Experts and Doctors on fungal proteins in United States

Summary

Locale: United States
Topic: fungal proteins

Top Publications

  1. Miller R, Heller K, Frisén L, Wallack D, Loayza D, Gammie A, et al. The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast. Mol Biol Cell. 1998;9:2051-68 pubmed
    ..Furthermore, we propose that Kip3p functions, in part, by depolymerizing microtubules and is required for the Kar9p-dependent orientation of the cytoplasmic microtubules. ..
  2. Roy N, Runge K. Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr Biol. 2000;10:111-4 pubmed
    ..As Zds2p, but not Zds1p, had strong two-hybrid interactions with Orc1p and the four Sir proteins, Zds1p might indirectly control Sir3p through a Sir3p kinase. ..
  3. Tripathi S, Xu T, Feng Q, Avula B, Shi X, Pan X, et al. Two plant-derived aporphinoid alkaloids exert their antifungal activity by disrupting mitochondrial iron-sulfur cluster biosynthesis. J Biol Chem. 2017;292:16578-16593 pubmed publisher
    ..Therefore, the identification of this pathway as a target for antifungal compounds has potential applications in the development of new antifungal therapies. ..
  4. Zhu H, Riggs A. Yeast flavohemoglobin is an ancient protein related to globins and a reductase family. Proc Natl Acad Sci U S A. 1992;89:5015-9 pubmed
    ..8 billion years, the estimated time of divergence of prokaryotes and eukaryotes provided that cross-species gene transfer has not occurred. ..
  5. Audet R, Brandhorst T, Klein B. Purification in quantity of the secreted form of WI-1: a major adhesin on Blastomyces dermatitidis yeasts. Protein Expr Purif. 1997;11:219-26 pubmed
    ..These findings advance our understanding of the WI-1 adhesin/antigen and our ability to express and purify WI-1 in quantity and will permit a study of the relationship between three-dimensional structure and activity of the molecule...
  6. Chattopadhyay S, Muzaffar N, Sherman F, Pearce D. The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis. J Bacteriol. 2000;182:6418-23 pubmed
    ..Increased expression of HSP30 and BTN2 in btn1-Delta strains and diminished growth of btn1-Delta, hsp30-Delta, and btn2-Delta strains at low pH reinforce our view that altered pH homeostasis is the underlying cause of Batten disease. ..
  7. Tran P, Simon J, Liskay R. Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2001;98:9760-5 pubmed
    ..Finally, our results show that much of the increase in spontaneous mutation observed in an exo1Delta strain is REV3-dependent, in turn suggesting that Exo1p is also involved in one or more MMR-independent mutation avoidance pathways. ..
  8. Carlson H, Ota S, Campbell C, Hurlin P. A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome. Hum Mol Genet. 2001;10:2403-13 pubmed
    ..Our results identify critical functional domains within the Tbx3 protein and facilitate interpretation of the functional consequences of present and future UMS mutations. ..
  9. Bachant J, Jessen S, Kavanaugh S, Fielding C. The yeast S phase checkpoint enables replicating chromosomes to bi-orient and restrain spindle extension during S phase distress. J Cell Biol. 2005;168:999-1012 pubmed
    ..We propose that by promoting replication fork integrity under these conditions Rad53 ensures centromere duplication. Replicating chromosomes can then bi-orient in a cohesin-independent manner to restrain untimely spindle extension. ..

More Information

Publications548 found, 100 shown here

  1. Yike I. Fungal proteases and their pathophysiological effects. Mycopathologia. 2011;171:299-323 pubmed publisher
    ..The involvement of fungal proteases in diverse pathological mechanisms makes them potential targets of therapeutic intervention and candidates for biomarkers of disease and exposure. ..
  2. Kim H, Ridenour J, Dunkle L, Bluhm B. Regulation of stomatal tropism and infection by light in Cercospora zeae-maydis: evidence for coordinated host/pathogen responses to photoperiod?. PLoS Pathog. 2011;7:e1002113 pubmed publisher
    ..zeae-maydis, and establishes a genetic framework for the molecular dissection of infection via stomata and the integration of host and pathogen responses to photoperiod. ..
  3. Arif M, Fletcher J, Marek S, Melcher U, Ochoa Corona F. Development of a rapid, sensitive, and field-deployable razor ex BioDetection system and quantitative PCR assay for detection of Phymatotrichopsis omnivora using multiple gene targets. Appl Environ Microbiol. 2013;79:2312-20 pubmed publisher
  4. Glazier V, Murante T, Murante D, Koselny K, Liu Y, Kim D, et al. Genetic analysis of the Candida albicans biofilm transcription factor network using simple and complex haploinsufficiency. PLoS Genet. 2017;13:e1006948 pubmed publisher
    ..Taken together, genetic interaction analysis of this network has provided new insights into the functions of individual TFs as well as into the role of the overall network topology in its function. ..
  5. Sidorova J, Breeden L. Analysis of the SWI4/SWI6 protein complex, which directs G1/S-specific transcription in Saccharomyces cerevisiae. Mol Cell Biol. 1993;13:1069-77 pubmed
    ..From these data, we propose that the sequence-specific DNA-binding domain resides in SWI4 but that SWI6 controls the accessibility of this domain in the SWI4/6 complex. ..
  6. Wuthrich M, Klein B. Investigation of anti-WI-1 adhesin antibody-mediated protection in experimental pulmonary blastomycosis. J Infect Dis. 2000;181:1720-8 pubmed
    ..Thus, antibody to WI-1 does not appear to improve the outcome of murine blastomycosis and may enhance the infection...
  7. Frolov M, Benevolenskaya E, Birchler J. The oxen gene of Drosophila encodes a homolog of subunit 9 of yeast ubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of gene expression in response to mitochondrial activity. Genetics. 2000;156:1727-36 pubmed
    ..The oxen mutation provides a model for the genetic analysis in multicellular organisms of the effect of mitochondrial activity on nuclear gene expression...
  8. Mehta S, Yang X, Chan C, Dobson M, Jayaram M, Velmurugan S. The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation?. J Cell Biol. 2002;158:625-37 pubmed
    ..Cohesin-mediated pairing and unpairing likely provides a counting mechanism for evenly partitioning plasmids either in association with or independently of the chromosomes. ..
  9. Goldstrohm A, Seay D, Hook B, Wickens M. PUF protein-mediated deadenylation is catalyzed by Ccr4p. J Biol Chem. 2007;282:109-14 pubmed
    ..Our data suggest that PUF proteins may enhance mRNA degradation and repress expression by both deadenylation-dependent and -independent mechanisms, using the same Pop2p bridge to recruit a multifunctional Pop2p complex to the mRNA. ..
  10. Taheri Talesh N, Horio T, Araújo Bazán L, Dou X, Espeso E, Peñalva M, et al. The tip growth apparatus of Aspergillus nidulans. Mol Biol Cell. 2008;19:1439-49 pubmed publisher
    ..Microtubules are important for delivering vesicles to the tip area and for holding the tip growth apparatus in position...
  11. Banuett F, Quintanilla R, Reynaga Peña C. The machinery for cell polarity, cell morphogenesis, and the cytoskeleton in the Basidiomycete fungus Ustilago maydis-a survey of the genome sequence. Fungal Genet Biol. 2008;45 Suppl 1:S3-S14 pubmed publisher
    ..In most cases, not surprisingly, the closest homolog is among filamentous fungi, not the yeasts, and in some cases it is among mammals...
  12. Bluhm B, Dunkle L. PHL1 of Cercospora zeae-maydis encodes a member of the photolyase/cryptochrome family involved in UV protection and fungal development. Fungal Genet Biol. 2008;45:1364-72 pubmed publisher
    ..This study presents the first characterization of a 6-4 photolyase ortholog in a filamentous fungus and provides evidence that PHL1 regulates responses to UV irradiation. ..
  13. Anju V, Kapros T, Waterborg J. Identification of a replication-independent replacement histone H3 in the basidiomycete Ustilago maydis. J Biol Chem. 2011;286:25790-800 pubmed publisher
  14. Sidorova J, Breeden L. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Genes Dev. 1997;11:3032-45 pubmed
    ..On the basis of these observations, we suggest that the Rad53-dependent phosphorylation of Swi6 may delay the transition to S phase by inhibiting CLN transcription. ..
  15. Stevens R, Davis T. Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae. J Cell Biol. 1998;142:711-22 pubmed
    ..High copies of MLC1 completely overcome the growth defects and increase the stability of Myo2p. Our results suggest that Mlc1p is responsible for stabilizing this myosin by binding to the neck region. ..
  16. Nair D, Kim Y, Myers L. Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts. J Biol Chem. 2005;280:33739-48 pubmed
  17. Vanden Wymelenberg A, Minges P, Sabat G, Martinez D, Aerts A, Salamov A, et al. Computational analysis of the Phanerochaete chrysosporium v2.0 genome database and mass spectrometry identification of peptides in ligninolytic cultures reveal complex mixtures of secreted proteins. Fungal Genet Biol. 2006;43:343-56 pubmed
    ..These included 4 lignin peroxidases, 3 lipases, 2 carboxylesterases, and 8 glycosyl hydrolases. The results underscore the rich genetic diversity and complexity of P. chrysosporium's extracellular enzyme systems...
  18. Robinson R, Franceschini S, Fedkenheuer M, Rodríguez P, Ellerbrock J, Romero E, et al. Arg279 is the key regulator of coenzyme selectivity in the flavin-dependent ornithine monooxygenase SidA. Biochim Biophys Acta. 2014;1844:778-84 pubmed publisher
    ..The results indicate that the positive charge at position 279 is critical for tight binding of NADPH and efficient hydroxylation. ..
  19. Shlezinger N, Irmer H, Dhingra S, Beattie S, Cramer R, Braus G, et al. Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death. Science. 2017;357:1037-1041 pubmed publisher
    ..Immune surveillance exploits a fungal apoptosis-like programmed cell death pathway to maintain sterilizing immunity in the lung. ..
  20. Gibson J, Chen J, Tower P, Tabita F. The form II fructose 1,6-bisphosphatase and phosphoribulokinase genes form part of a large operon in Rhodobacter sphaeroides: primary structure and insertional mutagenesis analysis. Biochemistry. 1990;29:8085-93 pubmed
    ..sphaeroides enzymes, including a protease-sensitive area located in a region equivalent to residues 51-71 of mammalian FBPase.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  21. Jeong S, Lang W, Reeder R. The release element of the yeast polymerase I transcription terminator can function independently of Reb1p. Mol Cell Biol. 1995;15:5929-36 pubmed
    ..We discuss possible mechanisms whereby this polI release element might function. ..
  22. Fu Y. Identification of a novel protein, DMAP, which interacts with the myotonic dystrophy protein kinase and shows strong homology to D1 snRNP. Genetica. 1996;97:117-25 pubmed
    ..This novel protein may be a member of the signal transduction pathway which is responsible for the manifestation of this disease. ..
  23. Del Priore V, Heath C, Snay C, MacMillan A, Gorsch L, Dagher S, et al. A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae. J Cell Sci. 1997;110 ( Pt 23):2987-99 pubmed
    ..In addition, we postulate that the N-terminal third of Rat7p/Nup159p plays an important role in mRNA export. ..
  24. Blader I, Cope M, Jackson T, Profit A, Greenwood A, Drubin D, et al. GCS1, an Arf guanosine triphosphatase-activating protein in Saccharomyces cerevisiae, is required for normal actin cytoskeletal organization in vivo and stimulates actin polymerization in vitro. Mol Biol Cell. 1999;10:581-96 pubmed
    ..These data provide in vivo and in vitro evidence that Gcs1p interacts directly with the actin cytoskeleton in S. cerevisiae. ..
  25. Nothwehr S, Bruinsma P, Strawn L. Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment. Mol Biol Cell. 1999;10:875-90 pubmed
    ..These data suggest a model in which distinct structural features within Vps35p are required for associating with the cytosolic domains of each cargo protein during the retrieval process. ..
  26. Polinko E, Strome S. Depletion of a Cks homolog in C. elegans embryos uncovers a post-metaphase role in both meiosis and mitosis. Curr Biol. 2000;10:1471-4 pubmed
    ..Specifically, cks-1(RNAi) embryos fail to exit M phase properly. We propose that CKS-1 has an essential role in the inactivation of MPF during early C. elegans embryogenesis...
  27. Friedman D, Kern J, Huneycutt B, Vinh D, Crawford D, Steiner E, et al. Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain. J Biol Chem. 2001;276:17958-67 pubmed
    ..Sites of Mps1p phosphorylation and Ser(36) are located within the N-terminal globular domain of Spc110p, which resides at the inner plaque of the SPB and binds the Tub4p complex. ..
  28. Stribinskis V, Gao G, Ellis S, Martin N. Rpm2, the protein subunit of mitochondrial RNase P in Saccharomyces cerevisiae, also has a role in the translation of mitochondrially encoded subunits of cytochrome c oxidase. Genetics. 2001;158:573-85 pubmed
    ..Moreover, there is a synthetic lethal interaction between the disruption of this novel respiratory function and the loss of wild-type mtDNA. This synthetic interaction explains why a complete deletion of RPM2 is lethal. ..
  29. Pintar J, Starmer W. The costs and benefits of killer toxin production by the yeast Pichia kluyveri. Antonie Van Leeuwenhoek. 2003;83:89-97 pubmed
    ..The data support the hypothesis that there are both costs and benefits to producing killer toxin, and based on this, selection may favor different phenotypes in different conditions. ..
  30. Schofield D, Westwater C, Warner T, Nicholas P, Paulling E, Balish E. Hydrolytic gene expression during oroesophageal and gastric candidiasis in immunocompetent and immunodeficient gnotobiotic mice. J Infect Dis. 2003;188:591-9 pubmed
  31. Wang Y, Jiang H. Interaction of beta-1,3-glucan with its recognition protein activates hemolymph proteinase 14, an initiation enzyme of the prophenoloxidase activation system in Manduca sexta. J Biol Chem. 2006;281:9271-8 pubmed
    ..These data are consistent with the current model on initiation and regulation of the prophenoloxidase activation cascade upon recognition of pathogen-associated molecular patterns by specific pattern recognition proteins. ..
  32. Krizek B, Sulli C. Mapping sequences required for nuclear localization and the transcriptional activation function of the Arabidopsis protein AINTEGUMENTA. Planta. 2006;224:612-21 pubmed
    ..Finally, we show that ANT is nuclear localized and that the sequence KKKR (amino acids 252-255) is required for nuclear localization of the protein. ..
  33. Grabińska K, Magnelli P, Robbins P. Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III activity and chitin chain length. Eukaryot Cell. 2007;6:328-36 pubmed
    ..Our results provide evidence that the prenyl moiety attached to Chs4p is a factor modulating the activity of CSIII both in vivo and in vitro. ..
  34. Kane P. The long physiological reach of the yeast vacuolar H+-ATPase. J Bioenerg Biomembr. 2007;39:415-21 pubmed
  35. Lewis Z, Adhvaryu K, Honda S, Shiver A, Knip M, Sack R, et al. DNA methylation and normal chromosome behavior in Neurospora depend on five components of a histone methyltransferase complex, DCDC. PLoS Genet. 2010;6:e1001196 pubmed publisher
    ..DIM-7 is required for DIM-5 localization and mediates interaction of DIM-5 with DDB1/CUL4 through DIM-9. These data support a two-step mechanism for H3K9 methylation in Neurospora...
  36. Song J, Singh M. From hub proteins to hub modules: the relationship between essentiality and centrality in the yeast interactome at different scales of organization. PLoS Comput Biol. 2013;9:e1002910 pubmed publisher
  37. Hurley J, Loros J, Dunlap J. The circadian system as an organizer of metabolism. Fungal Genet Biol. 2016;90:39-43 pubmed publisher
    ..This review describes both well understood and emerging links between the clock and metabolic output of fungi as well as the role that metabolism plays in influencing the rhythm set by the clock. ..
  38. Huie M, Scott E, Drazinic C, Lopez M, Hornstra I, Yang T, et al. Characterization of the DNA-binding activity of GCR1: in vivo evidence for two GCR1-binding sites in the upstream activating sequence of TPI of Saccharomyces cerevisiae. Mol Cell Biol. 1992;12:2690-700 pubmed
    ..Taken together, these experiments have allowed us to propose a consensus GCR1-binding site which is 5'-(T/A)N(T/C)N(G/A)NC(T/A)TCC(T/A)N(T/A)(T/A)(T/G)-3'. ..
  39. Feng L, Yoon H, Donahue T. Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae. Mol Cell Biol. 1994;14:5139-53 pubmed
    ..These genetic data appear to indicate that the modifications that we describe at the carboxyl end of the eIF-2 alpha protein are required for optimal eIF-2 function in S. cerevisiae. ..
  40. Zhao H, Eide D. The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Proc Natl Acad Sci U S A. 1996;93:2454-8 pubmed
    ..These results suggest that ZRT1 is regulated at the transcriptional level by the intracellular concentration of zinc. ZRT1 is an additional member of a growing family of metal transport proteins. ..
  41. Pang Q, Prolla T, Liskay R. Functional domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA mismatch repair proteins and their relevance to human hereditary nonpolyposis colorectal cancer-associated mutations. Mol Cell Biol. 1997;17:4465-73 pubmed
    ..We discuss the implications of these findings for the structural organization of the Mlh1p and Pms1p proteins and the importance of Mlh1p-Pms1p interaction. ..
  42. Maser R, Monsen K, Nelms B, Petrini J. hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. Mol Cell Biol. 1997;17:6087-96 pubmed
    ..Further, these data indicate that hMre11-hRad50 foci form in response to DNA DSBs and are dependent upon a DNA damage-induced signaling pathway. ..
  43. Jackson D, Stevens T. VMA12 encodes a yeast endoplasmic reticulum protein required for vacuolar H+-ATPase assembly. J Biol Chem. 1997;272:25928-34 pubmed
    ..We propose that Vma12p functions directly in the assembly of the V0 subunits into a complex in the ER, and that assembly is required for the stability of the V0 subunits and their transport as a complex out of this compartment. ..
  44. Lammer D, Mathias N, Laplaza J, Jiang W, Liu Y, Callis J, et al. Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev. 1998;12:914-26 pubmed
    ..Consistent with this model, both enr2delta and an allele of Cdc53p that is not Rub1p modified, render cells sensitive to alterations in the levels of Cdc4p, Cdc34p, and Cdc53p. ..
  45. Xie J, Beickman K, Otte E, Rymond B. Progression through the spliceosome cycle requires Prp38p function for U4/U6 snRNA dissociation. EMBO J. 1998;17:2938-46 pubmed
    ..Prp38p is the first tri-snRNP-specific protein shown to be dispensable for assembly, but required for conformational changes which lead to catalytic activation of the spliceosome. ..
  46. Lu Z, Cyr D. Protein folding activity of Hsp70 is modified differentially by the hsp40 co-chaperones Sis1 and Ydj1. J Biol Chem. 1998;273:27824-30 pubmed
    ..Ydj1 and Sis1 are structurally and functionally distinct Hsp40 proteins that can specify Ssa1 action by generating Hsp70:Hsp40 pairs that exhibit different chaperone activities. ..
  47. Yoon J, Wold B. The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm. Genes Dev. 2000;14:3204-14 pubmed
    ..We infer that pMesogenin1 is an essential upstream regulator of trunk paraxial mesoderm development and segmentation. ..
  48. Miller D, Holtzman S, Kalkbrenner A, Kaufman T. Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of the Drosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation. Mech Dev. 2001;102:17-32 pubmed
    ..We find that extrinsic specification of cell fate by signaling can be overridden by Hox protein expression in mesodermal cells and propose the term autonomic dominance for this phenomenon. ..
  49. Wang Z. Translesion synthesis by the UmuC family of DNA polymerases. Mutat Res. 2001;486:59-70 pubmed
    ..Recent studies of the UmuC superfamily are summarized and evidence is presented suggesting that this family of DNA polymerases is involved in translesion DNA synthesis. ..
  50. Wang L, Seeley E, Wickner W, Merz A. Vacuole fusion at a ring of vertex docking sites leaves membrane fragments within the organelle. Cell. 2002;108:357-69 pubmed
    ..Their vertex enrichment requires cis-SNARE complex disassembly and is thus part of the normal fusion pathway. ..
  51. Shridas P, Rush J, Waechter C. Identification and characterization of a cDNA encoding a long-chain cis-isoprenyltranferase involved in dolichyl monophosphate biosynthesis in the ER of brain cells. Biochem Biophys Res Commun. 2003;312:1349-56 pubmed
  52. Jun Y, Fratti R, Wickner W. Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE-dependent yeast vacuole fusion. J Biol Chem. 2004;279:53186-95 pubmed
    ..However, vacuoles purified from plc1Delta strains still retain PLC activity and significant 3-nitrocoumarin- and U73122-sensitive fusion, suggesting that there is another PLC in S. cerevisiae with an important role in vacuole fusion. ..
  53. Bowers H, Maroney P, Fairman M, Kastner B, Luhrmann R, Nilsen T, et al. Discriminatory RNP remodeling by the DEAD-box protein DED1. RNA. 2006;12:903-12 pubmed
    ..In addition, our study illuminates possible mechanisms for protein displacement by DExH/D proteins. ..
  54. Krajaejun T, Gauthier G, Rappleye C, Sullivan T, Klein B. Development and application of a green fluorescent protein sentinel system for identification of RNA interference in Blastomyces dermatitidis illuminates the role of septin in morphogenesis and sporulation. Eukaryot Cell. 2007;6:1299-309 pubmed
    ..Hence, this GFP sentinel system enables rapid detection of gene silencing and has revealed a pronounced role for septin in morphogenesis, budding, and sporulation of B. dermatitidis...
  55. Brodhagen M, Tsitsigiannis D, Hornung E, Goebel C, Feussner I, Keller N. Reciprocal oxylipin-mediated cross-talk in the Aspergillus-seed pathosystem. Mol Microbiol. 2008;67:378-91 pubmed publisher
    ..This report provides the first genetic evidence for reciprocal oxylipin cross-talk in the Aspergillus-seed pathosystem. ..
  56. Jwa M, Kim J, Chan C. Regulation of Sli15/INCENP, kinetochore, and Cdc14 phosphatase functions by the ribosome biogenesis protein Utp7. J Cell Biol. 2008;182:1099-111 pubmed publisher
    ..Thus, Utp7 is a multifunctional protein that plays essential roles in the vital cellular processes of ribosome biogenesis, chromosome segregation, and cell cycle control. ..
  57. Froehlich A, Chen C, Belden W, Madeti C, Roenneberg T, Merrow M, et al. Genetic and molecular characterization of a cryptochrome from the filamentous fungus Neurospora crassa. Eukaryot Cell. 2010;9:738-50 pubmed publisher
    ..Whole-genome microarray experiments failed to identify substantive transcriptional regulatory activity of cry under our laboratory conditions. ..
  58. Nett J, Sanchez H, Cain M, Ross K, Andes D. Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation. Eukaryot Cell. 2011;10:1660-9 pubmed publisher
    ..This novel connection helps explain how pathogens in a multicellular biofilm community are protected from anti-infective therapy. ..
  59. Saleh A, Esele J, Logrieco A, Ritieni A, Leslie J. Fusarium verticillioides from finger millet in Uganda. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29:1762-9 pubmed publisher
    ..verticillioides originated in Africa and not in the Americas, despite its widespread association with maize grown almost anywhere worldwide...
  60. Guo J, Catchmark J. Binding specificity and thermodynamics of cellulose-binding modules from Trichoderma reesei Cel7A and Cel6A. Biomacromolecules. 2013;14:1268-77 pubmed publisher
    ..Cello-oligosaccharides less than two glucose units did not bind with CBMs, and improved binding affinities were observed for cello-oligosaccharides with longer glucose units. ..
  61. Geraghty R, Talbot K, Callahan M, Harper W, Panganiban A. Cell type-dependence for Vpu function. J Med Primatol. 1994;23:146-50 pubmed
    ..A yeast GAL4 transcriptional activation system was used to screen for cellular proteins that may interact with Vpu. One such protein was identified which we provisionally designate "Vpu interactive protein" or VIP. ..
  62. Mai B, Breeden L. Xbp1, a stress-induced transcriptional repressor of the Saccharomyces cerevisiae Swi4/Mbp1 family. Mol Cell Biol. 1997;17:6491-501 pubmed
    ..These observations suggest that Xbp1 may contribute to the repression of specific transcripts and cause a transient cell cycle delay under stress conditions. ..
  63. Dunlap J, Loros J, Liu Y, Crosthwaite S. Eukaryotic circadian systems: cycles in common. Genes Cells. 1999;4:1-10 pubmed
    ..Post-transcriptional control governs the amount and type of FRQ and makes the clock responsive to temperature. ..
  64. Ravindra A, Weiss K, Simpson R. High-resolution structural analysis of chromatin at specific loci: Saccharomyces cerevisiae silent mating-type locus HMRa. Mol Cell Biol. 1999;19:7944-50 pubmed
    ..Features of the chromatin structure of this silent locus compared to the previously studied HMLalpha locus suggest differences in the mechanisms of silencing and may relate to donor selection during mating-type interconversion. ..
  65. Murray J, Johnson D. Isolation and characterization of Nrf1p, a novel negative regulator of the Cdc42p GTPase in Schizosaccharomyces pombe. Genetics. 2000;154:155-65 pubmed
    ..GFP-Nrf1p vacuolar localization depended on the S. pombe Cdc24p homolog Scd1p. Taken together, these data are consistent with Nrf1p functioning as a negative regulator of Cdc42p within the cell polarity pathway. ..
  66. Helfant A. Composition of the spindle pole body of Saccharomyces cerevisiae and the proteins involved in its duplication. Curr Genet. 2002;40:291-310 pubmed
    ..In addition, genetic and biochemical studies have revealed the functional and physical relationships of certain spindle pole components and proteins important for SPB duplication. ..
  67. Cummings W, Merino S, Young K, Li L, Johnson C, Sierra E, et al. The Coprinus cinereus adherin Rad9 functions in Mre11-dependent DNA repair, meiotic sister-chromatid cohesion, and meiotic homolog pairing. Proc Natl Acad Sci U S A. 2002;99:14958-63 pubmed
    ..Because the role of Rad9 in homolog pairing is not obviated by the absence of a sister chromatid, we conclude that adherins have one or more early meiotic functions distinct from the establishment of cohesion...
  68. Mennella T, Klinkenberg L, Zitomer R. Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein. Eukaryot Cell. 2003;2:1288-303 pubmed
    ..These findings suggest that the repression of different regulons or genes may invoke different mechanisms. ..
  69. Brown D, Dyer R, McCormick S, Kendra D, Plattner R. Functional demarcation of the Fusarium core trichothecene gene cluster. Fungal Genet Biol. 2004;41:454-62 pubmed
    ..These results provide evidence to demarcate both ends of the core trichothecene gene cluster. Index descriptors: Fungal secondary metabolite, Pathogenic fungi, Gene cluster, Fusarium, Trichothecene, DON ..
  70. Zhao B, Xie Z, Shen H, Wang Z. Role of DNA polymerase eta in the bypass of abasic sites in yeast cells. Nucleic Acids Res. 2004;32:3984-94 pubmed
  71. Otte S, Barlowe C. Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles. Nat Cell Biol. 2004;6:1189-94 pubmed
    ..Moreover, positive sorting signals seem to predominate over potential ER-retention mechanisms that may operate in localizing ER-resident proteins such as Kar2p. ..
  72. Bohse M, Woods J. Expression and interstrain variability of the YPS3 gene of Histoplasma capsulatum. Eukaryot Cell. 2007;6:609-15 pubmed
    ..This feature is similar to that seen with genes encoding several cell surface proteins in other fungi. ..
  73. Smith C, Robertson D, Yates B, Nielsen D, Brown D, Dean R, et al. The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus. Curr Genet. 2008;54:241-69 pubmed publisher
    ..This is the first report of a whole genome transcriptional analysis of NAT expression in a fungus...
  74. Bischoff K, Wicklow D, Jordan D, de Rezende S, Liu S, Hughes S, et al. Extracellular hemicellulolytic enzymes from the maize endophyte Acremonium zeae. Curr Microbiol. 2009;58:499-503 pubmed publisher
    ..The hydrolytic enzymes from A. zeae may be suitable for application in the bioconversion of lignocellulosic biomass into fermentable sugars...
  75. Dai Y, Jia Y, Correll J, Wang X, Wang Y. Diversification and evolution of the avirulence gene AVR-Pita1 in field isolates of Magnaporthe oryzae. Fungal Genet Biol. 2010;47:973-80 pubmed publisher
    ..These findings demonstrate that AVR-Pita1 is under positive selection and mutations of AVR-Pita1 are responsible for defeating race-specific resistance in nature. ..
  76. Kwon N, Park H, Jung S, Kim S, Yu J. The putative guanine nucleotide exchange factor RicA mediates upstream signaling for growth and development in Aspergillus. Eukaryot Cell. 2012;11:1399-412 pubmed publisher
    ..These findings suggest that the commencement of asexual development requires unknown RicA-mediated signaling input in A. nidulans...
  77. Hurley J, Chen C, Loros J, Dunlap J. Light-inducible system for tunable protein expression in Neurospora crassa. G3 (Bethesda). 2012;2:1207-12 pubmed publisher
    ..The vvd promoter is a highly tunable and regulatable system, which could be a useful instrument for those interested in efficient and controllable gene expression. ..
  78. Petit E, Giraud T, de Vienne D, Coelho M, Aguileta G, Amselem J, et al. Linkage to the mating-type locus across the genus Microbotryum: insights into nonrecombining chromosomes. Evolution. 2012;66:3519-33 pubmed publisher
    ..g., gene conversion) and encourages further work to dissect the evolutionary processes acting upon genomic regions that determine mating compatibility...
  79. Zhu P, Zhai B, Lin X, Idnurm A. Congenic strains for genetic analysis of virulence traits in Cryptococcus gattii. Infect Immun. 2013;81:2616-25 pubmed publisher
    ..The C. gattii congenic strains represent a new resource for exploring the evolution of virulence in the C. neoformans-C. gattii clade. ..
  80. Lee C, Zhang H, Baker A, Occhipinti P, Borsuk M, Gladfelter A. Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control. Dev Cell. 2013;25:572-84 pubmed publisher
    ..There is a widespread association between polyQ expansions and RNA-binding motifs, suggesting that this is a broadly exploited mechanism to produce spatially variable transcripts and heterogeneous cell behaviors. PAPERCLIP:..
  81. Kallstrom G, Hedges J, Johnson A. The putative GTPases Nog1p and Lsg1p are required for 60S ribosomal subunit biogenesis and are localized to the nucleus and cytoplasm, respectively. Mol Cell Biol. 2003;23:4344-55 pubmed
    ..Since Lsg1p is cytoplasmic, its role in nuclear export is likely to be indirect. We suggest that Lsg1p is needed to recycle an export factor(s) that shuttles from the nucleus associated with the nascent 60S subunit. ..
  82. Judelson H. Genomics of the plant pathogenic oomycete Phytophthora: insights into biology and evolution. Adv Genet. 2007;57:97-141 pubmed
    ..A better understanding of these remarkable pathogens should lead to new approaches for managing their diseases. ..
  83. Peever T, Barve M, Stone L. Evolutionary relationships among Ascochyta species infecting wild and cultivated hosts in the legume tribes Cicereae and Vicieae. Mycologia. 2007;99:59-77 pubmed
    ..Phylogenetic species identified among legume-associated Ascochyta spp. were fully concordant with previously described morphological and biological species. ..
  84. Chen D, Vollmar M, Rossi M, Phillips C, Kraehenbuehl R, Slade D, et al. Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. J Biol Chem. 2011;286:13261-71 pubmed publisher
    ..Our data support a novel function of macrodomains as OAADPr deacetylases and potential in vivo regulators of cellular OAADPr produced by NAD(+)-dependent deacetylation. ..
  85. Dockendorff T, Heath C, Goldstein A, Snay C, Cole C. C-terminal truncations of the yeast nucleoporin Nup145p produce a rapid temperature-conditional mRNA export defect and alterations to nuclear structure. Mol Cell Biol. 1997;17:906-20 pubmed
    ..Surprisingly, these strains grew efficiently at 37 degrees C in spite of a reduction in the level of synthesis of rRNAs to approximately 25% of the wild-type level. ..
  86. Wagner J, Jankowsky E, Company M, Pyle A, Abelson J. The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes. EMBO J. 1998;17:2926-37 pubmed
    ..Significantly, these data suggest that the DEAH-box proteins act directly on RNA substrates within the spliceosome. ..
  87. Lutz M, Ellis S, Martin N. Proteasome mutants, pre4-2 and ump1-2, suppress the essential function but not the mitochondrial RNase P function of the Saccharomyces cerevisiae gene RPM2. Genetics. 2000;154:1013-23 pubmed
    ..In an RPM2 wild-type background, pre4-2 and ump1-2 strains fail to grow at restrictive temperatures on nonfermentable carbon sources. These data link proteasome activity with Rpm2p and mitochondrial function. ..
  88. Miller R, Cheng S, Rose M. Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules. Mol Biol Cell. 2000;11:2949-59 pubmed
    ..These experiments demonstrate that the interaction of cytoplasmic microtubules with the Kar9p cortical attachment site requires the microtubule-binding protein Bim1p. ..
  89. Serin G, Gersappe A, Black J, Aronoff R, Maquat L. Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). Mol Cell Biol. 2001;21:209-23 pubmed
    ..The finding that hUpf3p-X is a shuttling protein provides additional indication that NMD has both nuclear and cytoplasmic components...
  90. Nigavekar S, Tan Y, Cannon J. Glc8 is a glucose-repressible activator of Glc7 protein phosphatase-1. Arch Biochem Biophys. 2002;404:71-9 pubmed
    ..In addition, extracellular glucose repressed the induction of Glc7 activity. These results are consistent with glucose repression of Glc8 expression and favor the role of Glc8 as a major Glc7 activator. ..
  91. Edmonson A, Mayfield D, Vervoort V, DuPont B, Argyropoulos G. Characterization of a human import component of the mitochondrial outer membrane, TOMM70A. Cell Commun Adhes. 2002;9:15-27 pubmed
    ..TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins. ..
  92. Pregueiro A, Price Lloyd N, Bell Pedersen D, Heintzen C, Loros J, Dunlap J. Assignment of an essential role for the Neurospora frequency gene in circadian entrainment to temperature cycles. Proc Natl Acad Sci U S A. 2005;102:2210-5 pubmed publisher
    ..Examination of several other phase markers as well as results of additional experimental tests indicate that the FLO is, at best, a slave oscillator to the TTFL, which underlies circadian rhythm generation in Neurospora...