Experts and Doctors on enzyme inhibitors in Japan


Locale: Japan
Topic: enzyme inhibitors

Top Publications

  1. Iwakawa T, Tanaka Y, Takashima A. A new galloylglucoside from Cleyera ochnacea DC. Chem Pharm Bull (Tokyo). 2001;49:1498-9 pubmed
    ..Theaceae). Its structure was elucidated on the basis of chemical and spectral analysis. Compound 1 showed inhibitory activity against rat cerebellar nitric oxide synthase (NOS)...
  2. Hinata N, Takemura T, Ikushima S, Yanagawa T, Ando T, Okada J, et al. Phenotype of regenerative epithelium in idiopathic interstitial pneumonias. J Med Dent Sci. 2003;50:213-24 pubmed
    ..The different origin of regenerative epithelium may reflect the severity and extent of the injury and the degree of consequent fibrosis in UIP and NSIP. ..
  3. Kyoi S, Otani H, Matsuhisa S, Akita Y, Enoki C, Tatsumi K, et al. Role of oxidative/nitrosative stress in the tolerance to ischemia/reperfusion injury in cardiomyopathic hamster heart. Antioxid Redox Signal. 2006;8:1351-61 pubmed
    ..These results suggest that oxidative/nitrosative stress plays a role in the tolerance to I/R injury in the cardiomyopathic heart through activation of PKC and the downstream effectors, K(ATP) channels. ..
  4. Yamazaki K, Inoue T, Yasuda N, Sato Y, Nagakura T, Takenaka O, et al. Comparison of efficacies of a dipeptidyl peptidase IV inhibitor and alpha-glucosidase inhibitors in oral carbohydrate and meal tolerance tests and the effects of their combination in mice. J Pharmacol Sci. 2007;104:29-38 pubmed
  5. Fukumoto T, Kubota Y, Kitanaka A, Yamaoka G, Ohara Waki F, Imataki O, et al. Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells. Cell Signal. 2009;21:1775-83 pubmed publisher
  6. Tanaka T, Ogawa M, Suzuki J, Sekinishi A, Itai A, Hirata Y, et al. Inhibition of I?B phosphorylation prevents load-induced cardiac dysfunction in mice. Am J Physiol Heart Circ Physiol. 2012;303:H1435-45 pubmed publisher
    ..In conclusion, IMD-1041 may be useful for preventing pressure overload-induced cardiac dysfunction and the transition of cardiac hypertrophy to contraction failure via suppression of NF-?B activation. ..
  7. Okada K, Takano Ohmuro H, Obinata T, Abe H. Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood. Exp Cell Res. 1996;227:116-22 pubmed
    ..Thus, we conclude that the dephosphorylation of cofilin is differently regulated depending on either fMLP or TPA activation. ..
  8. Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, et al. The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. Oncogene. 1997;14:3067-72 pubmed
  9. Miyasaka K, Suzuki S, Kanai S, Masuda M, Funakoshi A. Role of CCK-A receptor in the regulation of pancreatic bicarbonate secretion in conscious rats: a study in naturally occurring CCK-A receptor gene knockout rats. Pancreas. 1999;19:217-23 pubmed
    ..In conclusion, intravenous injection of CCK did not stimulate bicarbonate secretion, and the lack of CCK-A receptor decreased bicarbonate secretion in response to luminal stimulants. ..

More Information

Publications228 found, 100 shown here

  1. Ichikawa T, Ishihara K, Kusakabe T, Hiruma H, Kawakami T, Hotta K. CGRP modulates mucin synthesis in surface mucus cells of rat gastric oxyntic mucosa. Am J Physiol Gastrointest Liver Physiol. 2000;279:G82-9 pubmed
    ..These results show that CGRP-stimulated mucin biosynthesis mediated by NO is limited to surface mucus cells of the rat gastric oxyntic mucosa...
  2. Tamura T, Kataoka A, Shu L, Ashida A, Tanaka H, Inagaki K. An in vitro screening method for DNA cytosine-C5-methylase inhibitor. Nat Prod Lett. 2002;16:25-7 pubmed
    ..Our method uses a commercially available Hae III methylase (cytosine C5 methylase), its corresponding Hae III endonuclease, and lambda DNA as their substrate. ..
  3. Nakahara K, Roy M, Ono H, Maeda I, Ohnishi Kameyama M, Yoshida M, et al. Prenylated flavanones isolated from flowers of Azadirachta indica (the neem tree) as antimutagenic constituents against heterocyclic amines. J Agric Food Chem. 2003;51:6456-60 pubmed
    ..Thus, the antimutagenic effect of compounds 1-4 would be mainly based on the inhibition of the enzymatic activation of heterocyclic amines. ..
  4. Yamaji R, Fujita K, Nakanishi I, Nagao K, Naito M, Tsuruo T, et al. Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells. Arch Biochem Biophys. 2004;423:332-42 pubmed
  5. Suga H, Nakajima K, Shu E, Kanno Y, Hirade K, Ishisaki A, et al. Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells. Arch Biochem Biophys. 2005;438:137-45 pubmed
    ..These results suggest that PI3K/Akt plays a part in the AVP-induced phosphorylation of HSP27, maybe independently of p38 MAP kinase, in aortic smooth muscle A10 cells. ..
  6. Xie H, Wang T, Matsuda H, Morikawa T, Yoshikawa M, Tani T. Bioactive constituents from Chinese natural medicines. XV. Inhibitory effect on aldose reductase and structures of Saussureosides A and B from Saussurea medusa. Chem Pharm Bull (Tokyo). 2005;53:1416-22 pubmed
    ..In addition, some isolates were found to show an inhibitory effect on aldose reductase. ..
  7. Sakabe E, Tanaka N, Shimozono N, Gojobori T, Fujiwara S. Effects of U0126 and fibroblast growth factor on gene expression profile in Ciona intestinalis embryos as revealed by microarray analysis. Dev Growth Differ. 2006;48:391-400 pubmed
    ..The expression level and asymmetric distribution of these mRNA were independent of MEK signaling. ..
  8. Fujiwara K, Tsubaki M, Yamazoe Y, Nishiura S, Kawaguchi T, Ogaki M, et al. [Fluvastatin induces apoptosis on human tongue carcinoma cell line HSC-3]. Yakugaku Zasshi. 2008;128:153-8 pubmed
    ..The results of this study also indicate that fluvastatin may be used as an anticancer agent for tongue carcinoma. ..
  9. Shimizu T, Kagawa T, Inoue T, Nonaka A, Takada S, Aburatani H, et al. Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol. 2008;28:7427-41 pubmed publisher
    ..Thus, the GSK3beta/beta-catenin signaling axis regulated by FGF and Wnt signals plays a pivotal role in the maintenance of neural stem/precursor cells by linking the cell proliferation to the inhibition of differentiation. ..
  10. Masuo T, Okamura S, Zhang Y, Mori M. Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen. Cancer Lett. 2009;285:66-72 pubmed publisher
    ..Our results suggest that CaN promotes colorectal cancer proliferation probably by regulating levels of c-Myc, p21(WAF1/CIP1), and PCNA. ..
  11. Nakamura T, Matsushima M, Hayashi Y, Shibasaki M, Imaizumi K, Hashimoto N, et al. Attenuation of transforming growth factor-?-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1. Am J Respir Cell Mol Biol. 2011;44:614-20 pubmed publisher
  12. Satoh T, Miyoshi H, Sakamoto K, Iwamura H. Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases. Biochim Biophys Acta. 1996;1273:21-30 pubmed
    ..1990) Arch. Biochem. Biophys. 281, 305-311). It is noteworthy that several synthetic capsaicins discriminated between NDH-1 and NDH-2 much better than natural capsaicin. ..
  13. Yamada K, Takane Gyotoku N, Yuan X, Ichikawa F, Inada C, Nonaka K. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia. 1996;39:1306-12 pubmed
    ..beta-TC1 cells also expressed Fas mRNA when exposed to IL-1 alpha or IL-1 alpha plus interferon-gamma. These observations suggest that Fas-mediated apoptosis may be a mechanism of islet cell death in autoimmune insulitis...
  14. Imamura Y, Koga T, Higuchi T, Otagiri M, Sugino E, Hibino S. Inhibitory effect of drugs with a ketone group on reduction of acetohexamide catalyzed by carbonyl reductase from rabbit kidney. J Enzyme Inhib. 1997;11:285-92 pubmed
    ..Although nonsteroidal anti-inflammatory drugs with a ketone group such as suprofen and fenbufen were not reduced by the enzyme, they strongly inhibited the reduction of acetohexamide catalyzed by the enzyme...
  15. Goto A, Yamada K. Ouabain-like factor. Curr Opin Nephrol Hypertens. 1998;7:189-96 pubmed
    ..Several important questions remain, however, before it can be concluded that ouabain-like factor is indeed involved in the regulation of sodium homeostasis and blood pressure. ..
  16. Yoshida N, Yoshikawa T, Tanaka Y, Fujita N, Kassai K, Naito Y, et al. A new mechanism for anti-inflammatory actions of proton pump inhibitors--inhibitory effects on neutrophil-endothelial cell interactions. Aliment Pharmacol Ther. 2000;14 Suppl 1:74-81 pubmed
    ..These results indicate that proton pump inhibitors can attenuate neutrophil adherence to endothelial cells via inhibiting the expression of adhesion molecules, suggesting that proton pump inhibitors may have anti-inflammatory activity. ..
  17. Yamamoto Yamaguchi Y, Yamada K, Ishii Y, Asahi K, Tomoyasu S, Honma Y. Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator. Br J Haematol. 2001;112:697-705 pubmed
    ..Cotylenin A-induced differentiation was not affected by several inhibitors of signal transduction, suggesting that this inducer exhibits a unique mode of action. ..
  18. Tsuchiya E, Yukawa M, Miyakawa T, Kimura K, Takahashi H. Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. J Antibiot (Tokyo). 2001;54:84-90 pubmed
    ..Although the inhibition of CDK activity may not be a solo cause of the G1 arrest, our results indicate that borrelidin is a potential lead compound for developing novel CDK inhibitors of higher eukaryotes. ..
  19. Komatani H, Kotani H, Hara Y, Nakagawa R, Matsumoto M, Arakawa H, et al. Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. Cancer Res. 2001;61:2827-32 pubmed
    ..However, the transfectants were not resistant to mitoxantrone or topotecan, the drugs previously thought to be the substrates of BCRP. Thus, our study presents a novel mechanism of drug resistance mediated by BCRP...
  20. Oguchi T, Doursout M, Kashimoto S, Liang Y, Hartley C, Chelly J. Role of heparin and nitric oxide in the cardiac and regional hemodynamic properties of protamine in conscious chronically instrumented dogs. Anesthesiology. 2001;94:1016-25 pubmed
    ..The data provide evidence that the nitric oxide pathway is involved in the systemic and selective regional heparin-protamine-mediated vasodilatation in conscious dogs. ..
  21. Naito S, Nishimura M. Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes. Yakugaku Zasshi. 2001;121:989-94 pubmed
  22. Usami N, Yamamoto T, Shintani S, Ishikura S, Higaki Y, Katagiri Y, et al. Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002;25:441-5 pubmed
    ..Although cloxazolam was a potent and specific inhibitor of AKR1C3, diazepam, estazolam, flunitrazepam, medazepam and nitrazepam, that inhibited AKR1C1 and AKR1C2, may influence the neurosteroid metabolism. ..
  23. Harada N, Okajima K, Uchiba M, Katsuragi T. Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats. J Lab Clin Med. 2002;139:218-26 pubmed
    ..In the sensory neuron-mediated enhancement of endothelial production of prostacyclin, CGRP-induced activation of both endothelial NOS and cyclooxygenase-1 may be critically involved. ..
  24. Mori H, Abe F, Furukawa S, Furukawa S, Sakai F, Hino M, et al. FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC) II. Biological activities in animal models. J Antibiot (Tokyo). 2003;56:80-6 pubmed
    ..These results showed potential clinical use of this compound as a new type immunosuppressant in the fields of autoimmune diseases and organ transplantations. ..
  25. Sakimura R, Tanaka K, Nakatani F, Matsunobu T, Li X, Hanada M, et al. Antitumor effects of histone deacetylase inhibitor on Ewing's family tumors. Int J Cancer. 2005;116:784-92 pubmed
    ..These results suggest that HDACI might be a promising reagent for use in molecular-based chemotherapy against EFTs. ..
  26. Kawamura K, Fukuda J, Shimizu Y, Kodama H, Tanaka T. Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through phosphatidylinositol 3'-kinase pathway. Biol Reprod. 2005;73:1094-101 pubmed
    ..Thus, TGFA inhibits apoptosis in mouse blastocysts through upregulation of survivin expression via the PI3K pathway. ..
  27. Ohi N, Nishikawa Y, Tokairin T, Yamamoto Y, Doi Y, Omori Y, et al. Maintenance of Bad phosphorylation prevents apoptosis of rat hepatic sinusoidal endothelial cells in vitro and in vivo. Am J Pathol. 2006;168:1097-106 pubmed
    ..Our data suggest that maintenance of Bad phosphorylation is important in the prevention of SEC apoptosis and that the anti-apoptotic property of OV might have therapeutic utility. ..
  28. Watabe T, Yamashita J, Mishima K, Miyazono K. TGF-beta signaling in embryonic stem cell-derived endothelial cells. Methods Mol Biol. 2006;330:341-51 pubmed
    ..In this chapter, we present how to study the cellular and biochemical effects of TGF-beta signals on endothelial cells derived from mouse ESCs. ..
  29. Werle M, Makhlof A, Takeuchi H. Oral protein delivery: a patent review of academic and industrial approaches. Recent Pat Drug Deliv Formul. 2009;3:94-104 pubmed
    ..In addition, the technology platforms of several innovative drug delivery companies are highlighted. ..
  30. Gotoh K, Masaki T, Chiba S, Higuchi K, Kakuma T, Shimizu H, et al. Hypothalamic neuronal histamine signaling in the estrogen deficiency-induced obesity. J Neurochem. 2009;110:1796-805 pubmed publisher
    ..These results indicate that CRH and hypothalamic neuronal histamine mediate the suppressive effects of E2 on feeding behavior and body weight. ..
  31. Aoi W, Naito Y, Mizushima K, Takanami Y, Kawai Y, Ichikawa H, et al. The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity. Am J Physiol Endocrinol Metab. 2010;298:E799-806 pubmed publisher
    ..These observations demonstrate that miR-696 is a physical activity-dependent miRNA involved in the translational regulation of PGC-1alpha and skeletal muscle metabolism in mice. ..
  32. Hirano M, Nakamura T, Obata J, Fujioka D, Saito Y, Kawabata K, et al. Early improvement in carotid plaque echogenicity by acarbose in patients with acute coronary syndromes. Circ J. 2012;76:1452-60 pubmed
    ..The increase in IBS values was significantly correlated with a decrease in C-reactive protein levels. Acarbose rapidly improved carotid plaque echolucency within 1 month of therapy in patients with ACS and type 2 DM. ..
  33. Michikawa T, Hirota J, Kawano S, Hiraoka M, Yamada M, Furuichi T, et al. Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor. Neuron. 1999;23:799-808 pubmed
    ..These results indicate that the bell-shaped dependence on cytoplasmic Ca2+ is not an intrinsic property of the IP3R1, and the Ca2+-dependent inactivation is directly mediated by calmodulin. ..
  34. Usui T, Yoshida M, Honda A, Beppu T, Horinouchi S. A K-252a-resistance gene, sks1+, encodes a protein similar to the Caenorhabditis elegans F37 A4.5 gene product and confers multidrug resistance in Schizosaccharomyces pombe. Gene. 1995;161:93-6 pubmed
    ..It is therefore unlikely that the function of pmd1+ is involved in MDR conferred by sks1+. These results suggest that sks1+ is a functionally novel MDR gene. ..
  35. Miyaji H, Azuma T, Ito S, Suto H, Ito Y, Yamazaki Y, et al. Susceptibility of Helicobacter pylori isolates to metronidazole, clarithromycin and amoxycillin in vitro and in clinical treatment in Japan. Aliment Pharmacol Ther. 1997;11:1131-6 pubmed
    ..The failure of the H. pylori treatment results in the induction of resistance to CLAR and/or MNZ. Regimens with a high cure rate should be used in order to prevent the generation of acquired resistance to antibiotics. ..
  36. Kobayashi K, Kobayashi Y, Hashida Okumura A, Iimori S, Nagai K, Nakashima H. Increase in peripheral blood flow due to extraocular direct irradiation of visible light in rats. Am J Physiol Heart Circ Physiol. 2000;279:H1141-6 pubmed
    ..On the basis of the present results, we propose a photochemical model of the photosensitivity mechanism where optical absorption of the sixfold coordinated ferrous heme-NO complex plays a main role...
  37. Ding W, Kitasato H, Matsuura H. Involvement of calmodulin in glucagon-like peptide 1(7-36) amide-induced inhibition of the ATP-sensitive K+ channel in mouse pancreatic beta-cells. Exp Physiol. 2001;86:331-9 pubmed
  38. Aoki K, Obata T, Yamazaki Y, Mori Y, Hirokawa H, Koseki J, et al. Potent platelet-derived growth factor-beta receptor (PDGF-betaR) inhibitors: Synthesis and structure-activity relationships of 7-[3-(cyclohexylmethyl)ureido]-3-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}quinoxalin-2(1H)-one derivatives. Chem Pharm Bull (Tokyo). 2007;55:255-67 pubmed
    ..004 micromol/l in CPA, 0.0008 micromol/l in APA, KDR: IC50 = 0.008 micromol/l in APA). Herein we report a new and convenient synthetic method for this series of derivatives and its SAR study. ..
  39. Osonoi T, Saito M, Mochizuki K, Fukaya N, Muramatsu T, Inoue S, et al. The ?-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus. Metabolism. 2010;59:1816-22 pubmed publisher
  40. Yokota S, Kitahara M, Nagata K. Benzylidene lactam compound, KNK437, a novel inhibitor of acquisition of thermotolerance and heat shock protein induction in human colon carcinoma cells. Cancer Res. 2000;60:2942-8 pubmed
    ..We conclude that this drug is a novel inhibitor of the acquisition of thermotolerance caused by the induction of HSPs. ..
  41. Nedachi T, Akahori M, Ariga M, Sakamoto H, Suzuki N, Umesaki K, et al. Tyrosine kinase and phosphatidylinositol 3-kinase activation are required for cyclic adenosine 3',5'-monophosphate-dependent potentiation of deoxyribonucleic acid synthesis induced by insulin-like growth factor-I in FRTL-5 cells. Endocrinology. 2000;141:2429-38 pubmed
    ..These mechanisms appear to be necessary for cAMP-dependent potentiation of the DNA synthesis induced by IGF-I. ..
  42. Furuno T, Kanno T, Arita K, Asami M, Utsumi T, Doi Y, et al. Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition. Biochem Pharmacol. 2001;62:1037-46 pubmed
    ..These results indicate that some MPTs may be regulated by fatty acid metabolism and that the Pal-CoA-induced MPT plays an important role in the induction of apoptosis. ..
  43. Meguro M, Katsuramaki T, Kimura H, Isobe M, Nagayama M, Kukita K, et al. Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714. Transplantation. 2003;75:703-10 pubmed
    ..These necrotic changes were caused by the excess production of peroxynitrite, and ONO-1714 greatly attenuated I/R injuries as the result of inhibition of the peroxynitrite production. ..
  44. Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A. Neuroprotective effects of alpha-tocopherol on oxidative stress in rat striatal cultures. Eur J Pharmacol. 2003;465:15-22 pubmed
    ..These results suggest that alpha-tocopherol protects striatal neurons by the reduction of oxidative stress, presumably by decreasing intracellular O(2)(-) levels, and at least partly by the inhibition of apoptosis. ..
  45. Suzuki R, Satoh H, Ohtani H, Hori S, Sawada Y. Saturable binding of finasteride to steroid 5alpha-reductase as determinant of nonlinear pharmacokinetics. Drug Metab Pharmacokinet. 2010;25:208-13 pubmed
    ..Finasteride's saturable binding to 5alphaR2 is the likely cause of its nonlinear pharmacokinetics. The developed pharmacokinetic/pharmacodynamic model should allow prediction of plasma concentration profiles of finasteride and DHT. ..
  46. Shimoyama S, Kasai S, Kahn Perl├Ęs B, Kikuchi H. Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole. Biochim Biophys Acta. 2014;1839:107-15 pubmed publisher
    ..These results indicate that the signals from TCDD or OP caused PP2A-mediated dephosphorylation of Sp1 at Ser-59 and induced CYP1A1 transcription. This signaling pathway was independent of the AhR-mediated pathway. ..
  47. Abiko M, Rodgers K, Campeau J, Nakamura R, diZerega G. Alterations of angiotensin II Receptor levels in sutured wounds in rat skin. J Invest Surg. 1996;9:447-53 pubmed
    ..Because these data are consistent with those observed after excisional wounding, temporal changes in AII receptor expression may be integral to the process of wound healing. ..
  48. Nozaki Y, Hasegawa Y, Ichiyama S, Nakashima I, Shimokata K. Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages. Infect Immun. 1997;65:3644-7 pubmed
    ..These results clearly show that BCG-induced NO and its reactive product with the oxygen radical peroxynitrite could play an important role in the killing of BCG in human AM. ..
  49. Obata T, Yamanaka Y. Glibenclamide, an antagonist of ATP sensitive K+ channels, blocks free radical generation in the rat myocardium. Neurosci Lett. 1998;257:57-9 pubmed
    ..v. injection, the elevation of DHBA was not observed. These results suggest that openings of cardiac K(ATP) channel by depolarization evokes .OH generation via xanthine oxidase reaction. ..
  50. Ito N, Yokomizo T, Sasaki T, Kurosu H, Penninger J, Kanaho Y, et al. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem. 2002;277:44898-904 pubmed
    ..Thus, our results have clearly shown that LTB(4) binds BLT1 and activates G(i)-like protein, and both PI3-Kgamma activation and a sustained calcium elevation by calcium influx are necessary for enzyme release in these cells. ..
  51. Suwa A, Kurama T, Yamamoto T, Sawada A, Shimokawa T, Aramori I. Glucose metabolism activation by SHIP2 inhibitors via up-regulation of GLUT1 gene in L6 myotubes. Eur J Pharmacol. 2010;642:177-82 pubmed publisher
    ..These results suggest that pharmacological inhibition of SHIP2 activates glucose metabolism due, at least in part, to up-regulation of GLUT1 gene expression. ..
  52. Nakayama Y, Hayashi M, Yoshikawa K, Mochida K, Unemoto T. Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+ toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus. Biol Pharm Bull. 1999;22:1064-7 pubmed
    ..The site of Ag+ inhibition was the initial reaction of the NQR complex catalyzed by Nqr6 subunit. The time courses of Ag+ inhibition and the release of FAD indicate that the Ag+-denatured Nqr6 subunit gradually releases FAD. ..
  53. Hata K, Nishimura R, Ikeda F, Yamashita K, Matsubara T, Nokubi T, et al. Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell. 2003;14:545-55 pubmed
    ..Thus, BMP2 controls adipocytic differentiation by using two distinct signaling pathways that play differential roles in this process in C3H10T1/2 cells. ..
  54. Nobuoka A, Takayama T, Miyanishi K, Sato T, Takanashi K, Hayashi T, et al. Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid. Gastroenterology. 2004;127:428-43 pubmed
    ..Glutathione-S-transferase P1-1 protects aberrant crypt foci from deoxycholic acid-induced apoptosis and may play a pivotal role in early colon carcinogenesis. ..
  55. Morimura K, Ohi Y, Yamamura H, Ohya S, Muraki K, Imaizumi Y. Two-step Ca2+ intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes. Am J Physiol Cell Physiol. 2006;290:C388-403 pubmed
    ..In conclusion, global [Ca(2+)](i) rise triggered by a single action potential is not due mainly to Ca(2+) influx through VDCCs but is attributable to the subsequent two-step CICR. ..
  56. Ishibashi T, Nomura Nakamoto M, Abe F, Masuoka T, Imaizumi N, Yoshida J, et al. Effects of cyanamide, an aldehyde dehydrogenase type 2 inhibitor, on glyceryl trinitrate- and isosorbide dinitrate-induced vasodilation in rabbit excised aorta and in anesthetized whole animal. Biol Pharm Bull. 2013;36:556-63 pubmed
    ..In contrast, the activation mechanism(s) of ISDN is largely ALDH2-dependent in both aortic smooth muscle and whole body. Plasma NO(2)(-) may be derived from pathways other than the cyanamide-sensitive metabolic route...
  57. Igawa S, Sasaki J, Otani S, Shirasawa M, Niwa H, Kusuhara S, et al. Smoking History as a Predictor of Pemetrexed Monotherapy in Patients with Non-Squamous Non-Small Cell Lung Cancer. Oncology. 2016;91:41-7 pubmed publisher
    ..The clinical data obtained in this study may provide a valuable basis for the use of smoking status as a predictor of pemetrexed monotherapy in wild-type NSCLC patients. ..
  58. Ohkoshi M, Okuda S. Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403. Anticancer Res. 2001;21:1803-8 pubmed
    ..001) without any apparent side effects such as hair loss and body weight loss. The results suggest that ONO-3403 may be useful for the treatment of squamous cell carcinoma. ..
  59. Senga T, Iwamoto T, Humphrey S, Yokota T, Taparowsky E, Hamaguchi M. Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells. Oncogene. 2002;21:8186-91 pubmed
    ..These results indicate that Stat3 mediates cellular growth by modulating AP-1 activity through the induction of BATF. ..
  60. Niikura K, Nakajima S, Takano M, Yamazaki H. FR177995, a novel vacuolar ATPase inhibitor, exerts not only an inhibitory effect on bone destruction but also anti-immunoinflammatory effects in adjuvant-induced arthritic rats. Bone. 2007;40:888-94 pubmed
    ..These results strongly suggest that V-ATPase may be an interesting drug target in the treatment of rheumatoid arthritis. ..
  61. Kobayashi M, Kubo S, Iwata M, Ohtsu Y, Takahashi K, Shimizu Y. ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity. Int Immunopharmacol. 2011;11:732-9 pubmed publisher
    ..Although ASP3258 (3mg/kg) inhibited airway inflammation completely, it had no emetic activity. As such, this compound may be useful in treating airway inflammatory diseases such as asthma and COPD. ..
  62. Shiode N, Morishima N, Nakayama K, Yamagata T, Matsuura H, Kajiyama G. Flow-mediated vasodilation of human epicardial coronary arteries: effect of inhibition of nitric oxide synthesis. J Am Coll Cardiol. 1996;27:304-10 pubmed
    ..8 +/- 1.0%). Our data suggest that nitric oxide modulates basal coronary artery tone but that mediators other than nitric oxide may be responsible for the flow-mediated vasodilation of human epicardial coronary arteries. ..
  63. Tabata N, Ido M, Suga S, Ohgimoto S, Tsurudome M, Kawano M, et al. Protein tyrosine kinase activation provides an early and obligatory signal in anti-FRP-1/CD98/4F2 monoclonal antibody induced cell fusion mediated by HIV gp160. Med Microbiol Immunol. 1997;186:115-23 pubmed
    ..Thus, our study may present evidence for a novel pathway of protein tyrosine kinases that phosphorylate specific, still unknown protein substrates during polykaryocyte formation. ..
  64. Miyamoto N, Sugita K, Goi K, Inukai T, Lijima K, Tezuka T, et al. The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia. 2001;15:1758-68 pubmed
    ..These results indicate that AG490 exerts a potent inhibitory activity to B-precursor leukemia with specific chromosomal abnormalities, and a therapeutic approach using AG490 is expected. ..
  65. Yamamoto N, Takeshita K, Shichijo M, Kokubo T, Sato M, Nakashima K, et al. The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents. J Pharmacol Exp Ther. 2003;306:1174-81 pubmed
    ..Based on these anti-inflammatory effects of BAY 61-3606 both in vitro and in vivo, it was demonstrated that Syk may play a very critical role in the pathogenesis of allergic reactions. ..
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