Experts and Doctors on fungal proteins in Japan


Locale: Japan
Topic: fungal proteins

Top Publications

  1. Irie K, Araki H, Oshima Y. Mutations in a Saccharomyces cerevisiae host showing increased holding stability of the heterologous plasmid pSR1. Mol Gen Genet. 1991;225:257-65 pubmed
    ..Another mutation, smp3, at a locus linked to ade2 on chromosome XV, confers temperature-sensitive growth. The SMP3 gene encodes a 59.9 kDa hydrophobic protein and disruption of the gene is lethal. ..
  2. Tanaka K, Nakafuku M, Tamanoi F, Kaziro Y, Matsumoto K, Toh e A. IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein. Mol Cell Biol. 1990;10:4303-13 pubmed
    ..Expression of the IRA2 domain homologous with GAP is sufficient for complementation of the heat shock sensitivity of ira2, suggesting that IRA down regulates RAS activity by stimulating the GTPase activity of RAS proteins. ..
  3. Yun C, Tamaki H, Nakayama R, Yamamoto K, Kumagai H. G-protein coupled receptor from yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1997;240:287-92 pubmed
    ..It is likely that a Gpr1p monitors the extracellular signal such as nutrition and transduce it via Gpa2p a possible positive regulator of cAMP level. ..
  4. Kanai T, Takeshita S, Atomi H, Umemura K, Ueda M, Tanaka A. A regulatory factor, Fil1p, involved in derepression of the isocitrate lyase gene in Saccharomyces cerevisiae--a possible mitochondrial protein necessary for protein synthesis in mitochondria. Eur J Biochem. 1998;256:212-20 pubmed
  5. Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, et al. XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. J Biol Chem. 2000;275:34931-7 pubmed
    ..These results indicate that XAB2 is a novel component involved in transcription-coupled repair and transcription. ..
  6. Makino T, Suzuki Y, Gojobori T. Differential evolutionary rates of duplicated genes in protein interaction network. Gene. 2006;385:57-63 pubmed
  7. Kinoshita N, Goebl M, Yanagida M. The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control. Mol Cell Biol. 1991;11:5839-47 pubmed
    ..The role of the dis3+ gene product in mitosis is unknown, but this gene product may be directly or indirectly involved in the regulation of mitosis. ..
  8. Iwahashi H, Nwaka S, Obuchi K, Komatsu Y. Evidence for the interplay between trehalose metabolism and Hsp104 in yeast. Appl Environ Microbiol. 1998;64:4614-7 pubmed
    ..These results suggest that during heat shock, Hsp104 contributes to the simultaneous increase in both accumulation and degradation of trehalose. ..
  9. Tauchi H. Positional cloning and functional analysis of the gene responsible for Nijmegen breakage syndrome, NBS1. J Radiat Res. 2000;41:9-17 pubmed
    ..Functional analysis of the NBS1 protein is in progress and it should provide further clues to understanding the repair mechanism of radiation-induced DNA double-strand breaks. ..

More Information

Publications138 found, 100 shown here

  1. Ito T, Tani S, Itoh T, Tsukagoshi N, Kato M, Kobayashi T. Mode of AmyR binding to the CGGN8AGG sequence in the Aspergillus oryzae taaG2 promoter. Biosci Biotechnol Biochem. 2004;68:1906-11 pubmed
    ..The in vitro and in vivo analyses indicated that two AmyR molecules bind cooperatively to the 5'-CGGAAATTTAA-3' sequence by recognizing the CGG triplet at the 5'-end and the AGG triplet just downstream of the sequence. ..
  2. Ishiai M, Kimura M, Namikoshi K, Yamazoe M, Yamamoto K, Arakawa H, et al. DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation. Mol Cell Biol. 2004;24:10733-41 pubmed
    ..These results suggest that interaction between SNM1A and PIAS1 is required for ICL repair. ..
  3. Nakayama K, Nagasu T, Shimma Y, Kuromitsu J, Jigami Y. OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine-linked oligosaccharides. EMBO J. 1992;11:2511-9 pubmed
    ..Finally, the OCH1 gene was found to encode a novel mannosyltransferase which specifically transfers [14C]mannose to the unique acceptor, the core-like oligosaccharide of cell wall mannan accumulated in the och1 disruptant. ..
  4. Shirayama M, Matsui Y, Tanaka K, Toh e A. Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast. 1994;10:451-61 pubmed
    ..These results suggest that MSI2 is involved in the termination of M phase and that this process is regulated by a ras superfamily gene product. ..
  5. Takeuchi T, Miyahara K, Hirata D, Miyakawa T. Mutational analysis of Yap1 protein, an AP-1-like transcriptional activator of Saccharomyces cerevisiae. FEBS Lett. 1997;416:339-43 pubmed
    ..The carboxy-terminal domain of Yap1 appears to act negatively in cadmium resistance. ..
  6. Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, et al. Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata. Genes Cells. 2011;16:80-9 pubmed publisher
    ..These results suggest that in C. glabrata CgUPC2A but not in CgUPC2B is the main transcriptional regulator of the genes responsible for maintaining sterol homeostasis as well as susceptibility to sterol inhibitors...
  7. Katagiri H, Terasaki J, Murata T, Ishihara H, Ogihara T, Inukai K, et al. A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995;270:4963-6 pubmed
  8. Inoue M, Isomura M, Ikegawa S, Fujiwara T, Shin S, Moriya H, et al. Isolation and characterization of a human cDNA clone (GCN5L1) homologous to GCN5, a yeast transcription activator. Cytogenet Cell Genet. 1996;73:134-6 pubmed
    ..We isolated a genomic clone corresponding to this cDNA from a human cosmid library and mapped it to chromosome 12q13 --> q14 by fluorescent in situ hybridization (FISH). ..
  9. Miyahara K, Hirata D, Miyakawa T. Functional interaction of Isr1, a predicted protein kinase, with the Pkc1 pathway in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 1998;62:1376-80 pubmed
    ..These results suggest that Isr1 functions in an event important for growth in a manner redundant with a Mpk1-independent branch of the Pkc1 signalling pathways. ..
  10. Ohmiya R, Yamada H, Kato C, Aiba H, Mizuno T. The Prr1 response regulator is essential for transcription of ste11+ and for sexual development in fission yeast. Mol Gen Genet. 2000;264:441-51 pubmed
    ..These findings are discussed with special reference to the well-characterized transcription factors Pap1 and Atf1 of S. pombe. ..
  11. Yoshida S, Ichihashi R, Toh e A. Ras recruits mitotic exit regulator Lte1 to the bud cortex in budding yeast. J Cell Biol. 2003;161:889-97 pubmed
    ..These results suggest that Lte1 is a downstream effector protein of Ras in mitotic exit and that the Ras GEF domain of Lte1 is not essential for mitotic exit but required for its localization. ..
  12. Juvvadi P, Seshime Y, Kitamoto K. Genomics reveals traces of fungal phenylpropanoid-flavonoid metabolic pathway in the f ilamentous fungus Aspergillus oryzae. J Microbiol. 2005;43:475-86 pubmed
    ..In future, it is anticipated that these enzymes may be reasonable targets for metabolic engineering in fungi to produce agriculturally and nutritionally important metabolites. ..
  13. Kitamura K, Taki M, Tanaka N, Yamashita I. Fission yeast Ubr1 ubiquitin ligase influences the oxidative stress response via degradation of active Pap1 bZIP transcription factor in the nucleus. Mol Microbiol. 2011;80:739-55 pubmed publisher
    ..Coincidental dysfunction in both inhibitory pathways causes lethality because of prolonged activation of Pap1. Ubr1 is a critical regulator for the homeostasis of oxidative stress response. ..
  14. Yanagida M. Gene products required for chromosome separation. J Cell Sci Suppl. 1989;12:213-29 pubmed
  15. Hirata D, Yano K, Miyakawa T. Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Mol Gen Genet. 1994;242:250-6 pubmed
    ..A high-copy-number plasmid bearing YAP2 mediated cadmium-induced transcriptional activation of this promoter. The inductions were prevented by the antioxidant N-acetyl-L-cysteine. ..
  16. Kuge S, Jones N, Nomoto A. Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J. 1997;16:1710-20 pubmed
    ..We suggest therefore, that these cysteine residues are important in sensing the redox state of the cell and hence regulating yAP-1 activity...
  17. Koide T, Aso A, Yorihuzi T, Nagata K. Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47. J Biol Chem. 2000;275:27957-63 pubmed
    ..We also demonstrated that screening of combinatorial peptide libraries is a powerful strategy to determine conformational requirements as well as the elucidation of binding motifs in primary structure. ..
  18. Yoshida S, Toh e A. Regulation of the localization of Dbf2 and mob1 during cell division of saccharomyces cerevisiae. Genes Genet Syst. 2001;76:141-7 pubmed
  19. Tochikura T, Nakashima H, Ohashi Y, Yamamoto N. Inhibition (in vitro) of replication and of the cytopathic effect of human immunodeficiency virus by an extract of the culture medium of Lentinus edodes mycelia. Med Microbiol Immunol. 1988;177:235-44 pubmed
    ..Thus, the inhibitory effect of LEM and E-P-LEM on HIV could be due to a blocking of the initial stages of HIV infection. Moreover, reverse transcriptase activity of avian myeloblastosis virus was inhibited. ..
  20. Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, et al. Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1. Genomics. 1996;37:408-10 pubmed
  21. Kanoh J, Watanabe Y, Ohsugi M, Iino Y, Yamamoto M. Schizosaccharomyces pombe gad7+ encodes a phosphoprotein with a bZIP domain, which is required for proper G1 arrest and gene expression under nitrogen starvation. Genes Cells. 1996;1:391-408 pubmed
    ..Gad7 is a phosphoprotein, whose activity may be regulated by protein kinases including the cAMP-dependent protein kinase (Pka1) and Wis1 osmosensory MAP kinase kinase. ..
  22. Kitazume T, Takaya N, Nakayama N, Shoun H. Fusarium oxysporum fatty-acid subterminal hydroxylase (CYP505) is a membrane-bound eukaryotic counterpart of Bacillus megaterium cytochrome P450BM3. J Biol Chem. 2000;275:39734-40 pubmed
    ..P450foxy was classified in the new family, CYP505. ..
  23. Higashio H, Kohno K. A genetic link between the unfolded protein response and vesicle formation from the endoplasmic reticulum. Biochem Biophys Res Commun. 2002;296:568-74 pubmed
    ..These findings suggest that the activation of the UPR affects ER-to-Golgi transport via stimulation of COPII vesicle formation from the ER. ..
  24. Sutani T, Yanagida M. DNA renaturation activity of the SMC complex implicated in chromosome condensation. Nature. 1997;388:798-801 pubmed
    ..The activity of the mutant complex was heat sensitive. As DNA winding by renaturation is a potential cause of supercoiling, the SMC complex may be implicated in promoting the higher-order DNA coiling found in condensed chromosomes. ..
  25. Uemura H, Koshio M, Inoue Y, Lopez M, Baker H. The role of Gcr1p in the transcriptional activation of glycolytic genes in yeast Saccharomyces cerevisiae. Genetics. 1997;147:521-32 pubmed
    ..These results support the hypothesis that Gcr1p and Gcr2p play the central role in glycolytic gene expression and that the function of Rap1p is to facilitate the binding of Gcr1p to its target. ..
  26. Yabe K, Nakajima H. Enzyme reactions and genes in aflatoxin biosynthesis. Appl Microbiol Biotechnol. 2004;64:745-55 pubmed
    ..This review will summarize the enzymatic steps and the genes in aflatoxin/sterigmatocystin biosynthesis. ..
  27. Sotome K, Hattori T, Ota Y, To anun C, Salleh B, Kakishima M. Phylogenetic relationships of Polyporus and morphologically allied genera. Mycologia. 2008;100:603-15 pubmed
    ..This suggests that morphological characters used to define these groups have phylogenetic significance and reveals the need for a taxonomic revision of Polyporus and its allied genera. ..
  28. Umemoto N, Yoshihisa T, Hirata R, Anraku Y. Roles of the VMA3 gene product, subunit c of the vacuolar membrane H(+)-ATPase on vacuolar acidification and protein transport. A study with VMA3-disrupted mutants of Saccharomyces cerevisiae. J Biol Chem. 1990;265:18447-53 pubmed
    ..The disruption of the VMA3 gene causes yeast cells with considerable lesions in vacuolar biogenesis and protein transport to the vacuole and inhibits endocytosis of lucifer yellow CH completely. ..
  29. Ichinomiya M, Horiuchi H, Ohta A. Different functions of the class I and class II chitin synthase genes, chsC and chsA, are revealed by repression of chsB expression in Aspergillus nidulans. Curr Genet. 2002;42:51-8 pubmed
    ..Thus, it is suggested that the gene products of chsA and chsB themselves have different functions in hyphal morphogenesis. ..
  30. Watanabe S, Piyanart S, Makino K. Metabolic fate of L-lactaldehyde derived from an alternative L-rhamnose pathway. FEBS J. 2008;275:5139-49 pubmed publisher
    ..This suggests that the substrate specificities for L-lactaldehyde between fungal and bacterial LADHs have been acquired independently. ..
  31. Fujiwara H, Tanaka N, Yamashita I, Kitamura K. Essential role of Ubr11, but not Ubr1, as an N-end rule ubiquitin ligase in Schizosaccharomyces pombe. Yeast. 2013;30:1-11 pubmed publisher
    ..In unperturbed meiosis, chromosome segregation occurred almost normally and viable spores were produced in the ubr11? cells, irrespective of the presence of undegraded endogenous Rec8c peptides. ..
  32. Matsumoto K, Uno I, Ishikawa T. Genetic analysis of the role of cAMP in yeast. Yeast. 1985;1:15-24 pubmed
  33. Wadhwa R, Kaul S, Komatsu Y, Ikawa Y, Sarai A, Sugimoto Y. Identification and differential expression of yeast SEC23-related gene (Msec23) in mouse tissues. FEBS Lett. 1993;315:193-6 pubmed
    ..Further, Msec23 is differentially expressed in mouse tissues with its high level in brain and fibroblasts. ..
  34. Ogawa N, Saitoh H, Miura K, Magbanua J, Bun Ya M, Harashima S, et al. Structure and distribution of specific cis-elements for transcriptional regulation of PHO84 in Saccharomyces cerevisiae. Mol Gen Genet. 1995;249:406-16 pubmed
    ..The UAS function of the GCACGTTTT motif with respect to the Pi signal depends on its orientation in the promoter sequence. ..
  35. Yompakdee C, Ogawa N, Harashima S, Oshima Y. A putative membrane protein, Pho88p, involved in inorganic phosphate transport in Saccharomyces cerevisiae. Mol Gen Genet. 1996;251:580-90 pubmed
    ..Both disruption and high dosage of PHO88 or PHO86 resulted in reduced Pi uptake. These findings suggest that Pho88p is also involved in Pi transport and modulates Pho81p function together with Pho86p. ..
  36. Marui J, Yamane N, Ohashi Kunihiro S, Ando T, Terabayashi Y, Sano M, et al. Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)(2)Cys(6) transcriptional activator and induced by kojic acid at the transcriptional level. J Biosci Bioeng. 2011;112:40-3 pubmed publisher
    ..We determined that the gene was essential for KA production and the transcriptional activation of KA biosynthetic genes, which were triggered by the addition of KA...
  37. Ichimura K, Mizoguchi T, Irie K, Morris P, Giraudat J, Matsumoto K, et al. Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis. Biochem Biophys Res Commun. 1998;253:532-43 pubmed
    ..By contrast, other combinations of MAPKs and MAPKKs did not suppress these yeast mutations. These results suggest that ATMEKK1, ATMKK2/MEK1, and ATMPK4 may constitute a MAP kinase cascade. ..
  38. Liu W, Wang J, Mitsui K, Shen H, Tsurugi K. Interaction of the GTS1 gene product with glyceraldehyde- 3-phosphate dehydrogenase 1 required for the maintenance of the metabolic oscillations of the yeast Saccharomyces cerevisiae. Eur J Biochem. 2002;269:3560-9 pubmed
    ..Thus, we hypothesized that Gts1p plays a role in the regulation of metabolic oscillation by interacting with the TDH1 product, GAPDH1, in yeast. ..
  39. Ishii H, Miyamoto T, Ushio S, Kakishima M. Lack of cross-resistance to a novel succinate dehydrogenase inhibitor, fluopyram, in highly boscalid-resistant isolates of Corynespora cassiicola and Podosphaera xanthii. Pest Manag Sci. 2011;67:474-82 pubmed publisher
    ..This finding may lead to the discovery of unique SDHIs in the future. ..
  40. Nagata A, Igarashi M, Jinno S, Suto K, Okayama H. An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. New Biol. 1991;3:959-68 pubmed
    ..Thus, at least two homologs of the cdc25 gene exist and are both expressed in human cells. The implications of CDC25Hu2 overexpression in some cancer cells are discussed. ..
  41. Tsuruga H, Yabuta N, Hosoya S, Tamura K, Endo Y, Nojima H. HsMCM6: a new member of the human MCM/P1 family encodes a protein homologous to fission yeast Mis5. Genes Cells. 1997;2:381-99 pubmed
    ..We mapped the HsMCM6 gene at 2q12-14. The results indicate that the behaviour of HsMcm6 is reminiscent of replication licensing factor like other Mcm/P1 family members. ..
  42. Kurokawa Y, Kanemaki M, Makino Y, Tamura T. A notable example of an evolutionary conserved gene: studies on a putative DNA helicase TIP49. DNA Seq. 1999;10:37-42 pubmed
    ..The TIP49 gene family is thought to play a fundamental role in a biological activity. ..
  43. Araki H, Leem S, Phongdara A, Sugino A. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Proc Natl Acad Sci U S A. 1995;92:11791-5 pubmed
    ..These results strongly suggest that Dpb11 is a part of the DNA polymerase II complex during chromosomal DNA replication and also acts in a checkpoint pathway during the S phase of the cell cycle to sense stalled DNA replication. ..
  44. Tochikura T, Nakashima H, Yamamoto N. Antiviral agents with activity against human retroviruses. J Acquir Immune Defic Syndr. 1989;2:441-7 pubmed
    ..Moreover, the extent of inhibition of the fusion reaction by the substances varied significantly from strain to strain in HIV-1. ..
  45. Yamashita A, Watanabe Y, Yamamoto M. Microtubule-associated coiled-coil protein Ssm4 is involved in the meiotic development in fission yeast. Genes Cells. 1997;2:155-66 pubmed
    ..Ssm4 is a microtubule-colocalizing protein that plays a role specifically in meiosis. Ssm4 appears to modify the structure or the function of nuclear microtubules in order to promote the meiotic nuclear division. ..
  46. Saka Y, Fantes P, Yanagida M. Coupling of DNA replication and mitosis by fission yeast rad4/cut5. J Cell Sci Suppl. 1994;18:57-61 pubmed
    ..The restraint of mitosis until the completion of S phase is mediated by the cut5 protein, which can sense the state of chromosome duplication and negatively interacts with M phase regulators such as cdc25 and cdc2. ..
  47. Adachi Y, Usukura J, Yanagida M. A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast. Genes Cells. 1997;2:467-79 pubmed
    ..We have developed a procedure to purify fission yeast MCM proteins in a native hetero-oligomeric complex form for the first time, which opens an avenue to further biochemical analysis. ..
  48. Mizunuma M, Hirata D, Miyahara K, Tsuchiya E, Miyakawa T. Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. Nature. 1998;392:303-6 pubmed
    ..These cellular pathways also induce a G2-phase delay in response to hypotonic shock. ..
  49. Suzuki C, Kawano M, Kashiwagi T, Arata Y, Kawasumi T, Kashiwagi Y. Lethal effect of the expression of a killer gene SMK1 in Saccharomyces cerevisiae. Protein Eng. 2000;13:73-6 pubmed
    ..The result obtained upon substitutions of Ala, Ser or Glu for Leu207 suggested that the side chain of Leu207 stabilizes the hydrophobic environment that contributes to the overall structure of the SMK1 product...
  50. Wakabayashi M, Ishii C, Inoue H, Tanaka S. Genetic analysis of CHK1 and CHK2 homologues revealed a unique cross talk between ATM and ATR pathways in Neurospora crassa. DNA Repair (Amst). 2008;7:1951-61 pubmed publisher
    ..Furthermore, these double mutants showed severe growth defects. Our findings suggest that the DNA damage checkpoint of N. crassa is controlled by unique mechanisms...
  51. Yamada Okabe T, Mio T, Matsui M, Kashima Y, Arisawa M, Yamada Okabe H. Isolation and characterization of the Candida albicans gene for mRNA 5'-triphosphatase: association of mRNA 5'-triphosphatase and mRNA 5'-guanylyltransferase activities is essential for the function of mRNA 5'-capping enzyme in vivo. FEBS Lett. 1998;435:49-54 pubmed
  52. Sugimoto K, Sakamoto Y, Takahashi O, Matsumoto K. HYS2, an essential gene required for DNA replication in Saccharomyces cerevisiae. Nucleic Acids Res. 1995;23:3493-500 pubmed
    ..HYS2 encodes a 55 kDa protein that is essential for viability at all temperatures. Taken together, these data suggest that Hys2 plays a role in DNA replication. ..
  53. Heo S, Tatebayashi K, Ikeda H. The budding yeast cohesin gene SCC1/MCD1/RHC21 genetically interacts with PKA, CDK and APC. Curr Genet. 1999;36:329-38 pubmed
    ..The functional relationships between SCC1/MCD1/RHC21 and PKA, CDK or APC are discussed. ..
  54. Yashiroda H, Oguchi T, Yasuda Y, Toh e A, Kikuchi Y. Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:3255-63 pubmed
    ..We discuss the possibility that Bul1 functions together with Rsp5 in protein ubiquitination. ..
  55. Miyahara K, Hirata D, Miyakawa T. yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae. Curr Genet. 1996;29:103-5 pubmed
    ..A sequence similar to the yAP-1 recognition element recently identified in the stress-responsive yeast genes was found in this region and in the 5'-flanking sequences of SNQ2...
  56. Hao Z, Furunobu A, Nagata A, Okayama H. A zinc finger protein required for stationary phase viability in fission yeast. J Cell Sci. 1997;110 ( Pt 20):2557-66 pubmed
    ..Analysis also showed that cells need to receive starvation signals before entry into the stationary phase in order to maintain viability in a glucose-poor environment. ..
  57. Yamaguchi H, Miki H, Takenawa T. Two verprolin homology domains increase the Arp2/3 complex-mediated actin polymerization activities of N-WASP and WAVE1 C-terminal regions. Biochem Biophys Res Commun. 2002;297:214-9 pubmed
    ..Thus, the WAVE1 VCA fragment may exist in an unfavorable conformation to activate the Arp2/3 complex, implying the existence of a structural difference between WAVE1 and N-WASP VCAs in addition to the number of V motifs. ..
  58. Samejima I, Yanagida M. Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase. J Cell Biol. 1994;127:1655-70 pubmed
    ..The nuc2+ and cut9+ genes share an essential function to initiate anaphase. The cold-sensitive scn1 and scn2 mutations, defective in late anaphase, can suppress the ts phenotype of cut9. ..
  59. Nakai M, Kato Y, Ikeda E, Toh e A, Endo T. Yge1p, a eukaryotic Grp-E homolog, is localized in the mitochondrial matrix and interacts with mitochondrial Hsp70. Biochem Biophys Res Commun. 1994;200:435-42 pubmed
    ..We propose that Yge1p functions in cooperation with Ssc1p in a similar manner as bacterial GrpE with DnaK. ..
  60. Mizuno T, Nakazawa N, Remgsamrarn P, Kunoh T, Oshima Y, Harashima S. The Tup1-Ssn6 general repressor is involved in repression of IME1 encoding a transcriptional activator of meiosis in Saccharomyces cerevisiae. Curr Genet. 1998;33:239-47 pubmed
    ..These findings indicate that IME1 is negatively regulated by the Tup1-Ssn6 repressor complex through two distinct upstream regions in conjunction with unidentified DNA-binding proteins. ..
  61. Moriya H, Isono K. Analysis of genetic interactions between DHH1, SSD1 and ELM1 indicates their involvement in cellular morphology determination in Saccharomyces cerevisiae. Yeast. 1999;15:481-96 pubmed
    ..A triple mutant, delta dhh1 ssd1-d delta elm1, apparently had very fragile cell walls and could grow only in a medium supplemented with 1 M sorbitol. ..
  62. Tsukamoto Y, Kato J, Ikeda H. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature. 1997;388:900-3 pubmed
    ..We propose that Sir proteins act with Hdf1 to alter broken DNA ends to create an inactivated chromatin structure that is essential for the rejoining of DNA ends. ..
  63. Fujikawa T, Sakaguchi A, Nishizawa Y, Kouzai Y, Minami E, Yano S, et al. Surface ?-1,3-glucan facilitates fungal stealth infection by interfering with innate immunity in plants. PLoS Pathog. 2012;8:e1002882 pubmed publisher
    ..Because ?-1,3-glucan is nondegradable in plants, it is reasonable that many fungal plant pathogens utilize ?-1,3-glucan in the innate immune evasion mechanism and some in maintaining the structures. ..
  64. Nakamura M, Ogata K, Nagamine T, Tajima K, Matsui H, Benno Y. The replicon of the cryptic Plasmid pSBO1 isolated from Streptococcus bovis JB1. Curr Microbiol. 2001;43:11-6 pubmed
    ..bovis 12-U-1 and no8 strains. This result indicates that the putative rep encoded Rep and that the replicon of pSBO1 contained the DRs and the rep. Gel shift assays showed that the Rep of pSBO1 bound the 22-bp DRs. ..
  65. Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y. Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6. Cytogenet Cell Genet. 1996;73:224-7 pubmed
    ..5 kb long, was expressed ubiquitously in all human tissues examined, but a 2.0-kb alternative transcript lacking any long AU-rich element in the 3' non-coding region was expressed abundantly only in testis, heart and skeletal muscle. ..
  66. Hisamoto N, Sugimoto K, Matsumoto K. The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M. Mol Cell Biol. 1994;14:3158-65 pubmed
    ..These findings suggest that the glc7Y-170 mutation is defective in the G2/M phase of the cell cycle. Thus, type 1 protein phosphatase in Saccharomyces cerevisiae is essential for the G2/M transition. ..
  67. Tzelepis G, Hosomi A, Hossain T, Hirayama H, dubey m, Jensen D, et al. Endo-?-N-acetylglucosamidases (ENGases) in the fungus Trichoderma atroviride: possible involvement of the filamentous fungi-specific cytosolic ENGase in the ERAD process. Biochem Biophys Res Commun. 2014;449:256-61 pubmed publisher
    ..These results indicate that T. atroviride Eng18B may deglycosylate misfolded glycoproteins, substituting the function of the cytoplasmic PNGase in the ERAD process. ..
  68. Matsuura A, Anraku Y. Genetic interaction between the Ras-cAMP pathway and the Dis2s1/Glc7 protein phosphatase in Saccharomyces cerevisiae. Mol Gen Genet. 1994;242:257-62 pubmed
    ..Furthermore, the dis2s1ts mutation was shown to be suppressed by a multicopy plasmid harboring PDE2, a gene for cAMP phosphodiesterase. These results indicate that the Ras-cAMP pathway interacts genetically with the DIS2S1/GLC7 gene. ..
  69. Tanida I, Takita Y, Hasegawa A, Ohya Y, Anraku Y. Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non-exchangeable intracellular Ca2+ pool cooperatively with calcineurin. FEBS Lett. 1996;379:38-42 pubmed
    ..Given that FK506 inhibits the calcineurin activity, Cls2p likely functions in releasing Ca2+ flux from the endoplasmic reticulum, somehow cooperating with calcineurin. ..
  70. Wada Y, Nakamura N, Ohsumi Y, Hirata A. Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae. J Cell Sci. 1997;110 ( Pt 11):1299-306 pubmed
    ..We conclude from these observations that Vam3p is a novel member of syntaxin in the vacuoles and it provides the t-SNARE function in a late step of the vacuolar assembly. ..
  71. Watanabe N, Madaule P, Reid T, Ishizaki T, Watanabe G, Kakizuka A, et al. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 1997;16:3044-56 pubmed
    ..Overexpression of p140mDia in COS-7 cells induced homogeneous actin filament formation. These results suggest that Rho regulates actin polymerization by targeting profilin via p140mDia beneath the specific plasma membranes. ..
  72. Yamada H, Kumada K, Yanagida M. Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast. J Cell Sci. 1997;110 ( Pt 15):1793-804 pubmed
    ..In contrast, PP1 (Dis2) phosphatase mutation shows the reverse effect on the phenotype of cut9. The Cut9 subunit is likely to be a target for regulating APC/ cyclosome function through protein-protein interactions and phosphorylation. ..
  73. Futai E, Maeda T, Sorimachi H, Kitamoto K, Ishiura S, Suzuki K. The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation. Mol Gen Genet. 1999;260:559-68 pubmed
    ..These results indicate that a calpain-like cysteine protease, Cpl1p, plays an important role in alkaline adaptation and sporulation processes, via regulation of the turnover and processing of the transcription factor Rim101p. ..
  74. Suzuki S, Fukuoka M, Ookuchi H, Sano M, Ozeki K, Nagayoshi E, et al. Characterization of Aspergillus oryzae glycoside hydrolase family 43 beta-xylosidase expressed in Escherichia coli. J Biosci Bioeng. 2010;109:115-7 pubmed publisher
    ..To characterize this enzyme, the recombinant enzyme was expressed in Escherichia coli. Unlike known beta-xylosidases from fungal origins, the enzyme did not show substrate ambiguity and was stable at alkaline pH...
  75. Sugiyama T, Sugioka Sugiyama R. Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast. EMBO J. 2011;30:1027-39 pubmed publisher
    ..These results demonstrate that Red1 is involved in DSR-directed RNA decay to prevent ectopic expression of meiotic mRNAs in vegetative cells. ..
  76. Tanaka K, Nakafuku M, Satoh T, Marshall M, Gibbs J, Matsumoto K, et al. S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein. Cell. 1990;60:803-7 pubmed
    ..Overexpression of bovine GAP suppressed the phenotypes of ira mutants by reducing the level of RAS-GTP, suggesting that IRA proteins may be functionally analogous to mammalian GAP. ..
  77. Saka Y, Sutani T, Yamashita Y, Saitoh S, Takeuchi M, Nakaseko Y, et al. Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis. EMBO J. 1994;13:4938-52 pubmed
    ..Plasmids carrying the DNA topoisomerase I gene partly suppressed the temperature sensitive phenotype of cut3-477, suggesting that the cut3 protein might be involved in chromosome DNA topology. ..
  78. Yamada H, Mori H, Momoi H, Nakagawa Y, Ueguchi C, Mizuno T. A fission yeast gene encoding a protein that preferentially associates with curved DNA. Yeast. 1994;10:883-94 pubmed
    ..This protein appears to be located in the nucleus. The predicted protein sequence revealed that the 42 K-protein exhibits no significant similarity to any other known proteins, except to a hypothetical protein of Caenorhabditis elegans. ..
  79. Samejima I, Yanagida M. Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase. Mol Cell Biol. 1994;14:6361-71 pubmed
    ..The cek1+ gene is not an essential gene. Protein phosphorylation by cek1 may facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein. ..
  80. Saka Y, Yanagida M. Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Cell. 1993;74:383-93 pubmed
    ..The rad4+/cut5+ gene is unique in its positive role for replication/repair and in its negative role for mitosis/cytokinesis. We propose a single/twin chromatid marking model for rad4+/cut5+ function in cell cycle control. ..
  81. Benton B, Reid M, Okayama H. A Schizosaccharomyces pombe gene that promotes sexual differentiation encodes a helix-loop-helix protein with homology to MyoD. EMBO J. 1993;12:135-43 pubmed
    ..Thus, this MyoD/Myf-5-like protein appears to promote sexual differentiation by modulating responses to decreases in cAMP, a part of the nitrogen starvation signal that induces differentiation. ..
  82. Matsuura A, Anraku Y. Characterization of the MKS1 gene, a new negative regulator of the Ras-cyclic AMP pathway in Saccharomyces cerevisiae. Mol Gen Genet. 1993;238:6-16 pubmed
    ..The mks1 gal11 double mutant shows more marked phenotypic changes than the single mutants. These results suggest that MKS1 is involved in transcriptional regulation of several genes by cAMP. ..
  83. Tsuji E, Tsuji Y, Misumi Y, Fujita A, Sasaguri M, Ideishi M, et al. Molecular cloning of a novel rat salt-tolerant protein by functional complementation in yeast. Biochem Biophys Res Commun. 1996;229:134-8 pubmed
    ..STP contains 1964 bp nucleotides and an open reading frame which encodes 496 amino acid residues. Northern blot analysis showed that STP mRNA is expressed in various rat tissues. ..
  84. Wang J, Mitsui K, Tsurugi K. The GTS1 gene product influences the ultradian oscillation of glycolysis in cell suspension of the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1998;244:239-42 pubmed
    ..The effect of GTS1 on the amplitude was not caused by changing rates of glucose incorporation into cells as the rates were the same among the three strains during the macroscopic oscillation. ..
  85. Yamagata H, Uesugi M, Saka K, Iwasaki T, Aizono Y. Molecular cloning and characterization of a cDNA and a gene for subtilisin-like serine proteases from rice (Oryza sativa L.) and Arabidopsis thaliana. Biosci Biotechnol Biochem. 2000;64:1947-57 pubmed
  86. Mizunuma M, Hirata D, Miyaoka R, Miyakawa T. GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast. EMBO J. 2001;20:1074-85 pubmed
    ..The Ca2+-activated pathway may play a role in the rapid inactivation of Hsl1 at the cell cycle stage(s) when APC activity is low. ..
  87. Miura F, Yada T, Nakai K, Sakaki Y, Ito T. Differential display analysis of mutants for the transcription factor Pdr1p regulating multidrug resistance in the budding yeast. FEBS Lett. 2001;505:103-8 pubmed
    ..Intriguingly, among the latter, a previously unrecognized gene bearing a small putative open reading frame preceded by a functional PDRE was found. ..
  88. Kaneko A, Umeyama T, Hanaoka N, Monk B, Uehara Y, Niimi M. Tandem affinity purification of the Candida albicans septin protein complex. Yeast. 2004;21:1025-33 pubmed
    ..The successful application of TAP to the purification and analysis of the C. albicans septin complex indicates that this technology will have much wider application to proteomic studies of this pathogenic fungus. ..
  89. Sumita T, Yoko o T, Shimma Y, Jigami Y. Comparison of cell wall localization among Pir family proteins and functional dissection of the region required for cell wall binding and bud scar recruitment of Pir1p. Eukaryot Cell. 2005;4:1872-81 pubmed
    ..This is the first report that bud scars contain proteins like Pir1p as internal components. ..
  90. Mutoh N, Kawabata M, Hayashi Y. Tetramethylthiuram disulfide or dimethyldithiocarbamate induces the synthesis of cadystins, heavy metal chelating peptides, in Schizosaccharomyces pombe. Biochem Biophys Res Commun. 1991;176:1068-73 pubmed the fission yeast Schizosaccharomyces pombe. Amount of cadystins synthesized in TMTD or DMDTC treated cells is less than that synthesized in CdCl2 treated cells but much more than that synthesized in ZnCl2 or CuSO4 treated cells...
  91. Hirano T, Hiraoka Y, Yanagida M. A temperature-sensitive mutation of the Schizosaccharomyces pombe gene nuc2+ that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase. J Cell Biol. 1988;106:1171-83 pubmed
    ..In nuc2 mutant cells, however, soluble p76, perhaps an unprocessed precursor, accumulates in addition to insoluble p67. The role of nuc2+ gene may be to interconnect nuclear and cytoskeletal functions in chromosome separation. ..
  92. Sugimoto K, Matsumoto K, Kornberg R, Reed S, Wittenberg C. Dosage suppressors of the dominant G1 cyclin mutant CLN3-2: identification of a yeast gene encoding a putative RNA/ssDNA binding protein. Mol Gen Genet. 1995;248:712-8 pubmed
    ..HMD1 has at least one essential role independent of its effect on CLN3 since HMD1 remains essential for viability in the absence of a functional CLN3 gene. ..