Genomes and Genes
Experts and Doctors on fatty acids in Sweden
Topic: fatty acids
- Andersson M, Larsson K, Tjellström H, Liljenberg C, Sandelius A. Phosphate-limited oat. The plasma membrane and the tonoplast as major targets for phospholipid-to-glycolipid replacement and stimulation of phospholipases in the plasma membrane. J Biol Chem. 2005;280:27578-86 pubmed
- Wolk A, Furuheim M, Vessby B. Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men. J Nutr. 2001;131:828-33 pubmed..When adipose tissue is not available, 15:0 content in serum cholesterol esters or phospholipids might be used. Intake data based on repeated 24-h recalls are equally informative and may be an equivalent choice in nutritional studies. ..
- Comasco E, Nordquist N, Leppert J, Oreland L, Kronstrand R, Alling C, et al. Adolescent alcohol consumption: biomarkers PEth and FAEE in relation to interview and questionnaire data. J Stud Alcohol Drugs. 2009;70:797-804 pubmed..The absence of overlap between PEth and FAEE results and their poor agreement with self-reports suggested that biomarkers are unsuitable as screening tools for alcohol consumption in adolescents. ..
- Leonova S, Shelenga T, Hamberg M, Konarev A, Loskutov I, Carlsson A. Analysis of oil composition in cultivars and wild species of oat (Avena sp.). J Agric Food Chem. 2008;56:7983-91 pubmed publisher..Consequently, developing oat cultivars with highly unsaturated oils will need involvement of other techniques such as biotechnology. ..
- Vessby B, Ahren B, Warensjo E, Lindgarde F. Plasma lipid fatty acid composition, desaturase activities and insulin sensitivity in Amerindian women. Nutr Metab Cardiovasc Dis. 2012;22:176-81 pubmed publisher..The high SCD-1 activity in the Shuar women may reflect increased lipogenesis in adipose tissue. It also illustrates how a low fat diet rich in non-refined carbohydrates can be linked to a good metabolic situation. ..
- Eriksson S, Mellstrom D, Strandvik B. Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. Br J Nutr. 2009;102:407-12 pubmed publisher..Longitudinal studies are necessary to verify if different bone compartments and different grades of modelling are related to different FA patterns. ..
- Garscha U, Jernerén F, Chung D, Keller N, Hamberg M, Oliw E. Identification of dioxygenases required for Aspergillus development. Studies of products, stereochemistry, and the reaction mechanism. J Biol Chem. 2007;282:34707-18 pubmed..Identification of these oxygenases and their products will provide tools for analyzing the biological impact of oxylipin biosynthesis in Aspergilli. ..
- Jernerén F, Hoffmann I, Oliw E. Linoleate 9R-dioxygenase and allene oxide synthase activities of Aspergillus terreus. Arch Biochem Biophys. 2010;495:67-73 pubmed publisher..Our results demonstrate that linoleate 9R-dioxygenase linked to allene oxide synthase activities can be expressed in fungi. ..
- de Jong B, Siewers V, Nielsen J. Physiological and transcriptional characterization of Saccharomyces cerevisiae engineered for production of fatty acid ethyl esters. FEMS Yeast Res. 2016;16:fov105 pubmed publisher..In conclusion, our analysis clearly shows that engineering of fatty acid biosynthesis results in transcriptional reprogramming and has a significant effect on overall cellular metabolism. ..
- Ringbom T, Huss U, Stenholm A, Flock S, Skattebøl L, Perera P, et al. Cox-2 inhibitory effects of naturally occurring and modified fatty acids. J Nat Prod. 2001;64:745-9 pubmed
- Gleissman H, Yang R, Martinod K, Lindskog M, Serhan C, Johnsen J, et al. Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates. FASEB J. 2010;24:906-15 pubmed publisher..Gleissman, H., Yang, R., Martinod, K., Lindskog, M., Serhan, C. N., Johnsen, J. I., Kogner, P. Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates. ..
- Hammer E, Nasr H, Pallon J, Olsson P, Wallander H. Elemental composition of arbuscular mycorrhizal fungi at high salinity. Mycorrhiza. 2011;21:117-29 pubmed publisher..This could make them important in the alleviation of salinity stress in their plant hosts. ..
- Shi S, Ji H, Siewers V, Nielsen J. Improved production of fatty acids by Saccharomyces cerevisiae through screening a cDNA library from the oleaginous yeast Yarrowia lipolytica. FEMS Yeast Res. 2016;16:fov108 pubmed publisher..Our findings not only provide a novel method for high-throughput evaluation of the content of free FAs, but also give new insight into how enzymes from Y. lipolytica may increase the production of fatty acids in S. cerevisiae. ..
- Khoomrung S, Chumnanpuen P, Jansa ard S, Nookaew I, Nielsen J. Fast and accurate preparation fatty acid methyl esters by microwave-assisted derivatization in the yeast Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2012;94:1637-46 pubmed publisher..The new microwave-assisted derivatization method facilitates the preparation of FAMEs directly from yeast cells, but the method is likely to also be applicable for other biological samples. ..
- van Aarle I, Olsson P. Fungal lipid accumulation and development of mycelial structures by two arbuscular mycorrhizal fungi. Appl Environ Microbiol. 2003;69:6762-7 pubmed..We propose that the ratio of neutral lipids to phospholipids is more important than is the presence of vesicles in determining the storage status of AM fungi. ..
- Sahlin K, Mogensen M, Bagger M, Fernstrom M, Pedersen P. The potential for mitochondrial fat oxidation in human skeletal muscle influences whole body fat oxidation during low-intensity exercise. Am J Physiol Endocrinol Metab. 2007;292:E223-30 pubmed..The higher ADP sensitivity with PC than that with Pyr may influence fuel utilization at low rate of respiration. ..
- Freyschuss A, Al Schurbaji A, Bjorkhem I, Babiker A, Diczfalusy U, Berglund L, et al. On the anti-atherogenic effect of the antioxidant BHT in cholesterol-fed rabbits: inverse relation between serum triglycerides and atheromatous lesions. Biochim Biophys Acta. 2001;1534:129-38 pubmed..In conclusion, our results demonstrate that the degree of triglyceride exposure may be an important modulator of the anti-atherogenic effect of an antioxidant. ..
- Gustavsson C, Yassin K, Wahlström E, Cheung L, Lindberg J, Brismar K, et al. Sex-different hepaticglycogen content and glucose output in rats. BMC Biochem. 2010;11:38 pubmed publisher..Possibly these sex-differences reflect a higher ability for the healthy male rat liver to respond to increased energy demands. ..
- Kussak A, Weintraub A. Quadrupole ion-trap mass spectrometry to locate fatty acids on lipid A from Gram-negative bacteria. Anal Biochem. 2002;307:131-7 pubmed..The fatty acids were otherwise eliminated by a charge-remote fragmentation mechanism. The combined data show the usefulness of ion-trap mass spectrometers for this type of analysis. ..
- Andersson M, Hamberg M, Kourtchenko O, Brunnström A, McPhail K, Gerwick W, et al. Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E. J Biol Chem. 2006;281:31528-37 pubmed..In conclusion, the data presented suggest a role of enzymatically formed oxylipins, especially the octadecanoids and arabidopside E in race-specific resistance against bacterial pathogens. ..
- Korotkova M, Gabrielsson B, Holmang A, Larsson B, Hanson L, Strandvik B. Gender-related long-term effects in adult rats by perinatal dietary ratio of n-6/n-3 fatty acids. Am J Physiol Regul Integr Comp Physiol. 2005;288:R575-9 pubmed..These data suggest that the balance between n-6 and n-3 PUFA during perinatal development affects several metabolic parameters in adulthood, especially in the male animals. ..
- Svensson J, Rosenquist A, Ohlsson L. Postprandial lipid responses to an alpha-linolenic acid-rich oil, olive oil and butter in women: a randomized crossover trial. Lipids Health Dis. 2011;10:106 pubmed publisher..The ALA-rich oil significantly affected different plasma lipid fractions and improved the ratio of n-6 to n-3 fatty acids several hours postprandially. ..
- Olsson B, Bohlooly Y M, Brusehed O, Isaksson O, Ahren B, Olofsson S, et al. Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes. Am J Physiol Endocrinol Metab. 2003;285:E504-11 pubmed
- Druart N, Johansson A, Baba K, Schrader J, Sjodin A, Bhalerao R, et al. Environmental and hormonal regulation of the activity-dormancy cycle in the cambial meristem involves stage-specific modulation of transcriptional and metabolic networks. Plant J. 2007;50:557-73 pubmed..In summary, our data reveal the dynamics of transcriptional and metabolic networks and identify potential targets of environmental and hormonal signals in the regulation of the activity-dormancy cycle in cambial meristem. ..
- Hedberg M, Moore E, Svensson Stadler L, Hörstedt P, Baranov V, Hernell O, et al. Lachnoanaerobaculum gen. nov., a new genus in the Lachnospiraceae: characterization of Lachnoanaerobaculum umeaense gen. nov., sp. nov., isolated from the human small intestine, and Lachnoanaerobaculum orale sp. nov., isolated from saliva, and reclas. Int J Syst Evol Microbiol. 2012;62:2685-90 pubmed publisher..nov. Moreover, Eubacterium saburreum is reclassified as Lachnoanaerobaculum saburreum comb. nov. (type strain CCUG 28089(T) =ATCC 33271(T) =CIP 105341(T) =DSM 3986(T) =JCM 11021(T) =VPI 11763(T))...
- Sandager L, Gustavsson M, Stahl U, Dahlqvist A, Wiberg E, Banas A, et al. Storage lipid synthesis is non-essential in yeast. J Biol Chem. 2002;277:6478-82 pubmed..The strain is devoid of both TAG and steryl esters, and fluorescence microscopy revealed that it also lacks lipid bodies. We conclude that neither storage lipids nor lipid bodies are essential for growth in yeast. ..
- Bååth E, Díaz Raviña M, Bakken L. Microbial biomass, community structure and metal tolerance of a naturally Pb-enriched forest soil. Microb Ecol. 2005;50:496-505 pubmed..Comparison of isolates from Pb-enriched soil and isolates from unpolluted soils showed that T. inflatum was intrinsically Pb-tolerant, and that the prolonged conditions with high Pb had not selected for any increased tolerance. ..
- Lelliott C, Ljungberg A, Ahnmark A, William Olsson L, Ekroos K, Elmgren A, et al. Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation. Arterioscler Thromb Vasc Biol. 2007;27:2707-13 pubmed..Hepatic PGC-1beta overexpression reduced the potentially beneficial effects of PPARalpha activation on gene expression. Thus, inhibition of hepatic PGC-1beta may provide a therapy for treating combined hyperlipidemia. ..
- Tvrdik P, Westerberg R, Silve S, Asadi A, Jakobsson A, Cannon B, et al. Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol. 2000;149:707-18 pubmed..Our results strongly implicate this new mammalian gene family in tissue-specific synthesis of very long chain fatty acids and sphingolipids...
- Westin M, Hunt M, Alexson S. Peroxisomes contain a specific phytanoyl-CoA/pristanoyl-CoA thioesterase acting as a novel auxiliary enzyme in alpha- and beta-oxidation of methyl-branched fatty acids in mouse. J Biol Chem. 2007;282:26707-16 pubmed..Furthermore, Acot6 was identified as a target gene of the peroxisome proliferator-activated receptor alpha (PPARalpha) and is up-regulated in mouse liver in a PPARalpha-dependent manner. ..
- Korotkova M, Gabrielsson B, Lönn M, Hanson L, Strandvik B. Leptin levels in rat offspring are modified by the ratio of linoleic to alpha-linolenic acid in the maternal diet. J Lipid Res. 2002;43:1743-9 pubmed
- Fernandes S, Geueke B, Delgado O, Coleman J, Hatti Kaul R. Beta-galactosidase from a cold-adapted bacterium: purification, characterization and application for lactose hydrolysis. Appl Microbiol Biotechnol. 2002;58:313-21 pubmed..The enzyme could be immobilized to Sepharose via different chemistries with 60-70% retention of activity. The immobilized enzyme was more stable and its ability to hydrolyze lactose was similar to that of the soluble enzyme. ..
- Westerberg R, Tvrdik P, Unden A, Månsson J, Norlen L, Jakobsson A, et al. Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem. 2004;279:5621-9 pubmed..A functional consequence of this is that Elovl3-ablated mice exhibited a severe defect in water repulsion and increased trans-epidermal water loss...
- Andersson L, Carriere F, Lowe M, Nilsson A, Verger R. Pancreatic lipase-related protein 2 but not classical pancreatic lipase hydrolyzes galactolipids. Biochim Biophys Acta. 1996;1302:236-40 pubmed..Also, MGalDG and SQDG were hydrolyzed by GPLRP2 and RPLRP2. These data suggest a possible role of PLRP2 in the digestion of dietary galactolipids. ..
- Eggens I, Elmberger P, Low P. Polyisoprenoid, cholesterol and ubiquinone levels in human hepatocellular carcinomas. Br J Exp Pathol. 1989;70:83-92 pubmed..The high levels of sterols in contrast to the low polyisoprenol content suggests interference with the regulation of the mevalonate pathway, which is the common biosynthetic route for cholesterol, ubiquinone and dolichol...
- Johansson M, Chen X, Milanova S, Santos C, Petranovic D. PUFA-induced cell death is mediated by Yca1p-dependent and -independent pathways, and is reduced by vitamin C in yeast. FEMS Yeast Res. 2016;16:fow007 pubmed publisher..When deleting YCA1, the caspase-like activity and the oxidative stress decreased and although the lifespan was slightly prolonged, the phenotype could not be fully reversed, pointing that Yca1p was not the main executor of cell death. ..
- Devkota R, Svensk E, Ruiz M, Ståhlman M, Boren J, Pilon M. The adiponectin receptor AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 prevent membrane rigidification by exogenous saturated fatty acids. PLoS Genet. 2017;13:e1007004 pubmed publisher..We conclude that the PAQR-2 and AdipoR2 proteins share an evolutionarily conserved function that maintains membrane fluidity in the presence of exogenous saturated fatty acids. ..
- Martin C, Marcet M, Almazán O, Jönsson L. Adaptation of a recombinant xylose-utilizing Saccharomyces cerevisiae strain to a sugarcane bagasse hydrolysate with high content of fermentation inhibitors. Bioresour Technol. 2007;98:1767-73 pubmed..The xylose-utilizing ability of the yeast strain did not seem to be affected by the adaptation and the results suggest that ethanol rather than xylitol was formed from the consumed xylose...
- Edlund C, Soderberg M, Kristensson K, Dallner G. Ubiquinone, dolichol, and cholesterol metabolism in aging and Alzheimer's disease. Biochem Cell Biol. 1992;70:422-8 pubmed..The results indicate that Alzheimer's disease results in specific and significant changes in the levels of lipid products of the mevalonate pathway in the brain...
- Magnusson B, Asp L, Boström P, Ruiz M, Stillemark Billton P, Lindén D, et al. Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins. Arterioscler Thromb Vasc Biol. 2006;26:1566-71 pubmed
- Zhao G, Nyman M, Jönsson J. Rapid determination of short-chain fatty acids in colonic contents and faeces of humans and rats by acidified water-extraction and direct-injection gas chromatography. Biomed Chromatogr. 2006;20:674-82 pubmed..After validation, the methodology was applied on two faecal samples from rats fed diets containing different amount of dietary fibre and one faecal sample from human fed a normal diet to test the accuracy of the developed method. ..
- Hagström Toft E, Qvisth V, Nennesmo I, Ryden M, Bolinder H, Enoksson S, et al. Marked heterogeneity of human skeletal muscle lipolysis at rest. Diabetes. 2002;51:3376-83 pubmed..01). Thus there were marked differences in lipolytic activity among skeletal muscle groups at rest, possibly reflecting variations in fiber type. ..
- Månsson P, Eriksson C, Sjödin K. Antifeedants against Hylobius abietis pine weevils: an active compound in extract of bark of Tilia cordata linden. J Chem Ecol. 2005;31:989-1001 pubmed..Nonanoic acid was identified in both of these fractions. Subsequent testing in the microfeeding assay showed that nonanoic acid possessed strong antifeedant activity against H. abietis adults...
- Shabalina I, Jacobsson A, Cannon B, Nedergaard J. Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. J Biol Chem. 2004;279:38236-48 pubmed..We conclude that, when examined in its native environment, UCP1 functions as a proton (equivalent) carrier in the absence of exogenous or endogenous fatty acids. ..
- Kim H, Silva J, Iskandarov U, Andersson M, Cahoon R, Mockaitis K, et al. Structurally divergent lysophosphatidic acid acyltransferases with high selectivity for saturated medium chain fatty acids from Cuphea seeds. Plant J. 2015;84:1021-33 pubmed publisher..Identification of these LPATs provides tools for understanding the structural basis of LPAT substrate specificity and for generating altered oil functionalities. ..
- Shabalina I, Hoeks J, Kramarova T, Schrauwen P, Cannon B, Nedergaard J. Cold tolerance of UCP1-ablated mice: a skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects. Biochim Biophys Acta. 2010;1797:968-80 pubmed publisher
- Hagberg C, Falkevall A, Wang X, Larsson E, Huusko J, Nilsson I, et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature. 2010;464:917-21 pubmed publisher..The involvement of VEGF-B in lipid uptake may open up the possibility for novel strategies to modulate pathological lipid accumulation in diabetes, obesity and cardiovascular diseases. ..
- Chen Y, Osika W, Dangardt F, Gan L, Strandvik B, Friberg P. High levels of soluble intercellular adhesion molecule-1, insulin resistance and saturated fatty acids are associated with endothelial dysfunction in healthy adolescents. Atherosclerosis. 2010;211:638-42 pubmed publisher..In healthy adolescents impaired endothelial function is significantly associated with high level of soluble ICAM-1, HOMA-IR and SFA. ..
- Westin M, Hunt M, Alexson S. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. J Biol Chem. 2005;280:38125-32 pubmed
- Jakobsson A, Jorgensen J, Jacobsson A. Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation. Am J Physiol Endocrinol Metab. 2005;289:E517-26 pubmed..These data demonstrate differential transcriptional regulation and concomitantly different functional roles for fatty acid elongases in lipid metabolism of brown adipocytes, which reflects the metabolic status of the cells. ..
- Hamberg M. Isolation and structures of two divinyl ether fatty acids from Clematis vitalba. Lipids. 2004;39:565-9 pubmed..vitalba of a new divinyl ether synthase acting on 9-lipoxygenase-generated hydroperoxides. A close structural relationship between this enzyme and the well-studied divinyl ether synthase in the potato and tomato seems likely...
- Aronsson C, Vehik K, Yang J, Uusitalo U, Hay K, Joslowski G, et al. Use of dietary supplements in pregnant women in relation to sociodemographic factors - a report from The Environmental Determinants of Diabetes in the Young (TEDDY) study. Public Health Nutr. 2013;16:1390-402 pubmed publisher..The majority of the women used dietary supplements during pregnancy. The use was associated with sociodemographic and behavioural factors, such as parity, maternal age, education, BMI and maternal smoking. ..
- Svensk E, St hlman M, Andersson C, Johansson M, Bor n J, Pilon M. PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. PLoS Genet. 2013;9:e1003801 pubmed publisher..This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant...
- Elmberger P, Engfeldt P, Dallner G. Presence of dolichol and its derivatives in human blood. J Lipid Res. 1988;29:1651-62 pubmed..In a few pathological conditions where the level of blood cholesterol was increased, the total blood dolichol content was not affected. Apparently, dolichol is a stable lipid component of human high density lipoprotein...
- Shabalina I, Kramarova T, Nedergaard J, Cannon B. Carboxyatractyloside effects on brown-fat mitochondria imply that the adenine nucleotide translocator isoforms ANT1 and ANT2 may be responsible for basal and fatty-acid-induced uncoupling respectively. Biochem J. 2006;399:405-14 pubmed..The data are therefore compatible with a tentative model in which the ANT2 isoform mediates fatty-acid-induced uncoupling, whereas the ANT1 isoform may mediate a significant part of the high basal proton leak in brown-fat mitochondria. ..
- Westerberg R, Månsson J, Golozoubova V, Shabalina I, Backlund E, Tvrdik P, et al. ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. J Biol Chem. 2006;281:4958-68 pubmed..This points to ELOVL3 as an important regulator of endogenous synthesis of saturated very long chain fatty acids and triglyceride formation in brown adipose tissue during the early phase of the tissue recruitment. ..
- Shokri A, Veide A, Larsson G. RelA1 gene control of Escherichia coli lipid structure and cell performance during glucose limited fed-batch conditions. Appl Microbiol Biotechnol. 2006;73:464-73 pubmed..These findings suggest that the relA1 gene has a defined, but ppGpp-independent, role in cells with a slowly decreasing metabolism of glucose to control the membrane morphology. ..
- Shabalina I, Backlund E, Bar Tana J, Cannon B, Nedergaard J. Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism. Biochim Biophys Acta. 2008;1777:642-50 pubmed publisher..Thus, neither the ability to be metabolized nor an innate uncoupling/protonophoric ability is a necessary property of UCP1 activators within brown-fat cells. ..
- Carlsson L, Linden D, Jalouli M, Oscarsson J. Effects of fatty acids and growth hormone on liver fatty acid binding protein and PPARalpha in rat liver. Am J Physiol Endocrinol Metab. 2001;281:E772-81 pubmed..Moreover, GH has different effects on PPARalpha-responsive genes and does not counteract the effect of LCFA on the expression of these gene products...
- Svensson L, Alexson S, Hiltunen J. Very long chain and long chain acyl-CoA thioesterases in rat liver mitochondria. Identification, purification, characterization, and induction by peroxisome proliferators. J Biol Chem. 1995;270:12177-83 pubmed..Comparison of physical and catalytical characteristics of the enzymes studied here and previously purified acyl-CoA thioesterases suggest that MTE-I and MTE-II are novel enzymes. ..
- Pinhassi J, Bowman J, Nedashkovskaya O, Lekunberri I, Gomez Consarnau L, Pedrós Alió C. Leeuwenhoekiella blandensis sp. nov., a genome-sequenced marine member of the family Flavobacteriaceae. Int J Syst Evol Microbiol. 2006;56:1489-93 pubmed..nov. is proposed. The type strain is MED 217(T) (=CECT 7118(T)=CCUG 51940(T))...
- Idborg H, Olsson P, Leclerc P, Raouf J, Jakobsson P, Korotkova M. Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice. Prostaglandins Other Lipid Mediat. 2013;107:18-25 pubmed publisher..These effects of mPGES-1 deletion on eicosanoid and fatty acid metabolism have important implications for future mPGES-1 inhibitors and deserve further investigation. ..
- Ruales J, de Grijalva Y, Lopez Jaramillo P, Nair B. The nutritional quality of an infant food from quinoa and its effect on the plasma level of insulin-like growth factor-1 (IGF-1) in undernourished children. Int J Food Sci Nutr. 2002;53:143-54 pubmed
- Isaac G, Pernber Z, Gieselmann V, Hansson E, Bergquist J, Mansson J. Sulfatide with short fatty acid dominates in astrocytes and neurons. FEBS J. 2006;273:1782-90 pubmed..Based on our results, we speculate that the fatty acid chain length of sulfatide might determine its intracellular (short chain) or extracellular (long chain) location and thereby its functions. ..
- Andersson E, Hernell O, Bläckberg L, Fält H, Lindquist S. BSSL and PLRP2: key enzymes for lipid digestion in the newborn examined using the Caco-2 cell line. J Lipid Res. 2011;52:1949-56 pubmed publisher..We conclude the key enzymes in intestinal fat digestion are different in newborns than later in life. Further studies are needed to fully understand this difference and its implication for designing optimal neonatal nutrition. ..
- Ding B, Liénard M, Wang H, Zhao C, Löfstedt C. Terminal fatty-acyl-CoA desaturase involved in sex pheromone biosynthesis in the winter moth (Operophtera brumata). Insect Biochem Mol Biol. 2011;41:715-22 pubmed publisher..These results provide evidence that a terminal desaturation step is involved in the winter moth pheromone biosynthesis, prior to the decarboxylation. ..
- Lidell M, Seifert E, Westergren R, Heglind M, Gowing A, Sukonina V, et al. The adipocyte-expressed forkhead transcription factor Foxc2 regulates metabolism through altered mitochondrial function. Diabetes. 2011;60:427-35 pubmed publisher..We previously showed that a high-calorie diet and insulin induce Foxc2 in adipocytes; the current findings identify a previously unknown role for Foxc2 as an important metabo-regulator of mitochondrial morphology and metabolism. ..
- Hamberg M, Sanz A, Castresana C. alpha-oxidation of fatty acids in higher plants. Identification of a pathogen-inducible oxygenase (piox) as an alpha-dioxygenase and biosynthesis of 2-hydroperoxylinolenic acid. J Biol Chem. 1999;274:24503-13 pubmed..It was concluded that the recombinant enzymes from tobacco and Arabidopsis were both alpha-dioxygenases, and that members of this new class of enzymes catalyze the first step of alpha-oxidation in plant tissue. ..
- Wolters M, Dering C, Siani A, Russo P, Kaprio J, Rise P, et al. The role of a FADS1 polymorphism in the association of fatty acid blood levels, BMI and blood pressure in young children-Analyses based on path models. PLoS ONE. 2017;12:e0181485 pubmed publisher..Thus, polymorphisms with an impact on the D5D activity may play a role for the BP level mediated through PUFA and BMI. Therefore, health effects of dietary n-6 and n-3 PUFA may vary depending on genetic FADS1 variants. ..
- Frank J, Kamal Eldin A, Lundh T, Määttä K, Törrönen R, Vessby B. Effects of dietary anthocyanins on tocopherols and lipids in rats. J Agric Food Chem. 2002;50:7226-30 pubmed..05). In conclusion, dietary C3G, BC, and EC appear to have little effect on cholesterol levels and the fatty acid pattern in the liver but seem to be capable of sparing vitamin E in healthy, growing rats...
- Carlsson M, Orho Melander M, Hedenbro J, Almgren P, Groop L. The T 54 allele of the intestinal fatty acid-binding protein 2 is associated with a parental history of stroke. J Clin Endocrinol Metab. 2000;85:2801-4 pubmed..We also present novel evidence that genetic variation in the FABP2 gene may increase susceptibility to stroke. ..
- Andersson A, Sjodin A, Hedman A, Olsson R, Vessby B. Fatty acid profile of skeletal muscle phospholipids in trained and untrained young men. Am J Physiol Endocrinol Metab. 2000;279:E744-51 pubmed..This difference was not explained by different fiber-type distribution alone but appears to be a direct consequence of changes in fatty acid metabolism due to the higher level of physical activity...
- Sundh I, Bastviken D, Tranvik L. Abundance, activity, and community structure of pelagic methane-oxidizing bacteria in temperate lakes. Appl Environ Microbiol. 2005;71:6746-52 pubmed..They represent a potentially important pathway for reentry of carbon and energy into pelagic food webs that would otherwise be lost as evasion of CH4...
- Pinhassi J, Nedashkovskaya O, Hagström A, Vancanneyt M. Winogradskyella rapida sp. nov., isolated from protein-enriched seawater. Int J Syst Evol Microbiol. 2009;59:2180-4 pubmed publisher..nov. is proposed. The type strain is SCB36T (=CECT 7392T=CCUG 56098T). ..
- Hansson A, Hance N, Dufour E, Rantanen A, Hultenby K, Clayton D, et al. A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. Proc Natl Acad Sci U S A. 2004;101:3136-41 pubmed..It can thus be concluded that at least some of the secondary gene expression alterations in mitochondrial cardiomyopathy do not compensate but rather directly contribute to heart failure progression. ..
- O Byrne J, Hunt M, Rai D, Saeki M, Alexson S. The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine. J Biol Chem. 2003;278:34237-44 pubmed..Therefore, the cytosolic BACAT enzyme may play important roles in protection against toxicity by accumulation of unconjugated bile acids and non-esterified very long-chain fatty acids. ..
- Jonsson K, Barman M, Moberg S, Sjöberg A, Brekke H, Hesselmar B, et al. Fat intake and breast milk fatty acid composition in farming and nonfarming women and allergy development in the offspring. Pediatr Res. 2016;79:114-23 pubmed publisher..Low maternal consumption of margarine and vegetable oils might contribute to the allergy-preventive effect of growing up on small dairy farms. ..
- Boström P, Andersson L, Li L, Perkins R, Højlund K, Boren J, et al. The assembly of lipid droplets and its relation to cellular insulin sensitivity. Biochem Soc Trans. 2009;37:981-5 pubmed publisher..Thus both SNAP-23 and syntaxin-5 are highly involved in the development of insulin resistance. ..
- Magnusson B, Gummesson A, Glad C, Goedecke J, Jernas M, Lystig T, et al. Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism. Metabolism. 2008;57:1307-13 pubmed publisher..Thus, we suggest that CIDEC is a regulator of adipocyte lipid metabolism and may be important for the adipocyte to adapt to changes in energy availability. ..
- Hunt M, Alexson S. Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism. Prog Lipid Res. 2008;47:405-21 pubmed publisher..This review will therefore focus on new and emerging roles for these enzymes in assisting with the oxidation of various lipids, amidation of lipids for excretion from peroxisomes, and in controlling coenzyme A levels in peroxisomes...
- Reilly S, O Shea E, Andersson U, O Byrne J, Alexson S, Hunt M. A peroxisomal acyltransferase in mouse identifies a novel pathway for taurine conjugation of fatty acids. FASEB J. 2007;21:99-107 pubmed