Experts and Doctors on endothelial cells in United States

Summary

Locale: United States
Topic: endothelial cells

Top Publications

  1. Razandi M, Pedram A, Merchenthaler I, Greene G, Levin E. Plasma membrane estrogen receptors exist and functions as dimers. Mol Endocrinol. 2004;18:2854-65 pubmed
    ..In summary, endogenous membrane ERs exist as dimers, a structural requirement that supports rapid signal transduction and affects cell physiology. ..
  2. Jiang Z, Nuttall A, Zhao H, Dai C, Guan B, Si J, et al. Electrical coupling and release of K+ from endothelial cells co-mediate ACh-induced smooth muscle hyperpolarization in guinea-pig inner ear artery. J Physiol. 2005;564:475-87 pubmed
    ..The role ratio of K(ir) and pump current activation is at 8 : 1 or less. ..
  3. Kaiser V, Sifri Z, Dikdan G, Berezina T, Zaets S, Lu Q, et al. Trauma-hemorrhagic shock mesenteric lymph from rat contains a modified form of albumin that is implicated in endothelial cell toxicity. Shock. 2005;23:417-25 pubmed
    ..Further investigations are needed to determine the type of RSA modification and the identity of the lipid factors and their role in MODS...
  4. Lominadze D, Roberts A, Tyagi N, Moshal K, Tyagi S. Homocysteine causes cerebrovascular leakage in mice. Am J Physiol Heart Circ Physiol. 2006;290:H1206-13 pubmed
    ..Treatment with a broad-range MMP inhibitor (GM-6001; 1 microM) ameliorated Hcy-induced F-actin formation. These data suggest that Hcy increases microvascular permeability, in part, through MMP-9 activation. ..
  5. Parry T, Brosius R, Thyagarajan R, Carter D, Argentieri D, Falotico R, et al. Drug-eluting stents: sirolimus and paclitaxel differentially affect cultured cells and injured arteries. Eur J Pharmacol. 2005;524:19-29 pubmed
    ..These results suggest that sirolimus reduces neointimal hyperplasia through a cytostatic mechanism while paclitaxel produces apoptotic cell death. ..
  6. Dabo S, Confer A, Saliki J, Anderson B. Binding of Bartonella henselae to extracellular molecules: identification of potential adhesins. Microb Pathog. 2006;41:10-20 pubmed
    ..Taken together, the above data suggest that interactions between B. henselae and ECM molecules such as Fn may play an important role in the bacterium adherence to and invasion of host cells. ..
  7. Abrahamson D, St John P, Isom K, Robert B, Miner J. Partial rescue of glomerular laminin alpha5 mutations by wild-type endothelia produce hybrid glomeruli. J Am Soc Nephrol. 2007;18:2285-93 pubmed
  8. Jones C, Han Z, Presley T, Varadharaj S, Zweier J, Ilangovan G, et al. Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite. Am J Physiol Cell Physiol. 2008;295:C180-91 pubmed publisher
    ..Hence, the hyperoxia of in vitro EC flow studies, via increased NO and mitochondrial O(2)(*-) production, leads to enhanced ONOO(-) formation intramitochondrially and suppression of respiration. ..
  9. Lin Z, Natesan V, Shi H, Dong F, Kawanami D, Mahabeleshwar G, et al. Kruppel-like factor 2 regulates endothelial barrier function. Arterioscler Thromb Vasc Biol. 2010;30:1952-9 pubmed publisher
    ..These observations identify KLF2 as a novel transcriptional regulator of vascular barrier function. ..

More Information

Publications450 found, 100 shown here

  1. Pascal T, Abrol R, Mittal R, Wang Y, Prasadarao N, Goddard W. Experimental validation of the predicted binding site of Escherichia coli K1 outer membrane protein A to human brain microvascular endothelial cells: identification of critical mutations that prevent E. coli meningitis. J Biol Chem. 2010;285:37753-61 pubmed publisher
    ..These studies suggest that inhibition of the interactions of these residues of Loop 1, 2, and 4 with Ecgp96 could provide a therapeutic strategy to prevent neonatal meningitis due to E. coli K1. ..
  2. Taylor M, Lee Y, Schiemann W. Role of TGF-β and the tumor microenvironment during mammary tumorigenesis. Gene Expr. 2011;15:117-32 pubmed
    ..Here we highlight recent findings demonstrating the essential function of tumor microenvironments in regulating the oncogenic activities of TGF-beta and its stimulation of metastatic progression during mammary tumorigenesis. ..
  3. McCarthy R, Kosman D. Mechanistic analysis of iron accumulation by endothelial cells of the BBB. Biometals. 2012;25:665-75 pubmed publisher
    ..These results are the first to demonstrate multiple mechanism(s) of TBI and NTBI reduction and uptake by endothelial cells (EC) of the BBB. ..
  4. Han S, Han S, Toborek M, Hennig B. EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes. Toxicol Appl Pharmacol. 2012;261:181-8 pubmed publisher
    ..These data suggest that EGCG can inhibit AhR regulated genes and induce Nrf2-regulated antioxidant enzymes, thus providing protection against PCB-induced inflammatory responses in endothelial cells. ..
  5. Lathia J, Li M, Hall P, Gallagher J, Hale J, Wu Q, et al. Laminin alpha 2 enables glioblastoma stem cell growth. Ann Neurol. 2012;72:766-78 pubmed publisher
  6. Golden J, McCormick T, Ward N. IL-17 in psoriasis: implications for therapy and cardiovascular co-morbidities. Cytokine. 2013;62:195-201 pubmed publisher
  7. Bateman H, Liang Q, Fan D, Rodriguez V, Lessner S. Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells. PLoS ONE. 2013;8:e70500 pubmed publisher
    ..Overall, SsnB caused a significant reduction in angiogenesis (ANOVA, p<0.05), demonstrating its ex vivo efficacy. ..
  8. Li X, Padhan N, Sjöström E, Roche F, Testini C, Honkura N, et al. VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nat Commun. 2016;7:11017 pubmed publisher
    ..Blocking VEGFA-induced disassembly of endothelial junctions, thereby suppressing tumour oedema and metastatic spread, may be preferable to full vascular suppression in the treatment of certain cancer forms. ..
  9. Liu S, Premont R, Singh S, Rockey D. Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells. Am J Pathol. 2017;187:896-907 pubmed publisher
    ..This process takes place in injured, but not in normal, SECs. ..
  10. Volk Draper L, Hall K, Wilber A, Ran S. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. PLoS ONE. 2017;12:e0179257 pubmed publisher
    ..This information can be further exploited for research and therapeutic purposes. ..
  11. Rose P, Carroll J, Carroll P, Defilippis V, Lagunoff M, Moses A, et al. The insulin receptor is essential for virus-induced tumorigenesis of Kaposi's sarcoma. Oncogene. 2007;26:1995-2005 pubmed
    ..Similarly, treatment with the IR-specific small-molecule inhibitor HNMPA-(AM(3)) inhibited postconfluent growth. These data suggest a role for the IR, but not the IGF-IR, in KSHV-induced transformation of vascular ECs. ..
  12. Tang L, Luo B, Patel R, Ling Y, Zhang J, Fallon M. Modulation of pulmonary endothelial endothelin B receptor expression and signaling: implications for experimental hepatopulmonary syndrome. Am J Physiol Lung Cell Mol Physiol. 2007;292:L1467-72 pubmed
    ..These findings support that increased pulmonary microvascular endothelial ET(B) receptor expression modulates ET-1-mediated eNOS activation, independent of Akt, and contributes to the development of HPS. ..
  13. Roberts C, Rivera B, Grzybowski D, Mahmoud A, Weber P. Effect of low fluence diode laser irradiation on the hydraulic conductivity of perfused trabecular meshwork endothelial cell monolayers. Curr Eye Res. 2007;32:625-38 pubmed
  14. Behling Kelly E, Kim K, Czuprynski C. Haemophilus somnus activation of brain endothelial cells: potential role for local cytokine production and thrombosis in central nervous system (CNS) infection. Thromb Haemost. 2007;98:823-30 pubmed
    ..These changes would be expected to promote thrombus formation in vessels of the CNS, and potentially contribute to the pathogenesis of TME...
  15. Kang I, Panneerselvam D, Panoskaltsis V, Eppell S, Marchant R, Doerschuk C. Changes in the hyperelastic properties of endothelial cells induced by tumor necrosis factor-alpha. Biophys J. 2008;94:3273-85 pubmed publisher
    ..These changes can be modeled as changes in a chain network structure within the ECs. ..
  16. Gao C, Ho C, Reineke E, Lam M, Cheng X, Stanya K, et al. Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation. Mol Cell Biol. 2008;28:5658-67 pubmed publisher
    ..Importantly, HDAC7 knockdown inhibits tumor necrosis factor alpha-induced PML sumoylation and the formation of PML NBs in HUVECs. These results demonstrate a novel function of HDAC7 and provide a regulatory mechanism of PML sumoylation...
  17. Liu X, Strable M, Ntambi J. Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv Nutr. 2011;2:15-22 pubmed publisher
    ..Thus, normal cellular function requires the expression of SCD1 to be tightly controlled. This review summarizes the current understanding of the role of SCD1 in modulating inflammation and stress. ..
  18. Hileman C, Wohl D, Tisch D, Debanne S, McComsey G. Short communication: initiation of an abacavir-containing regimen in HIV-infected adults is associated with a smaller decrease in inflammation and endothelial activation markers compared to non-abacavir-containing regimens. AIDS Res Hum Retroviruses. 2012;28:1561-4 pubmed publisher
    ..When taken with an NNRTI, abacavir induced a smaller decrease in inflammation biomarkers in this cohort, suggesting a possible proinflammatory effect of this nucleoside analogue. ..
  19. He X, Dziak R, Yuan X, Mao K, Genco R, Swihart M, et al. BMP2 genetically engineered MSCs and EPCs promote vascularized bone regeneration in rat critical-sized calvarial bone defects. PLoS ONE. 2013;8:e60473 pubmed publisher
    ..This system could ultimately enable clinicians to better reconstruct the craniofacial bone and avoid donor site morbidity for CSBDs. ..
  20. Schilling W, Snyder D, Sinkins W, Estacion M. Palytoxin-induced cell death cascade in bovine aortic endothelial cells. Am J Physiol Cell Physiol. 2006;291:C657-67 pubmed
    ..These results demonstrate that PTX initiates a cell death cascade characteristic of Ca(2+) overload. ..
  21. Dangaria J, Butler P. Macrorheology and adaptive microrheology of endothelial cells subjected to fluid shear stress. Am J Physiol Cell Physiol. 2007;293:C1568-75 pubmed
    ..Such studies provide insight into pathologies such as atherosclerosis, which may find their origins in EC mechanics. ..
  22. Feng W, McCabe N, Mahabeleshwar G, Somanath P, Phillips D, Byzova T. The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells. J Cell Biol. 2008;183:1145-57 pubmed publisher
    ..Thus, beta(3) integrin has the potential to control processes such as tumor growth and wound healing by regulating BMDC recruitment to sites undergoing pathological and adaptive angiogenesis. ..
  23. Coats S, To T, Jain S, Braham P, Darveau R. Porphyromonas gingivalis resistance to polymyxin B is determined by the lipid A 4'-phosphatase, PGN_0524. Int J Oral Sci. 2009;1:126-35 pubmed publisher
    ..These data strongly implicate PGN_0524 as a critical virulence factor for the ability of P. gingivalis to evade front-line host innate defenses that are dependent upon cationic antimicrobial peptide activity and TLR 4 sensing. ..
  24. Lu H, Huang D, Saederup N, Charo I, Ransohoff R, Zhou L. Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury. FASEB J. 2011;25:358-69 pubmed publisher
    ..Within injured muscle, these cells conduct phagocytosis, contribute to accumulation of intramuscular Ly-6C(-) macrophages, and produce a high level of IGF-I to promote muscle regeneration. ..
  25. West X, Malinin N, Merkulova A, Tischenko M, Kerr B, Borden E, et al. Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands. Nature. 2010;467:972-6 pubmed publisher
    ..Taken together, these findings establish a new function of TLR2 as a sensor of oxidation-associated molecular patterns, providing a key link connecting inflammation, oxidative stress, innate immunity and angiogenesis. ..
  26. Majkova Z, Layne J, Sunkara M, Morris A, Toborek M, Hennig B. Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. Toxicol Appl Pharmacol. 2011;251:41-9 pubmed publisher
    ..Our data implicate A?/J?-NPs as mediators of omega-3 fatty acid-mediated protection against the endothelial toxicity of coplanar PCBs. ..
  27. Walsh J, Young M. Interrelationship between protein phosphatase 1 and TGF-{beta} in regulating motility and cytoskeletal architecture of endothelial cells. Anticancer Res. 2010;30:4861-6 pubmed
    ..These studies suggest that the interplay between TGF-? and PP-1 regulates the motility of endothelial cells that is critical to the process of angiogenesis. ..
  28. LaMarca B, Wallace K, Herse F, Wallukat G, Martin J, Weimer A, et al. Hypertension in response to placental ischemia during pregnancy: role of B lymphocytes. Hypertension. 2011;57:865-71 pubmed publisher
    ..These data demonstrate the important roles that B-lymphocyte activation and agonistic autoantibodies to the angiotensin II type I receptors play in the pathophysiology of hypertension in response to placental ischemia. ..
  29. Zhu X, Urbieta Caceres V, Krier J, Textor S, Lerman A, Lerman L. Mesenchymal stem cells and endothelial progenitor cells decrease renal injury in experimental swine renal artery stenosis through different mechanisms. Stem Cells. 2013;31:117-25 pubmed publisher
    ..These results support development of cell-based approaches for management of renovascular disease and suggest cell selection based on the underlying pathophysiology of kidney injury...
  30. Petriello M, Han S, Newsome B, Hennig B. PCB 126 toxicity is modulated by cross-talk between caveolae and Nrf2 signaling. Toxicol Appl Pharmacol. 2014;277:192-9 pubmed publisher
    ..These data demonstrate novel cross-talk mechanisms between Cav-1 and Nrf2 and implicate the reduction of Cav-1 as a protective mechanism for PCB-induced cellular dysfunction and inflammation. ..
  31. Agarwal A, Munoz Najar U, Klueh U, Shih S, Claffey K. N-acetyl-cysteine promotes angiostatin production and vascular collapse in an orthotopic model of breast cancer. Am J Pathol. 2004;164:1683-96 pubmed
    ..These results suggest that systemic NAC therapy promotes anti-angiogenesis through angiostatin production, resulting in endothelial apoptosis and vascular collapse in the tumor. ..
  32. Burns M, DePaola N. Flow-conditioned HUVECs support clustered leukocyte adhesion by coexpressing ICAM-1 and E-selectin. Am J Physiol Heart Circ Physiol. 2005;288:H194-204 pubmed
  33. Kuckleburg C, Tiwari R, Czuprynski C. Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species. Thromb Haemost. 2008;99:363-72 pubmed publisher
    ..These findings suggest that bacterial activation of platelets may contribute to endothelial cell dysfunction observed during sepsis, specifically by inducing endothelial cell apoptosis...
  34. Korda M, Kubant R, Patton S, Malinski T. Leptin-induced endothelial dysfunction in obesity. Am J Physiol Heart Circ Physiol. 2008;295:H1514-21 pubmed publisher
    ..Hyperleptinemia triggers an endothelial NO/ONOO(-) imbalance characteristic of dysfunctional endothelium observed in other vascular disorders, i.e., atherosclerosis and diabetes. ..
  35. Tyagi N, Moshal K, Sen U, Vacek T, Kumar M, Hughes W, et al. H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid Redox Signal. 2009;11:25-33 pubmed publisher
    ..In conclusion, the administration of H2S protected the cells from oxidative stress induced by hyperhomocysteinemia (HHcy), which suggested that NaHS/H2S may have therapeutic potential against Met-induced oxidative stress. ..
  36. Gu J, Manning R, Young E, Shparago M, Sartin B, Bailey A. Vascular endothelial growth factor receptor inhibitor enhances dietary salt-induced hypertension in Sprague-Dawley rats. Am J Physiol Regul Integr Comp Physiol. 2009;297:R142-8 pubmed publisher
    ..These results suggest that VEGF receptor inhibition enhances dietary salt-induced hypertension and kidney injury, possibly by direct damage on renal cells and decreasing NO production by eNOS. ..
  37. Song Y, Wang K, Chen D, Magness R, Zheng J. Suppression of protein phosphatase 2 differentially modulates VEGF- and FGF2-induced signaling in ovine fetoplacental artery endothelial cells. Placenta. 2009;30:907-13 pubmed publisher
    ..These data also suggest that signaling molecules other than ERK1/2, AKT1, and p38 MAPK are important mediators for VEGF- and FGF2-stimulated OFPAE cell proliferation after PPP2CA suppression. ..
  38. Kaplan A, Joseph K. The bradykinin-forming cascade and its role in hereditary angioedema. Ann Allergy Asthma Immunol. 2010;104:193-204 pubmed publisher
    ..Inhibition of bradykinin formation by novel agentscan provide targeted therapeutic approaches that address the pathophysiologic abnormalities. ..
  39. Beauvais D, Rapraeger A. Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation. J Cell Sci. 2010;123:3796-807 pubmed publisher
  40. Wu T, Dai M, Shi X, Jiang Z, Nuttall A. Functional expression of P2X4 receptor in capillary endothelial cells of the cochlear spiral ligament and its role in regulating the capillary diameter. Am J Physiol Heart Circ Physiol. 2011;301:H69-78 pubmed publisher
    ..These findings support our hypothesis that extracellular ATP regulates cochlear lateral blood flow through P2X4 activation in ECs. ..
  41. Steg A, Katre A, Goodman B, Han H, Nick A, Stone R, et al. Targeting the notch ligand JAGGED1 in both tumor cells and stroma in ovarian cancer. Clin Cancer Res. 2011;17:5674-85 pubmed publisher
    ..Dual inhibition represents an attractive therapeutic strategy for ovarian and potentially other malignancies. ..
  42. Khaled S, Gupta K, Kucik D. Ionizing radiation increases adhesiveness of human aortic endothelial cells via a chemokine-dependent mechanism. Radiat Res. 2012;177:594-601 pubmed
    ..Therefore, radiation induces increased adhesiveness of aortic endothelial cells through chemokine-dependent signaling from endothelial cells to leukocytes, even in the absence of increased expression of the adhesion molecules involved. ..
  43. Man S, Tucky B, Cotleur A, Drazba J, Takeshita Y, Ransohoff R. CXCL12-induced monocyte-endothelial interactions promote lymphocyte transmigration across an in vitro blood-brain barrier. Sci Transl Med. 2012;4:119ra14 pubmed publisher
  44. Chandran P, Riviere J, Monteiro Riviere N. Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells. Nanotoxicology. 2017;11:507-519 pubmed publisher
  45. Gifford S, Grummer M, Pierre S, Austin J, Zheng J, Bird I. Functional characterization of HUVEC-CS: Ca2+ signaling, ERK 1/2 activation, mitogenesis and vasodilator production. J Endocrinol. 2004;182:485-99 pubmed
    ..In conclusion, HUVEC-CS are indeed endothelial cells and appear to be functionally very similar to primary HUVEC. These cells will prove a valuable tool for future studies in both basic and therapeutic sciences. ..
  46. Pal S, Wu J, Murray J, Gellman S, Wozniak M, Keely P, et al. An antiangiogenic neurokinin-B/thromboxane A2 regulatory axis. J Cell Biol. 2006;174:1047-58 pubmed
    ..These results establish a conserved mechanism in which NK-B instigates multiple activities that collectively oppose vascular remodeling. ..
  47. Peltz A, Sherwani S, Kotha S, Mazerik J, O Connor Butler E, Kuppusamy M, et al. Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells. Int J Toxicol. 2009;28:190-206 pubmed publisher
  48. Bogatcheva N, Zemskova M, Kovalenkov Y, Poirier C, Verin A. Molecular mechanisms mediating protective effect of cAMP on lipopolysaccharide (LPS)-induced human lung microvascular endothelial cells (HLMVEC) hyperpermeability. J Cell Physiol. 2009;221:750-9 pubmed publisher
    ..Our data indicate that while PKA-dependent VASP phosphorylation contributes to the protective effect of cAMP elicited on LPS-compromised monolayers, filamin1 phosphorylation is unlikely to play a significant role in this process. ..
  49. Shao R, Hamel K, Petersen L, Cao Q, Arenas R, Bigelow C, et al. YKL-40, a secreted glycoprotein, promotes tumor angiogenesis. Oncogene. 2009;28:4456-68 pubmed publisher
    ..These findings provide novel insights into angiogenic activities and molecular mechanisms of YKL-40 in cancer development. ..
  50. Koo B, Coe D, Dixon L, Somerville R, Nelson C, Wang L, et al. ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Am J Pathol. 2010;176:1494-504 pubmed publisher
    ..Taken together, these data identify ADAMTS9 as a novel, constitutive, endogenous angiogenesis inhibitor that operates cell-autonomously in ECs via molecular mechanisms that are distinct from those used by ADAMTS1. ..
  51. Lindner H, Zhang A, Eldridge J, Demcheva M, Tsichlis P, Tsichilis P, et al. Anti-bacterial effects of poly-N-acetyl-glucosamine nanofibers in cutaneous wound healing: requirement for Akt1. PLoS ONE. 2011;6:e18996 pubmed publisher
    ..Moreover, these findings support the use of sNAG nanofibers as a novel method for enhancing wound closure while simultaneously decreasing wound infection. ..
  52. Bagher P, Davis M, Segal S. Visualizing calcium responses to acetylcholine convection along endothelium of arteriolar networks in Cx40BAC-GCaMP2 transgenic mice. Am J Physiol Heart Circ Physiol. 2011;301:H794-802 pubmed publisher
  53. Wong V, Crawford J. Vasculogenic cytokines in wound healing. Biomed Res Int. 2013;2013:190486 pubmed publisher
    ..This paper will highlight major cytokines involved in vasculogenesis within the context of cutaneous wound healing. ..
  54. Mendoza F, Piera Velazquez S, Farber J, Feghali Bostwick C, Jimenez S. Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis-Associated Interstitial Lung Disease. Arthritis Rheumatol. 2016;68:210-7 pubmed publisher
    ..Collectively, these observations demonstrate the occurrence of EndoMT in the lungs of patients with SSc-associated ILD. ..
  55. Bryant A, Carrick R, McConaha M, Jones B, Shay S, Moore C, et al. Endothelial HIF signaling regulates pulmonary fibrosis-associated pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2016;310:L249-62 pubmed publisher
    ..As such, HIF and HIF-regulated targets represent a therapeutic target in these conditions. ..
  56. Son S, Moroney G, Butler P. ?1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent. Biophys J. 2017;113:1080-1092 pubmed publisher
  57. Sumanasekera W, Zhao L, Ivanova M, Morgan D, Noisin E, Keynton R, et al. Effect of estradiol and dihydrotestosterone on hypergravity-induced MAPK signaling and occludin expression in human umbilical vein endothelial cells. Cell Tissue Res. 2006;324:243-53 pubmed
  58. Seldin M, Meng Y, Qi H, Zhu W, Wang Z, Hazen S, et al. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. J Am Heart Assoc. 2016;5: pubmed publisher
    ..Our results suggest a likely contributory mechanism for TMAO-dependent enhancement in atherosclerosis and cardiovascular risks. ..
  59. McAllister S, Hansen S, Ruhl R, Raggo C, DeFilippis V, Greenspan D, et al. Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells. Blood. 2004;103:3465-73 pubmed
    ..Treatment with the HO-1 inhibitor chromium mesoporphyrin IX abolished heme-induced proliferation. These data suggest that HO-1 is a potential therapeutic target for KS that warrants further study. ..
  60. Holland S, Powell M, Franci C, Chan E, Friera A, Atchison R, et al. Multiple roles for the receptor tyrosine kinase axl in tumor formation. Cancer Res. 2005;65:9294-303 pubmed
    ..Disruption of Axl signaling using a small-molecule inhibitor will hence simultaneously affect both the tumor and stromal cell compartments and thus represents a unique approach for cancer therapeutic development. ..
  61. Das A, Fernandez Zapico M, Cao S, Yao J, Fiorucci S, Hebbel R, et al. Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration. J Biol Chem. 2006;281:39105-13 pubmed
    ..Thus, together, these studies identify a mechanism for antagonizing Sp/KLF protein repression function via SHP, with this process regulating endothelial cell motility. ..
  62. Sithu S, English W, Olson P, Krubasik D, Baker A, Murphy G, et al. Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration. J Biol Chem. 2007;282:25010-9 pubmed
    ..MT1-MMP localization with cells expressing ICAM-1 mutations was reduced and diffused. These results indicate that the cytoplasmic tail of ICAM-1 regulates leukocyte transmigration through MT1-MMP interaction. ..
  63. Shen H, Oesterling E, Stromberg A, Toborek M, MacDonald R, Hennig B. Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling. J Am Coll Nutr. 2008;27:577-87 pubmed
    ..These studies suggest that zinc nutrition can markedly modulate mechanisms of the pathology of inflammatory diseases such as atherosclerosis. ..
  64. Kim S, von Recum H. Endothelial progenitor populations in differentiating embryonic stem cells I: Identification and differentiation kinetics. Tissue Eng Part A. 2009;15:3709-18 pubmed publisher
    ..Our findings show the differentiation kinetics of the various EC promoters and how different endothelial promoters can be used to select distinct subpopulations of ECs and endothelial precursors across a spectrum of differentiation. ..
  65. Yi F, Boeldt D, Gifford S, Sullivan J, Grummer M, Magness R, et al. Pregnancy enhances sustained Ca2+ bursts and endothelial nitric oxide synthase activation in ovine uterine artery endothelial cells through increased connexin 43 function. Biol Reprod. 2010;82:66-75 pubmed publisher
  66. Vartanian K, Berny M, McCarty O, Hanson S, Hinds M. Cytoskeletal structure regulates endothelial cell immunogenicity independent of fluid shear stress. Am J Physiol Cell Physiol. 2010;298:C333-41 pubmed publisher
    ..Therefore, the cellular elongation and cytoskeletal alignment of MPECs regulated immunogenic gene expression and functions and may act synergistically with FSS to create an EC surface with reduced inflammatory capability. ..
  67. Go Y, Zhang J, Timoney P, Cook R, Horohov D, Balasuriya U. Complex interactions between the major and minor envelope proteins of equine arteritis virus determine its tropism for equine CD3+ T lymphocytes and CD14+ monocytes. J Virol. 2010;84:4898-911 pubmed publisher
    ..This study shows, for the first time, that CD3(+) T lymphocytes may play an important role in the pathogenesis of equine viral arteritis when horses are infected with the virulent strains of EAV. ..
  68. Chiou S, Hodges A, Hoa N. Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury. J Pharmacol Exp Ther. 2010;334:693-702 pubmed publisher
  69. Rice L, Pampo C, Lepler S, Rojiani A, Siemann D. Support of a free radical mechanism for enhanced antitumor efficacy of the microtubule disruptor OXi4503. Microvasc Res. 2011;81:44-51 pubmed publisher
    ..These findings indicate that while the predominant in vivo effect of OXi4503 is clearly due to microtubule collapse and vascular shut-down, the formation of toxic free radicals likely contributes to its enhanced potency...
  70. Shaw J, Xiang L, Shah A, Yin W, Lloyd P. Placenta growth factor expression is regulated by hydrogen peroxide in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2011;300:C349-55 pubmed publisher
    ..To our knowledge, this is the first study to describe H(2)O(2) as a regulator of PLGF expression and therefore an upstream mediator of PLGF-driven arteriogenesis. ..
  71. Tateya S, Rizzo N, Handa P, Cheng A, Morgan Stevenson V, Daum G, et al. Endothelial NO/cGMP/VASP signaling attenuates Kupffer cell activation and hepatic insulin resistance induced by high-fat feeding. Diabetes. 2011;60:2792-801 pubmed publisher
    ..Our findings also identify the NO/VASP pathway as a novel potential target for the treatment of obesity-associated liver insulin resistance. ..
  72. Hall K, Volk Draper L, Flister M, Ran S. New model of macrophage acquisition of the lymphatic endothelial phenotype. PLoS ONE. 2012;7:e31794 pubmed publisher
    ..As such, this model can provide a valuable tool for understanding the LECP and lymphatic biology. ..
  73. Cheng X, Liu Y, Chu H, Kao H. Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor ? (TNF?) and interferon ? (IFN?). J Biol Chem. 2012;287:23356-67 pubmed publisher
    ..Taken together, our data provide novel mechanistic insights that PML functions as a negative regulator in EC network formation and migration. ..
  74. Scully S, Francescone R, Faibish M, Bentley B, Taylor S, Oh D, et al. Transdifferentiation of glioblastoma stem-like cells into mural cells drives vasculogenic mimicry in glioblastomas. J Neurosci. 2012;32:12950-60 pubmed publisher
  75. Artiushin S, Timoney J, Nally J, Verma A. Host-inducible immunogenic sphingomyelinase-like protein, Lk73.5, of Leptospira interrogans. Infect Immun. 2004;72:742-9 pubmed
    ..The host-inducible immunogenic Lk73.5 should have value in distinguishing vaccine from infection immune response...
  76. Han M, Pendem S, Teh S, Sukumaran D, Wu F, Wilson J. Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A. Free Radic Biol Med. 2010;48:128-35 pubmed publisher
  77. Kruser T, Wheeler D, Armstrong E, Iida M, Kozak K, van der Kogel A, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res. 2010;16:3639-47 pubmed publisher
    ..These findings suggest that clinical investigations examining combinations of radiation and motesanib are warranted in HNSCC. ..
  78. Porter A, Klinge C, Gobin A. Biomimetic hydrogels with VEGF induce angiogenic processes in both hUVEC and hMEC. Biomacromolecules. 2011;12:242-6 pubmed publisher
    ..Our data suggest that our biomimetic system is equally effective in stimulating proliferation, migration, and survival of apoptosis in hMEC as compared to the response to hUVEC. ..
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