Experts and Doctors on endosomes in United States

Summary

Locale: United States
Topic: endosomes

Top Publications

  1. Aikawa Y, Lynch K, Boswell K, Martin T. A second SNARE role for exocytic SNAP25 in endosome fusion. Mol Biol Cell. 2006;17:2113-24 pubmed
    ..Our results indicate that SNAP25 has a second function as an endosomal Q-SNARE in trafficking from the sorting endosome to the recycling endosome and that BoNT E has effects linked to disruption of the endosome recycling pathway. ..
  2. Cervantes J, Weinerman B, Basole C, Salazar J. TLR8: the forgotten relative revindicated. Cell Mol Immunol. 2012;9:434-8 pubmed publisher
    ..The functions of TLR8 extend beyond the recognition of foreign pathogens and include cross-talk with other endosomal TLRs, a process that may also have a role in the generation of autoimmunity. ..
  3. Aikawa Y, Martin T. ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis. J Cell Biol. 2003;162:647-59 pubmed
    ..We conclude that ARF6 plays a role in Ca2+-dependent DCV exocytosis by regulating the activity of PIP5K for the synthesis of an essential plasma membrane pool of PIP2. ..
  4. Deschamps A, Yarbrough W, Squires C, Allen R, McClister D, Dowdy K, et al. Trafficking of the membrane type-1 matrix metalloproteinase in ischemia and reperfusion: relation to interstitial membrane type-1 matrix metalloproteinase activity. Circulation. 2005;111:1166-74 pubmed
    ..These unique results demonstrate that a specific MMP type, MT1-MMP, is increased in abundance and activity with I/R and is likely attributed, at least in part, to changes in intracellular trafficking. ..
  5. Bomberger J, Barnaby R, Stanton B. The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. J Biol Chem. 2009;284:18778-89 pubmed publisher
    ..These studies demonstrate a novel function for USP10 in facilitating the deubiquitination of CFTR in early endosomes and thereby enhancing the endocytic recycling of CFTR. ..
  6. Tower Gilchrist C, Styers M, Yoder B, Berbari N, Sztul E. Monitoring endosomal trafficking of the g protein-coupled receptor somatostatin receptor 3. Methods Enzymol. 2014;534:261-80 pubmed publisher
  7. Frederick T, Chebukati J, Mair C, Goff P, Fanucci G. Bis(monoacylglycero)phosphate forms stable small lamellar vesicle structures: insights into vesicular body formation in endosomes. Biophys J. 2009;96:1847-55 pubmed publisher
  8. Duex J, Mullins M, Sorkin A. Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking. Exp Cell Res. 2010;316:2136-51 pubmed publisher
    ..Together, the data show that elevated levels of Uev1B protein in cells lead to decreased efficiency of endosomal sorting by associating with ubiquitinated proteins and Hrs. ..
  9. Frederick T, Goff P, Mair C, Farver R, Long J, Fanucci G. Effects of the endosomal lipid bis(monoacylglycero)phosphate on the thermotropic properties of DPPC: A 2H NMR and spin label EPR study. Chem Phys Lipids. 2010;163:703-11 pubmed publisher
    ..Additionally, the results demonstrate that BMP mixes with other phospholipids as a phospholipid and not as a detergent molecule as once speculated. ..

More Information

Publications197 found, 100 shown here

  1. Keith D, Sanderson J, Gibson E, Woolfrey K, Robertson H, Olszewski K, et al. Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms. J Neurosci. 2012;32:7119-36 pubmed publisher
    ..These findings emphasize the emerging importance of palmitoylation in controlling synaptic function and reveal novel roles for the AKAP79/150 signaling complex in dendritic endosomes. ..
  2. Saric A, Hipolito V, Kay J, Canton J, Antonescu C, Botelho R. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Mol Biol Cell. 2016;27:321-33 pubmed publisher
    ..Overall our work provides tantalizing evidence that mTOR plays a role in controlling lysosome morphology and trafficking by modulating microtubule-based motor activity in leukocytes. ..
  3. Kostenko O, Tsacoumangos A, Crooks D, Kil S, Carlin C. Gab1 signaling is regulated by EGF receptor sorting in early endosomes. Oncogene. 2006;25:6604-17 pubmed
    ..We conclude that 679-LL has dual functions in EGF receptor trafficking and threshold signaling through a subset of signaling molecules including p44/42 MAPK and Gab1. ..
  4. Anitei M, Pfeiffer S. Myelin biogenesis: sorting out protein trafficking. Curr Biol. 2006;16:R418-21 pubmed
    ..Recent studies indicate that soluble neuronal signals may control the surface expression of proteolipid protein, a process that involves reduced endocytosis and/or increased transport carrier recruitment from an intracellular pool. ..
  5. Robert S, Chary S, Drakakaki G, Li S, Yang Z, Raikhel N, et al. Endosidin1 defines a compartment involved in endocytosis of the brassinosteroid receptor BRI1 and the auxin transporters PIN2 and AUX1. Proc Natl Acad Sci U S A. 2008;105:8464-9 pubmed publisher
    ..No effect was detected in auxin signaling. Thus, PIN2, AUX1, and BRI1 use interactive pathways involving an early SYP61/VHA-a1 endosomal compartment. ..
  6. Goldman S, Krise J. Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo. J Biol Chem. 2010;285:4983-94 pubmed publisher
    ..Collectively, these results suggest that NPC1 and NPC2 can function independently of one another in the egress of certain membrane-impermeable lysosomal cargo. ..
  7. Methner D, Mayfield R. Ethanol alters endosomal recycling of human dopamine transporters. J Biol Chem. 2010;285:10310-7 pubmed publisher
    ..These results define a novel trafficking mechanism by which ethanol regulates DAT function. ..
  8. Lewis C, Cobb B. Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling. J Immunol. 2010;184:3789-800 pubmed publisher
  9. Gu Y, Innes R. The KEEP ON GOING protein of Arabidopsis recruits the ENHANCED DISEASE RESISTANCE1 protein to trans-Golgi network/early endosome vesicles. Plant Physiol. 2011;155:1827-38 pubmed publisher
    ..Collectively, these data suggest that EDR1 and KEG function together to regulate endocytic trafficking and/or the formation of signaling complexes on TGN/EE vesicles during stress responses. ..
  10. Shivanna V, Kim Y, Chang K. The crucial role of bile acids in the entry of porcine enteric calicivirus. Virology. 2014;456-457:268-78 pubmed publisher
    ..In summary, our results suggest that bile acids play a critical role in virus entry for successful replication. ..
  11. Howard T, Stauffer D, Degnin C, Hollenberg S. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. J Cell Sci. 2001;114:2395-404 pubmed
    ..These observations identify the conserved CHMP/Chmp family as a set of proteins fundamental to understanding multivesicular body sorting in eukaryotic organisms. ..
  12. Sharma D, Choudhury A, Singh R, Wheatley C, Marks D, Pagano R. Glycosphingolipids internalized via caveolar-related endocytosis rapidly merge with the clathrin pathway in early endosomes and form microdomains for recycling. J Biol Chem. 2003;278:7564-72 pubmed
  13. Jin L, Shie F, Maezawa I, Vincent I, Bird T. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. Am J Pathol. 2004;164:975-85 pubmed
    ..Our results suggest that endosomal abnormalities related to abnormal lipid trafficking in NPC may contribute to abnormal APP processing and Abeta42/C99/APP-CTF deposition. ..
  14. MacDonald C, Payne J, Aboian M, Smith W, Katzmann D, Piper R. A family of tetraspans organizes cargo for sorting into multivesicular bodies. Dev Cell. 2015;33:328-42 pubmed publisher
    ..Expression of these proteins increases during nutrient stress through an NAD(+)/Sir2-dependent mechanism that in turn accelerates the downregulation of a broad range of cell-surface proteins. ..
  15. Chen Y, Honeychurch K, Yang G, Byrd C, Harver C, Hruby D, et al. Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis. Virol J. 2009;6:44 pubmed publisher
    ..These results suggest that p37 localizes to the LE and interacts with proteins associated with LE-derived transport vesicle biogenesis to facilitate assembly of extracellular forms of virus...
  16. Mayers J, Fyfe I, Schuh A, Chapman E, Edwardson J, Audhya A. ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously. J Biol Chem. 2011;286:9636-45 pubmed publisher
    ..Based on these data, we present a revised model for ESCRT-0 function in cargo recruitment and concentration at the endosome. ..
  17. Carrithers L, Hulseberg P, Sandor M, Carrithers M. The human macrophage sodium channel NaV1.5 regulates mycobacteria processing through organelle polarization and localized calcium oscillations. FEMS Immunol Med Microbiol. 2011;63:319-27 pubmed publisher
    ..5 and mitochondrial-dependent calcium signaling regulate mycobacteria phagocytosis and phagosome maturation in human macrophages through spatial-temporal coordination of calcium signaling within a unique subcellular region. ..
  18. Eisenlohr L. Alternative generation of MHC class II-restricted epitopes: not so exceptional?. Mol Immunol. 2013;55:169-71 pubmed publisher
    ..The potential ramifications for this fundamentally altered view of MHCII peptide supply are discussed. ..
  19. Oomens A, Wertz G. The baculovirus GP64 protein mediates highly stable infectivity of a human respiratory syncytial virus lacking its homologous transmembrane glycoproteins. J Virol. 2004;78:124-35 pubmed
    ..These results demonstrate the potential of GP64 for both practical applications requiring stable pseudotypes in mammalian systems and for studies of viral glycoprotein requirements in assembly and pathogenesis. ..
  20. Baldys A, Raymond J. Role of c-Cbl carboxyl terminus in serotonin 5-HT2A receptor recycling and resensitization. J Biol Chem. 2011;286:24656-65 pubmed publisher
    ..Taken together, these studies have led to the discovery that the C-terminal region of c-Cbl plays a crucial role in the temporal and spatial control of 5-HT(2A)R recycling. ..
  21. Fischer A. Synchronized chaperone function of botulinum neurotoxin domains mediates light chain translocation into neurons. Curr Top Microbiol Immunol. 2013;364:115-37 pubmed publisher
    ..This article discusses the individual functions of each module as well as the mechanisms by which each domain serves as a chaperone for the others, working in concert to achieve productive intoxication. ..
  22. Malik R, Soh U, Trejo J, Marchese A. Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem. 2012;287:9013-27 pubmed publisher
    ..Thus, our study reveals a novel function for ubiquitin in the regulation of CXCR4 signaling, which may be broadly applicable to other G protein-coupled receptors. ..
  23. Singh D, Qi R, Jordan J, San Mateo L, Kao C. The human antimicrobial peptide LL-37, but not the mouse ortholog, mCRAMP, can stimulate signaling by poly(I:C) through a FPRL1-dependent pathway. J Biol Chem. 2013;288:8258-68 pubmed publisher
    ..These results show that LL-37 and mCRAMP have different activities in TLR3 signaling and that LL-37 can redirect trafficking of poly(I:C) to effect signaling by TLR3 in early endosomes in a mechanism that involves FPRL1. ..
  24. Hardwick J, Clason T, Tompkins J, Girard B, Baran C, Merriam L, et al. Recruitment of endosomal signaling mediates the forskolin modulation of guinea pig cardiac neuron excitability. Am J Physiol Cell Physiol. 2017;313:C219-C227 pubmed publisher
  25. Miranda M, Wu C, Sorkina T, Korstjens D, Sorkin A. Enhanced ubiquitylation and accelerated degradation of the dopamine transporter mediated by protein kinase C. J Biol Chem. 2005;280:35617-24 pubmed
    ..Altogether, these data suggest that PKC-induced DAT ubiquitylation may target DAT to lysosomal degradation. ..
  26. Herrera R, Morris M, Rosbe K, Feng Z, Weinberg A, Tugizov S. Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells. Virology. 2016;487:172-87 pubmed publisher
    ..The anti-HIV effect of combining hBD2 and hBD3 was substantially higher than that of the individual peptides. These findings advance our understanding of the mechanisms of anti-HIV resistance in adult oral epithelium. ..
  27. Jones B, Thomas L, Molloy S, Thulin C, Fry M, Walsh K, et al. Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. EMBO J. 1995;14:5869-83 pubmed
    ..Thus, routing of furin is a two-tiered process combining a set of trafficking signals comprised of the primary amino acid sequence of the tail with its phosphorylation state. ..
  28. Craven R, Mallory J, Hand R. Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51. J Biol Chem. 2007;282:36543-51 pubmed
  29. Ge L, Ly Y, Hollenberg M, DeFea K. A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J Biol Chem. 2003;278:34418-26 pubmed
  30. Eckhardt E, Cai L, Sun B, Webb N, van der Westhuyzen D. High density lipoprotein uptake by scavenger receptor SR-BII. J Biol Chem. 2004;279:14372-81 pubmed
    ..We conclude that SR-BII may influence cellular cholesterol trafficking and homeostasis in a manner that is distinct from SR-BI. ..
  31. Wen Y, Stavrou I, Bersuker K, Brady R, De Lozanne A, O Halloran T. AP180-mediated trafficking of Vamp7B limits homotypic fusion of Dictyostelium contractile vacuoles. Mol Biol Cell. 2009;20:4278-88 pubmed publisher
    ..Dictyostelium contractile vacuoles offer a valuable system to study clathrin-coated vesicles on internal organelles within eukaryotic cells. ..
  32. Rozema D, Ekena K, Lewis D, Loomis A, Wolff J. Endosomolysis by masking of a membrane-active agent (EMMA) for cytoplasmic release of macromolecules. Bioconjug Chem. 2003;14:51-7 pubmed
    ..This approach avoids cellular toxicity by restricting melittin's activity until it reaches the endosomal compartment. The utility of this approach was demonstrated by delivery phosphorodiamidate morpholino oligonucleotides (PMOs). ..
  33. Ge L, Shenoy S, Lefkowitz R, DeFea K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. J Biol Chem. 2004;279:55419-24 pubmed
  34. Jones B, Hinkle P. Subcellular trafficking of the TRH receptor: effect of phosphorylation. Mol Endocrinol. 2009;23:1466-78 pubmed publisher
  35. Canton J, Kima P. Interactions of pathogen-containing compartments with the secretory pathway. Cell Microbiol. 2012;14:1676-86 pubmed publisher
    ..Not unexpectedly, our understanding of the extent of these interactions is variable. An underlying theme that is brought to the fore is that PCCs establish preferential interactions with distinct compartments of the secretory pathway. ..
  36. Thomsen A, Plouffe B, Cahill T, Shukla A, Tarrasch J, Dosey A, et al. GPCR-G Protein-?-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. 2016;166:907-919 pubmed publisher
    ..The formation of such megaplexes provides a potential physical basis for the newly appreciated sustained G protein signaling from internalized GPCRs. ..
  37. Lackey C, Press O, Hoffman A, Stayton P. A biomimetic pH-responsive polymer directs endosomal release and intracellular delivery of an endocytosed antibody complex. Bioconjug Chem. 2002;13:996-1001 pubmed
    ..The striking enhancement of protein delivery to the cytoplasm by complexed PPAAc suggests that this polymer could provide a new delivery agent for therapeutic, vaccine, and diagnostics development. ..
  38. Olabisi O, Mahon G, Kostenko E, Liu Z, Ozer H, Whitehead I. Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. Cancer Res. 2006;66:6250-7 pubmed
    ..Taken together, these observations suggest that Bcr is a component of the mammalian ESCRT complexes and plays an important role in cellular trafficking of growth factor receptors. ..
  39. Yin X, Kidd G, Wrabetz L, Feltri M, Messing A, Trapp B. Schwann cell myelination requires timely and precise targeting of P(0) protein. J Cell Biol. 2000;148:1009-20 pubmed
    ..These results indicate that P(0) gene multiplication causes P(0) mistargeting to mesaxon membranes, and through obligate P(0) homophilic adhesion, renders these dynamic membranes inert and halts myelination. ..
  40. Gimelbrant A, Haley S, McClintock T. Olfactory receptor trafficking involves conserved regulatory steps. J Biol Chem. 2001;276:7285-90 pubmed
    ..These results also indicate that some components of the regulatory mechanism are conserved. ..
  41. May V, Lutz E, MacKenzie C, Schutz K, Dozark K, Braas K. Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. J Biol Chem. 2010;285:9749-61 pubmed publisher
    ..The partitioning of PACAP-mediated Akt signaling in endosomes may be a key mechanism contributing to the high spatial and temporal specificity in signal transduction necessary for survival pathways. ..
  42. Jarry T, Cheung A. Staphylococcus aureus escapes more efficiently from the phagosome of a cystic fibrosis bronchial epithelial cell line than from its normal counterpart. Infect Immun. 2006;74:2568-77 pubmed
    ..These results demonstrate a fundamental difference in the fate of live S. aureus after invasion of CFT-1 versus LCFSN cell lines and may explain the propensity of S. aureus to cause chronic lung infection in CF patients. ..
  43. Muresan Z, Muresan V. The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration. Mol Biol Cell. 2007;18:3835-44 pubmed
    ..We conclude that distinct pathways of APP phosphorylation operate in proliferating, differentiating, stressed, and degenerating neurons. ..
  44. Das S, Vasanji A, Pellett P. Three-dimensional structure of the human cytomegalovirus cytoplasmic virion assembly complex includes a reoriented secretory apparatus. J Virol. 2007;81:11861-9 pubmed
    ..Our model of AC structure suggests a mechanism by which the virus can regulate the order of tegument assembly. ..
  45. Galperin E, Abdelmoti L, Sorkin A. Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells. PLoS ONE. 2012;7:e36469 pubmed publisher
  46. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    ..Altogether, this study provides valuable insights into the mechanisms regulating cholesterol homeostasis and LDLR trafficking. ..
  47. Aikawa Y, Xia X, Martin T. SNAP25, but not syntaxin 1A, recycles via an ARF6-regulated pathway in neuroendocrine cells. Mol Biol Cell. 2006;17:711-22 pubmed
    ..Our results characterize a robust ARF6-dependent internalization mechanism that maintains an intracellular pool of SNAP25, which is compatible with possible intracellular roles for SNAP25 in neuroendocrine cells. ..
  48. Zeng X, Carlin C. Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells. J Virol. 2013;87:2307-19 pubmed publisher
    ..Many viruses have evolved mechanisms to induce autophagy in order to aid their own replication. Our studies reveal a novel role for host cell autophagy that could have a significant impact on the outcome of respiratory infections...
  49. Cho B, Fischer J. Ral inhibits ligand-independent Notch signaling in Drosophila. Small Gtpases. 2012;3:186-91 pubmed publisher
    ..In this Commentary, we discuss the phenomenon of ligand-independent Notch receptor activation and how this event might be regulated by Ral. ..
  50. Kolb A, Needham P, Rothenberg C, Guerriero C, Welling P, Brodsky J. ESCRT regulates surface expression of the Kir2.1 potassium channel. Mol Biol Cell. 2014;25:276-89 pubmed publisher
    ..ERAD and ESCRT also mediate Kir2.1 degradation in human cells, with ESCRT playing a more prominent role. Thus multiple proteolytic pathways control Kir2.1 levels at the plasma membrane. ..
  51. Duck K, Simpson I, Connor J. Regulatory mechanisms for iron transport across the blood-brain barrier. Biochem Biophys Res Commun. 2017;494:70-75 pubmed publisher
    ..Moreover, our data provide an explanation for the disparity in the ratio of Tf to iron transport into the brain that has confounded the field. ..
  52. Nothwehr S, Bruinsma P, Strawn L. Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment. Mol Biol Cell. 1999;10:875-90 pubmed
    ..These data suggest a model in which distinct structural features within Vps35p are required for associating with the cytosolic domains of each cargo protein during the retrieval process. ..
  53. Sugii S, Lin S, Ohgami N, Ohashi M, Chang C, Chang T. Roles of endogenously synthesized sterols in the endocytic pathway. J Biol Chem. 2006;281:23191-206 pubmed
    ..These results also supported the concept that endosomal motility plays an important role in controlling cholesterol trafficking activities. ..
  54. Aromolaran K, Benzow K, Cribbs L, Koob M, Piedras Rentería E. Kelch-like 1 protein upregulates T-type currents by an actin-F dependent increase in ?(1H) channels via the recycling endosome. Channels (Austin). 2009;3:402-12 pubmed
    ..Our findings afford insight on a novel mechanism of T-type channel modulation that could have overall functional implications for T-type channel function in the brain. ..
  55. Watanabe T, Sorensen E, Naito A, Schott M, Kim S, Ahlquist P. Involvement of host cellular multivesicular body functions in hepatitis B virus budding. Proc Natl Acad Sci U S A. 2007;104:10205-10 pubmed
    ..Moreover, HBV enveloped virions, enveloped subviral particles, and unenveloped nucleocapsids are all released by distinct pathways with separate host factor requirements. ..
  56. Zhu M, Ma J, Parrington J, Calcraft P, Galione A, Evans A. Calcium signaling via two-pore channels: local or global, that is the question. Am J Physiol Cell Physiol. 2010;298:C430-41 pubmed publisher
    ..This may call for a revision of current views on the mechanisms of intracellular calcium signaling. The purpose of this review is, therefore, to provide an appropriate framework for future studies in this area. ..
  57. Maier O, Marvin S, Wodrich H, Campbell E, Wiethoff C. Spatiotemporal dynamics of adenovirus membrane rupture and endosomal escape. J Virol. 2012;86:10821-8 pubmed publisher
    ..Thus, Ad5 membrane rupture and endosomal escape appear to be both spatially and temporally distinct events. ..
  58. Oner S, Vural A, Lanier S. Translocation of activator of G-protein signaling 3 to the Golgi apparatus in response to receptor activation and its effect on the trans-Golgi network. J Biol Chem. 2013;288:24091-103 pubmed publisher
    ..The regulated movement of AGS3 between the cell cortex and the GA offers unexpected mechanisms for modulating protein secretion and/or endosome recycling events at the trans-Golgi network. ..
  59. Moharir A, Peck S, Budden T, Lee S. The role of N-glycosylation in folding, trafficking, and functionality of lysosomal protein CLN5. PLoS ONE. 2013;8:e74299 pubmed publisher
    ..Our results suggest that there are functional differences in various N-glycosylation sites of CLN5 which affect folding, trafficking, and lysosomal function of CLN5. ..
  60. Anafu A, Bowen C, Chin C, Brass A, Holm G. Interferon-inducible transmembrane protein 3 (IFITM3) restricts reovirus cell entry. J Biol Chem. 2013;288:17261-71 pubmed publisher
    ..These data provide the first evidence that IFITM3 restricts infection by a nonenveloped virus and suggest that IFITM3 targets an increasing number of viruses through a shared requirement for endosomes during cell entry. ..
  61. Nothwehr S, Ha S, Bruinsma P. Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p. J Cell Biol. 2000;151:297-310 pubmed
    ..These data strongly support a model in which Vps35p acts as a "receptor" protein for recognition of the retrieval signal domains of cargo proteins during their recruitment into retrograde vesicles. ..
  62. Qu Y, Franchi L, Nunez G, Dubyak G. Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol. 2007;179:1913-25 pubmed
    ..Our findings suggest an alternative model of IL-1 beta release that may involve the P2X7R-induced formation of multivesicular bodies that contain exosomes with entrapped IL-1 beta, caspase-1, and other inflammasome components. ..
  63. Shah A, Cianciola N, Mills J, SONNICHSEN F, Carlin C. Adenovirus RIDalpha regulates endosome maturation by mimicking GTP-Rab7. J Cell Biol. 2007;179:965-80 pubmed
    ..We conclude that RIDalpha coordinates recruitment of these GTP-Rab7 effectors to compartments that would ordinarily be perceived as early endosomes, thereby promoting the degradation of selected cargo. ..
  64. Rush J, Ceresa B. RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms. Mol Cell Endocrinol. 2013;381:188-97 pubmed publisher
    ..These two proteins regulate EGFR slow, perinuclear recycling, via distinct mechanism and are new molecular targets that regulate cell surface EGFR expression. ..
  65. Selyunin A, Iles L, Bartholomeusz G, Mukhopadhyay S. Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking. J Cell Biol. 2017;216:3249-3262 pubmed publisher
    ..These results provide new information about STx2 trafficking mechanisms and may advance efforts to generate therapeutically viable toxin-trafficking inhibitors. ..
  66. Idkowiak Baldys J, Baldys A, Raymond J, Hannun Y. Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. J Biol Chem. 2009;284:22322-31 pubmed publisher
    ..Taken together, these results demonstrate a novel role for sustained receptor stimulation in regulation of intracellular trafficking, and this process requires sustained stimulation of PKC and PLD. ..
  67. Ben Nissan G, Yang Y, Lee J. Partitioning of casein kinase 1-like 6 to late endosome-like vesicles. Protoplasma. 2010;240:45-56 pubmed publisher
  68. Bartee E, Eyster C, Viswanathan K, Mansouri M, Donaldson J, Fruh K. Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. PLoS ONE. 2010;5:e15132 pubmed publisher
    ..Our data thus suggest a role of MARCH-VIII and MARCH-IV in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins. ..
  69. Takahashi M, Frost C, Oyadomari K, Pinho M, Sao D, Chima Okereke O, et al. A novel immunodetection screen for vacuolar defects identifies a unique allele of VPS35 in S. cerevisiae. Mol Cell Biochem. 2008;311:121-36 pubmed publisher
    ..Our results indicate that ENV genes may define new gene functions at the late endosome to vacuole interface. ..
  70. Lowther K, Nikolaev V, Mehlmann L. Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest. Reproduction. 2011;141:737-47 pubmed publisher
  71. Finnigan G, Cronan G, Park H, Srinivasan S, Quiocho F, Stevens T. Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p. J Biol Chem. 2012;287:19487-500 pubmed publisher
    ..These data define a novel sorting signal that is both necessary and sufficient for trafficking of the V-ATPase within the Golgi/endosomal network. ..
  72. Zhao N, Gao J, Enns C, Knutson M. ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin. J Biol Chem. 2010;285:32141-50 pubmed publisher
    ..These results suggest that endosomal ZIP14 participates in the cellular assimilation of iron from transferrin, thus identifying a potentially new role for ZIP14 in iron metabolism. ..
  73. Smith J, Xiong S, Markesbery W, Lovell M. Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain. Neuroscience. 2006;140:879-88 pubmed
    ..05) increased in hippocampus/parahippocampal gyrus of early Alzheimer's disease and Alzheimer's disease subjects. Zn transporter-6 is also increased (P<0.1) in the superior and middle temporal gyrus of Alzheimer's disease brain. ..
  74. Pacheco Quinto J, Eckman E. Endothelin-converting enzymes degrade intracellular ?-amyloid produced within the endosomal/lysosomal pathway and autophagosomes. J Biol Chem. 2013;288:5606-15 pubmed publisher
    ..This study highlights the existence of A? clearance mechanisms by ECEs at intracellular sites of production. Alterations in ECE activity may be considered as a cause for increased intraneuronal A? in Alzheimer disease. ..
  75. Xie L, O Reilly C, Chapes S, Mora S. Adiponectin and leptin are secreted through distinct trafficking pathways in adipocytes. Biochim Biophys Acta. 2008;1782:99-108 pubmed publisher
    ..Taken together, these results suggest that leptin and adiponectin secretion involve distinct intracellular compartments and that endosomal compartments are required for adiponectin but not for leptin secretion. ..
  76. Nothwehr S, Hindes A. The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi. J Cell Sci. 1997;110 ( Pt 9):1063-72 pubmed
    ..These results support a model in which Vps5p is required for retrieval of membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus. ..
  77. Mansouri M, Bartee E, Gouveia K, Hovey Nerenberg B, Barrett J, Thomas L, et al. The PHD/LAP-domain protein M153R of myxomavirus is a ubiquitin ligase that induces the rapid internalization and lysosomal destruction of CD4. J Virol. 2003;77:1427-40 pubmed
    ..Since a similar mechanism was recently proposed for KSHV K5, it seems that members of the unrelated families of gamma-2 herpesviruses and poxviruses share a common immune evasion mechanism that targets host cell immune receptors. ..
  78. Sehgal P. Paradigm shifts in the cell biology of STAT signaling. Semin Cell Dev Biol. 2008;19:329-40 pubmed publisher
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