Genomes and Genes
Experts and Doctors on g protein coupled receptors in Germany
Topic: g protein coupled receptors
- Bufe B, Hofmann T, Krautwurst D, Raguse J, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. 2002;32:397-401 pubmed..If the ability of TAS2R16 to detect substances with common molecular properties is typical of the bitter receptor family, it may explain how a few receptors permit the perception of numerous bitter substances...
- Tanrikulu Y, Schneider G. Pseudoreceptor models in drug design: bridging ligand- and receptor-based virtual screening. Nat Rev Drug Discov. 2008;7:667-77 pubmed publisher..Here, we review the field of pseudoreceptor modelling techniques along with recent hit and lead finding applications, and critically discuss prerequisites, advantages and limitations of the various approaches. ..
- Scheel H, Tomiuk S, Hofmann K. A common protein interaction domain links two recently identified epilepsy genes. Hum Mol Genet. 2002;11:1757-62 pubmed..The EAR domain is likely to play an important role in the pathogenesis of epilepsy, either by binding to an unknown anti-epileptic ligand, or more likely by interfering with axon guidance or synaptogenesis. ..
- Weigert A, Weis N, Brüne B. Regulation of macrophage function by sphingosine-1-phosphate. Immunobiology. 2009;214:748-60 pubmed publisher..Here, we summarize the current knowledge of the function of S1P in macrophage biology and discuss potential implications for pathology. ..
- Panther E, Idzko M, Corinti S, Ferrari D, Herouy Y, Mockenhaupt M, et al. The influence of lysophosphatidic acid on the functions of human dendritic cells. J Immunol. 2002;169:4129-35 pubmed..In summary, our study implicates that LPA might regulate the trafficking, cytokine production, and T cell-activating functions of DCs. ..
- Rissling I, Körner Y, Geller F, Stiasny Kolster K, Oertel W, Moller J. Preprohypocretin polymorphisms in Parkinson disease patients reporting "sleep attacks". Sleep. 2005;28:871-5 pubmed
- Fueller M, Wang D, Tigyi G, Siess W. Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. Cell Signal. 2003;15:367-75 pubmed..Our study is the first report showing the receptor-mediated activation of human monocytic cells by low nanomolar concentrations of LPA and S1P, and suggests a role of these lipid mediators in inflammation and atherogenesis. ..
- Aust G, Steinert M, Schutz A, Boltze C, Wahlbuhl M, Hamann J, et al. CD97, but not its closely related EGF-TM7 family member EMR2, is expressed on gastric, pancreatic, and esophageal carcinomas. Am J Clin Pathol. 2002;118:699-707 pubmed..Taken together, significant numbers of gastric, esophageal, and pancreatic carcinomas are CD97+, whereas its homolog, EMR2, does not have any role in such tumors. ..
- Heisenberg C, Solnica Krezel L. Back and forth between cell fate specification and movement during vertebrate gastrulation. Curr Opin Genet Dev. 2008;18:311-6 pubmed publisher..The current challenge is to delineate the molecular mechanisms via which the major signaling pathways regulate cell fate specification and movements, and how these two processes are coordinated to ensure normal development. ..
- Klenk C, Humrich J, Quitterer U, Lohse M. SUMO-1 controls the protein stability and the biological function of phosducin. J Biol Chem. 2006;281:8357-64 pubmed..Together, these findings show that phosducin is a previously unrecognized target of SUMO modification and that SUMOylation controls phosducin stability in cells as well as its functional properties. ..
- Fischer M, Reeh P. Sensitization to heat through G-protein-coupled receptor pathways in the isolated sciatic mouse nerve. Eur J Neurosci. 2007;25:3570-5 pubmed..To a surprising degree, peripheral nerve axons resemble peripheral sensory terminals in their common properties of sensory and signal transduction. ..
- Kuhn C, Bufe B, Batram C, Meyerhof W. Oligomerization of TAS2R bitter taste receptors. Chem Senses. 2010;35:395-406 pubmed publisher..Thus, our results show that receptor oligomerization occurs between TAS2R bitter taste receptors; however, functional consequences of hetero-oligomerization were not obvious. ..
- Wieland H, Soll R, Doods H, Stenkamp D, Hurnaus R, Lämmle B, et al. The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. Eur J Biochem. 2002;269:1128-35 pubmed..Amino acid prediction of this A -->G change results in an isoleucine --> valine substitution at the protein level, which may provide evidence for an editing process. ..
- Niedernberg A, Blaukat A, Schoneberg T, Kostenis E. Regulated and constitutive activation of specific signalling pathways by the human S1P5 receptor. Br J Pharmacol. 2003;138:481-93 pubmed..Our results suggest that different signal transduction pathways are not equally activated through constitutively active GPCRs with promiscuous signalling characteristics. ..
- Bakthavatsalam D, Meijer H, Noegel A, Govers F. Novel phosphatidylinositol phosphate kinases with a G-protein coupled receptor signature are shared by Dictyostelium and Phytophthora. Trends Microbiol. 2006;14:378-82 pubmed..It is hypothesized that, upon activation, GPCR-PIPKs are able to trigger heterotrimeric G-protein signaling and phosphoinositide second-messenger synthesis. ..
- Hornuss C, Hammermann R, Fuhrmann M, Juergens U, Racke K. Human and rat alveolar macrophages express multiple EDG receptors. Eur J Pharmacol. 2001;429:303-8 pubmed
- Kleine T, Lockhart P, Batschauer A. An Arabidopsis protein closely related to Synechocystis cryptochrome is targeted to organelles. Plant J. 2003;35:93-103 pubmed..That is, CRY1 and CRY2 genes may originate from an endosymbiotic ancestor of modern-day alpha-proteobacteria, while the CRY3 gene may originate from an endosymbiotic ancestor of modern-day cyanobacteria. ..
- Hofmann K, Scheerer P, Hildebrand P, Choe H, Park J, Heck M, et al. A G protein-coupled receptor at work: the rhodopsin model. Trends Biochem Sci. 2009;34:540-52 pubmed publisher..The Galpha C-terminal helix is used as a transmission rod to the nucleotide binding site. The mechanism relies on dynamic interactions between conserved residues and could therefore be common to other GPCRs. ..
- Fischer O, Giordano S, Comoglio P, Ullrich A. Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells. J Biol Chem. 2004;279:28970-8 pubmed
- Roelle S, Grosse R, Aigner A, Krell H, Czubayko F, Gudermann T. Matrix metalloproteinases 2 and 9 mediate epidermal growth factor receptor transactivation by gonadotropin-releasing hormone. J Biol Chem. 2003;278:47307-18 pubmed..Our findings suggest a novel role for gelatinases in the endocrine regulation of pituitary gonadotropes. ..
- Johren O, Neidert S, Kummer M, Dendorfer A, Dominiak P. Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats. Endocrinology. 2001;142:3324-31 pubmed..Moreover, the sexually dimorphic expression of OX(1) and OX(2) receptors in the hypothalamus, pituitary, and adrenal glands suggests gender-specific roles of orexins in the control of endocrine functions. ..
- Prabhu Y, Eichinger L. The Dictyostelium repertoire of seven transmembrane domain receptors. Eur J Cell Biol. 2006;85:937-46 pubmed..discoideum was surprising because they had not been observed outside the animal kingdom before. Their presence suggests unprecedentedly complex and so far unknown signaling activities in this lower eukaryote. ..
- Niedernberg A, Tunaru S, Blaukat A, Harris B, Kostenis E. Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. J Biomol Screen. 2003;8:500-10 pubmed..The findings suggest that assays in a given cellular background may vary significantly with respect to suitability for agonist finding and that ligands producing a response may not readily be detectable in all agonist assays. ..
- Uhlenbrock K, Gassenhuber H, Kostenis E. Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. Cell Signal. 2002;14:941-53 pubmed..Constitutive activation of AC and mobilization of [Ca(2+)](i) can be modulated by the sphingophospholipids S1P and DHS1P, adding three additional members to the family of S1P receptors. ..
- zu Heringdorf D, Vincent M, Lipinski M, Danneberg K, Stropp U, Wang D, et al. Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1). Cell Signal. 2003;15:677-87 pubmed..Co-expression of S1P(1) with S1P(3), but not S1P(2), reversed the inhibitory effect of S1P(1), furthermore suggesting a specific interplay of S1P receptor subtypes usually found within a single cell type. ..
- Tiemann U, Tomek W, Schneider F, Wollenhaupt K, Kanitz W, Becker F, et al. Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. Prostaglandins Other Lipid Mediat. 2001;65:125-41 pubmed..We suggest that the bovine endometrium produces PAF-like activity, expresses the PAF-R and possesses a PAF-AH activity which varies during pregnancy. ..
- Igel P, Geyer R, Strasser A, Dove S, Seifert R, Buschauer A. Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. J Med Chem. 2009;52:6297-313 pubmed publisher..2-Carbamoyl-1-[2-(1H-imidazol-4-yl)ethyl]-3-(3-phenylpropyl)guanidine (UR-PI97, 88) was unexpectedly identified as a highly potent and selective hH3R inverse agonist (pKB = 8.42, >300-fold selectivity over the other HR subtypes). ..
- Schwartzkopff F, Brandt E, Petersen F, Flad H, Bock L, Ludwig A. The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor. J Interferon Cytokine Res. 2002;22:257-67 pubmed..Thus, a role for NAP-2 may be to limit PAF-dependent vascular tissue damage by preventing degranulation of neutrophils without affecting their migration into the inflamed tissue. ..
- Jöhren O, Brüggemann N, Dendorfer A, Dominiak P. Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors. Endocrinology. 2003;144:1219-25 pubmed
- Tang Z, El Far O, Betz H, Scheschonka A. Pias1 interaction and sumoylation of metabotropic glutamate receptor 8. J Biol Chem. 2005;280:38153-9 pubmed..Our results are consistent with post-translational sumoylation providing a novel mechanism of group III mGluR regulation. ..
- Dutta S, Dietrich J, Aspöck G, Burdine R, Schier A, Westerfield M, et al. pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development. 2005;132:1579-90 pubmed..During mid-somitogenesis, Hedgehog then acts on the established median placode as a necessary and sufficient signal to specify pituitary cell types. ..
- Park J, Scheerer P, Hofmann K, Choe H, Ernst O. Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature. 2008;454:183-7 pubmed publisher..The opsin structure sheds new light on ligand binding to GPCRs and on GPCR activation...
- Parthier C, Kleinschmidt M, Neumann P, Rudolph R, Manhart S, Schlenzig D, et al. Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor. Proc Natl Acad Sci U S A. 2007;104:13942-7 pubmed..The presentation of a well structured, alpha-helical ligand by the ECD is expected to be conserved among other hormone receptors of this class. ..
- Bakthavatsalam D, Brazill D, Gomer R, Eichinger L, Rivero F, Noegel A. A G protein-coupled receptor with a lipid kinase domain is involved in cell-density sensing. Curr Biol. 2007;17:892-7 pubmed..Inactivation of Galpha1, a negative regulator of CMF signaling, rescued the developmental defect of the rpkA- cells, suggesting that RpkA actions are mediated by Galpha1. ..
- Klammt C, Srivastava A, Eifler N, Junge F, Beyermann M, Schwarz D, et al. Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation. FEBS J. 2007;274:3257-69 pubmed..Our approach represents an efficient expression technique for G-protein-coupled receptors such as human endothelin B receptor, and might provide a valuable tool for fast structural and functional characterizations. ..
- Hager U, Hein A, Lennerz J, Zimmermann K, Neuhuber W, Reeh P. Morphological characterization of rat Mas-related G-protein-coupled receptor C and functional analysis of agonists. Neuroscience. 2008;151:242-54 pubmed..Thus, BAM22 sensitizes the capsaicin- and heat-induced CGRP release in an apparently MrgC-unrelated way. The sensitization to heat appears unusually resistant against pharmacological interventions and does not involve TRPV1. ..
- Kouba M, Vanetti M, Wang X, Schafer M, Hollt V. Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue. FEBS Lett. 1993;321:173-8 pubmed..5 kb mRNA species in various brain regions and neuronal cell lines, whereas in the spleen a 3 kb transcript is predominant. This distribution suggests a role of NLR in the nervous and immune systems. ..
- Wu Y, Chen Z, Ullrich A. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol Chem. 2003;384:1215-26 pubmed..Our findings support a broader role of FRS2 in EGFR-controlled signaling pathways in A-431 cells and provide insight into a molecular mechanism for ligand-stimulated feedback regulation with FRS2 as a central regulatory switch point. ..
- Obermann H, Samalecos A, Osterhoff C, Schröder B, Heller R, Kirchhoff C. HE6, a two-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev. 2003;64:13-26 pubmed..Immunohistochemical studies revealed that both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia. ..
- Stuebner S, Faus Kessler T, Fischer T, Wurst W, Prakash N. Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Dev Dyn. 2010;239:246-60 pubmed publisher..Fzd3 and Fzd6 thus control proper midbrain morphogenesis by a yet unknown mechanism in the mouse. ..
- Petersenn S, Rasch A, Penshorn M, Beil F, Schulte H. Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor. Endocrinology. 2001;142:2649-59 pubmed..These studies demonstrate the nature of the human GHS-R gene and identify its 5'-flanking region. Furthermore, pituitary-specific activity of the promoter and regulation by various hormones are demonstrated. ..
- Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 2010;35:157-70 pubmed publisher..Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs. ..
- Alenina N, Bader M, Walther T. Imprinting of the murine MAS protooncogene is restricted to its antisense RNA. Biochem Biophys Res Commun. 2002;290:1072-8 pubmed..Our results strongly suggest that Mas is not imprinted in mice but that an antisense RNA probably starting in the neighboring Igf2r gene is maternally imprinted in both embryos and adult organs. ..
- Alenina N, Baranova T, Smirnow E, Bader M, Lippoldt A, Patkin E, et al. Cell type-specific expression of the Mas proto-oncogene in testis. J Histochem Cytochem. 2002;50:691-6 pubmed..The strong ontogenetically controlled and cell type-specific expression of this membrane-bound receptor in testis implicates a role for the Mas proto-oncogene in testis maturation and function. ..
- Walther T, Balschun D, Voigt J, Fink H, Zuschratter W, Birchmeier C, et al. Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene. J Biol Chem. 1998;273:11867-73 pubmed..Thus, Mas is an important modulating factor in the electrophysiology of the hippocampus and is involved in behavioral pathways in the adult brain. ..
- Klonisch T, Hombach Klonisch S, Froehlich C, Kauffold J, Steger K, Steinetz B, et al. Canine preprorelaxin: nucleic acid sequence and localization within the canine placenta. Biol Reprod. 1999;60:551-7 pubmed..The uterine glands and nonplacental uterine areas of the canine zonary girdle placenta were devoid of relaxin mRNA and relaxin. We conclude that the syncytiotrophoblast is the source of relaxin in the canine placenta. ..
- Xu P, Santos R, Bader M, Alenina N. Alterations in gene expression in the testis of angiotensin-(1-7)-receptor Mas-deficient mice. Regul Pept. 2007;138:51-5 pubmed..Three of these genes, coding for proteins involved in mitochondrial function and steroidogenesis, become henceforth targets for our continuing search for the physiological function of Mas in testis. ..
- von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. Interaction between Mas and the angiotensin AT1 receptor in the amygdala. J Neurophysiol. 2000;83:2012-21 pubmed..The use of different angiotensin receptor antagonists provides the first in vitro evidence for a functional interaction between the Mas-protooncogene and the AT1 receptor...
- Kirchhoff C, Osterhoff C, Samalecos A. HE6/GPR64 adhesion receptor co-localizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Reproduction. 2008;136:235-45 pubmed publisher..Comparable immunostaining patterns were observed in human and mouse; however, a specific feature of the human ductuli efferentes was an intense HE6/GPR64-related labelling of crypt-like grooves or furrows of hitherto unknown function. ..
- Lanfranco F, Gromoll J, von Eckardstein S, Herding E, Nieschlag E, Simoni M. Role of sequence variations of the GnRH receptor and G protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism. Eur J Endocrinol. 2005;153:845-52 pubmed..Mutations of the GnRHR and of the GPR54 gene are rare in IHH and should be investigated especially in cases with autosomal recessive transmission. Common SNPs of the GnRHR and GPR54 genes do not play any role in IHH. ..
- Osterhoff C, Ivell R, Kirchhoff C. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. DNA Cell Biol. 1997;16:379-89 pubmed..The predicted extracellular amino-terminal extension, however, was much longer than in the other members, and showed similarity to highly glycosylated mucin-like cell-surface molecules. ..
- Vogler R, Sauer B, Kim D, Schäfer Korting M, Kleuser B. Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. J Invest Dermatol. 2003;120:693-700 pubmed..Microinjections of sphingosine-1-phosphate in keratinocytes also reduce proliferation suggesting that both sphingosine-1-phosphate receptors as well as intracellular actions mediate sphingosine-1-phosphate- induced cell growth arrest. ..
- von Kügelgen I, Schiedel A, Hoffmann K, Alsdorf B, Abdelrahman A, Muller C. Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain. Mol Pharmacol. 2008;73:469-77 pubmed..In summary, our data show that a second mammalian DNA sequence encodes for a G(i)-coupled GPCR activated by low, nanomolar concentrations of adenine. ..
- Budnik L, Brunswig Spickenheier B, Mukhopadhyay A. Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?. Mol Endocrinol. 2003;17:1593-606 pubmed..The findings indicate that LPA transiently stimulates MAPK ERK in LPA1/edg2-expressing theca cells and suggest an alternative mechanism regulating the activation of ERK that differs from the canonical EGF-Ras-MAPK kinase pathway...
- Ciarimboli G, Struwe K, Arndt P, Gorboulev V, Koepsell H, Schlatter E, et al. Regulation of the human organic cation transporter hOCT1. J Cell Physiol. 2004;201:420-8 pubmed..Regulation pathways were the same in the two expression systems. Since apparent substrate affinities depend on activity of regulatory pathways, the expression system plays a role in determining the substrate affinities. ..
- Satagopam V, Theodoropoulou M, Stampolakis C, Pavlopoulos G, Papandreou N, Bagos P, et al. GPCRs, G-proteins, effectors and their interactions: human-gpDB, a database employing visualization tools and data integration techniques. Database (Oxford). 2010;2010:baq019 pubmed publisher..Database URLs: http://schneider.embl.de/human_gpdb; http://bioinformatics.biol.uoa.gr/human_gpdb/ ..
- Alenina N, Xu P, Rentzsch B, Patkin E, Bader M. Genetically altered animal models for Mas and angiotensin-(1-7). Exp Physiol. 2008;93:528-37 pubmed..In conclusion, the angiotensin-(1-7)-Mas axis has important functional implications for vascular regulation and blood pressure control, particularly in pathophysiological situations. ..
- Behrens M, Brockhoff A, Batram C, Kuhn C, Appendino G, Meyerhof W. The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin. J Agric Food Chem. 2009;57:9860-6 pubmed publisher..Insights into the general breadth of tuning, functional redundancies, and relationships between pharmacological activation patterns and amino acid homologies for this receptor subfamily are presented. ..
- Wagner C, Isermann K, Fehrenbach H, Roeder T. Molecular architecture of the fruit fly's airway epithelial immune system. BMC Genomics. 2008;9:446 pubmed publisher..This architecture will allow reacting if confronted with different bacterial or fungal elicitors by activation of a multitude of effectors. ..
- Arias Carrión O, Murillo Rodriguez E. Cell transplantation: a future therapy for narcolepsy?. CNS Neurol Disord Drug Targets. 2009;8:309-14 pubmed..This article reviews the current understanding of narcolepsy and discusses the opportunity to explore the potential use of transplants as a therapeutical tool in order to treat narcolepsy. ..
- Spangenberg C, Winterpacht A, Zabel B, Löbbert R. Cloning and characterization of a novel gene (TM7SF1) encoding a putative seven-pass transmembrane protein that is upregulated during kidney development. Genomics. 1998;48:178-85 pubmed..Studies on Wilms tumor samples showed variable TM7SF1 expression, ranging from nearly undetectable levels to an abundant level of expression comparable to that of adult kidney tissue. ..
- Ignatov A, Lintzel J, Hermans Borgmeyer I, Kreienkamp H, Joost P, Thomsen S, et al. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. J Neurosci. 2003;23:907-14 pubmed
- Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, et al. Bitter taste receptors for saccharin and acesulfame K. J Neurosci. 2004;24:10260-5 pubmed..Consistent with the in vitro data, cross-adaptation studies in human subjects also support the existence of common receptors for both sulfonyl amide sweeteners...
- Pandur P, Maurus D, Kuhl M. Increasingly complex: new players enter the Wnt signaling network. Bioessays. 2002;24:881-4 pubmed
- Jäger D, Schmalenbach C, Prilla S, Schrobang J, Kebig A, Sennwitz M, et al. Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation. J Biol Chem. 2007;282:34968-76 pubmed..This study provides first evidence for a role of an allosteric E2/transmembrane helix 7 contact region for muscarinic receptor activation by orthosteric agonists. ..
- Aust G, Kamprad M, Lamesch P, Schmücking E. CXCR6 within T-helper (Th) and T-cytotoxic (Tc) type 1 lymphocytes in Graves' disease (GD). Eur J Endocrinol. 2005;152:635-43 pubmed..CXCR6 was overexpressed in Th1 and Tc1 TLs compared with PBLs in GD. CXCR6 could be a marker for lymphocytes that have migrated into the thyroid and assist in the thyroid, independently of the bias of the underlying disease. ..
- Niedernberg A, Scherer C, Busch A, Kostenis E. Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. Biochem Pharmacol. 2002;64:1243-50 pubmed..Taken together, our data imply that differences between hS1P(5) and rS1P(5) will be an important point to be considered in the development of selective receptor antagonists. ..
- Süsens U, Hermans Borgmeyer I, Urny J, Schaller H. Characterisation and differential expression of two very closely related G-protein-coupled receptors, GPR139 and GPR142, in mouse tissue and during mouse development. Neuropharmacology. 2006;50:512-20 pubmed..GPR139 signal transduction in Chinese hamster ovary cells requires coupling to an inhibitory G-protein and is mediated by phospholipase C. Dimer formation may be necessary for proper function. ..
- Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, et al. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood. 2006;108:965-73 pubmed..Our findings implicate the evolutionarily conserved WNT/Frizzled signaling system in bridging innate and adaptive immunity to infections. ..
- Michel N, Ganter K, Venzke S, Bitzegeio J, Fackler O, Keppler O. The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling. Mol Biol Cell. 2006;17:3578-90 pubmed..Nef uses a mechanism that is distinct from well-established pathways orchestrating CKR metabolism and offers an interesting tool to study the multifaceted biology of CKRs. ..
- Hirth I, Deitmer J. 5-Hydroxytryptamine-mediated increase in glutamate uptake by the leech giant glial cell. Glia. 2006;54:786-94 pubmed..Our results suggest that 5-HT enhances the glial uptake of glutamate via cAMP- and PKA-mediated pathway...
- Weber U, Paricio N, Mlodzik M. Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development. 2000;127:3619-29 pubmed
- Breunig E, Michel K, Zeller F, Seidl S, Weyhern C, Schemann M. Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. J Physiol. 2007;583:731-42 pubmed..These data may form the basis of identification of new targets to treat inflammatory and functional gut disorders. ..
- Orth J, Lang S, Preuss I, Milligan G, Aktories K. Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors. Cell Signal. 2007;19:2174-82 pubmed..The data indicate that activation of Galpha(q) by PMT is persistent and independent of a functional interaction of G(q) with G-protein-coupled receptors...
- Hänze J, Groneberg D, Rose F, Hanisch A, Dotsch J, Peiser C, et al. Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia. Biochem Biophys Res Commun. 2002;291:1160-5 pubmed..Analysis of the two human pulmonary epithelial cell lines, H23 and A549, showed significant mRNA induction of this receptor subtype in hypoxia. ..
- Ansari K, Martin S, Farkasovsky M, Ehbrecht I, Küntzel H. Phospholipase C binds to the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae. J Biol Chem. 1999;274:30052-8 pubmed..Our data suggest that phospholipase C modulates the interaction of the putative nutrient sensor Gpr1p with the Galpha protein Gpa2p as a downstream effector of filamentation control. ..
- Neumann J, Schaale K, Farhat K, Endermann T, Ulmer A, Ehlers S, et al. Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages. FASEB J. 2010;24:4599-612 pubmed publisher..The current data support the notion that evolutionarily conserved Wnt/Fzd signaling is involved in balancing the inflammatory response to microbial stimulation of innate immune cells of vertebrate origin. ..
- Mederos y Schnitzler M, Storch U, Meibers S, Nurwakagari P, Breit A, Essin K, et al. Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction. EMBO J. 2008;27:3092-103 pubmed publisher..This inhibitory effect is enhanced in blood vessels of mice deficient in the regulator of G-protein signalling-2. These findings suggest that G(q/11)-coupled receptors function as sensors of membrane stretch in VSM cells. ..
- Laemmle B, Schindler M, Beilmann M, Hamilton B, Doods H, Wieland H. Characterization of the NPGP receptor and identification of a novel short mRNA isoform in human hypothalamus. Regul Pept. 2003;111:21-9 pubmed..However, hypothalamic NPGPR mRNA was unchanged in both models. Therefore, our evidence does not support the hypothesis that NPGPR is involved in feeding regulation. ..
- Nofer J, van der Giet M, Tölle M, Wolinska I, von Wnuck Lipinski K, Baba H, et al. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. J Clin Invest. 2004;113:569-81 pubmed..This mechanism may contribute to the vasoactive effect of HDL and represent a novel aspect of its antiatherogenic function. ..
- Ignatov A, Hermans Borgmeyer I, Schaller H. Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. Neuropharmacology. 2004;46:1114-20 pubmed..A weak activation of GalRL by galanin suggests that the endogenous ligand shares structural features with galanin. ..
- Schäfer B, Marg B, Gschwind A, Ullrich A. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. J Biol Chem. 2004;279:47929-38 pubmed..Thus, ADAM15 and -17 function as effectors of GPCR-mediated signaling and define critical characteristics of cancer cells. ..
- Sergeeva O, Andreeva N, Garret M, Scherer A, Haas H. Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit. J Neurosci. 2005;25:88-95 pubmed..The infrequent expression of the epsilon-subunit may be a key factor in the recently discovered central role of the tuberomamillary nucleus in anesthesia. ..
- Müller T, Bayer H, Myrtek D, Ferrari D, Sorichter S, Ziegenhagen M, et al. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. Am J Respir Cell Mol Biol. 2005;33:601-9 pubmed..In summary, our data provide evidence for a distinct physiologic role of P2Y(14) in the selective release of specific chemokines from human airway epithelial cells. ..
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