Experts and Doctors on enzyme activation in United Kingdom


Locale: United Kingdom
Topic: enzyme activation

Top Publications

  1. Wan K, Sambi B, Frame M, Tate R, Pyne N. The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. J Biol Chem. 2001;276:37802-8 pubmed
    ..We conclude that PDEgamma is an entirely novel intermediate regulating mitogenic signaling from both receptor tyrosine kinase and G-protein-coupled receptors in human embryonic kidney 293 cells. ..
  2. Dean J, Sarsfield S, Tsounakou E, Saklatvala J. p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. J Biol Chem. 2003;278:39470-6 pubmed
  3. Gil J, Kerai P, Lleonart M, Bernard D, Cigudosa J, Peters G, et al. Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res. 2005;65:2179-85 pubmed
    ..These results give a partial explanation for the physiologic role of c-Myc overexpression in prostate cancer. ..
  4. Prag S, Parsons M, Keppler M, Ameer Beg S, Barber P, Hunt J, et al. Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42. Mol Biol Cell. 2007;18:2935-48 pubmed
    ..Together these data suggest a mechanism whereby precise spatial guanine nucleotide exchange of Cdc42 by Dbl is dependent on functional ERM proteins and is important for directional cell migration. ..
  5. Bunkoczi G, Salah E, Filippakopoulos P, Fedorov O, Muller S, Sobott F, et al. Structural and functional characterization of the human protein kinase ASK1. Structure. 2007;15:1215-26 pubmed
    ..The determined high-resolution structure of ASK1 and identified ATP mimetic inhibitors will provide a first starting point for the further development of selective inhibitors. ..
  6. Sharp G, Ma H, Saunders P, Norman J. A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in infection-induced preterm labour. PLoS ONE. 2013;8:e70180 pubmed publisher
  7. Evans D, McGrogan M, Scott R, Carrell R. Protease specificity and heparin binding and activation of recombinant protease nexin I. J Biol Chem. 1991;266:22307-12 pubmed
  8. Bai Z, Harvey L, McNeil B. Physiological responses of chemostat cultures of Aspergillus niger (B1-D) to simulated and actual oxidative stress. Biotechnol Bioeng. 2003;82:691-701 pubmed
    ..The dynamic culture response was characterized by rapid elevation of intracellular superoxide anions and associated protective enzymes, especially SOD, and was clearly distinct from the adaptive response just described. ..
  9. Ley R, Ewings K, Hadfield K, Howes E, Balmanno K, Cook S. Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J Biol Chem. 2004;279:8837-47 pubmed
    ..Our findings provide new insights into the post-translational regulation of Bim(EL) and the role of the ERK1/2 pathway in cell survival signaling. ..

More Information

Publications217 found, 100 shown here

  1. Bosch M, Franklin Tong V. Temporal and spatial activation of caspase-like enzymes induced by self-incompatibility in Papaver pollen. Proc Natl Acad Sci U S A. 2007;104:18327-32 pubmed
    ..Because both cytosolic acidification and nuclear caspase localization are observed during apoptosis in animal cells, our data provide striking parallels between SI-induced PCD and apoptosis in animal cells...
  2. Gerasimenko J, Lur G, Sherwood M, Ebisui E, Tepikin A, Mikoshiba K, et al. Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors. Proc Natl Acad Sci U S A. 2009;106:10758-63 pubmed publisher
  3. Dodson C, Bayliss R. Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic. J Biol Chem. 2012;287:1150-7 pubmed publisher
  4. Wang Y, Rahman D, Lehner T. A comparative study of stress-mediated immunological functions with the adjuvanticity of alum. J Biol Chem. 2012;287:17152-60 pubmed publisher
    ..The results suggest that the three stress agents elicit HSP70, a hallmark of stress, as well as inflammasomes and adjuvanticity, commensurate with those of alum, which may provide an alternative strategy in developing novel adjuvants. ..
  5. Patel R, Gao M, Ahmad I, Fleming J, Singh L, Rai T, et al. Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. J Clin Invest. 2013;123:1157-75 pubmed publisher
    ..Overall, we propose SPRY2, PTEN, and PP2A status as an important determinant of prostate cancer progression. Characterization of this trio may facilitate patient stratification for targeted therapies and chemopreventive interventions. ..
  6. Gould K, Moreno S, Tonks N, Nurse P. Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase. Science. 1990;250:1573-6 pubmed
    ..The complementary DNA that encoded the tyrosine phosphatase replaced the mitotic activator p80cdc25, closely associating the cdc25(+)-activating pathway with tyrosine dephosphorylation of pp34. ..
  7. Palmer T, Stiles G. Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms. Biochemistry. 1999;38:14833-42 pubmed
    ..In addition, it is likely that phosphorylation controls interactions with regulatory proteins distinct from those involved in the classical cAMP signaling pathway utilized by this receptor. ..
  8. Sellers L, Simon J, Lundahl T, Cousens D, Humphrey P, Barnard E. Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. J Biol Chem. 2001;276:16379-90 pubmed
    ..The transient SAPK activity did not evoke transcription factor phosphorylation but was required for the P2Y(1) receptor-mediated apoptotic function. ..
  9. Niedbala W, Wei X, Campbell C, Thomson D, Komai Koma M, Liew F. Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP. Proc Natl Acad Sci U S A. 2002;99:16186-91 pubmed
    ..Our results also provide an example of the regulation of cytokine receptor expression by NO. The selectivity of such action via cGMP suggests that it is amenable to therapeutic intervention. ..
  10. Hardie R, Martin F, Chyb S, Raghu P. Rescue of light responses in the Drosophila "null" phospholipase C mutant, norpAP24, by the diacylglycerol kinase mutant, rdgA, and by metabolic inhibition. J Biol Chem. 2003;278:18851-8 pubmed
  11. Mitsopoulos C, Zihni C, Garg R, Ridley A, Morris J. The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. J Biol Chem. 2003;278:18085-91 pubmed
    ..These results demonstrate that PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity. ..
  12. Prosser I, Altug I, Phillips A, König W, Bouwmeester H, Beale M. Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif. Arch Biochem Biophys. 2004;432:136-44 pubmed
  13. González Martínez D, Kim S, Hu Y, Guimond S, Schofield J, Winyard P, et al. Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism. J Neurosci. 2004;24:10384-92 pubmed
  14. Wang X, Nadarajah B, Robinson A, McColl B, Jin J, Dajas Bailador F, et al. Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death. Mol Cell Biol. 2007;27:7935-46 pubmed
    ..Together, our data demonstrate for the first time that MKK4 is an essential activator of JNK required for the normal development of the brain. ..
  15. Pellegrin S, Mellor H. Rho GTPase activation assays. Curr Protoc Cell Biol. 2008;Chapter 14:Unit 14.8 pubmed publisher
    ..This unit describes the techniques for preparing the reagents required for assays of RhoA, Rac, and Cdc42 and gives practical tips for the successful application of the assay in a range of situations. ..
  16. Fuller W, Howie J, McLatchie L, Weber R, Hastie C, Burness K, et al. FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. Am J Physiol Cell Physiol. 2009;296:C1346-55 pubmed publisher
    ..We conclude that T69 is a previously undescribed phosphorylation site in FXYD1. Acute T69 phosphorylation elicits stimulation of the sodium pump additional to that induced by S63 and S68 phosphorylation. ..
  17. O Keeffe G, Tyers P, Aarsland D, Dalley J, Barker R, Caldwell M. Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc Natl Acad Sci U S A. 2009;106:8754-9 pubmed publisher
    ..We have therefore demonstrated a unique role for EGF as a mediator of dopamine-induced precursor cell proliferation in the SVZ, which has potential implications for future therapies in PD. ..
  18. Hale B, Kerry P, Jackson D, Precious B, Gray A, Killip M, et al. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. Proc Natl Acad Sci U S A. 2010;107:1954-9 pubmed publisher
    ..Overall, these data suggest that both direct binding of NS1 to p85beta (resulting in repositioning of the N-terminal SH2 domain) and possible NS1:p110 contacts contribute to PI3K activation. ..
  19. Dragoni S, Hudson N, Kenny B, Burgoyne T, McKenzie J, Gill Y, et al. Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions. J Immunol. 2017;198:4074-4085 pubmed publisher
  20. Rodriguez R, Matsuda M, Perisic O, Bravo J, Paul A, Jones N, et al. Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. J Biol Chem. 2001;276:47982-92 pubmed
  21. Patel S, Lochhead P, Rena G, Fumagalli S, Pende M, Kozma S, et al. Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity. J Biol Chem. 2002;277:9889-95 pubmed
    ..Therefore, although the insulin-responsive sequence of the G6Pase gene promoter is related to that of the IGFBP-1 promoter, the signaling pathways that mediate suppression of these genes are distinct. ..
  22. Mead J, Hughes T, Irvine S, Singh N, Ramji D. Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription. J Biol Chem. 2003;278:17741-51 pubmed
  23. Dumaz N, Marais R. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem. 2003;278:29819-23 pubmed
    ..These studies suggest that Raf-1 and cAMP form a signaling complex in cells. Upon activation of PKA, Raf-1 is phosphorylated and 14-3-3 binds, blocking Raf-1 recruitment to the plasma membrane and preventing its activation. ..
  24. Kenneth N, Ramsbottom B, Gomez Roman N, Marshall L, Cole P, White R. TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription. Proc Natl Acad Sci U S A. 2007;104:14917-22 pubmed
    ..The selective acetylation of histone H3 distinguishes pol III activation by c-Myc from mechanisms observed in other systems. ..
  25. Wang Q, Franks H, Lax S, El Refaee M, Malecka A, Shah S, et al. The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells. J Immunol. 2013;190:3246-55 pubmed publisher
    ..In summary, ATM activation or inhibition, respectively, inhibited or augmented IL-23 release. This novel role of the ATM pathway represents a new therapeutic target in autoimmunity and vaccine development. ..
  26. Shieh J, Wilkinson M, Millar J. The Win1 mitotic regulator is a component of the fission yeast stress-activated Sty1 MAPK pathway. Mol Biol Cell. 1998;9:311-22 pubmed
    ..Our results suggest that the stress-activated Sty1 MAPK integrates information from multiple signaling pathways. ..
  27. Braga V, Betson M, Li X, Lamarche Vane N. Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes. Mol Biol Cell. 2000;11:3703-21 pubmed
    ..Because Rac activity is also necessary for migration, Rac is a good candidate to coordinately regulate cell-cell and cell-substratum adhesion during tumorigenesis. ..
  28. Whittaker S, Walton M, Garrett M, Workman P. The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Res. 2004;64:262-72 pubmed
    ..In addition to providing useful insights into the molecular pharmacology of CYC202 in human cancer cells, the results also suggest potential pharmacodynamic end points for use in clinical trials with the drug. ..
  29. Kiss Toth E, Bagstaff S, Sung H, Jozsa V, Dempsey C, Caunt J, et al. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem. 2004;279:42703-8 pubmed
    ..These results suggest that Trbs control both the extent and the specificity of MAPK kinase activation of MAPK. ..
  30. Foresti R, Hoque M, Monti D, Green C, Motterlini R. Differential activation of heme oxygenase-1 by chalcones and rosolic acid in endothelial cells. J Pharmacol Exp Ther. 2005;312:686-93 pubmed
    ..Thus, this study identified novel plant constituents that highly induce HO-1 in endothelial cells and investigated some of the mechanisms involved in this effect. ..
  31. Pierrat O, Maxwell A. Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase. Biochemistry. 2005;44:4204-15 pubmed
    ..We suggest that the binding site of MccB17 is in the C-terminal domain of GyrB. ..
  32. Sooranna S, Engineer N, Loudon J, Terzidou V, Bennett P, Johnson M. The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1{beta}. J Clin Endocrinol Metab. 2005;90:3517-27 pubmed
    ..We found no evidence of a synergistic effect of IL-1beta and stretch on myometrial expression of PGHS-2 and IL-8 mRNA. ..
  33. Welch H, Condliffe A, Milne L, Ferguson G, Hill K, Webb L, et al. P-Rex1 regulates neutrophil function. Curr Biol. 2005;15:1867-73 pubmed
    ..In conclusion, P-Rex1 is an important regulator of neutrophil function by mediating a subset of Rac-dependent neutrophil responses. However, P-Rex1 is not an essential regulator of neutrophil chemotaxis and degranulation. ..
  34. Hale B, Jackson D, Chen Y, Lamb R, Randall R. Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci U S A. 2006;103:14194-9 pubmed
    ..These data suggest that activation of PI3K signaling in influenza A virus-infected cells is important for efficient virus replication. ..
  35. Johnson T, Antrobus R, Johnson L. Plk1 activation by Ste20-like kinase (Slk) phosphorylation and polo-box phosphopeptide binding assayed with the substrate translationally controlled tumor protein (TCTP). Biochemistry. 2008;47:3688-96 pubmed publisher
    ..Knowledge of kinase regulatory mechanisms and the structures of the Plk1 individual domains has allowed for a model to be proposed for these activatory events. ..
  36. Sales K, Grant V, Jabbour H. Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element. Mol Cell Endocrinol. 2008;285:51-61 pubmed publisher
    ..These data indicate that PGE(2) and PGF(2alpha) biosynthesized locally within endometrial adenocarcinomas can regulate tumor cell function in an autocrine/paracrine manner via the FP receptor. ..
  37. Komander D, Patel M, Laurin M, Fradet N, Pelletier A, Barford D, et al. An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling. Mol Biol Cell. 2008;19:4837-51 pubmed publisher
    ..Significantly, although this does not affect DOCK180 GEF activity toward Rac in vivo, Rac signaling is impaired, implying additional roles for ELMO in mediating intracellular Rac signaling. ..
  38. Fan H, Zhang X, McNaughton P. Activation of the TRPV4 ion channel is enhanced by phosphorylation. J Biol Chem. 2009;284:27884-91 pubmed publisher
  39. Schilling T, Eder C. Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation. Cell Immunol. 2010;265:87-90 pubmed publisher
    ..Since ROS regulate caspase-1 activity in LPC-stimulated microglia, the effects of lipid raft-disrupting agents on caspase-1 activation can be related to their inhibition of NADPH oxidase-mediated ROS production. ..
  40. Wingler A, Delatte T, O Hara L, Primavesi L, Jhurreea D, Paul M, et al. Trehalose 6-phosphate is required for the onset of leaf senescence associated with high carbon availability. Plant Physiol. 2012;158:1241-51 pubmed publisher
    ..Transfer of plants to and from glucose-containing medium suggested that glucose determines senescence during late development but that the effects of T6P on senescence are established by the sugar response of young plants. ..
  41. Zilio N, Williamson C, Eustermann S, Shah R, West S, Neuhaus D, et al. DNA-dependent SUMO modification of PARP-1. DNA Repair (Amst). 2013;12:761-73 pubmed publisher
    ..Our results suggest that PARP-1's alternative modes of DNA recognition serve as a means to differentiate between distinct aspects of the enzyme's function. ..
  42. Deegan T, Diffley J. MCM: one ring to rule them all. Curr Opin Struct Biol. 2016;37:145-51 pubmed publisher
    ..Here, we review recent progress in this area. ..
  43. MacKenzie M, Jordan S, Budd P, Jackson I. Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo. Dev Biol. 1997;192:99-107 pubmed
    ..Our data do not describe a dependence upon Kit for melanoblast migration or differentiation. ..
  44. Chang W, Di Capite J, Singaravelu K, Nelson C, Halse V, Parekh A. Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. J Biol Chem. 2008;283:4622-31 pubmed
  45. Carnicer R, Hale A, Suffredini S, Liu X, Reilly S, Zhang M, et al. Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation. Circ Res. 2012;111:718-27 pubmed publisher
    ..Our findings suggest that GCH1 may be a valuable target for the treatment of LV diastolic dysfunction. ..
  46. Katso R, Russell R, Ganesan T. Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family. Mol Cell Biol. 1999;19:6427-40 pubmed
    ..Homology modelling of the catalytic domain of H-Ryk provides a rationale for these findings. Thus, the signalling properties of H-Ryk are divergent from those of other classical receptor tyrosine kinases. ..
  47. Dalziel M, Whitehouse C, McFarlane I, Brockhausen I, Gschmeissner S, Schwientek T, et al. The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. J Biol Chem. 2001;276:11007-15 pubmed
    ..Thus, even when C2GnT1 is expressed, the O-glycans added to MUC1 become core 1-dominated structures, provided expression of ST3Gal-I is increased as it is in breast cancer. ..
  48. Venien Bryan C, Lowe E, Boisset N, Traxler K, Johnson L, Carlson G. Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b. Structure. 2002;10:33-41 pubmed
    ..The PhK/GPb model provides an explanation for the formation of hybrid GPab intermediates in the PhK-catalyzed phosphorylation of GPb. ..
  49. Gilmour P, Rahman I, Donaldson K, MacNee W. Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am J Physiol Lung Cell Mol Physiol. 2003;284:L533-40 pubmed
    ..Acetylation of H4 mediated by PM(10) was associated with the promoter region of the IL-8 gene. These data suggest that remodeling of chromatin by histone acetylation plays a role in PM(10)-mediated responses in the lungs. ..
  50. Imokawa Y, Brockes J. Selective activation of thrombin is a critical determinant for vertebrate lens regeneration. Curr Biol. 2003;13:877-81 pubmed
    ..Our results indicate that selective activation of thrombin is the pivotal signal linking tissue injury to the initiation of vertebrate regeneration...
  51. Jones A, Lamle S, Pershad H, Vincent K, Albracht S, Armstrong F. Enzyme electrokinetics: electrochemical studies of the anaerobic interconversions between active and inactive states of Allochromatium vinosum [NiFe]-hydrogenase. J Am Chem Soc. 2003;125:8505-14 pubmed
    ..Activation is favored by a large positive entropy, consistent with the release of a ligand and/or relaxation of the structure around the active site. ..
  52. Boushaba R, Kumpalume P, Slater N. Kinetics of whole serum and prepurified IgG digestion by pepsin for F(ab')2 manufacture. Biotechnol Prog. 2003;19:1176-82 pubmed
  53. Lawrence C, Botting C, Antrobus R, Coote P. Evidence of a new role for the high-osmolarity glycerol mitogen-activated protein kinase pathway in yeast: regulating adaptation to citric acid stress. Mol Cell Biol. 2004;24:3307-23 pubmed
    ..Supporting this, Mdh1p and Idh1p, both TCA cycle enzymes, were up-regulated in response to citric acid. ..
  54. Cronshaw D, Owen C, Brown Z, Ward S. Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis. J Immunol. 2004;172:7761-70 pubmed
    ..These data demonstrate that although there is PI(3,4,5)P(3) accumulation downstream of CCR4, phosphoinositide 3-kinase activity is a dispensable signal for CCR4-stimulated chemotaxis of Th2 cells and the CEM T cell line. ..
  55. Ogunwobi O, Mutungi G, Beales I. Leptin stimulates proliferation and inhibits apoptosis in Barrett's esophageal adenocarcinoma cells by cyclooxygenase-2-dependent, prostaglandin-E2-mediated transactivation of the epidermal growth factor receptor and c-Jun NH2-terminal kinase activat. Endocrinology. 2006;147:4505-16 pubmed
    ..Subsequent PGE2-mediated transactivation of the epidermal growth factor receptor and JNK activation are essential to the leptin effects. These effects may contribute to the greatly increased risk of esophageal adenocarcinoma in obesity. ..
  56. Sansom O, Meniel V, Wilkins J, Cole A, Oien K, Marsh V, et al. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proc Natl Acad Sci U S A. 2006;103:14122-7 pubmed
    ..These data imply a window of opportunity for anti-K-ras therapies after tumor initiation in preventing tumor growth and invasion. ..
  57. Hauton D. Does long-term metformin treatment increase cardiac lipoprotein lipase?. Metabolism. 2011;60:32-42 pubmed publisher
    ..05) but not by high-dose metformin. These data suggest that AMPK activation increased cardiac endothelial LPL, yet acute and chronic activation of AMPK may yield increased LPL through differing mechanisms. ..
  58. Kong K, Butcher A, McWilliams P, Jones D, Wess J, Hamdan F, et al. M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A. 2010;107:21181-6 pubmed publisher
  59. Moore C, Omikorede O, Gomez E, Willars G, Herbert T. PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic ?-cells. Mol Endocrinol. 2011;25:315-26 pubmed publisher
  60. Meadows N, Saxty B, Albury M, Kettleborough C, Ashcroft F, Moore A, et al. A high-throughput assay for modulators of NNT activity in permeabilized yeast cells. J Biomol Screen. 2011;16:734-43 pubmed publisher
    ..The identification of NNT activators may help in the elucidation of the role of NNT in mammalian cells and assessing its potential as a therapeutic target for insulin secretion disorders. ..
  61. Thaventhiran J, Hoffmann A, Magiera L, de la Roche M, Lingel H, Brunner Weinzierl M, et al. Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell. Proc Natl Acad Sci U S A. 2012;109:E2223-9 pubmed publisher
    ..The CTLA-4/Hippo pathway/Blimp-1 system may couple terminal differentiation of CD8(+) T cell with the magnitude of clonal expansion. ..
  62. Chaikuad A, Alfano I, Kerr G, Sanvitale C, Boergermann J, Triffitt J, et al. Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva. J Biol Chem. 2012;287:36990-8 pubmed publisher
    ..The presented ALK2 structure offers a valuable template for the further design of specific inhibitors of BMP signaling. ..
  63. Tedaldi L, Pierce M, Wagner G. Optimised chemical synthesis of 5-substituted UDP-sugars and their evaluation as glycosyltransferase inhibitors. Carbohydr Res. 2012;364:22-7 pubmed publisher
  64. Pye D, Rubio I, Pusch R, Lin K, Pettitt A, Till K. Chemokine unresponsiveness of chronic lymphocytic leukemia cells results from impaired endosomal recycling of Rap1 and is associated with a distinctive type of immunological anergy. J Immunol. 2013;191:1496-504 pubmed publisher
  65. Moore T, Garg R, Johnson C, Coptcoat M, Ridley A, Morris J. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. J Biol Chem. 2000;275:4311-22 pubmed
    ..PSK is the first member of the STE20 family lacking a Cdc42/Rac binding domain that has been shown to regulate both the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and the actin cytoskeleton. ..
  66. Boyle K, Gyori D, Sindrilaru A, Scharffetter Kochanek K, Taylor P, Mócsai A, et al. Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011;186:2978-89 pubmed publisher
    ..These results start to define the signaling network controlling neutrophil ROS responses to A. fumigatus hyphae. ..
  67. Thoms H, Dunlop M, Stark L. p38-mediated inactivation of cyclin D1/cyclin-dependent kinase 4 stimulates nucleolar translocation of RelA and apoptosis in colorectal cancer cells. Cancer Res. 2007;67:1660-9 pubmed
    ..These novel findings have considerable relevance to the rational design of novel chemotherapeutic and chemopreventative strategies. ..
  68. Jacquet S, Nishino Y, Kumphune S, Sicard P, Clark J, Kobayashi K, et al. The role of RIP2 in p38 MAPK activation in the stressed heart. J Biol Chem. 2008;283:11964-71 pubmed publisher
    ..Although RIP2 can cause myocardial p38 MAPK dual phosphorylation in the heart under some circumstances, it is not responsible for the SB203580-sensitive pattern of activation during ischemia. ..
  69. Hall B, Bot C, Wilkinson S. Nifurtimox activation by trypanosomal type I nitroreductases generates cytotoxic nitrile metabolites. J Biol Chem. 2011;286:13088-95 pubmed publisher
    ..These experiments indicate that the basis for the selectivity of nifurtimox against T. brucei lies in the expression of a parasite-encoded type I nitroreductase. ..
  70. Bate C, Williams A. Neurodegeneration induced by clustering of sialylated glycosylphosphatidylinositols of prion proteins. J Biol Chem. 2012;287:7935-44 pubmed publisher
  71. Clerk A, Fuller S, Michael A, Sugden P. Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses. J Biol Chem. 1998;273:7228-34 pubmed
    ..These data are consistent with a role for reactive oxygen species in the activation of SR-MAPKs during ischemia/reperfusion. ..
  72. Lahne M, Gale J. Damage-induced activation of ERK1/2 in cochlear supporting cells is a hair cell death-promoting signal that depends on extracellular ATP and calcium. J Neurosci. 2008;28:4918-28 pubmed publisher
    ..Thus, activation of ERK1/2 in cochlear supporting cells in vitro is a common damage signaling mechanism that acts to promote hair cell death, indicating a direct role for supporting cells in regulating hair cell death. ..
  73. Codina A, Love J, Li Y, Lazar M, Neuhaus D, Schwabe J. Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proc Natl Acad Sci U S A. 2005;102:6009-14 pubmed
    ..Importantly, one surface-exposed lysine is required for activation of HDAC3, but not for interaction. This lysine may play a uniquely important role in the mechanism of activating HDAC3. ..
  74. Herbert S, Ponnambalam S, Walker J. Cytosolic phospholipase A2-alpha mediates endothelial cell proliferation and is inactivated by association with the Golgi apparatus. Mol Biol Cell. 2005;16:3800-9 pubmed
    ..Thus, cPLA2alpha activity and function in controlling endothelial cell proliferation is regulated by reversible association with the Golgi apparatus. ..
  75. Morgan L, Neame S, Child H, Chung R, Shah B, Barden L, et al. Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system. Neurosci Lett. 2006;395:143-8 pubmed
    ..Our procedures enable analysis of JNK pathway signalling in a CNS model and, also, should be applicable to that of other protein phosphorylation events in vivo. ..
  76. Chang C, Dietrich J, Harpur A, Lindquist J, Haude A, Loke Y, et al. Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J Immunol. 1999;163:4651-4 pubmed
    ..In addition, we identify KAP10 as being able to bind the adapter protein Grb2. Based on our data, we suggest that this molecule is involved in stimulation and costimulation in cells of both myeloid and lymphoid origin. ..
  77. Baillie J, Sahlender D, Sinclair J. Human cytomegalovirus infection inhibits tumor necrosis factor alpha (TNF-alpha) signaling by targeting the 55-kilodalton TNF-alpha receptor. J Virol. 2003;77:7007-16 pubmed
  78. Jeffery L, Wood A, Qureshi O, Hou T, Gardner D, Briggs Z, et al. Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J Immunol. 2012;189:5155-64 pubmed publisher
    ..These data indicate that the level of free 25(OH)D(3) available to DCs determines the inflammatory/regulatory balance of ensuing T cell responses. ..
  79. Guo C, Piacentini L. Type I collagen-induced MMP-2 activation coincides with up-regulation of membrane type 1-matrix metalloproteinase and TIMP-2 in cardiac fibroblasts. J Biol Chem. 2003;278:46699-708 pubmed
    ..These results suggest that the migration and invasion of cardiac fibroblasts is furin-dependent and that the active species of MT1-MMP and MMP-2 may be involved in both events. ..
  80. Jeyapalan J, Mendez Bermudez A, Zaffaroni N, Dubrova Y, Royle N. Evidence for alternative lengthening of telomeres in liposarcomas in the absence of ALT-associated PML bodies. Int J Cancer. 2008;122:2414-21 pubmed publisher
    ..This has major implications for the use of cancer treatments targeted at TMMs. ..
  81. Ning K, Miller L, Laidlaw H, Watterson K, Gallagher J, Sutherland C, et al. Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels. J Biol Chem. 2009;284:9331-40 pubmed publisher
    ..These results demonstrate a significant role for PTEN in leptin signal transmission and identify GSK3 as a potential important signaling node contributing to divergent outputs for these hormones. ..
  82. Waugh C, Sinclair L, Finlay D, Bayascas J, Cantrell D. Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation. Mol Cell Biol. 2009;29:5952-62 pubmed publisher
    ..Low levels of PKB activity can be sufficient for T-cell proliferation but insufficient to initiate the migratory program of effector T cells. ..
  83. Bunney T, Harris R, Gandarillas N, Josephs M, Roe S, Sorli S, et al. Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell. 2006;21:495-507 pubmed
    ..Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity. ..
  84. Li J, Taylor I, Lloyd J, Clapperton J, Howell S, Macmillan D, et al. Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions. J Biol Chem. 2008;283:36019-30 pubmed publisher
  85. Chiloeches A, Paterson H, Marais R, Clerk A, Marshall C, Sugden P. Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras. J Biol Chem. 1999;274:19762-70 pubmed
    ..We conclude that PKC- and Gi-dependent mechanisms mediate the activation of Ras in myocytes and that Ras activation is required for stimulation of extracellular signal-regulated kinase by PMA. ..
  86. Chaudhri B, Del Monte F, Hajjar R, Harding S. Interaction between increased SERCA2a activity and beta -adrenoceptor stimulation in adult rabbit myocytes. Am J Physiol Heart Circ Physiol. 2002;283:H2450-7 pubmed
    ..We find no evidence for Ca(2+) overload induced by SERCA2a overexpression alone or in combination with catecholamines. ..
  87. Lau K, McLoughlin D, Standen C, Miller C. X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains. Mol Cell Neurosci. 2000;16:557-65 pubmed
    ..These results suggest that the X11 regulation of APP processing is controlled, at least in part, via their interactions with APP and presenilin-1. ..
  88. Wolthers K, Scrutton N. Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation. Biochemistry. 2007;46:6696-709 pubmed
    ..The structural and functional consequences of complex formation are discussed in light of the known crystal structure of human activation domain and the inferred conformational heterogeneity of the multidomain MSR-MS complex. ..
  89. Endicott J, Noble M, Johnson L. The structural basis for control of eukaryotic protein kinases. Annu Rev Biochem. 2012;81:587-613 pubmed publisher
    ..Mechanisms for kinase activation through phosphorylation, additional domains or subunits, by scaffolding proteins and by kinase dimerization are discussed. ..
  90. Unsworth A, Flora G, Sasikumar P, Bye A, Sage T, Kriek N, et al. RXR Ligands Negatively Regulate Thrombosis and Hemostasis. Arterioscler Thromb Vasc Biol. 2017;37:812-822 pubmed publisher
    ..This mechanism may offer a possible explanation for the cardioprotective effects described in vivo after treatment with RXR ligands. ..
  91. Burgoyne J, Prysyazhna O, Rudyk O, Eaton P. cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control. Hypertension. 2012;60:1301-8 pubmed publisher
    ..Consequently, cGMP depletion sensitizes PKG to oxidation; this happens to a lesser extent in aortas than in mesenteries, because the conduit vessels generate more NO and express more peroxiredoxin. ..
  92. Ben Smith A, Dove S, Martin A, Wakelam M, Savage C. Antineutrophil cytoplasm autoantibodies from patients with systemic vasculitis activate neutrophils through distinct signaling cascades: comparison with conventional Fcgamma receptor ligation. Blood. 2001;98:1448-55 pubmed
    ..These results demonstrate that though ligation of FcgammaRIIa and FcgammaRIIIb may be necessary, it is likely that ANCAs require other membrane cofactors for neutrophil activation. ..