Genomes and Genes
Experts and Doctors on fungal proteins in United Kingdom
Locale: United Kingdom
Topic: fungal proteins
Publications124 found, 100 shown here
- Tauber E, Miller Fleming L, Mason R, Kwan W, Clapp J, Butler N, et al. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. J Biol Chem. 2011;286:410-9 pubmed publisher..In total, these observations suggest that pharmacological manipulation of translation may have therapeutic value in HD. ..
- Bhattacharya A, Kourmpetli S, Ward D, Thomas S, Gong F, Powers S, et al. Characterization of the fungal gibberellin desaturase as a 2-oxoglutarate-dependent dioxygenase and its utilization for enhancing plant growth. Plant Physiol. 2012;160:837-45 pubmed publisher..Thus, des has the potential to enable substantial growth increases, with practical implications, for example, in biomass production. ..
- al Khodairy F, Fotou E, Sheldrick K, Griffiths D, Lehmann A, Carr A. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast. Mol Biol Cell. 1994;5:147-60 pubmed
- Ponting C. SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins. Protein Sci. 1995;4:1928-30 pubmed..Its appearance in byr2 and STE11, which are MEK kinases, and in proteins containing pleckstrain homology, src homology 3, and discs-large homologous region domains, suggests possible participation in signal transduction pathways. ..
- Penney M, Wilkinson C, Wallace M, Javerzat J, Ferrell K, Seeger M, et al. The Pad1+ gene encodes a subunit of the 26 S proteasome in fission yeast. J Biol Chem. 1998;273:23938-45 pubmed..In this study we describe the identification of Pad1 as a subunit of the 26 S proteasome in fission yeast. ..
- Flynn P, Reece R. Activation of transcription by metabolic intermediates of the pyrimidine biosynthetic pathway. Mol Cell Biol. 1999;19:882-8 pubmed..These results are discussed in terms of (i) regulation of the pyrimidine biosynthetic pathway and (ii) a novel mechanism of regulating gene expression. ..
- Wang S, Toda T, MacCallum R, Harris A, Norbury C. Cid1, a fission yeast protein required for S-M checkpoint control when DNA polymerase delta or epsilon is inactivated. Mol Cell Biol. 2000;20:3234-44 pubmed..Genetic data suggest that Cid1 acts in association with Crb2/Rhp9 and through the checkpoint-signaling kinase Chk1 to inhibit unscheduled mitosis specifically when DNA polymerase delta or epsilon is inhibited. ..
- Radcliffe P, Garcia M, Toda T. The cofactor-dependent pathways for alpha- and beta-tubulins in microtubule biogenesis are functionally different in fission yeast. Genetics. 2000;156:93-103 pubmed..We conclude that the cofactor-dependent biogenesis of microtubules comprises an essential and a nonessential pathway, both of which are required for microtubule integrity. ..
- Siligardi G, Hu B, Panaretou B, Piper P, Pearl L, Prodromou C. Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. J Biol Chem. 2004;279:51989-98 pubmed..These data indicated that Sba1 and Aha1 regulate Hsp90 by influencing the conformational state of the "ATP lid" and consequent N-terminal dimerization, whereas Sti1 does not. ..
- Fitzgibbon G, Morozov I, Jones M, Caddick M. Genetic analysis of the TOR pathway in Aspergillus nidulans. Eukaryot Cell. 2005;4:1595-8 pubmed publisher..Unlike the situation in Saccharomyces cerevisiae, there is only a single Tor kinase, as in plant and animal systems, and mutant phenotypes suggest that the TOR pathway plays only a minor role in regulating nitrogen metabolism...
- Bicho C, de Lima Alves F, Chen Z, Rappsilber J, Sawin K. A genetic engineering solution to the "arginine conversion problem" in stable isotope labeling by amino acids in cell culture (SILAC). Mol Cell Proteomics. 2010;9:1567-77 pubmed publisher..This strategy for addressing the "arginine conversion problem" may be more broadly applicable to organisms amenable to genetic manipulation. ..
- Gueidan C, Ruibal C, de Hoog G, Schneider H. Rock-inhabiting fungi originated during periods of dry climate in the late Devonian and middle Triassic. Fungal Biol. 2011;115:987-96 pubmed publisher..The paleoclimate record provides a good explanation for the diversification of fungi subjected to abiotic stresses and adapted to life on rock surfaces in nutrient-poor habitats. ..
- De Simone A, Kitchen C, Kwan A, Sunde M, Dobson C, Frenkel D. Intrinsic disorder modulates protein self-assembly and aggregation. Proc Natl Acad Sci U S A. 2012;109:6951-6 pubmed publisher..More generally, our findings suggest a key role that specific flexible structural elements can play to ensure the existence of soluble and functional states of proteins under physiological conditions. ..
- Baker R, Harreman M, Eccleston J, Corbett A, Stewart M. Interaction between Ran and Mog1 is required for efficient nuclear protein import. J Biol Chem. 2001;276:41255-62 pubmed..Our results indicate that a primary function of Mog1 requires binding to Ran and that the Mog1-Ran interaction is necessary for efficient nuclear protein import in vivo. ..
- Wilson R, Gibson R, Quispe C, Littlechild J, Talbot N. An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus. Proc Natl Acad Sci U S A. 2010;107:21902-7 pubmed publisher..oryzae requires a regulatory mechanism involving an NADPH sensor protein, Tps1, a set of NADP-dependent transcriptional corepressors, and the nonconsuming interconversion of NADPH and NADP acting as signal transducer. ..
- Conforti L, Tarlton A, Mack T, Mi W, Buckmaster E, Wagner D, et al. A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse. Proc Natl Acad Sci U S A. 2000;97:11377-82 pubmed..These data reveal both a candidate gene for Wld and the potential of the Wld(S) mutant for studies of ubiquitin and retinoid metabolism. ..
- Weitzer S, Lehane C, Uhlmann F. A model for ATP hydrolysis-dependent binding of cohesin to DNA. Curr Biol. 2003;13:1930-40 pubmed..After DNA replication, two DNA strands may be trapped to promote sister chromatid cohesion. In anaphase, Scc1 cleavage opens the ring to release sister chromatids. ..
- Wilson R, Talbot N. Under pressure: investigating the biology of plant infection by Magnaporthe oryzae. Nat Rev Microbiol. 2009;7:185-95 pubmed publisher..oryzae. We also look ahead to the key questions that need to be addressed to provide a better understanding of the molecular processes that lead to plant disease and the prospects for sustainable control of rice blast. ..
- Aerne B, Johnson A, Toyn J, Johnston L. Swi5 controls a novel wave of cyclin synthesis in late mitosis. Mol Biol Cell. 1998;9:945-56 pubmed..Consistent with this a synthetic interaction was observed between pho85delta and strains deleted for SIC1, SWI5, and SPO12. These and other studies support the notion that the M/G1 switch is a major cell cycle transition. ..
- Richards T, Dacks J, Jenkinson J, Thornton C, Talbot N. Evolution of filamentous plant pathogens: gene exchange across eukaryotic kingdoms. Curr Biol. 2006;16:1857-64 pubmed
- Goryachev A, Pokhilko A. Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Lett. 2008;582:1437-43 pubmed publisher..This exchange explains why only one bud forms per cell cycle, because the winner-takes-all competition of candidate sites inevitably selects a single site. ..
- Marshall R, Kombrink A, Motteram J, Loza Reyes E, Lucas J, Hammond Kosack K, et al. Analysis of two in planta expressed LysM effector homologs from the fungus Mycosphaerella graminicola reveals novel functional properties and varying contributions to virulence on wheat. Plant Physiol. 2011;156:756-69 pubmed publisher..These data highlight different functions for MgLysM effector homologs during plant infection, including novel activities that distinguish these proteins from C. fulvum Ecp6. ..
- Wong M, Scott Drew S, Hayes M, Howard P, Murray J. RSC2, encoding a component of the RSC nucleosome remodeling complex, is essential for 2 microm plasmid maintenance in Saccharomyces cerevisiae. Mol Cell Biol. 2002;22:4218-29 pubmed..This represents the first specific role for Rsc2 that has been related to a change in chromatin structure, as well as the first direct evidence linking chromatin structure to 2 microm segregation. ..
- Rowland O, Ludwig A, Merrick C, Baillieul F, Tracy F, Durrant W, et al. Functional analysis of Avr9/Cf-9 rapidly elicited genes identifies a protein kinase, ACIK1, that is essential for full Cf-9-dependent disease resistance in tomato. Plant Cell. 2005;17:295-310 pubmed publisher..Moreover, VIGS of LeACIK1 in tomato decreased Cf-9-mediated resistance to C. fulvum, showing the importance of ACIK1 in disease resistance...
- de Keyzer J, Steel G, Hale S, Humphries D, Stirling C. Nucleotide binding by Lhs1p is essential for its nucleotide exchange activity and for function in vivo. J Biol Chem. 2009;284:31564-71 pubmed publisher..Thus, Lhs1p-dependent nucleotide exchange activity is vital for ER protein biogenesis in vivo. ..
- Howard S, Harrison E, Bowyer P, Varga J, Denning D. Cryptic species and azole resistance in the Aspergillus niger complex. Antimicrob Agents Chemother. 2011;55:4802-9 pubmed publisher..niger complex" by clinical laboratories. Itraconazole resistance was common in this data set, but azole cross-resistance was unusual. The mechanism of resistance remains obscure. ..
- Lewis M, Nichols B, Prescianotto Baschong C, Riezman H, Pelham H. Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes. Mol Biol Cell. 2000;11:23-38 pubmed..We propose that these represent early endosomes in which sorting of Snc1p and late Golgi proteins occurs, and that transport can occur directly from them to the Golgi apparatus. ..
- Labib K, Kearsey S, Diffley J. MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell. 2001;12:3658-67 pubmed..Our data indicate that pre-RCs do not play a direct role in checkpoint control during chromosome replication. ..
- Scheper W, Thaminy S, Kais S, Stagljar I, Römisch K. Coordination of N-glycosylation and protein translocation across the endoplasmic reticulum membrane by Sss1 protein. J Biol Chem. 2003;278:37998-8003 pubmed..Our data suggest that Sss1p coordinates translocation across the ER membrane and N-linked glycosylation of secretory proteins. ..
- Flint J, Bolam D, Nurizzo D, Taylor E, Williamson M, Walters C, et al. Probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules. J Biol Chem. 2005;280:23718-26 pubmed..The interactions of CBM29-2 with the O2 of glucose or mannose contribute little to binding affinity, explaining why this CBM displays dual gluco/manno specificity...
- Hunt S, Thompson S, Elvin M, Heintzen C. VIVID interacts with the WHITE COLLAR complex and FREQUENCY-interacting RNA helicase to alter light and clock responses in Neurospora. Proc Natl Acad Sci U S A. 2010;107:16709-14 pubmed publisher..VVD interacts with FRH in the absence of WCC and FRQ but does not seem to control the exosome-mediated negative feedback loop. Instead, VVD acts to modulate the transcriptional activity of the WCC. ..
- Chapa y Lazo B, Lee S, Regan H, Sudbery P. The mating projections of Saccharomyces cerevisiae and Candida albicans show key characteristics of hyphal growth. Fungal Biol. 2011;115:547-56 pubmed publisher..Taken together this work shows that mating projections of both S. cerevisiae and C. albicans show the key characteristics of hyphal growth. ..
- Morais do Amaral A, Antoniw J, Rudd J, Hammond Kosack K. Defining the predicted protein secretome of the fungal wheat leaf pathogen Mycosphaerella graminicola. PLoS ONE. 2012;7:e49904 pubmed publisher..This detailed M. graminicola secretome analysis provides the basis for further functional and comparative genomics studies. ..
- Dix I, Russell C, O Keefe R, Newman A, Beggs J. Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae. RNA. 1998;4:1239-50 pubmed..This and the close proximity of the spliceosomal translocase, Snu114p, to U5 loop 1 and Prp8p support and extend the proposal that Snu114p mimics U5 loop 1 during a translocation event in the spliceosome. ..
- Whitehall S, Stacey P, Dawson K, Jones N. Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription. Mol Biol Cell. 1999;10:3705-15 pubmed
- Murai K, Treisman R. Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1. Mol Cell Biol. 2002;22:7083-92 pubmed..Combinatorial interactions between SRF and TCF proteins are thus likely to play an important role in determining the relative sensitivity of SRF target genes to Ras- and Rho-controlled signal transduction pathways. ..
- Bindschedler L, McGuffin L, Burgis T, Spanu P, Cramer R. Proteogenomics and in silico structural and functional annotation of the barley powdery mildew Blumeria graminis f. sp. hordei. Methods. 2011;54:432-41 pubmed publisher..Thus, these unknown proteins present potentially new protein folds that can be specific to the interaction of the pathogen with its host. ..
- Aranda A, Proudfoot N. Transcriptional termination factors for RNA polymerase II in yeast. Mol Cell. 2001;7:1003-11 pubmed..Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events. ..
- Geymonat M, Spanos A, Smith S, Wheatley E, Rittinger K, Johnston L, et al. Control of mitotic exit in budding yeast. In vitro regulation of Tem1 GTPase by Bub2 and Bfa1. J Biol Chem. 2002;277:28439-45 pubmed..Therefore, we propose that Bfa1 acts both as an adaptor to connect Bub2 and Tem1 and as an allosteric effector that facilitates this interaction. ..
- Wright D, Munro E, Corbett M, Bentley A, Fullwood N, Murray S, et al. The Saccharomyces cerevisiae actin cytoskeletal component Bsp1p has an auxiliary role in actomyosin ring function and in the maintenance of bud-neck structure. Genetics. 2008;178:1903-14 pubmed publisher..Compromise of Iqg1p function, in the absence of Bsp1p function, leads to a profound change in the distribution of actin and the pattern of cell growth accompanied by a failure to complete cytokinesis and cell separation. ..
- Wilkinson C, Wallace M, Seeger M, Dubiel W, Gordon C. Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2. J Biol Chem. 1997;272:25768-77 pubmed..We provide genetic and physical evidence to suggest that the Mts4 protein interacts with the product of the mts2(+) gene, an ATPase which has previously been shown to be subunit 4 of the 26 S protease. ..
- Smith D, Toone W, Chen D, Bahler J, Jones N, Morgan B, et al. The Srk1 protein kinase is a target for the Sty1 stress-activated MAPK in fission yeast. J Biol Chem. 2002;277:33411-21 pubmed
- Samejima I, Lourenco P, Snaith H, Sawin K. Fission yeast mto2p regulates microtubule nucleation by the centrosomin-related protein mto1p. Mol Biol Cell. 2005;16:3040-51 pubmed..These experiments establish mto2p as a major regulator of mto1p-mediated microtubule nucleation by the gamma-tubulin complex. ..
- Soanes D, Talbot N. Comparative genome analysis reveals an absence of leucine-rich repeat pattern-recognition receptor proteins in the kingdom Fungi. PLoS ONE. 2010;5:e12725 pubmed publisher..The absence of pattern recognition receptors in fungi, coupled with their abundance in oomycetes, suggests this may be a unique characteristic of the fungal kingdom rather than a consequence of the osmotrophic growth form. ..
- Brown N, Antoniw J, Hammond Kosack K. The predicted secretome of the plant pathogenic fungus Fusarium graminearum: a refined comparative analysis. PLoS ONE. 2012;7:e33731 pubmed publisher..graminearum secreted proteins can be considered to be either species or sequenced strain specific. ..
- Daggett D, Boyd C, Gautier P, Bryson Richardson R, Thisse C, Thisse B, et al. Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula. Curr Biol. 2004;14:1632-8 pubmed..Our results provide direct evidence for the deployment of developmentally restricted actin-regulatory molecules in the control of morphogenetic cell movements during vertebrate development. ..
- Tucker S, Besi M, Galhano R, Franceschetti M, Goetz S, Lenhert S, et al. Common genetic pathways regulate organ-specific infection-related development in the rice blast fungus. Plant Cell. 2010;22:953-72 pubmed publisher..oryzae ortholog of exportin-5/Msn5p (EXP5). Mutants lacking EXP5 were much less virulent on roots, suggesting an important involvement of proteins and/or RNAs transported by EXP5 during M. oryzae root infection...
- Eastwood D, Herman B, Noble R, Dobrovin Pennington A, Sreenivasaprasad S, Burton K. Environmental regulation of reproductive phase change in Agaricus bisporus by 1-octen-3-ol, temperature and CO?. Fungal Genet Biol. 2013;55:54-66 pubmed publisher..Three gene clusters linking increased transcription with developmental stage were identified. Analysis of promoter regions revealed cluster-specific conserved motifs indicative of co-ordinated regulation of transcription...
- Murphy M, Leuenberger D, Curran S, Oppliger W, Koehler C. The essential function of the small Tim proteins in the TIM22 import pathway does not depend on formation of the soluble 70-kilodalton complex. Mol Cell Biol. 2001;21:6132-8 pubmed
- Sawin K, Nurse P. Regulation of cell polarity by microtubules in fission yeast. J Cell Biol. 1998;142:457-71 pubmed..In addition, TBZ induces a shift in ral3-GFP distribution from cell ends to the cell middle, suggesting that a protein complex containing ral3 may be part of the cue that specifies the position of branch formation. ..
- Steel G, Laude A, Boojawan A, Harvey D, Morgan A. Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: implications for the molecular mechanism of membrane fusion. Biochemistry. 1999;38:7764-72 pubmed..We conclude that the mechanistic properties of NSF and SNAPs are shared by Sec18p and Sec17p, thus demonstrating that the biochemistry of membrane fusion is conserved from yeast to mammals. ..
- Tottey S, Rondet S, Borrelly G, Robinson P, Rich P, Robinson N. A copper metallochaperone for photosynthesis and respiration reveals metal-specific targets, interaction with an importer, and alternative sites for copper acquisition. J Biol Chem. 2002;277:5490-7 pubmed..Conversely, activity in Deltaatx1DeltactaA was less than in either respective single mutant, revealing that Atx1 can function without the major copper importer and consistent with a role in recycling endogenous copper. ..
- Quinn J, Findlay V, Dawson K, Millar J, Jones N, Morgan B, et al. Distinct regulatory proteins control the graded transcriptional response to increasing H(2)O(2) levels in fission yeast Schizosaccharomyces pombe. Mol Biol Cell. 2002;13:805-16 pubmed..Our results demonstrate that S. pombe uses a combination of stress-responsive regulatory proteins to gauge and effect the appropriate transcriptional response to increasing concentrations of H(2)O(2). ..
- Davies A, Friedberg E, Tomkinson A, Wood R, West S. Role of the Rad1 and Rad10 proteins in nucleotide excision repair and recombination. J Biol Chem. 1995;270:24638-41 pubmed..The role that Rad1-Rad10 plays in recombination is likely to resemble its activity in NER by acting upon partially unpaired DNA intermediates such as those formed by recombination mechanisms involving single-strand DNA annealing. ..
- Robins P, Pappin D, Wood R, Lindahl T. Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I. J Biol Chem. 1994;269:28535-8 pubmed..The protein sequence retains conserved residues and shows significant homology to the sequences of the 5'-nuclease domain of E. coli DNA polymerase I and related microbial enzymes. ..
- Wittschieben B, Otero G, de Bizemont T, Fellows J, Erdjument Bromage H, Ohba R, et al. A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell. 1999;4:123-8 pubmed..These results suggest a role for a novel, tightly RNAPII-associated HAT in transcription of DNA packaged in chromatin. ..
- Bishop N, Woodman P. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol Biol Cell. 2000;11:227-39 pubmed..The phenotype described here is largely consistent with the defects in vacuolar sorting associated with class E vps mutants in yeast, and a role for mammalian VPS4 is discussed in this context. ..
- Bishop N, Woodman P. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. J Biol Chem. 2001;276:11735-42 pubmed..We conclude that TSG101 and its interacting components are directly involved in endosomal sorting. ..
- Shah R, Jensen S, Frenz L, Johnson A, Johnston L. The Spo12 protein of Saccharomyces cerevisiae: a regulator of mitotic exit whose cell cycle-dependent degradation is mediated by the anaphase-promoting complex. Genetics. 2001;159:965-80 pubmed..This result is the first indication that Spo12 may carry out the same biochemical function in mitosis as it does in meiosis. ..
- Rouse J, Jackson S. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol Cell. 2002;9:857-69 pubmed..Recruitment of Lcd1p to these lesions is independent of Mec1p and Rad9p/Rad24p. Thus, recruitment of Mec1p to DNA lesions by Lcd1p is crucial for the DNA damage response. ..
- Read R, Martinho R, Wang S, Carr A, Norbury C. Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest. Proc Natl Acad Sci U S A. 2002;99:12079-84 pubmed..Cytoplasmic polyadenylation is known to be an important regulatory mechanism during early development in animals. Our findings in yeast suggest that this level of gene regulation is of more general significance in eukaryotic cells. ..
- Moreau J, Lee M, Mahachi N, Vary J, Mellor J, Tsukiyama T, et al. Regulated displacement of TBP from the PHO8 promoter in vivo requires Cbf1 and the Isw1 chromatin remodeling complex. Mol Cell. 2003;11:1609-20 pubmed..The results point to a promoter-specific Isw1p-dependent mechanism for targeted regulation of basal transcription by displacement of TBP from a promoter. ..
- Jermy A, Willer M, Davis E, Wilkinson B, Stirling C. The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons. J Biol Chem. 2006;281:7899-906 pubmed..Our data indicate that the SEC' complex is required for co-translational protein translocation across the yeast ER membrane. ..
- Hentges P, Ahnesorg P, Pitcher R, Bruce C, Kysela B, Green A, et al. Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. J Biol Chem. 2006;281:37517-26 pubmed..We therefore conclude that XLF family proteins interact with the ligase IV-XRCC4 complex to constitute the evolutionarily conserved enzymatic core of the NHEJ machinery. ..
- Anderson V, Prudden J, Prochnik S, Giddings T, Hardwick K. Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function. Mol Biol Cell. 2007;18:2047-56 pubmed..3 microm apart. Importantly, these SPBs have completed duplication, but they are not separated, suggesting a possible defect in splitting of the bridge. We discuss possible roles for Sfi1p in this step in bipolar spindle assembly. ..
- Eydmann T, Sommariva E, Inagawa T, Mian S, Klar A, Dalgaard J. Rtf1-mediated eukaryotic site-specific replication termination. Genetics. 2008;180:27-39 pubmed publisher..Together our data establish that multiple protein DNA and protein-protein interactions between Rtf1 molecules and both the repeated motifs and the enhancer region of RTS1 are required for site-specific termination at the RTS1 element. ..
- Williams B, Elliot C, Burri L, Kido Y, Kita K, Moore A, et al. A broad distribution of the alternative oxidase in microsporidian parasites. PLoS Pathog. 2010;6:e1000761 pubmed publisher..The physiological role of AOX microsporidia may be to reoxidise reducing equivalents produced by glycolysis, in a manner comparable to that observed in trypanosomes. ..
- McCue H, Haynes L, Burgoyne R. The diversity of calcium sensor proteins in the regulation of neuronal function. Cold Spring Harb Perspect Biol. 2010;2:a004085 pubmed publisher..In this article, we summarize synaptotagmins in neurotransmitter release, the neuronal roles of calmodulin, and the functional significance of the NCS and the CaBP/calneuron protein families of neuronal Ca(2+) sensors. ..
- Thorne T, Ho H, Huvet M, Haynes K, Stumpf M. Prediction of putative protein interactions through evolutionary analysis of osmotic stress response in the model yeast Saccharomyces cerevisae. Fungal Genet Biol. 2011;48:504-11 pubmed publisher..We do find that correlated evolution provides some useful information for the prediction of protein-protein interactions, but that these alone are not sufficient to explain detectable patterns of correlated evolution. ..
- Ponting C. Evidence for PDZ domains in bacteria, yeast, and plants. Protein Sci. 1997;6:464-8 pubmed..The known affinity of Escherichia coli tsp for C-terminal polypeptides is proposed to be mediated by its PDZ-like domain, in a similar manner to the binding of C-terminal polypeptides by animal PDZ domains. ..
- Donovan S, Harwood J, Drury L, Diffley J. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast. Proc Natl Acad Sci U S A. 1997;94:5611-6 pubmed..From these results, we propose that Cdc6p (and the origin recognition complex) nucleates the binding of Mcm proteins to chromatin, but once bound, the Mcm proteins appear to interact tightly with some other component of chromatin. ..
- Unkles S, Smith J, Kanan G, Millar L, Heck I, Boxer D, et al. The Aspergillus nidulans cnxABC locus is a single gene encoding two catalytic domains required for synthesis of precursor Z, an intermediate in molybdenum cofactor biosynthesis. J Biol Chem. 1997;272:28381-90 pubmed
- Wiggins C, Munro S. Activity of the yeast MNN1 alpha-1,3-mannosyltransferase requires a motif conserved in many other families of glycosyltransferases. Proc Natl Acad Sci U S A. 1998;95:7945-50 pubmed
- Dix I, Russell C, O Keefe R, Newman A, Beggs J. Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae. RNA. 1998;4:1675-86 pubmed..This and the close proximity of the spliceosomal translocase, Snu114p, to U5 loop 1 and Prp8p support and extend the proposal that Snu114p mimics U5 loop 1 during a translocation event in the spliceosome. ..
- Freeman A, Morris L, Mills A, Stoeber K, Laskey R, Williams G, et al. Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res. 1999;5:2121-32 pubmed
- Bouquin N, Johnson A, Morgan B, Johnston L. Association of the cell cycle transcription factor Mbp1 with the Skn7 response regulator in budding yeast. Mol Biol Cell. 1999;10:3389-400 pubmed..Thus, Skn7 and Mbp1 seem to form a transcription factor independent of MBF. Genetic data suggest that this new transcription factor could be involved in the bud-emergence process. ..
- Crane R, Craig R, Murray R, Dunand Sauthier I, Humphrey T, Norbury C. A fission yeast homolog of Int-6, the mammalian oncoprotein and eIF3 subunit, induces drug resistance when overexpressed. Mol Biol Cell. 2000;11:3993-4003 pubmed..Studies in fission yeast may therefore help to explain the ways in which Int-6 function can be perturbed during MMTV-induced mammary tumorigenesis. ..
- Seki T, Diffley J. Stepwise assembly of initiation proteins at budding yeast replication origins in vitro. Proc Natl Acad Sci U S A. 2000;97:14115-20 pubmed..Extracts from cells arrested in mitosis also can support the binding of ORC but are unable to load either Cdc6p or MCM2-7 proteins. This system should be useful for studying the mechanism and regulation of pre-RC assembly. ..
- Anderson L, Henderson C, Adachi Y. Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol Cell Biol. 2001;21:1719-29 pubmed..These results suggest a role for 53BP1 in the DNA damage response and/or checkpoint control which may involve signaling of damage to p53. ..
- Millband D, Hardwick K. Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner. Mol Cell Biol. 2002;22:2728-42 pubmed..We discuss the implications of these findings in the context of our current understanding of spindle checkpoint function. ..
- Dunand Sauthier I, Walker C, Wilkinson C, Gordon C, Crane R, Norbury C, et al. Sum1, a component of the fission yeast eIF3 translation initiation complex, is rapidly relocalized during environmental stress and interacts with components of the 26S proteasome. Mol Biol Cell. 2002;13:1626-40 pubmed..Furthermore, Sum1 interacts with the Mts2 and Mts4 components of the 26S proteasome. These data indicate a functional link between components of the structurally related eIF3 translation initiation and 26S proteasome complexes. ..
- Bruno M, Flaus A, Stockdale C, Rencurel C, Ferreira H, Owen Hughes T. Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities. Mol Cell. 2003;12:1599-606 pubmed..This provides eukaryotes with additional means by which they may manipulate chromatin structure. ..
- James S, Bond C, Stratford M, Roberts I. Molecular evidence for the existence of natural hybrids in the genus Zygosaccharomyces. FEMS Yeast Res. 2005;5:747-55 pubmed..rouxii and given rise to hybrid strains. Additional approaches to define precise taxonomic status and mechanisms of hybrid genome formation amongst yeast species are discussed...
- Court H, Sudbery P. Regulation of Cdc42 GTPase activity in the formation of hyphae in Candida albicans. Mol Biol Cell. 2007;18:265-81 pubmed..These results suggest the development of hyphal-specific characteristics is promoted by Cdc42-GTP in a process that also requires the intrinsic GTPase activity of Cdc42. ..
- Flott S, Alabert C, Toh G, Toth R, Sugawara N, Campbell D, et al. Phosphorylation of Slx4 by Mec1 and Tel1 regulates the single-strand annealing mode of DNA repair in budding yeast. Mol Cell Biol. 2007;27:6433-45 pubmed..These results indicate that Slx4 has multiple functions in responding to DNA damage and that a subset of these are regulated by Mec1/Tel1-dependent phosphorylation. ..
- Castillo A, Mellone B, Partridge J, Richardson W, Hamilton G, Allshire R, et al. Plasticity of fission yeast CENP-A chromatin driven by relative levels of histone H3 and H4. PLoS Genet. 2007;3:e121 pubmed..Thus, CENP-A(Cnp1) chromatin assembly in fission yeast exhibits plasticity with respect to the underlying sequences and is sensitive to the levels of CENP-A(Cnp1) and other core histones. ..
- Evans D, Stark M. Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis. Genetics. 1997;145:227-41 pubmed..Remarkably, the multiple defects of Ts- pph22 mutant cells were suppressed by a viable allele (SSD1-v1) of the polymorphic SSD1 gene. ..
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