Experts and Doctors on enzyme induction in Finland


Locale: Finland
Topic: enzyme induction

Top Publications

  1. Laakso J, Mervaala E, Himberg J, Teräväinen T, Karppanen H, Vapaatalo H, et al. Increased kidney xanthine oxidoreductase activity in salt-induced experimental hypertension. Hypertension. 1998;32:902-6 pubmed
    ..However, further studies on renal XOR activity during the development of hypertension are needed to assess the importance of XOR in the pathophysiology of arterial hypertension. ..
  2. Kivistö K, Villikka K, Nyman L, Anttila M, Neuvonen P. Tamoxifen and toremifene concentrations in plasma are greatly decreased by rifampin. Clin Pharmacol Ther. 1998;64:648-54 pubmed
    ..Concomitant use of rifampin or other potent inducers of CYP3A4 with tamoxifen and toremifene may reduce the efficacy of these antiestrogens. ..
  3. Mäkelä M, Lundell T, Hatakka A, Hildén K. Effect of copper, nutrient nitrogen, and wood-supplement on the production of lignin-modifying enzymes by the white-rot fungus Phlebia radiata. Fungal Biol. 2013;117:62-70 pubmed publisher
    ..radiata with pI value of 4.9, thereby complementing our previous findings on gene expression, and cloning of a second laccase of this fungus...
  4. Pohjanvirta R. Transgenic mouse lines expressing rat AH receptor variants--a new animal model for research on AH receptor function and dioxin toxicity mechanisms. Toxicol Appl Pharmacol. 2009;236:166-82 pubmed publisher
    ..Thus, these transgenic mouse lines provide a novel promising tool for molecular studies on dioxin toxicity and AHR function. ..
  5. Lakkisto P, Csonka C, Fodor G, Bencsik P, Voipio Pulkki L, Ferdinandy P, et al. The heme oxygenase inducer hemin protects against cardiac dysfunction and ventricular fibrillation in ischaemic/reperfused rat hearts: role of connexin 43. Scand J Clin Lab Invest. 2009;69:209-18 pubmed publisher
    ..Our results show that pharmacological modulation of HO-1 pathway may provide a new therapeutic approach to protect the heart against post-ischaemic dysfunction and I/R-induced VF possibly by a Cx43 dependent mechanism. ..
  6. Kiss J, Yegutkin G, Koskinen K, Savunen T, Jalkanen S, Salmi M. IFN-beta protects from vascular leakage via up-regulation of CD73. Eur J Immunol. 2007;37:3334-8 pubmed
    ..Moreover, IFN-beta treatment may be useful in alleviating vascular leakage induced by ischemia-reperfusion injury. ..
  7. Luo C, Peng Y, Santti R, He M, Lin M. COX-1 and -2 expressions in sex-related organs of neonatally estrogen-treated rats and in activated and nonactivated macrophage RAW264.7 cells with phytoestrogen. Endocrine. 2006;29:161-7 pubmed
  8. Saukkonen K, Tomasetto C, Narko K, Rio M, Ristimaki A. Cyclooxygenase-2 expression and effect of celecoxib in gastric adenomas of trefoil factor 1-deficient mice. Cancer Res. 2003;63:3032-6 pubmed
    ..These findings support the effort to initiate clinical studies to investigate the effect of Cox-2 inhibitors as a chemotherapeutic modality for dysplasias of the stomach. ..
  9. Leivonen S, Chantry A, Hakkinen L, Han J, Kahari V. Smad3 mediates transforming growth factor-beta-induced collagenase-3 (matrix metalloproteinase-13) expression in human gingival fibroblasts. Evidence for cross-talk between Smad3 and p38 signaling pathways. J Biol Chem. 2002;277:46338-46 pubmed
    ..e. Smad3 and p38alpha). In addition, these findings provide evidence for a novel type of cross-talk between Smad and p38 mitogen-activated protein kinase signaling cascades, which involves activation of Smad3 by p38alpha. ..

More Information


  1. Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syvaoja J. E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2. Nucleic Acids Res. 2001;29:2810-21 pubmed
    ..Mitogenic activation of the POLE2 promoter by an E2F-mediated mechanism resembles that of POLA2, but the regulation of basal promoter activity is different between these two genes. ..
  2. Salonpää P, Iscan M, Pasanen M, Arvela P, Pelkonen O, Raunio H. Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice. Biochem Pharmacol. 1992;44:1269-74 pubmed
    ..These data indicate that the Cyp2a-4/5 complex is regulated in a different way in DBA/2 and C57BL/6 mice and that some association exists between the development of liver damage and COH induction. ..
  3. Kaliste Korhonen E, Tuovinen K, Hanninen O. Effect of phenobarbital and beta-naphthoflavone on activities of different rat esterases after paraoxon exposure. Gen Pharmacol. 1998;31:307-12 pubmed
    ..7. The results indicated the great importance of peripheral cholinesterases and carboxylesterases as a detoxifying mechanism of paraoxon. The role of serum paraoxonase was not critical. ..
  4. Reponen P, Leivo I, Sahlberg C, Apte S, Olsen B, Thesleff I, et al. 92-kDa type IV collagenase and TIMP-3, but not 72-kDa type IV collagenase or TIMP-1 or TIMP-2, are highly expressed during mouse embryo implantation. Dev Dyn. 1995;202:388-96 pubmed
    ..The results suggest a central role for 92 kDa type IV collagenase and TIMP-3 in the extracellular proteolysis associated with implantation of the early embryo. ..
  5. Lang M, Juvonen R, Jarvinen P, Honkakoski P, Raunio H. Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes. Arch Biochem Biophys. 1989;271:139-48 pubmed
    ..This may suggest that P450Coh has a closer association to the steroid 15 alpha-hydroxylase gene family than to the P450IIB subfamily of phenobarbital-inducible isoenzymes. ..
  6. Honkakoski P, Lang M. Mouse liver phenobarbital-inducible P450 system: purification, characterization, and differential inducibility of four cytochrome P450 isozymes from D2 mouse. Arch Biochem Biophys. 1989;273:42-57 pubmed
    ..This mouse PB-inducible P450 model may be valuable in further studies on the induction mechanisms of PB and TCPOBOP. ..
  7. Hahnemann B, Salonpää P, Pasanen M, Maenpaa J, Honkakoski P, Juvonen R, et al. Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression. Biochem J. 1992;286 ( Pt 1):289-94 pubmed
  8. Honkakoski P, Kojo A, Lang M. Regulation of the mouse liver cytochrome P450 2B subfamily by sex hormones and phenobarbital. Biochem J. 1992;285 ( Pt 3):979-83 pubmed
    ..The fact that P4502b-9 does not respond to phenobarbital, while P4502b-10 is regulated by both phenobarbital and sex hormones, demonstrates the complexity of P450 expression even within one subfamily. ..
  9. Salonpää P, Krause K, Pelkonen O, Raunio H. Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver. Naunyn Schmiedebergs Arch Pharmacol. 1995;351:446-52 pubmed
    ..These results show that porphyrinogenic agents act as efficient inducers of CYP2A5, and suggest that regulation of the transcription of the Cyp2a-5 gene could in some instances involve heme-sensitive factors. ..