Experts and Doctors on fungal proteins in Switzerland


Locale: Switzerland
Topic: fungal proteins

Top Publications

  1. Sohrmann M, Fankhauser C, Brodbeck C, Simanis V. The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast. Genes Dev. 1996;10:2707-19 pubmed
    ..When the septum is completed and the cells separate, Dmf1p staining is once again nuclear. These data implicate Dmf1p as an important element in assuring correct placement of the division septum in Schizosaccharomyces pombe cells. ..
  2. Henstrand J, Schaller A, Braun M, Amrhein N, Schmid J. Saccharomyces cerevisiae chorismate synthase has a flavin reductase activity. Mol Microbiol. 1996;22:859-66 pubmed
    ..With this knowledge, S. cerevisiae could be used as a genetic system for studying the physiological consequences of bifunctionality. The phylogenetic relationship amongst known CSs is discussed. ..
  3. Gotta M, Strahl Bolsinger S, Renauld H, Laroche T, Kennedy B, Grunstein M, et al. Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J. 1997;16:3243-55 pubmed
    ..The unexpected nucleolar localization of Sir2p and Sir3p correlates with observed effects of sir mutations on rDNA stability and yeast longevity, defining a new site of action for silent information regulatory factors. ..
  4. Jakob C, Burda P, Roth J, Aebi M. Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure. J Cell Biol. 1998;142:1223-33 pubmed
    ..They may indicate the presence of a Man8GlcNAc2-binding lectin involved in targeting of misfolded glycoproteins to degradation in S. cerevisiae. ..
  5. Gotta M, Palladino F, Gasser S. Functional characterization of the N terminus of Sir3p. Mol Cell Biol. 1998;18:6110-20 pubmed
  6. Pedruzzi I, Bürckert N, Egger P, De Virgilio C. Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J. 2000;19:2569-79 pubmed
    ..Moreover, PDS element-driven expression, which is negatively regulated by the Ras/cAMP pathway and which is induced upon nutrient limitation, is almost entirely dependent on the presence of Gis1. ..
  7. Hohl M, Christensen O, Kunz C, Naegeli H, Fleck O. Binding and repair of mismatched DNA mediated by Rhp14, the fission yeast homologue of human XPA. J Biol Chem. 2001;276:30766-72 pubmed
    ..Rhp14 is likely part of the recognition complex but alone is not sufficient for the high discrimination of nucleotide excision repair for modified DNA. ..
  8. Limacher A, Glaser A, Meier C, Schmid Grendelmeier P, Zeller S, Scapozza L, et al. Cross-reactivity and 1.4-A crystal structure of Malassezia sympodialis thioredoxin (Mala s 13), a member of a new pan-allergen family. J Immunol. 2007;178:389-96 pubmed
  9. Lettieri T, Kraehenbuehl R, Capiaghi C, Livingstone Zatchej M, Thoma F. Functionally distinct nucleosome-free regions in yeast require Rad7 and Rad16 for nucleotide excision repair. DNA Repair (Amst). 2008;7:734-43 pubmed publisher
    ..The data are consistent with a role of Rad7-Rad16 in damage recognition and processing in absence of nucleosomes. An additional role in nucleosome remodelling is discussed. ..

More Information

Publications149 found, 100 shown here

  1. Butty A, Pryciak P, Huang L, Herskowitz I, Peter M. The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating. Science. 1998;282:1511-6 pubmed
    ..Thus, Far1p functions as an adaptor that recruits polarity establishment proteins to the site of extracellular signaling marked by Gbetagamma to polarize assembly of the cytoskeleton in a morphogenetic gradient. ..
  2. Flury I, Benachour A, Conzelmann A. YLL031c belongs to a novel family of membrane proteins involved in the transfer of ethanolaminephosphate onto the core structure of glycosylphosphatidylinositol anchors in yeast. J Biol Chem. 2000;275:24458-65 pubmed
    ..e. the group that links the GPI lipid anchor to proteins, whereas Mcd4p and Gpi7p transfer ethanolaminephosphate onto the alpha1-4- and alpha1-6-linked mannoses of the GPI anchor, respectively. ..
  3. Schmelzle T, Beck T, Martin D, Hall M. Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast. Mol Cell Biol. 2004;24:338-51 pubmed
    ..Our findings suggest that TOR signals through the RAS/cAMP pathway, independently of TAP42/SIT4. Therefore, the RAS/cAMP pathway may be a novel TOR effector branch. ..
  4. Schweingruber A, Dlugonski J, Edenharter E, Schweingruber M. Thiamine in Schizosaccharomyces pombe: dephosphorylation, intracellular pool, biosynthesis and transport. Curr Genet. 1991;19:249-54 pubmed
    ..4) Thiamine uptake is a thiamine regulated process, probably occurs by active transport and is controlled by the gene ptr1. ..
  5. Grishchuk A, Kohli J. Five RecA-like proteins of Schizosaccharomyces pombe are involved in meiotic recombination. Genetics. 2003;165:1031-43 pubmed
    ..On the basis of our results, we present a model for the involvement of five RecA-like proteins of S. pombe in meiotic recombination and discuss their respective roles. ..
  6. Van Melckebeke H, Wasmer C, Lange A, Ab E, Loquet A, Böckmann A, et al. Atomic-resolution three-dimensional structure of HET-s(218-289) amyloid fibrils by solid-state NMR spectroscopy. J Am Chem Soc. 2010;132:13765-75 pubmed publisher
    ..The high-resolution structure obtained includes the less ordered but biologically important C-terminal part and improves the overall accuracy by including a large number of ambiguous distance restraints. ..
  7. Schmidt A, Beck T, Koller A, Kunz J, Hall M. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 1998;17:6924-31 pubmed
    ..Thus, the TOR nutrient signalling pathway also controls growth by inhibiting a stationary phase (G0) programme. The control of NPR1 by TOR is analogous to the control of p70 s6 kinase and 4E-BP1 by mTOR in mammalian cells. ..
  8. Wyss A, von Stockar U, Marison I. A novel reactive perstraction system based on liquid-core microcapsules applied to lipase-catalyzed biotransformations. Biotechnol Bioeng. 2006;93:28-39 pubmed
    ..5 to 9.0. The presence of an organic phase within the capsule core allowed direct product separation and lead to a decrease in product inhibition of the lipase-catalyzed reaction. ..
  9. Crespo J, Hall M. Elucidating TOR signaling and rapamycin action: lessons from Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 2002;66:579-91, table of contents pubmed
    ..The current understanding of TOR and rapamycin is derived largely from studies with S. cerevisiae. In this review, we discuss the contributions made by S. cerevisiae to understanding rapamycin action and TOR function. ..
  10. Gaillard H, Fitzgerald D, Smith C, Peterson C, Richmond T, Thoma F. Chromatin remodeling activities act on UV-damaged nucleosomes and modulate DNA damage accessibility to photolyase. J Biol Chem. 2003;278:17655-63 pubmed
    ..Similar activities might relieve the inhibitory effect of nucleosomes on DNA repair processes in living cells. ..
  11. Gunde T, Tanner S, Auf der Maur A, Petrascheck M, Barberis A. Quenching accumulation of toxic galactose-1-phosphate as a system to select disruption of protein-protein interactions in vivo. Biotechniques. 2004;37:844-52 pubmed
    ..Decreased GAL1 gene expression upon dissociation of interacting proteins causes reduction of intracellular galactose-1-phosphate concentrations, thus allowing cell growth under selective conditions. ..
  12. Spirig U, Glavas M, Bodmer D, Reiss G, Burda P, Lippuner V, et al. The STT3 protein is a component of the yeast oligosaccharyltransferase complex. Mol Gen Genet. 1997;256:628-37 pubmed
    ..These genetic and biochemical data show that the highly conserved Stt3p is a component of the oligosaccharyltransferase complex. ..
  13. Jaquenoud M, Gulli M, Peter K, Peter M. The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex. EMBO J. 1998;17:5360-73 pubmed
    ..Finally, our data indicate that degradation of Gic2p may be part of a mechanism which restricts cytoskeletal polarization in the G1 phase of the cell cycle. ..
  14. Galliker P, Hommes G, Schlosser D, Corvini P, Shahgaldian P. Laccase-modified silica nanoparticles efficiently catalyze the transformation of phenolic compounds. J Colloid Interface Sci. 2010;349:98-105 pubmed publisher
    ..Additionally, the developed analytical methods allowed the identification of the transformation products formed during the enzymatic reaction. ..
  15. Geli M, Wesp A, Riezman H. Distinct functions of calmodulin are required for the uptake step of receptor-mediated endocytosis in yeast: the type I myosin Myo5p is one of the calmodulin targets. EMBO J. 1998;17:635-47 pubmed
    ..Additionally, genetic and biochemical evidence obtained with a collection of cmd1 mutant alleles strongly suggests that Cmd1p plays an additional role in the internalization step of receptor-mediated endocytosis in yeast. ..
  16. Akhmedov A, Frei C, Tsai Pflugfelder M, Kemper B, Gasser S, Jessberger R. Structural maintenance of chromosomes protein C-terminal domains bind preferentially to DNA with secondary structure. J Biol Chem. 1998;273:24088-94 pubmed
    ..Consistent with their in vitro DNA binding activity, we show that overexpression of the SMC C termini increases plasmid loss without altering viability or cell cycle progression. ..
  17. Habazettl J, Allan M, Jenal U, Grzesiek S. Solution structure of the PilZ domain protein PA4608 complex with cyclic di-GMP identifies charge clustering as molecular readout. J Biol Chem. 2011;286:14304-14 pubmed publisher
    ..We propose that the movement of the termini and the resulting negative surface form the basis for downstream signaling. ..
  18. Galan J, Peter M. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism. Proc Natl Acad Sci U S A. 1999;96:9124-9 pubmed
  19. Thoma F. Light and dark in chromatin repair: repair of UV-induced DNA lesions by photolyase and nucleotide excision repair. EMBO J. 1999;18:6585-98 pubmed
    ..These repair pathways provide insight into the structural and dynamic properties of chromatin and suggest how other DNA repair processes could work in chromatin. ..
  20. Prescianotto Baschong C, Riezman H. Ordering of compartments in the yeast endocytic pathway. Traffic. 2002;3:37-49 pubmed
    ..On the other hand, traffic to the early recycling endosome is less dependent on Rab5 homologs and does not require Vps27p. ..
  21. Hines V, Schatz G. Precursor binding to yeast mitochondria. A general role for the outer membrane protein Mas70p. J Biol Chem. 1993;268:449-54 pubmed
    ..We conclude that Mas70p is an import receptor for most, if not all authentic mitochondrial precursor proteins, but that its function is not always rate-limiting in import experiments with isolated mitochondria. ..
  22. Koehler C, Jarosch E, Tokatlidis K, Schmid K, Schweyen R, Schatz G. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science. 1998;279:369-73 pubmed
    ..Neither protein was required for protein import into the other mitochondrial compartments. Both proteins may function as intermembrane space chaperones for the highly insoluble carrier proteins. ..
  23. Bleichenbacher M, Tan S, Richmond T. Novel interactions between the components of human and yeast TFIIA/TBP/DNA complexes. J Mol Biol. 2003;332:783-93 pubmed
    ..Of particular interest is a previously unobserved region of TFIIA that extends the binding interface with TBP in the yeast, but not in the human complex, and that further elucidates biochemical and genetic results. ..
  24. te Heesen S, Knauer R, Lehle L, Aebi M. Yeast Wbp1p and Swp1p form a protein complex essential for oligosaccharyl transferase activity. EMBO J. 1993;12:279-84 pubmed
    ..Wbp1p and Swp1p can be chemically cross-linked, suggesting that both proteins are essential constituents of the N-oligosaccharyl transferase complex. ..
  25. Barbet N, Schneider U, Helliwell S, Stansfield I, Tuite M, Hall M. TOR controls translation initiation and early G1 progression in yeast. Mol Biol Cell. 1996;7:25-42 pubmed
    ..Such a pathway may constitute a checkpoint that prevents early G1 progression and growth in the absence of nutrients. ..
  26. Shimada Y, Gulli M, Peter M. Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating. Nat Cell Biol. 2000;2:117-24 pubmed
    ..This sequestration regulates cell polarity in response to pheromones by restricting activation of Cdc42 to the site of pheromone receptor activation. ..
  27. Laroche T, Martin S, Tsai Pflugfelder M, Gasser S. The dynamics of yeast telomeres and silencing proteins through the cell cycle. J Struct Biol. 2000;129:159-74 pubmed
    ..Using live GFP fluorescence we show that the diffuse mitotic distribution of GFP-Rap1p is restored to the interphase pattern of foci in early G1-phase. ..
  28. Louvion J, Abbas Terki T, Picard D. Hsp90 is required for pheromone signaling in yeast. Mol Biol Cell. 1998;9:3071-83 pubmed
    ..These findings further corroborate the view that molecular chaperones must also be considered as transient or stable components of signal transduction pathways. ..
  29. Egli D, Hafen E, Schaffner W. An efficient method to generate chromosomal rearrangements by targeted DNA double-strand breaks in Drosophila melanogaster. Genome Res. 2004;14:1382-93 pubmed
    ..We therefore speculate that physical constraints on chromosomal movement are modulated during DSB repair, to facilitate the homology search throughout the genome. ..
  30. Ludin K, Hilti N, Schweingruber M. Schizosaccharomyces pombe rds1, an adenine-repressible gene regulated by glucose, ammonium, phosphate, carbon dioxide and temperature. Mol Gen Genet. 1995;248:439-45 pubmed
    ..We speculate that expression of the rds1 gene is regulated by one or several components of the adenine nucleotide pool and that its gene product has a function in stress-related responses of the cell. ..
  31. Stefanato F, Abou Mansour E, Buchala A, Kretschmer M, Mosbach A, Hahn M, et al. The ABC transporter BcatrB from Botrytis cinerea exports camalexin and is a virulence factor on Arabidopsis thaliana. Plant J. 2009;58:499-510 pubmed publisher
    ..Here we demonstrate that an ABC transporter is a virulence factor that increases tolerance of the pathogen towards a phytoalexin, and the complete restoration of virulence on host plants lacking this phytoalexin. ..
  32. Fairhead M, Thöny Meyer L. Cross-linking and immobilisation of different proteins with recombinant Verrucomicrobium spinosum tyrosinase. J Biotechnol. 2010;150:546-51 pubmed publisher
    ..The resulting aggregates can be collected by centrifugation and retain high levels of activity and may find applications in biocatalysis. ..
  33. Teixeira M, Forstemann K, Gasser S, Lingner J. Intracellular trafficking of yeast telomerase components. EMBO Rep. 2002;3:652-9 pubmed
    ..Altogether, our results suggest a role of the nucleolus in telomerase biogenesis. We also describe experiments that support a transient cytoplasmic localization of TLC1 RNA. ..
  34. Kronidou N, Oppliger W, Bolliger L, Hannavy K, Glick B, Schatz G, et al. Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A. 1994;91:12818-22 pubmed
    ..This arrangement is reminiscent of the protein transport systems of the yeast endoplasmic reticulum and the bacterial plasma membrane. ..
  35. Heuchel R, Radtke F, Georgiev O, Stark G, Aguet M, Schaffner W. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J. 1994;13:2870-5 pubmed
    ..These results demonstrate that MTF-1 is essential for metallothionein gene regulation. Finally, we present evidence that MTF-1 itself is a zinc sensor, which exhibits increased DNA binding activity upon zinc treatment. ..
  36. Collart M. The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters. Mol Cell Biol. 1996;16:6668-76 pubmed
  37. Helliwell S, Howald I, Barbet N, Hall M. TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics. 1998;148:99-112 pubmed
    ..These genes encode proteins that are involved in phosphoinositide metabolism and signaling. Thus, the two functions (readouts) of TOR2 appear to involve two related signaling pathways controlling cell growth. ..
  38. Glaser A, Limacher A, Flückiger S, Scheynius A, Scapozza L, Crameri R. Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. Biochem J. 2006;396:41-9 pubmed
    ..We identified conserved solvent-exposed residues in the fungal and human structures that are potentially involved in the IgE-mediated cross-reactivity. ..
  39. Coste A, Ramsdale M, Ischer F, Sanglard D. Divergent functions of three Candida albicans zinc-cluster transcription factors (CTA4, ASG1 and CTF1) complementing pleiotropic drug resistance in Saccharomyces cerevisiae. Microbiology. 2008;154:1491-501 pubmed publisher
    ..In conclusion, C. albicans possesses functional homologues of the S. cerevisiae Pdr1p and Pdr3p transcription factors; however, their properties in C. albicans have been rewired to other functions. ..
  40. Grünig C, Duò A, Sieber T, Holdenrieder O. Assignment of species rank to six reproductively isolated cryptic species of the Phialocephala fortinii s.1.-Acephala applanata species complex. Mycologia. 2008;100:47-67 pubmed
    ..Based on these data we propose to assign species rank to six CSP of P. fortinii: P. turiciensis, P. letzii, P. europaea, P. helvetica, P. uotolensis, P. subalpina spp. nov. and P. fortinii s.s. ..
  41. Sutterlin C, Horvath A, Gerold P, Schwarz R, Wang Y, Dreyfuss M, et al. Identification of a species-specific inhibitor of glycosylphosphatidylinositol synthesis. EMBO J. 1997;16:6374-83 pubmed
    ..These results suggest that despite the conserved core structure, the GPI biosynthetic machinery may be different enough between mammalian and protozoa to represent a target for anti-protozoan chemotherapy. ..
  42. Fleck O, Lehmann E, Schär P, Kohli J. Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair. Nat Genet. 1999;21:314-7 pubmed
    ..We identify here the NER genes rhpl4, swi10 and rad16 as components of this repair pathway and show that they act independently of msh2 and pms1. ..
  43. Delley P, Hall M. Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol. 1999;147:163-74 pubmed
    ..Thus, activated RHO1 can mediate both polarized and depolarized cell growth via the same effector, PKC1, suggesting that RHO1 may function as a rheostat rather than as a simple on-off switch. ..
  44. Crespo J, Powers T, Fowler B, Hall M. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A. 2002;99:6784-9 pubmed
    ..Furthermore, as glutamine starvation affects only a subset of TOR-controlled transcription factors, TOR appears to discriminate between different nutrient conditions to elicit a response appropriate to a given condition. ..
  45. Morais E, Chame D, Melo E, de Carvalho Oliveira J, de Paula A, Peixoto A, et al. TLR 9 involvement in early protection induced by immunization with rPb27 against Paracoccidioidomycosis. Microbes Infect. 2016;18:137-47 pubmed publisher
    ..Our findings demonstrate that TLR 9 plays a role in the protection induced by immunization with rPb27 and confirms the importance of TLR9 in the initial protection against Paracoccidioidomycosis. ..
  46. Helliwell S, Wagner P, Kunz J, Deuter Reinhard M, Henriquez R, Hall M. TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell. 1994;5:105-18 pubmed
    ..Thus, TOR1 and TOR2 are likely similar but not identical, rapamycin-sensitive PI kinases possibly regulated by phosphorylation. TOR1 and TOR2 may be components of a novel signal transduction pathway controlling progression through G1. ..
  47. Le Goff X, Buvelot S, Salimova E, Guerry F, Schmidt S, Cueille N, et al. The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network. FEBS Lett. 2001;508:136-42 pubmed
    ..Loss of par1p function rescues mutants in cdc11, cdc7, and spg1, but no other SIN mutants. Our data suggest that PP2A-par1p acts as a negative regulator of SIN signalling. ..
  48. van Drogen Petit A, Zwahlen C, Peter M, Bonvin A. Insight into molecular interactions between two PB1 domains. J Mol Biol. 2004;336:1195-210 pubmed
    ..Our results provide insight into the molecular structure of the Bem1-Cdc24 PB1-mediated heterodimer, which allowed identification of critical residues at the binding interface. ..
  49. Kraemer R, Deloséa N, Ballinari P, Gallati S, Crameri R. Effect of allergic bronchopulmonary aspergillosis on lung function in children with cystic fibrosis. Am J Respir Crit Care Med. 2006;174:1211-20 pubmed
    ..The relationship between sensitization to Aspergillus fumigatus and progression of pulmonary function is not yet established in cystic fibrosis (CF)...
  50. Buser R, Lazar Z, Käser S, Kunzler M, Aebi M. Identification, characterization, and biosynthesis of a novel N-glycan modification in the fruiting body of the basidiomycete Coprinopsis cinerea. J Biol Chem. 2010;285:10715-23 pubmed publisher
    ..Expression of the CcGnt1 locus was up-regulated in fruiting body, but down-regulation of expression by means of RNAi decreased the level of bisected NLO; however had no apparent effect on fruiting body formation. ..
  51. Fahrenkrog B, Hurt E, Aebi U, Pante N. Molecular architecture of the yeast nuclear pore complex: localization of Nsp1p subcomplexes. J Cell Biol. 1998;143:577-88 pubmed
    ..Accordingly, Nsp1p resides in three distinct subcomplexes which are located at the entry and exit of the central gated channel and at the terminal ring of the nuclear basket. ..
  52. Franzoi M, van Heuvel Y, Thomann S, Schürch N, Kallio P, Venier P, et al. Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin. Biochemistry. 2017;56:4992-5001 pubmed publisher
    ..These structural studies provide a better understanding of how defensins can be developed toward antibacterial therapies less prone to resistance issues...
  53. Minvielle Sebastia L, Preker P, Keller W. RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor. Science. 1994;266:1702-5 pubmed
    ..Biochemical complementation experiments and reconstitution of both activities with partially purified cleavage factor I (CF I) validated the genetic prediction. ..
  54. Jenny A, Minvielle Sebastia L, Preker P, Keller W. Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I. Science. 1996;274:1514-7 pubmed
    ..This finding was unexpected because in contrast to CPSF, PFI is only required for the polyadenylation reaction. These results contribute to the understanding of how 3'-end processing factors may have evolved. ..
  55. Kunz J, Schneider U, Howald I, Schmidt A, Hall M. HEAT repeats mediate plasma membrane localization of Tor2p in yeast. J Biol Chem. 2000;275:37011-20 pubmed
    ..Our studies therefore place Tor proteins at the site of action of their known downstream effectors and suggest that they may be part of a multiprotein complex. ..
  56. Wiederkehr A, Meier K, Riezman H. Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Yeast. 2001;18:759-73 pubmed
    ..Some of the mutants identified in this screen that sort carboxypeptidase Y correctly may affect endocytosis at an early post-internalization step before the intersection of the endocytic with the vacuolar protein-sorting pathway. ..
  57. Marks J, Fankhauser C, Reymond A, Simanis V. Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe. J Cell Sci. 1992;101 ( Pt 3):517-28 pubmed
    ..Our data suggest that sct1 encodes a protein that is dependent upon cdc10+ either for its normal function or expression, or is a component of a checkpoint that monitors execution of p85cdc10 function. ..
  58. Koehler C, Leuenberger D, Merchant S, Renold A, Junne T, Schatz G. Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A. 1999;96:2141-6 pubmed
    ..The deafness dystonia syndrome thus is a novel type of mitochondrial disease that probably is caused by a defective mitochondrial protein-import system...
  59. Pardini G, De Groot P, Coste A, Karababa M, Klis F, de Koster C, et al. The CRH family coding for cell wall glycosylphosphatidylinositol proteins with a predicted transglycosidase domain affects cell wall organization and virulence of Candida albicans. J Biol Chem. 2006;281:40399-411 pubmed
    ..In conclusion, this work establishes the role of UTR2, CRH11, and CRH12 in cell wall organization and integrity. ..
  60. Grimminger Marquardt V, Lashuel H. Structure and function of the molecular chaperone Hsp104 from yeast. Biopolymers. 2010;93:252-76 pubmed publisher
  61. Suzuki C, Suda K, Wang N, Schatz G. Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. Science. 1994;264:273-6 pubmed
    ..Lon- cells were also impaired in their ability to catalyze the energy-dependent degradation of several mitochondrial matrix proteins and they accumulated electron-dense inclusions in their mitochondrial matrix. ..
  62. Ferrari S, Simmen K, Dusserre Y, Muller K, Fourel G, Gilson E, et al. Chromatin domain boundaries delimited by a histone-binding protein in yeast. J Biol Chem. 2004;279:55520-30 pubmed
  63. Raths S, Rohrer J, Crausaz F, Riezman H. end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae. J Cell Biol. 1993;120:55-65 pubmed
    ..Other vesicle-mediated processes seem to be normal in end3 and end4 mutants. END3 and END4 are the first genes shown to be necessary for the internalization step of receptor-borne and fluid-phase markers in yeast. ..
  64. Coppolecchia R, Buser P, Stotz A, Linder P. A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase. EMBO J. 1993;12:4005-11 pubmed
    ..The Stm1 protein has potential RNP1 and RNP2 motifs characteristic for RNA-binding proteins. The protein also contains six highly conserved direct repeats of 21-26 amino acids and one partial repeat. ..
  65. De Rubertis F, Kadosh D, Henchoz S, Pauli D, Reuter G, Struhl K, et al. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature. 1996;384:589-91 pubmed
    ..This function of RPD3, which is in contrast to the general correlation between histone acetylation and increased transcription, might be due to a specialized chromatin structure at silenced loci. ..
  66. Preker P, Keller W. The HAT helix, a repetitive motif implicated in RNA processing. Trends Biochem Sci. 1998;23:15-6 pubmed
  67. Muniz M, Nuoffer C, Hauri H, Riezman H. The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles. J Cell Biol. 2000;148:925-30 pubmed
    ..Gap1p, which was not affected by emp24 mutation, was not cross-linked. These results suggest that the Emp24 complex acts as a cargo receptor in vesicle biogenesis from the ER. ..
  68. Shimada K, Pasero P, Gasser S. ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase. Genes Dev. 2002;16:3236-52 pubmed
    ..Our data suggest the existence of an S-phase-specific threshold that may be necessary to allow cells to tolerate damage-like DNA structures present at normal replication forks. ..
  69. Horst M, Oppliger W, Rospert S, Schönfeld H, Schatz G, Azem A. Sequential action of two hsp70 complexes during protein import into mitochondria. EMBO J. 1997;16:1842-9 pubmed
    ..A precursor protein entering the matrix interacts first with the import complex and then with the folding complex. A chaperone can thus function as part of two different complexes within the same organelle. ..
  70. Desrivieres S, Cooke F, Parker P, Hall M. MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae. J Biol Chem. 1998;273:15787-93 pubmed
    ..These results suggest that MSS4 is the major PI(4)P 5-kinase in yeast and provide a link between phosphoinositide metabolism and organization of the actin cytoskeleton in vivo. ..
  71. Schaerer Brodbeck C, Riezman H. Functional interactions between the p35 subunit of the Arp2/3 complex and calmodulin in yeast. Mol Biol Cell. 2000;11:1113-27 pubmed
    ..This is the first report linking Arp2/3 complex function with calmodulin through which it exercises at least one of its endocytic functions. ..
  72. Rivier A, Castillon G, Michon L, Fukasawa M, Romanova Michaelides M, Jaensch N, et al. Exit of GPI-anchored proteins from the ER differs in yeast and mammalian cells. Traffic. 2010;11:1017-33 pubmed publisher
    ..These findings suggest that GPI-APs use different mechanisms to concentrate in COPII vesicles in the two organisms, and the difference might explain their propensity to segregate from other secretory proteins upon ER exit. ..
  73. Rudolph C, Fleck O, Kohli J. Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1. Curr Genet. 1998;34:343-50 pubmed
    ..Furthermore, msh2 delta was epistatic over exo1 delta, and the ExoI enzyme is likely to be redundant with other exonucleases. ..
  74. Barabino S, Ohnacker M, Keller W. Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs. EMBO J. 2000;19:3778-87 pubmed
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    ..Thus, TOR2 signals to the actin cytoskeleton through a GTPase switch composed of RHO1, RHO2, ROM2, and SAC7. TOR2 activates this switch via ROM2, possibly via the ROM2 PH domain. ..
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