287:R369-74 pubmed
    ..Thus we postulate that PAFR expression and/or function underlies critical components of IH-induced LTVF but does not play a role in the potentiation of the hypoxic ventilatory response after IH exposures. ..
  8. Paik J, Skoura A, Chae S, Cowan A, Han D, Proia R, et al. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. 2004;18:2392-403 pubmed
    ..S1P-induced trafficking and activation of N-cadherin provides a novel mechanism for the stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis and vascular diseases. ..
  9. Plager D, Kahl J, Asmann Y, Nilson A, Pallanch J, Friedman O, et al. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. PLoS ONE. 2010;5:e11450 pubmed publisher
    ..The identified gene expression changes provide additional diagnostic and therapeutic targets for aCRSwNP and other eosinophilic epithelial diseases. ..
  10. Zhang G, Mao L, Liu X, Wang J. Long-lasting up-regulation of orexin receptor type 2 protein levels in the rat nucleus accumbens after chronic cocaine administration. J Neurochem. 2007;103:400-7 pubmed
    ..This OXR2 up-regulation may reflect a key adaptation of limbic orexinergic transmission to chronic drug exposure and may thus be critical for the expression of motor plasticity. ..
  11. Kim W, Jessen H, Auger A, Terasawa E. Postmenopausal increase in KiSS-1, GPR54, and luteinizing hormone releasing hormone (LHRH-1) mRNA in the basal hypothalamus of female rhesus monkeys. Peptides. 2009;30:103-10 pubmed publisher
    ..Collectively, in the primate the reduction in the negative feedback control by ovarian steroids appears to be responsible for the aging changes in kisspeptin-GPR54 signaling and the elevated state of the LHRH-1 neuronal system. ..
  12. Hanson G, Hanson B. Fluorescent probes for cellular assays. Comb Chem High Throughput Screen. 2008;11:505-13 pubmed
    ..This review will give a broad overview of types of fluorescent probes, types of fluorescent assays, and their application in cellular assays for a number of pharmaceutically relevant target classes. ..
  13. Tanaka S, Shaikh I, Chiocca E, Saeki Y. The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development. PLoS ONE. 2009;4:e5922 pubmed publisher
    ..These results thus indicate that GPR3 is a novel antiproliferative mediator of CGPs in the postnatal development of murine cerebellum. ..
  14. Fadel J, Burk J. Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention. Brain Res. 2010;1314:112-23 pubmed publisher
    ..Dysfunction in orexin-acetylcholine interactions may play a role in the arousal and attentional deficits that accompany neurodegenerative conditions as diverse as drug addiction and age-related cognitive decline. ..
  15. Cason A, Smith R, Tahsili Fahadan P, Moorman D, Sartor G, Aston Jones G. Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol Behav. 2010;100:419-28 pubmed publisher
    ..The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. ..
  16. Kluk M, Colmont C, Wu M, Hla T. Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells. FEBS Lett. 2003;533:25-8 pubmed
    ..These data question the generality of the concept that S1P1 GPCR is a critical downstream component of PDGF-induced chemotaxis. ..
  17. Mishina Y, Wilson C, Bruett L, Smith J, Stoop Myer C, Jong S, et al. Multiplex GPCR assay in reverse transfection cell microarrays. J Biomol Screen. 2004;9:196-207 pubmed
  18. Wang Y, Pierce M, Schneper L, Güldal C, Zhang X, Tavazoie S, et al. Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast. PLoS Biol. 2004;2:E128 pubmed
    ..These studies provide a paradigm for extracting the topology of signal transduction pathways from expression data. ..
  19. Mo Z, Zecevic N. Human fetal radial glia cells generate oligodendrocytes in vitro. Glia. 2009;57:490-8 pubmed publisher
    ..In summary, our in vitro experiments revealed that a portion of cortical RG cells isolated from human forebrain at the second trimester of gestation generates OL progenitors and this suggests a role of SHH in this process. ..
  20. Jia H, Liu Y, Xia R, Tong C, Yue T, Jiang J, et al. Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem. 2010;285:37218-26 pubmed publisher
    ..We showed that CK2 prevents Ci ubiquitination and degradation by the proteasome. Thus, CK2 promotes Hh signaling activity by regulating multiple pathway components. ..
  21. Lado D, Browe C, Gaskin A, Borden J, MacLennan A. Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions. Gene. 1994;149:331-6 pubmed
    ..Therefore, edg-1 may play a cell-type-specific role in differentiation and also participate in neurotransmission. ..
  22. Lu W, Yamamoto V, Ortega B, Baltimore D. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004;119:97-108 pubmed
    ..Thus, Ryk appears to play a crucial role in Wnt-mediated signaling. ..
  23. Chung W, Kermode J. Suramin disrupts receptor-G protein coupling by blocking association of G protein alpha and betagamma subunits. J Pharmacol Exp Ther. 2005;313:191-8 pubmed
    ..This action can explain how it both disrupts receptor-G protein coupling and inhibits guanine nucleotide release. The improved understanding of suramin's action advances the development of selective inhibitors of G protein signaling. ..
  24. Casillan A, Gonzalez N, Johnson J, Steiner D, Wood J. Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. J Appl Physiol (1985). 2003;94:2313-22 pubmed
  25. Gottsch M, Cunningham M, Smith J, Popa S, Acohido B, Crowley W, et al. A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology. 2004;145:4073-7 pubmed
    ..We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH. ..
  26. Green J, Inoue T, Sternberg P. Opposing Wnt pathways orient cell polarity during organogenesis. Cell. 2008;134:646-56 pubmed publisher
    ..Thus, tissue polarity is determined by the integration of multiple Wnt pathways...
  27. Van Brocklyn J, Behbahani B, Lee N. Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors. Biochim Biophys Acta. 2002;1582:89-93 pubmed
    ..We show that S1P receptors form both homodimers as well as heterodimers with other members of the S1P subfamily of receptors. We also discuss the role that GPCR dimers play in receptor function and what this may mean for S1P signaling. ..
  28. Reese E, Bunzow J, Arttamangkul S, Sonders M, Grandy D. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J Pharmacol Exp Ther. 2007;321:178-86 pubmed
    ..Taken together, these in vitro results suggest that, in vivo, TAAR1 could be a novel mediator of the effects of these drugs...
  29. Norris R, Freudzon L, Freudzon M, Hand A, Mehlmann L, Jaffe L. A G(s)-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-G(s) signaling. Dev Biol. 2007;310:240-9 pubmed
    ..However, LH does not cause a change in Galpha(s) localization, indicating that LH does not act by terminating receptor-G(s) signaling. ..
  30. Arai A, Orwig N. Factors that regulate KiSS1 gene expression in the hippocampus. Brain Res. 2008;1243:10-8 pubmed publisher
    ..In additional experiments, KiSS1 mRNA was found to be increased after orchidectomy and thus expression may be regulated also by gonadal hormones. ..
  31. Bradshaw H, Lee S, McHugh D. Orphan endogenous lipids and orphan GPCRs: a good match. Prostaglandins Other Lipid Mediat. 2009;89:131-4 pubmed publisher
    ..Working to deorphanize both lipids and GPCRs together provides a unique opportunity for a greater understanding of cellular signaling and a challenge to find them all a home. ..
  32. West A, Llamas L, Snow P, Benzer S, Bjorkman P. Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan. Proc Natl Acad Sci U S A. 2001;98:3744-9 pubmed
    ..The Mth structure is analyzed in relation to predicted Mth homologs and potential ligand binding features. ..
  33. Dong M, Zang M, Pinon D, Li Z, Lybrand T, Miller L. Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus. Mol Endocrinol. 2002;16:2490-501 pubmed
    ..Additional experimentally derived constraints will be necessary to determine the spatial positioning of this complex with the remainder of the SecR. ..
  34. Webster J, Bentley M, Wojcikiewicz R. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits ligand binding to certain G protein-coupled receptors. Eur J Pharmacol. 2003;474:1-5 pubmed
    ..TPEN may have widespread antagonistic activity towards G protein-coupled receptors of this kind. ..
  35. Maye P, Zheng J, Li L, Wu D. Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J Biol Chem. 2004;279:24659-65 pubmed
    ..Knockdown of Wnt11 expression using siRNA resulted in increased LEF-1 reporter activity, thus indicating that Wnt11-mediated suppression of canonical signaling exists in vivo. ..
  36. Smith J, Clifton D, Steiner R. Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. Reproduction. 2006;131:623-30 pubmed
  37. MacLennan A, Browe C, Gaskin A, Lado D, Shaw G. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol Cell Neurosci. 1994;5:201-9 pubmed
    ..Finally, all of the sequence motifs characteristic of Src homology 2 domains are present in pH218 but in a unique arrangement. We conclude that pH218 may function as a growth factor receptor. ..
  38. Brailoiu E, Cooper R, Dun N. Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction. Br J Pharmacol. 2002;136:1093-7 pubmed
    ..The result provides the first evidence that S1-P acting intracellularly but not extracellularly enhances spontaneous transmitter release at the frog neuromuscular junction. ..
  39. Wang C, Dehghani B, Li Y, Kaler L, Proctor T, Vandenbark A, et al. Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J Immunol. 2009;182:3294-303 pubmed publisher
    ..This study is the first to evaluate the protective effect of GPR30 activation on EAE, and provides a strong foundation for the clinical application of GPR30 agonists such as G-1 in multiple sclerosis. ..
  40. Tweedle M. Peptide-targeted diagnostics and radiotherapeutics. Acc Chem Res. 2009;42:958-68 pubmed publisher
    ..In particular, multivalent interactions can lead to unpredictable and useful biochemical information, as well as new drug candidates. ..
  41. Ogden S, Ascano M, Stegman M, Robbins D. Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol. 2004;67:805-14 pubmed
    ..Here, we review what is known about regulation of individual Hh signaling components, concentrating on the mechanisms by which the Hh signal is propagated through Smo to the HSC. ..
  42. Mehlmann L. Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes. Dev Biol. 2005;288:397-404 pubmed
  43. Spalding E. Ion channels and the transduction of light signals. Plant Cell Environ. 2000;23:665-74 pubmed
    ..Also included is some discussion of the technical aspects of studies that combine electrophysiology and photobiology...
  44. Heo J, Han S, Vaidehi N, Wendel J, Kekenes Huskey P, Goddard W. Prediction of the 3D structure of FMRF-amide neuropeptides bound to the mouse MrgC11 GPCR and experimental validation. Chembiochem. 2007;8:1527-39 pubmed
    ..Similar studies were made with the mMrgA1 receptor, which did not bind the R-F-NH(2) dipeptide; we explain this to be due to the increased hydrophobic character of the binding pocket in mMrgA1. ..
  45. Frick K, Krieger N, Nehrke K, Bushinsky D. Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1. J Bone Miner Res. 2009;24:305-13 pubmed publisher
    ..Perfusion with MET induced a rapid increase in Ca(i) in OGR1-transfected CHO cells. These data indicate that OGR1 induces an increase in Ca(i) in response to MET and is a prime candidate for an osteoblast proton sensor. ..
  46. Nei M, Niimura Y, Nozawa M. The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity. Nat Rev Genet. 2008;9:951-63 pubmed publisher
    ..It seems that mutation by gene duplication and inactivation has important roles in both the adaptive and non-adaptive evolution of chemosensation. ..
  47. Wehr M, Hostick U, Kyweriga M, Tan A, Weible A, Wu H, et al. Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR). J Neurophysiol. 2009;102:2554-62 pubmed publisher
    ..When crossed to other transactivator lines expressing in defined neuronal cell types, this AlstR/tetO line should prove a very useful tool for the analysis of intact central neural circuits. ..
  48. Xie Y, Gibbs T, Meier K. Lysophosphatidic acid as an autocrine and paracrine mediator. Biochim Biophys Acta. 2002;1582:270-81 pubmed
    ..Studies addressing these issues with respect to the potential roles of LPA as an autocrine and paracrine mediator are reviewed, with examples. ..
  49. Brothers S, Cornea A, Janovick J, Conn P. Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Mol Endocrinol. 2004;18:1787-97 pubmed
  50. Farzana L, Brown S. Hedgehog signaling pathway function conserved in Tribolium segmentation. Dev Genes Evol. 2008;218:181-92 pubmed publisher
  51. Prescott S, Lalouel J, Leppert M. From linkage maps to quantitative trait loci: the history and science of the Utah genetic reference project. Annu Rev Genomics Hum Genet. 2008;9:347-58 pubmed publisher
    ..As with the earlier efforts, this project involved collaborations among many investigators and has yielded insights into multiple traits. ..
  52. Zhang R, Zhang X, Bian F, Pu X, Schilling K, Oberdick J. 3'UTR-dependent localization of a Purkinje cell messenger RNA in dendrites. Cerebellum. 2008;7:482-93 pubmed publisher
    ..Using expression of modified transgenes in vivo, we show that the 3'UTR, only 65 bases long, is necessary in this process. ..
  53. Liu C, Hla T. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997;43:15-24 pubmed
    ..However, the activity of the 5'-flanking region was suppressed by the repressor activity within the first intron. These data provide the basis for the further characterization of the regulation of the orphan GPR edg-1. ..
  54. Ding W, Kuntz S, Böhmig M, Wiedenmann B, Miller L. Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma. Gastroenterology. 2002;122:500-11 pubmed
    ..The aim of the present study was to explore the molecular basis for positive and false-negative secretin-stimulation test results in patients with these tumors...
  55. Itagaki K, Kannan K, Singh B, Hauser C. Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils. J Immunol. 2004;172:601-7 pubmed
  56. Luttrell L. Transmembrane signaling by G protein-coupled receptors. Methods Mol Biol. 2006;332:3-49 pubmed
    ..In some cases, these processes appear to generate signals in conjunction with, or even independent of, G protein activation. ..
  57. Nishijima I, Yamagata T, Spencer C, Weeber E, Alekseyenko O, Sweatt J, et al. Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior. Hum Mol Genet. 2006;15:3241-50 pubmed
    ..Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior. ..
  58. Blair S, Ralston A. Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. Development. 1997;124:4053-63 pubmed
    ..Our results suggest that compartmentalization is a complex process involving intercompartmental signalling; models based on changes in affinity or growth will be discussed. ..
  59. Ogden S, Ascano M, Stegman M, Suber L, Hooper J, Robbins D. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol. 2003;13:1998-2003 pubmed
    ..This work fills in the last major gap in our understanding of the Hh signal transduction pathway by suggesting that no intermediate signal is required to connect Smo to the HSC. ..
  60. Scott G, Jacobs S, Pentland A. sPLA2-X stimulates cutaneous melanocyte dendricity and pigmentation through a lysophosphatidylcholine-dependent mechanism. J Invest Dermatol. 2006;126:855-61 pubmed
    ..Because secretory phospholipases are released during inflammation and are regulated by UV irradiation, our data suggest an important role for sPLA2-X in cutaneous pigmentation through the release of LPC. ..
  61. Sheffler D, Kroeze W, Garcia B, Deutch A, Hufeisen S, Leahy P, et al. p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci U S A. 2006;103:4717-22 pubmed
    ..Because RSK2-inactivating mutations in humans lead to Coffin-Lowry syndrome, our results imply that alterations in GPCR signaling may account for some of its clinical manifestations...
  62. Vortherms T, Mosier P, Westkaemper R, Roth B. Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor. J Biol Chem. 2007;282:3146-56 pubmed
    ..These findings imply that differences in the helical orientation of helix 2 are critical for the selectivity of salvinorin A binding to KOR and provide a structurally novel basis for ligand selectivity. ..
  63. Steiner M, Urso J, Klein J, Steiner S. Multiple astrocyte responses to lysophosphatidic acids. Biochim Biophys Acta. 2002;1582:154-60 pubmed
    ..There are important aspects of astrocyte LPA responses still to be fully evaluated, including functions in development and activation, synergy between LPA and other biomediators, and astrocyte interactions with other cells. ..
  64. Baig Lewis S, Peterson Nedry W, Wehrli M. Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP. Dev Biol. 2007;306:94-111 pubmed
    ..The amplification function of Arrow/LRP appears to be particularly important for long-range signaling, and may reflect a general mechanism for potentiating signals in the shallow part of a morphogen gradient. ..
  65. Link A, Skretas G, Strauch E, Chari N, Georgiou G. Efficient production of membrane-integrated and detergent-soluble G protein-coupled receptors in Escherichia coli. Protein Sci. 2008;17:1857-63 pubmed publisher
  66. Oner S, Maher E, Breton B, Bouvier M, Blumer J. Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai. J Biol Chem. 2010;285:20588-94 pubmed publisher
    ..These data suggest that AGS4-Galpha(i) complexes directly couple to a G-protein-coupled receptor and may serve as substrates for agonist-induced G-protein activation...
  67. Erickson J, Wu J, Goddard J, Tigyi G, Kawanishi K, Tomei L, et al. Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J Biol Chem. 1998;273:1506-10 pubmed
    ..These results indicate that Edg-2 encodes a highly specific LPA receptor. ..
  68. Whippo C, Hangarter R. Second positive phototropism results from coordinated co-action of the phototropins and cryptochromes. Plant Physiol. 2003;132:1499-507 pubmed
    ..Based on our results, we hypothesize that phototropins and cryptochromes regulate phototropism by coordinating the balance between stimulation and inhibition of growth of the hypocotyl depending on the fluence rate of blue light. ..
  69. Schwendt M, Hearing M, See R, McGinty J. Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum. Neuroreport. 2007;18:1261-5 pubmed
    ..Changes in RGS4 mRNA levels might signal abnormal receptor G-protein coupling that impacts cocaine seeking. ..
  70. Tailor C, Nouri A, Lee C, Kozak C, Kabat D. Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses. Proc Natl Acad Sci U S A. 1999;96:927-32 pubmed
    ..We propose that X-MLVs and P-MLVs comprise a single family of retroviruses that have coevolved in response to diversification in X-receptor genes of the host. ..
  71. Bhandari D, Robia S, Marchese A. The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol Biol Cell. 2009;20:1324-39 pubmed publisher
  72. Ju B, Spitsbergen J, Eden C, Taylor M, Chen W. Co-activation of hedgehog and AKT pathways promote tumorigenesis in zebrafish. Mol Cancer. 2009;8:40 pubmed publisher
    ..These results suggest that co-activation of the hedgehog and AKT pathways promote tumorigenesis, and that the binary transgenic approach is a useful tool for studying interaction of oncogenes and oncogenic pathways in zebrafish. ..
  73. Bullesbach E, Schwabe C. Mouse relaxin: synthesis and biological activity of the first relaxin with an unusual crosslinking pattern. Biochem Biophys Res Commun. 1993;196:311-9 pubmed
  74. Marin M, Tailor C, Nouri A, Kozak S, Kabat D. Polymorphisms of the cell surface receptor control mouse susceptibilities to xenotropic and polytropic leukemia viruses. J Virol. 1999;73:9362-8 pubmed
    ..Because failure of interference is a hallmark of several exceptionally pathogenic retroviruses, we propose that it contributes to P-MLV-induced diseases. ..
  75. Lee M, Thangada S, Claffey K, Ancellin N, Liu C, Kluk M, et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. 1999;99:301-12 pubmed
    ..Indeed, SPP synergized with polypeptide angiogenic growth factors in the formation of mature neovessels in vivo. These data define SPP as a novel regulator of angiogenesis. ..
  76. Terra S, McGorray S, Wu R, McNamara D, Cavallari L, Walker J, et al. Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. Int J Obes (Lond). 2005;29:746-54 pubmed
    ..Given that 50% of all women die from coronary heart disease, and a higher percentage have heart disease during their lifetime, our results are likely generalizable to many American women. ..
  77. Sanchez T, Skoura A, Wu M, Casserly B, Harrington E, Hla T. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol. 2007;27:1312-8 pubmed
    ..S1P2R activation in endothelial cells increases vascular permeability. The balance of S1P1 and S1P2 receptors in the endothelium may determine the regulation of vascular permeability by S1P. ..
  78. Huang Y, Fan J, Yang J, Zhu G. Characterization of GPR56 protein and its suppressed expression in human pancreatic cancer cells. Mol Cell Biochem. 2008;308:133-9 pubmed
    ..Taken together, these results define the biochemical properties of GPR56 protein, and suggest that the expression of GPR56 protein is suppressed in human pancreatic cancer cells. ..
  79. Arehart E, Stitham J, Asselbergs F, Douville K, MacKenzie T, Fetalvero K, et al. Acceleration of cardiovascular disease by a dysfunctional prostacyclin receptor mutation: potential implications for cyclooxygenase-2 inhibition. Circ Res. 2008;102:986-93 pubmed publisher
    ..Combining both biochemical and clinical approaches, we conclude that diminished prostacyclin receptor signaling may contribute, in part, to the underlying adverse cardiovascular outcomes observed with cyclooxygenase-2 inhibition. ..
  80. Shahed A, Young K. Differential ovarian expression of KiSS-1 and GPR-54 during the estrous cycle and photoperiod induced recrudescence in Siberian hamsters (Phodopus sungorus). Mol Reprod Dev. 2009;76:444-52 pubmed publisher
    ..Transient increases in KiSS-1/GPR54 expression following LD stimulation are also suggestive of possible involvement in ovulation and/or restoration of ovarian function...
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    ..Collectively, E(2) induces a rapid excitatory effect on primate LHRH neurons, and this rapid action of E(2) appears to be mediated, in part, through GPR30...
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    ..Our findings provide evidence for functional LPA receptors on microglia. Thus, LPA might play an important role as a mediator of microglial activation in response to central nervous system injury. ..
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    ..Transactivation of GPCRs by Akt may constitute a specificity switch to integrate rapid G protein-dependent signals into long-term cellular phenomena such as cell migration. ..
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    ..These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva. ..
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    ..These results demonstrate that human oocytes maintain meiotic arrest prior to the LH surge using a signaling pathway similar to that of rodent oocytes. ..
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    ..These studies show that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon...
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    ..Our findings indicate that the RXFP2 signaling pathway plays an important role in mediating androgen action to stimulate gubernaculum development during inguinoscrotal testis descent. ..
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    ..This M1 FA assay offers advantages over traditional radioligandbinding assays as it eliminates radioactivity while allowing investigation of orthosteric or allosteric muscarinic M1 ligands in a homogeneous format...
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    ..The inability of EE to reduce disease in GPR30KO mice indicates an important but still undefined role for GPR30 in regulating immune reactivity. ..
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    ..Nevertheless, they clearly demonstrate that loss of ovarian steroid negative feedback that occurs during perimenopause plays a major role in modulating the activity of KNDy circuits of the aging primate ARC-ME...