Experts and Doctors on exotoxins in Japan
Tao M, Yamashita H, Watanabe K, Nagatake T. Possible virulence factors of Staphylococcus aureus in a mouse septic model. FEMS Immunol Med Microbiol. 1999;23:135-46 pubmed
..In addition, among the extracellular products, those which have cytotoxic activity to Vero cells may contribute to the lethality in sepsis caused by S. aureus in this murine model. ..
Iwase H, Takahashi T, Takatori T, Shimizu T, Aono K, Yamada Y, et al
. pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. Biochem Biophys Res Commun. 1995;215:945-51 pubmed
..Furthermore, leukotoxin in human leukemia cells (THP-1) was stained immunohistochemically by a monoclonal anti-leukotoxin antibody...
Mizukane R, Hirakata Y, Kaku M, Ishii Y, Furuya N, Ishida K, et al
. Comparative in vitro exoenzyme-suppressing activities of azithromycin and other macrolide antibiotics against Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1994;38:528-33 pubmed
..These findings indicate that AZM, EM, RXM, and RKM each has an inhibitory effect on exoenzyme production separate from the antimicrobial effect and that, of these macrolides, AZM has the strongest virulence-suppressing effect. ..
Sawada H, Takeuchi T, Matsuda I. Comparative analysis of Pseudomonas syringae pv. actinidiae and pv. phaseolicola based on phaseolotoxin-resistant ornithine carbamoyltransferase gene (argK) and 16S-23S rRNA intergenic spacer sequences. Appl Environ Microbiol. 1997;63:282-8 pubmed
..syringae pv. actinidiae and/or pv. phaseolicola...
Watanabe D, Inokawa H, Hashimoto K, Suzuki N, Kano M, Shigemoto R, et al
. Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. Cell. 1998;95:17-27 pubmed
..Furthermore, this integration can adapt after Golgi cell elimination so as not to evoke overexcitation by the reduction of NMDA receptors. ..
Sawada H, Suzuki F, Matsuda I, Saitou N. Phylogenetic analysis of Pseudomonas syringae pathovars suggests the horizontal gene transfer of argK and the evolutionary stability of hrp gene cluster. J Mol Evol. 1999;49:627-44 pubmed
Tamura F, Nakagawa R, Akuta T, Okamoto S, Hamada S, Maeda H, et al
. Proapoptotic effect of proteolytic activation of matrix metalloproteinases by Streptococcus pyogenes thiol proteinase (Streptococcus pyrogenic exotoxin B). Infect Immun. 2004;72:4836-47 pubmed
..pyogenes infection. These results suggest that SpeB or SpeB-activated MMPs contribute to tissue damage and streptococcal invasion in the host via extracellular release of TNF-alpha and sFasL. ..
Ishige K, Shoda J, Kawamoto T, Matsuda S, Ueda T, Hyodo I, et al
. Potent in vitro and in vivo antitumor activity of interleukin-4-conjugated Pseudomonas exotoxin against human biliary tract carcinoma. Int J Cancer. 2008;123:2915-22 pubmed publisher
..5 weeks in treated and untreated mice, respectively). These results indicate that IL-4 receptor-targeted cytotoxin is a potent agent that may provide a new therapeutic option for BTC. ..
Sawada H, Kanaya S, Tsuda M, Suzuki F, Azegami K, Saitou N. A phylogenomic study of the OCTase genes in Pseudomonas syringae pathovars: the horizontal transfer of the argK-tox cluster and the evolutionary history of OCTase genes on their genomes. J Mol Evol. 2002;54:437-57 pubmed publisher
..Thus, the horizontal gene transfer and the genomic rearrangement were proven to have played an important role in the pathogenic differentiation and diversification of P. syringae...