Experts and Doctors on exodeoxyribonucleases in Italy


Locale: Italy
Topic: exodeoxyribonucleases

Top Publications

  1. Avvedimento V, Musti A, Fusco A, Bonapace M, Di Lauro R. Neoplastic transformation inactivates specific trans-acting factor(s) required for the expression of the thyroglobulin gene. Proc Natl Acad Sci U S A. 1988;85:1744-8 pubmed
    ..Fusion of transformed thyroid cells to liver cells does not reactivate the reporter under control of the thyroglobulin promoter...
  2. Manfrini N, Guerini I, Citterio A, Lucchini G, Longhese M. Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases. J Biol Chem. 2010;285:11628-37 pubmed publisher
    ..Furthermore, the helicase Sgs1 and the nucleases Exo1 and Dna2 participate in lengthening the 5'-3' resection tracts during meiosis by controlling a step subsequent to Spo11 removal. ..
  3. Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein K, Rothstein R, et al. HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature. 2011;471:74-79 pubmed publisher
    ..We propose that Rpd3, Hda1 and Gcn5 control chromosome stability by coordinating the ATR checkpoint and double-strand-break processing with autophagy. ..
  4. Pulliero A, Marengo B, Domenicotti C, Longobardi M, Fazzi E, Orcesi S, et al. Inhibition of neuroblastoma cell growth by TREX1-mutated human lymphocytes. Oncol Rep. 2012;27:1689-94 pubmed publisher
    ..The results obtained provide evidence that mutations of the TREX1 gene increase the capability of T-lymphocytes to inhibit growth of neoplastic neuronal cells and related angiogenesis. ..
  5. Federico A, Di Donato I, Bianchi S, Di Palma C, Taglia I, Dotti M. Hereditary cerebral small vessel diseases: a review. J Neurol Sci. 2012;322:25-30 pubmed publisher
    ..Specific diagnostic tools are recommended, genetic analysis being the gold standard for the diagnosis. ..
  6. Kolinjivadi A, Sannino V, De Antoni A, Zadorozhny K, Kilkenny M, Técher H, et al. Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments. Mol Cell. 2017;67:867-881.e7 pubmed publisher
    ..These results indicate that Brca2 and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarcal1 and Mre11 predisposes to genome instability. ..
  7. Loregian A, Case A, Cancellotti E, Valente C, Marsden H, Palu G. Cloning, expression, and functional characterization of the equine herpesvirus 1 DNA polymerase and its accessory subunit. J Virol. 2006;80:6247-58 pubmed
    ..Taken together, the results indicate that pORF30 and pORF18 are the equine herpesvirus 1 counterparts of herpes simplex virus type 1 UL30 and UL42 and share many, but not all, of their characteristics...
  8. Clerici M, Mantiero D, Guerini I, Lucchini G, Longhese M. The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep. 2008;9:810-8 pubmed publisher
    ..Moreover, DSB resection in ykuDelta cells occurs independently of CDK activity, suggesting that it might be promoted by CDK-dependent inhibition of Yku. ..
  9. Doksani Y, Bermejo R, Fiorani S, Haber J, Foiani M. Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell. 2009;137:247-58 pubmed publisher
    ..Our findings have implications for those genome instability syndromes that accumulate DNA breaks during S phase and for forks encountering eroding telomeres. ..

More Information


  1. Clerici M, Trovesi C, Galbiati A, Lucchini G, Longhese M. Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends. EMBO J. 2014;33:198-216 pubmed publisher
    ..Thus, Mec1 regulates the generation of ssDNA at DSBs, and this control is important to coordinate Mec1 and Tel1 signaling activities at these breaks. ..