Experts and Doctors on flavins in France
Valton J, Fontecave M, Douki T, Kendrew S, Niviere V. An aromatic hydroxylation reaction catalyzed by a two-component FMN-dependent Monooxygenase. The ActVA-ActVB system from Streptomyces coelicolor. J Biol Chem. 2006;281:27-35 pubmed
..The previously postulated product of the ActVA-ActVB system, the antibiotic actinorhodin, was not found to be formed during the oxidation reaction. ..
Picaud T, Desbois A. Interaction of glutathione reductase with heavy metal: the binding of Hg(II) or Cd(II) to the reduced enzyme affects both the redox dithiol pair and the flavin. Biochemistry. 2006;45:15829-37 pubmed
..The bound metal ion then acts on the bending of the isoalloxazine ring of FAD as well as on the hydrophobicity of its microenvironment. ..
Zeghouf M, Fontecave M, Macherel D, Coves J. The flavoprotein component of the Escherichia coli sulfite reductase: expression, purification, and spectral and catalytic properties of a monomeric form containing both the flavin adenine dinucleotide and the flavin mononucleotide cofactors. Biochemistry. 1998;37:6114-23 pubmed
..Despite the conservation of the bi-flavin-domain structure between these proteins over evolutionary time, each of them provides significantly different flavin reactivities. ..
Lattard V, Longin Sauvageon C, Lachuer J, Delatour P, Benoit E. Cloning, sequencing, and tissue-dependent expression of flavin-containing monooxygenase (FMO) 1 and FMO3 in the dog. Drug Metab Dispos. 2002;30:119-28 pubmed
..By Northern blotting, the probe for FMO1 specifically hybridized a 2.6-kilobase (kb) transcript in liver and lung samples only. The probe for FMO3 hybridized two transcripts of approximately 3 and 4.2 kb in the liver and lung samples. ..
Leduc D, Escartin F, Nijhout H, Reed M, Liebl U, Skouloubris S, et al
. Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria. J Bacteriol. 2007;189:8537-45 pubmed
..In addition, our observations suggest that the presence of flavin-dependent thymidylate synthase X provides growth benefits under conditions in which the level of reduced folate derivatives is compromised. ..
Boubacar A, Pethe S, Mahy J, Lederer F. Flavocytochrome b2: reactivity of its flavin with molecular oxygen. Biochemistry. 2007;46:13080-8 pubmed
..An inspection of the available structures of family members does not provide a rationale for the difference between the oxidases and the electron transferases. ..
Balland V, Byrdin M, Eker A, Ahmad M, Brettel K. What makes the difference between a cryptochrome and DNA photolyase? A spectroelectrochemical comparison of the flavin redox transitions. J Am Chem Soc. 2009;131:426-7 pubmed publisher
..Functional and evolutionary implications are discussed, highlighting the role of an asparagine-to-aspartate replacement close to N5 of the flavin. ..
Lombard M, Hamdane D. Flavin-dependent epitranscriptomic world. Arch Biochem Biophys. 2017;632:28-40 pubmed publisher
..In this review, we summarize recent knowledges on the flavin-dependent RNA-modifying enzymes and discuss the relevance of their activity within a cellular context. ..