Experts and Doctors on enterobactin in United States


Locale: United States
Topic: enterobactin

Top Publications

  1. Naka H, López C, Crosa J. Reactivation of the vanchrobactin siderophore system of Vibrio anguillarum by removal of a chromosomal insertion sequence originated in plasmid pJM1 encoding the anguibactin siderophore system. Environ Microbiol. 2008;10:265-77 pubmed
    ..Our results underscore the importance of the anguibactin system in the survival of V. anguillarum 775 under conditions of iron limitation. ..
  2. Christoffersen C, Brickman T, Hook Barnard I, McIntosh M. Regulatory architecture of the iron-regulated fepD-ybdA bidirectional promoter region in Escherichia coli. J Bacteriol. 2001;183:2059-70 pubmed
  3. Naikare H, Butcher J, Flint A, Xu J, Raymond K, Stintzi A. Campylobacter jejuni ferric-enterobactin receptor CfrA is TonB3 dependent and mediates iron acquisition from structurally different catechol siderophores. Metallomics. 2013;5:988-96 pubmed publisher
    ..These results further highlight the importance of iron transport for efficient C. jejuni colonization...
  4. Ma L, Payne S. AhpC is required for optimal production of enterobactin by Escherichia coli. J Bacteriol. 2012;194:6748-57 pubmed publisher
    ..These data suggested that AhpC affected the activity of EntC or the availability of the chorismate substrate...
  5. Devireddy L, Hart D, Goetz D, Green M. A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell. 2010;141:1006-17 pubmed publisher
    ..Siderophore-depleted mammalian cells and zebrafish embryos fail to synthesize heme, an iron-dependent mitochondrial process. Our results reveal features of intracellular iron homeostasis that are conserved from bacteria through humans. ..
  6. Drake E, Nicolai D, Gulick A. Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction with the EntE adenylation domain. Chem Biol. 2006;13:409-19 pubmed
    ..Mutational studies on EntE support our previous hypothesis that members of the adenylate-forming family of enzymes adopt two distinct conformations to catalyze the two-step reactions. ..
  7. Flo T, Smith K, Sato S, Rodriguez D, Holmes M, Strong R, et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature. 2004;432:917-21 pubmed
    ..Our finding represents a new component of the innate immune system and the acute phase response to infection. ..
  8. Barnard T, Watson M, McIntosh M. Mutations in the Escherichia coli receptor FepA reveal residues involved in ligand binding and transport. Mol Microbiol. 2001;41:527-36 pubmed
    ..A third region formed a cluster near the barrel wall around positions 75 and 126 of the plug. These mutations provide initial insight into the mechanisms of ligand binding and transport through the FepA receptor. ..
  9. Shea C, McIntosh M. Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli. Mol Microbiol. 1991;5:1415-28 pubmed
    ..In addition, the transcriptional organization of these genes was examined and primer extension analysis identified a single iron-regulated bidirectional promoter between the P43 gene and the fepDGC operon. ..

More Information


  1. Hantash F, Earhart C. Membrane association of the Escherichia coli enterobactin synthase proteins EntB/G, EntE, and EntF. J Bacteriol. 2000;182:1768-73 pubmed
  2. Bearden S, Staggs T, Perry R. An ABC transporter system of Yersinia pestis allows utilization of chelated iron by Escherichia coli SAB11. J Bacteriol. 1998;180:1135-47 pubmed
    ..The approximately 21-kDa protein encoded by the separately transcribed yfeE gene may be located in the cell envelope, since a yfeE::TnphoA fusion is PhoA+. Mutations in this gene abrogate growth of SAB11 on iron-chelated media...
  3. Wyckoff E, Stoebner J, Reed K, Payne S. Cloning of a Vibrio cholerae vibriobactin gene cluster: identification of genes required for early steps in siderophore biosynthesis. J Bacteriol. 1997;179:7055-62 pubmed
    ..cholerae strain with a chromosomal mutation in vibA was constructed by marker exchange. This strain was unable to produce vibriobactin or DHBA, confirming that in V. cholerae VibA catalyzes an early step in vibriobactin biosynthesis...
  4. Hunt M, Pettis G, McIntosh M. Promoter and operator determinants for fur-mediated iron regulation in the bidirectional fepA-fes control region of the Escherichia coli enterobactin gene system. J Bacteriol. 1994;176:3944-55 pubmed
    ..These observations suggest a mechanism of Fur-mediated regulation in this compact control region that may involve other regulatory components. ..
  5. Elkins M, Earhart C. Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB. J Bacteriol. 1989;171:5443-51 pubmed
    ..Processing of proFepB remains unclear, but the appearance of the three smaller members of the FepB family required the action of leader peptidase and the presence of the entire fepB gene. ..
  6. Staab J, Elkins M, Earhart C. Nucleotide sequence of the Escherichia coli entE gene. FEMS Microbiol Lett. 1989;50:15-9 pubmed
    ..33. Genetic evidence combined with this and previous sequencing data indicate that the genes entCEB(G)A are transcribed as unit from a promoter upstream of entC. ..
  7. Wyckoff E, Valle A, Smith S, Payne S. A multifunctional ATP-binding cassette transporter system from Vibrio cholerae transports vibriobactin and enterobactin. J Bacteriol. 1999;181:7588-96 pubmed
    ..These mutations reduced, but did not completely eliminate, vibriobactin utilization. This suggests that V. cholerae contains genes in addition to viuPDGC that function in the transport of catechol siderophores...
  8. Bearden S, Fetherston J, Perry R. Genetic organization of the yersiniabactin biosynthetic region and construction of avirulent mutants in Yersinia pestis. Infect Immun. 1997;65:1659-68 pubmed
    ..Finally, Y. pestis strains with mutations in either the psn or irp2 gene were avirulent in mice when inoculated subcutaneously...
  9. Sundlov J, Garringer J, Carney J, Reger A, Drake E, Duax W, et al. Determination of the crystal structure of EntA, a 2,3-dihydro-2,3-dihydroxybenzoic acid dehydrogenase from Escherichia coli. Acta Crystallogr D Biol Crystallogr. 2006;62:734-40 pubmed
    ..Analysis of the structure in light of recent structural and bioinformatic analysis of other members of the SCOR family provides insight into the residues involved in cofactor and substrate binding. ..
  10. Coderre P, Earhart C. The entD gene of the Escherichia coli K12 enterobactin gene cluster. J Gen Microbiol. 1989;135:3043-55 pubmed
    ..The data are also consistent with previous evidence that the entD product is unstable. ..
  11. Wyckoff E, Payne S. The Vibrio cholerae VctPDGC system transports catechol siderophores and a siderophore-free iron ligand. Mol Microbiol. 2011;81:1446-58 pubmed publisher
    ..We also show that VctPDGC is the previously unidentified siderophore-independent iron transporter in V. cholerae, and this appears to complete the list of iron transport systems in V. cholerae...