Experts and Doctors on fungal genes in Japan

Summary

Locale: Japan
Topic: fungal genes

Top Publications

  1. Samejima I, Yanagida M. Identification of cut8+ and cek1+, a novel protein kinase gene, which complement a fission yeast mutation that blocks anaphase. Mol Cell Biol. 1994;14:6361-71 pubmed
    ..The cek1+ gene is not an essential gene. Protein phosphorylation by cek1 may facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein. ..
  2. Katayama S, Adachi N, Takao K, Nakagawa T, Matsuda H, Kawamukai M. Molecular cloning and sequencing of the hcs gene, which encodes 3-hydroxy-3-methylglutaryl coenzyme A synthase of Schizosaccharomyces pombe. Yeast. 1995;11:1533-7 pubmed
    ..However the hcs-defective mutant could be grown on a medium containing 5 mg/ml mevalonate. These results strongly support that the hcs gene encodes HMG-CoA synthase and S. pombe contains a single copy of the hcs gene. ..
  3. Yamashita A, Watanabe Y, Yamamoto M. Microtubule-associated coiled-coil protein Ssm4 is involved in the meiotic development in fission yeast. Genes Cells. 1997;2:155-66 pubmed
    ..Ssm4 is a microtubule-colocalizing protein that plays a role specifically in meiosis. Ssm4 appears to modify the structure or the function of nuclear microtubules in order to promote the meiotic nuclear division. ..
  4. Nagata A, Igarashi M, Jinno S, Suto K, Okayama H. An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. New Biol. 1991;3:959-68 pubmed
    ..Thus, at least two homologs of the cdc25 gene exist and are both expressed in human cells. The implications of CDC25Hu2 overexpression in some cancer cells are discussed. ..
  5. Kakinuma Y, Maruyama T, Nozaki T, Wada Y, Ohsumi Y, Igarashi K. Cloning of the gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1995;216:985-92 pubmed
    ..The results suggest that spermine uptake by this organism is probably regulated by phosphorylation and dephosphorylation. ..
  6. Aiba H, Yamada H, Ohmiya R, Mizuno T. The osmo-inducible gpd1+ gene is a target of the signaling pathway involving Wis1 MAP-kinase kinase in fission yeast. FEBS Lett. 1995;376:199-201 pubmed
  7. Tachikawa H, Takeuchi Y, Funahashi W, Miura T, Gao X, Fujimoto D, et al. Isolation and characterization of a yeast gene, MPD1, the overexpression of which suppresses inviability caused by protein disulfide isomerase depletion. FEBS Lett. 1995;369:212-6 pubmed
    ..MPD1 was not essential for growth, but overexpression of the gene suppressed the maturation defect of carboxypeptidase Y caused by PDI1 deletion, indicative of the related function to PDI in the yeast ER. ..
  8. Sato K, Nishikawa S, Nakano A. Membrane protein retrieval from the Golgi apparatus to the endoplasmic reticulum (ER): characterization of the RER1 gene product as a component involved in ER localization of Sec12p. Mol Biol Cell. 1995;6:1459-77 pubmed
    ..From these results, we suggest that Rer1p functions in the Golgi membrane to return Sec12p that has escaped from the static retention system of the ER. ..
  9. Saitoh S, Takahashi K, Nabeshima K, Yamashita Y, Nakaseko Y, Hirata A, et al. Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase. J Cell Biol. 1996;134:949-61 pubmed
    ..A reduced level of fatty acid thus led to impaired separation of non-chromosomal nuclear components. We propose that fatty acid is directly or indirectly required for separating the mother nucleus into two equal daughters. ..

More Information

Publications109 found, 100 shown here

  1. Yamada Okabe T, Mio T, Kashima Y, Matsui M, Arisawa M, Yamada Okabe H. The Candida albicans gene for mRNA 5-cap methyltransferase: identification of additional residues essential for catalysis. Microbiology. 1999;145 ( Pt 11):3023-33 pubmed
  2. Nakai M, Kato Y, Ikeda E, Toh e A, Endo T. Yge1p, a eukaryotic Grp-E homolog, is localized in the mitochondrial matrix and interacts with mitochondrial Hsp70. Biochem Biophys Res Commun. 1994;200:435-42 pubmed
    ..We propose that Yge1p functions in cooperation with Ssc1p in a similar manner as bacterial GrpE with DnaK. ..
  3. Yashiroda H, Oguchi T, Yasuda Y, Toh e A, Kikuchi Y. Bul1, a new protein that binds to the Rsp5 ubiquitin ligase in Saccharomyces cerevisiae. Mol Cell Biol. 1996;16:3255-63 pubmed
    ..We discuss the possibility that Bul1 functions together with Rsp5 in protein ubiquitination. ..
  4. Mizuno T, Nakazawa N, Remgsamrarn P, Kunoh T, Oshima Y, Harashima S. The Tup1-Ssn6 general repressor is involved in repression of IME1 encoding a transcriptional activator of meiosis in Saccharomyces cerevisiae. Curr Genet. 1998;33:239-47 pubmed
    ..These findings indicate that IME1 is negatively regulated by the Tup1-Ssn6 repressor complex through two distinct upstream regions in conjunction with unidentified DNA-binding proteins. ..
  5. Moriya H, Isono K. Analysis of genetic interactions between DHH1, SSD1 and ELM1 indicates their involvement in cellular morphology determination in Saccharomyces cerevisiae. Yeast. 1999;15:481-96 pubmed
    ..A triple mutant, delta dhh1 ssd1-d delta elm1, apparently had very fragile cell walls and could grow only in a medium supplemented with 1 M sorbitol. ..
  6. Kawasaki M, Anzawa K, Tanabe H, Mochizuki T, Ishizaki H, Nishimura K. Intra-species variation of genotypes of Exophiala jeanselmei isolated from patients in Japan. Nihon Ishinkin Gakkai Zasshi. 2005;46:261-5 pubmed
    ..jeanselmei and Type 8 was identified as E. jeanselmei var. lecanii-corni based on the genotypes of type strains of these species. However, two other types were still designated as E. jeanselmei Type 6 and E. jeanselmei Type 10. ..
  7. Bun Ya M, Nishimura M, Harashima S, Oshima Y. The PHO84 gene of Saccharomyces cerevisiae encodes an inorganic phosphate transporter. Mol Cell Biol. 1991;11:3229-38 pubmed
    ..Gene disruption of PHO84 was not lethal. By comparison of nucleotide sequences and by tetrad analysis with GAL80 as a standard, the PHO84 locus was mapped at a site beside the TUB3 locus on the left arm of chromosome XIII. ..
  8. Lund P, Hasegawa Y, Kitamura K, Shimoda C, Fukui Y, Yamamoto M. Mapping of the ras1 gene of Schizosaccharomyces pombe. Mol Gen Genet. 1987;209:627-9 pubmed
    ..Furthermore, we have shown that ras1 is allelic with ste5, one of the sterility genes described by O. Girgsdies. The map position previously reported for ste5 eventually turned out to be false. ..
  9. Nakashima N, Tanaka K, Sturm S, Okayama H. Fission yeast Rep2 is a putative transcriptional activator subunit for the cell cycle 'start' function of Res2-Cdc10. EMBO J. 1995;14:4794-802 pubmed
    ..Our data suggest that Rep2 is a transcriptional activator subunit which interacts with the MCB binding subunit complex formed by Res2 and Cdc10. ..
  10. Sakai Y, Murdanoto A, Konishi T, Iwamatsu A, Kato N. Regulation of the formate dehydrogenase gene, FDH1, in the methylotrophic yeast Candida boidinii and growth characteristics of an FDH1-disrupted strain on methanol, methylamine, and choline. J Bacteriol. 1997;179:4480-5 pubmed
  11. Watanabe M, Sumida N, Murakami S, Anzai H, Thompson C, Tateno Y, et al. A phosphonate-induced gene which promotes Penicillium-mediated bioconversion of cis-propenylphosphonic acid to fosfomycin. Appl Environ Microbiol. 1999;65:1036-44 pubmed
    ..In P. decumbens, expression of the bar reporter gene was induced by cPA, FOM, and phosphorous acid but not by phosphoric acid. ..
  12. Nakamichi N, Yamamoto E, Yamada H, Aiba H, Mizuno T. Identification and characterization of a novel gene, hos2+, the function of which is necessary for growth under high osmotic stress in fission yeast. Biosci Biotechnol Biochem. 2000;64:2493-6 pubmed
    ..For this hos2delta mutant, three multicopy suppressor genes were isolated and one of which was identified as the pgk1+ gene, encoding a phosphoglycerate kinase. ..
  13. Mochizuki N, Yamamoto M. Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast. Mol Gen Genet. 1992;233:17-24 pubmed
    ..Disruption of pde1 made S. pombe cells partially sterile and meiosis-deficient, indicating that this cAMP phosphodiesterase plays an important role in balancing the cAMP level in vivo. ..
  14. Hashimoto H, Yoda K. Novel membrane protein complexes for protein glycosylation in the yeast Golgi apparatus. Biochem Biophys Res Commun. 1997;241:682-6 pubmed
    ..These complexes with similar but partially different constituents may represent essential parts of glycosylation machinery in the yeast Golgi compartments. ..
  15. Ogura Y, Yoshida Y, Ichimura K, Aoyagi C, Yabe N, Hasunuma K. Isolation and characterization of Neurospora crassa nucleoside diphosphate kinase NDK-1. Eur J Biochem. 1999;266:709-14 pubmed
    ..NDK-1 also showed rapid autophosphorylation activity and protein kinase activity against myelin basic protein with a Km value of 0.36 mM. These results suggest that NDK-1 acts as a signal transducer by phosphorylating proteins. ..
  16. Namiki F, Matsunaga M, Okuda M, Inoue I, Nishi K, Fujita Y, et al. Mutation of an arginine biosynthesis gene causes reduced pathogenicity in Fusarium oxysporum f. sp. melonis. Mol Plant Microbe Interact. 2001;14:580-4 pubmed
    ..Complementation of FMMP95-1 with the ARG1 gene caused a recovery in pathogenicity, indicating that arginine auxotrophic mutation causes reduced pathogenicity in this pathogen. ..
  17. Kimura A, Umehara T, Horikoshi M. Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nat Genet. 2002;32:370-7 pubmed
    ..Thus, the Sas2p and Sir2p function in concert to regulate transcription in yeast, by acetylating and deacetylating H4-Lys16 in a mechanism that may be common to all eukaryotes. ..
  18. Nakazawa T, Tatsuta Y, Fujita T, Nakahori K, Kamada T. Mutations in the Cc.rmt1 gene encoding a putative protein arginine methyltransferase alter developmental programs in the basidiomycete Coprinopsis cinerea. Curr Genet. 2010;56:361-7 pubmed publisher
    ..Cc.rmt1 is predicted to encode a putative protein arginine methyltransferase, some homologs of which have been shown to be involved in the regulation of gene expression in eukaryotes. ..
  19. Wada Y, Kitamoto K, Kanbe T, Tanaka K, Anraku Y. The SLP1 gene of Saccharomyces cerevisiae is essential for vacuolar morphogenesis and function. Mol Cell Biol. 1990;10:2214-23 pubmed
  20. Irie K, Yamaguchi K, Kawase K, Matsumoto K. The yeast MOT2 gene encodes a putative zinc finger protein that serves as a global negative regulator affecting expression of several categories of genes, including mating-pheromone-responsive genes. Mol Cell Biol. 1994;14:3150-7 pubmed
    ..These observations suggest that Mot2 functions as a general negative regulator of transcription in the same processes as Cdc36 and Cdc39. ..
  21. Nakayama K, Feng Y, Tanaka A, Jigami Y. The involvement of mnn4 and mnn6 mutations in mannosylphosphorylation of O-linked oligosaccharide in yeast Saccharomyces cerevisiae. Biochim Biophys Acta. 1998;1425:255-62 pubmed
    ..The amount of mannosylphosphorylated mannotriose was 7% of total O-linked oligosaccharides (20% of neutral mannotriose) of chitinase in strain mnn1. ..
  22. Shiratori A, Shibata T, Arisawa M, Hanaoka F, Murakami Y, Eki T. Systematic identification, classification, and characterization of the open reading frames which encode novel helicase-related proteins in Saccharomyces cerevisiae by gene disruption and Northern analysis. Yeast. 1999;15:219-53 pubmed
    ..This suggests that helicase-like genes may be involved in the biosynthesis of nucleic acids and proteins, and that the genes can be transcriptionally activated by heat shock to compensate for the repressed synthesis of mRNA and protein. ..
  23. Takeuchi J, Toh e A. Genetic evidence for interaction between components of the yeast 26S proteasome: combination of a mutation in RPN12 (a lid component gene) with mutations in RPT1 (an ATPase gene) causes synthetic lethality. Mol Gen Genet. 1999;262:145-53 pubmed
  24. Roy S, Chiba Y, Takeuchi M, Jigami Y. Characterization of Yeast Yea4p, a uridine diphosphate-N-acetylglucosamine transporter localized in the endoplasmic reticulum and required for chitin synthesis. J Biol Chem. 2000;275:13580-7 pubmed
    ..Our results indicate that YEA4 encodes an ER-localized UDP-GlcNAc transporter that is required for cell wall chitin synthesis in S. cerevisiae. ..
  25. Yoshida S, Anraku Y. Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity. Mol Gen Genet. 2000;263:877-88 pubmed
  26. Aono N, Sutani T, Tomonaga T, Mochida S, Yanagida M. Cnd2 has dual roles in mitotic condensation and interphase. Nature. 2002;417:197-202 pubmed
    ..These interphase and mitotic defects provide insight into the mechanistic role of non-SMC subunits that interact with the globular SMC domains in the heteropentameric holocomplex. ..
  27. Shimanuki M, Goebl M, Yanagida M, Toda T. Fission yeast sts1+ gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation. Mol Biol Cell. 1992;3:263-73 pubmed
    ..Disruption of the sts1+ gene does not lead to a sensitivity to thiabendazole or hydroxyurea. ..
  28. Umemoto N, Yoshihisa T, Hirata R, Anraku Y. Roles of the VMA3 gene product, subunit c of the vacuolar membrane H(+)-ATPase on vacuolar acidification and protein transport. A study with VMA3-disrupted mutants of Saccharomyces cerevisiae. J Biol Chem. 1990;265:18447-53 pubmed
    ..The disruption of the VMA3 gene causes yeast cells with considerable lesions in vacuolar biogenesis and protein transport to the vacuole and inhibits endocytosis of lucifer yellow CH completely. ..
  29. Maeda T, Mochizuki N, Yamamoto M. Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1990;87:7814-8 pubmed
    ..pombe. We suggest that fission yeast controls the level of intracellular cAMP primarily to regulate sexual development rather than to drive or arrest the cell cycle. ..
  30. Utatsu I, Sakamoto S, Imura T, Toh e A. Yeast plasmids resembling 2 micron DNA: regional similarities and diversities at the molecular level. J Bacteriol. 1987;169:5537-45 pubmed
  31. Hagan I, Yanagida M. The product of the spindle formation gene sad1+ associates with the fission yeast spindle pole body and is essential for viability. J Cell Biol. 1995;129:1033-47 pubmed
    ..Sad1 may play a role in SPB structure, such as maintaining a functional interface with the nuclear membrane or in providing an anchor for the attachment of microtubule motor proteins. ..
  32. Sugimoto K, Matsumoto K, Kornberg R, Reed S, Wittenberg C. Dosage suppressors of the dominant G1 cyclin mutant CLN3-2: identification of a yeast gene encoding a putative RNA/ssDNA binding protein. Mol Gen Genet. 1995;248:712-8 pubmed
    ..HMD1 has at least one essential role independent of its effect on CLN3 since HMD1 remains essential for viability in the absence of a functional CLN3 gene. ..
  33. Eki T, Okumura K, Shiratori A, Abe M, Nogami M, Taguchi H, et al. Assignment of the closest human homologue (DNA2L:KIAA0083) of the yeast Dna2 helicase gene to chromosome band 10q21.3-q22.1. Genomics. 1996;37:408-10 pubmed
  34. Tachikawa H, Funahashi W, Takeuchi Y, Nakanishi H, Nishihara R, Katoh S, et al. Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Biochem Biophys Res Commun. 1997;239:710-4 pubmed
    ..Mutagenesis analysis revealed that Mpd2p can compensate for the loss of PDI with its CXXC sequence. ..
  35. Yabe K, Nakajima H. Enzyme reactions and genes in aflatoxin biosynthesis. Appl Microbiol Biotechnol. 2004;64:745-55 pubmed
    ..This review will summarize the enzymatic steps and the genes in aflatoxin/sterigmatocystin biosynthesis. ..
  36. Harimoto Y, Hatta R, Kodama M, Yamamoto M, Otani H, Tsuge T. Expression profiles of genes encoded by the supernumerary chromosome controlling AM-toxin biosynthesis and pathogenicity in the apple pathotype of Alternaria alternata. Mol Plant Microbe Interact. 2007;20:1463-76 pubmed
    ..Thus, the genes upregulated in AM-toxin-producing cultures contain ideal candidates for novel AM-toxin biosynthetic genes. ..
  37. Tanaka K, Davey J, Imai Y, Yamamoto M. Schizosaccharomyces pombe map3+ encodes the putative M-factor receptor. Mol Cell Biol. 1993;13:80-8 pubmed
    ..Furthermore, this study provides strong support for the notion that pheromone signaling is essential for initiation of meiosis in S. pombe and that either M-factor signaling or P-factor signaling alone is sufficient. ..
  38. Wang X, Nakayama K, Shimma Y, Tanaka A, Jigami Y. MNN6, a member of the KRE2/MNT1 family, is the gene for mannosylphosphate transfer in Saccharomyces cerevisiae. J Biol Chem. 1997;272:18117-24 pubmed
  39. Matsui Y, Toh e A. Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1. Mol Cell Biol. 1992;12:5690-9 pubmed
  40. Ohkura H, Yanagida M. S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1. Cell. 1991;64:149-57 pubmed
    ..We propose that the sds22+ protein forms a repeating helical rod that is capable of enhancing a PP1-dependent dephosphorylation activity that is essential in midmitosis. ..
  41. Kasai H, Isono K. Dual modes of transcriptional and translational initiation of SSP1, the gene for a mitochondrial HSP70, responding to heat-shock in Schizosaccharomyces pombe. Nucleic Acids Res. 1991;19:5331-7 pubmed
    ..A possible mechanism is proposed for the response of the SSP1 gene towards heat-shock by the differential initiation of its transcription and translation. ..
  42. Hughes D, Fukui Y, Yamamoto M. Homologous activators of ras in fission and budding yeast. Nature. 1990;344:355-7 pubmed
    ..Homologues of ste6 and CDC25 could regulate ras activity in other eukaryotic cells...
  43. Fujioka H, Shimoda C. A mating-type-specific sterility gene map1 is required for transcription of a mating-type gene mat1-Pi in the fission yeast Schizosaccharomyces pombe. FEMS Microbiol Lett. 1989;51:45-8 pubmed
    ..Transcription of mat1-Pi was totally absent in the map1 mutant. The mei2 gene encoding a positive regulator for meiosis was normally transcribed in the map1 mutant, suggesting that the map1 function was specific to mat1-Pi. ..
  44. Fukui Y, Yamamoto M. Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1-. Mol Gen Genet. 1988;215:26-31 pubmed
    ..The ral3 gene may influence this pathway. Analysis of these gene products will aid identification of factors which interact with Ras proteins. ..
  45. Hirata D, Yano K, Miyakawa T. Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae. Mol Gen Genet. 1994;242:250-6 pubmed
    ..A high-copy-number plasmid bearing YAP2 mediated cadmium-induced transcriptional activation of this promoter. The inductions were prevented by the antioxidant N-acetyl-L-cysteine. ..
  46. Yoshida S, Ohya Y, Nakano A, Anraku Y. Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiae. Mol Gen Genet. 1994;242:631-40 pubmed
    ..Based on genetic and biochemical data, we suggest that MSS4 acts downstream of STT4, but in a pathway that does not involve PKC1. ..
  47. Hisamoto N, Sugimoto K, Matsumoto K. The Glc7 type 1 protein phosphatase of Saccharomyces cerevisiae is required for cell cycle progression in G2/M. Mol Cell Biol. 1994;14:3158-65 pubmed
    ..These findings suggest that the glc7Y-170 mutation is defective in the G2/M phase of the cell cycle. Thus, type 1 protein phosphatase in Saccharomyces cerevisiae is essential for the G2/M transition. ..
  48. Fujimura K, Tanaka K, Toh e A. A dominant interfering mutation in RAS1 of Saccharomyces cerevisiae. Mol Gen Genet. 1993;241:280-6 pubmed
    ..These results suggest that the RAS1Ser22 gene product interferes with the normal interaction of Ras with Cdc25 by forming a dead-end complex between Ras1Ser22 and Cdc25 proteins. ..
  49. Aso T, Conrad M. Molecular cloning of DNAs encoding the regulatory subunits of elongin from Saccharomyces cerevisiae and Drosophila melanogaster. Biochem Biophys Res Commun. 1997;241:334-40 pubmed
    ..The expression of yeast Elongin C mRNA is dramatically upregulated during sporulation; however, the gene is not essential for sporulation and viability in yeast cell. ..
  50. Inoue Y, Sugiyama K, Izawa S, Kimura A. Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiae. Biochim Biophys Acta. 1998;1395:315-20 pubmed
    ..The GSH2 gene was not essential for growth of yeast cell, and glutathione was not detected from the gsh2 disrupter. ..
  51. Kobayashi A, Miyake T, Ohyama Y, Kawaichi M, Kokubo T. Mutations in the TATA-binding protein, affecting transcriptional activation, show synthetic lethality with the TAF145 gene lacking the TAF N-terminal domain in Saccharomyces cerevisiae. J Biol Chem. 2001;276:395-405 pubmed
  52. Liu W, Wang J, Mitsui K, Shen H, Tsurugi K. Interaction of the GTS1 gene product with glyceraldehyde- 3-phosphate dehydrogenase 1 required for the maintenance of the metabolic oscillations of the yeast Saccharomyces cerevisiae. Eur J Biochem. 2002;269:3560-9 pubmed
    ..Thus, we hypothesized that Gts1p plays a role in the regulation of metabolic oscillation by interacting with the TDH1 product, GAPDH1, in yeast. ..
  53. Iwahashi H, Kitagawa E, Suzuki Y, Ueda Y, Ishizawa Y, Nobumasa H, et al. Evaluation of toxicity of the mycotoxin citrinin using yeast ORF DNA microarray and Oligo DNA microarray. BMC Genomics. 2007;8:95 pubmed
    ..The reproducibility of the expression profiles was much better with the Oligo DNA microarray. However, the Oligo DNA microarray did not completely overcome cross hybridization. ..
  54. Toda T, Shimanuki M, Saka Y, Yamano H, Adachi Y, Shirakawa M, et al. Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1. Mol Cell Biol. 1992;12:5474-84 pubmed
    ..These results suggest the functional importance of chromosome structure on the regulation of gene expression through the pap1 transcription factor. ..
  55. Toda T, Shimanuki M, Yanagida M. Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Genes Dev. 1991;5:60-73 pubmed
    ..The pap1+ gene is required for spk1(+)-conferred staurosporine resistance. These two genes appear to function as a part of the fission yeast growth control pathway. ..
  56. Nakafuku M, Obara T, Kaibuchi K, Miyajima I, Miyajima A, Itoh H, et al. Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A. 1988;85:1374-8 pubmed
    ..These results suggest that GPA2 may be involved in the regulation of cAMP levels in S. cerevisiae. ..
  57. Utsugi T, Toh e A, Kikuchi Y. A high dose of the STM1 gene suppresses the temperature sensitivity of the tom1 and htr1 mutants in Saccharomyces cerevisiae. Biochim Biophys Acta. 1995;1263:285-8 pubmed
    ..The predicted gene product (29,999 Da) is basic and partially homologous to various histone H1. The level of the gene expression increased 2-fold when exposed to mating pheromone. ..
  58. Samejima I, Yanagida M. Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase. J Cell Biol. 1994;127:1655-70 pubmed
    ..The nuc2+ and cut9+ genes share an essential function to initiate anaphase. The cold-sensitive scn1 and scn2 mutations, defective in late anaphase, can suppress the ts phenotype of cut9. ..
  59. Shobuike T, Sugano S, Yamashita T, Ikeda H. Characterization of cDNA encoding mouse homolog of fission yeast dhp1+ gene: structural and functional conservation. Nucleic Acids Res. 1995;23:357-61 pubmed
    ..The Dhm1 gene on a multicopy plasmid rescued the temperature-sensitivity of dhp1ts and lethality of dhp1 null mutation, suggesting that Dhm1 is a mouse homolog of S.pombe dhp1+ and functions similarly in mouse as dhp1+. ..
  60. Maeda T, Watanabe Y, Kunitomo H, Yamamoto M. Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe. J Biol Chem. 1994;269:9632-7 pubmed
    ..pombe has only one gene encoding it. This situation contrasts with the case of S. cerevisiae, in which three genes encode the catalytic subunits. ..
  61. Ajimura M, Leem S, Ogawa H. Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics. 1993;133:51-66 pubmed
    ..Among six alleles of HOP1 that were isolated, an unusual pattern of intragenic complementation was observed. ..
  62. Yabana N, Yamamoto M. Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression. Mol Cell Biol. 1996;16:3420-8 pubmed
    ..On the basis of these observations, we speculate that Map1 may be a transcriptional regulator of cell-type-specific genes similar to S. cerevisiae MCM1, whose activity is modulated by the oil and alpha2 mating-type gene products. ..
  63. Yompakdee C, Ogawa N, Harashima S, Oshima Y. A putative membrane protein, Pho88p, involved in inorganic phosphate transport in Saccharomyces cerevisiae. Mol Gen Genet. 1996;251:580-90 pubmed
    ..Both disruption and high dosage of PHO88 or PHO86 resulted in reduced Pi uptake. These findings suggest that Pho88p is also involved in Pi transport and modulates Pho81p function together with Pho86p. ..
  64. Nozaki T, Nishimura K, Michael A, Maruyama T, Kakinuma Y, Igarashi K. A second gene encoding a putative serine/threonine protein kinase which enhances spermine uptake in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1996;228:452-8 pubmed
    ..The results indicate that polyamine transport of yeast is regulated by multiple phosphorylation/dephosphorylation pathways. ..
  65. Saitoh S, Takahashi K, Yanagida M. Mis6, a fission yeast inner centromere protein, acts during G1/S and forms specialized chromatin required for equal segregation. Cell. 1997;90:131-43 pubmed
    ..The ability to establish correct biorientation of sister centromeres in metaphase cells requires the Mis6-containing chromatin and originates during the passage of G1/S. ..
  66. Tatebayashi K, Kato J, Ikeda H. Isolation of a Schizosaccharomyces pombe rad21ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: possible involvement of Rad21 in ubiquitin-mediated proteolysis. Genetics. 1998;148:49-57 pubmed
    ..The results suggest that these diverse functions of Rad21 may be facilitated through ubiquitin-mediated proteolysis. ..
  67. Miyazaki Y, Nakamura M, Babasaki K. Molecular cloning of developmentally specific genes by representational difference analysis during the fruiting body formation in the basidiomycete Lentinula edodes. Fungal Genet Biol. 2005;42:493-505 pubmed
    ..edodes. ..
  68. Miyazaki Y, Sunagawa M, Higashibata A, Ishioka N, Babasaki K, Yamazaki T. Differentially expressed genes under simulated microgravity in fruiting bodies of the fungus Pleurotus ostreatus. FEMS Microbiol Lett. 2010;307:72-9 pubmed publisher
    ..Our results suggest that the differentially expressed genes responding to gravitational change are involved in several potential cellular mechanisms during fruiting body formation of P. ostreatus. ..
  69. Tanaka K, Okazaki K, Okazaki N, Ueda T, Sugiyama A, Nojima H, et al. A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products. EMBO J. 1992;11:4923-32 pubmed
  70. Izumiya H, Yamamoto M. Cloning and functional analysis of the ndk1 gene encoding nucleoside-diphosphate kinase in Schizosaccharomyces pombe. J Biol Chem. 1995;270:27859-64 pubmed
    ..pombe NDK may also perform such a role in regulation of sexual development in the fission yeast. ..
  71. Ogawa N, Noguchi K, Sawai H, Yamashita Y, Yompakdee C, Oshima Y. Functional domains of Pho81p, an inhibitor of Pho85p protein kinase, in the transduction pathway of Pi signals in Saccharomyces cerevisiae. Mol Cell Biol. 1995;15:997-1004 pubmed
    ..An in vitro assay showed that a glutathione S-transferase-Pho81p fusion protein inhibits the Pho85p protein kinase. Association of Pho81p with Pho85p or with the Pho80p-Pho85p complex was demonstrated by the two-hybrid system. ..
  72. Shirayama M, Matsui Y, Tanaka K, Toh e A. Isolation of a CDC25 family gene, MSI2/LTE1, as a multicopy suppressor of ira1. Yeast. 1994;10:451-61 pubmed
    ..These results suggest that MSI2 is involved in the termination of M phase and that this process is regulated by a ras superfamily gene product. ..
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