Experts and Doctors on endosomes in Australia


Locale: Australia
Topic: endosomes

Top Publications

  1. Redpath G, Sophocleous R, Turnbull L, Whitchurch C, Cooper S. Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins. Traffic. 2016;17:245-66 pubmed publisher
    ..Thus, type-I and type-II ferlins segregate as PM/late-endosomal or trans-Golgi/recycling ferlins, consistent with different ferlins mediating vesicle fusion events in specific subcellular locations. ..
  2. Bhat P, Anderson D. Hepatitis B virus translocates across a trophoblastic barrier. J Virol. 2007;81:7200-7 pubmed
    ..This study suggests a mechanism by which mother-infant transmission may occur. ..
  3. Kerr M, Lindsay M, Luetterforst R, Hamilton N, Simpson F, Parton R, et al. Visualisation of macropinosome maturation by the recruitment of sorting nexins. J Cell Sci. 2006;119:3967-80 pubmed
    ..Collectively these findings provide a detailed real-time characterisation of the maturation process of the macropinocytic endosome. ..
  4. Vajjhala P, Catchpoole E, Nguyen C, Kistler C, Munn A. Vps4 regulates a subset of protein interactions at the multivesicular endosome. FEBS J. 2007;274:1894-907 pubmed
    ..Our studies indicate that the MIT domain has a dual role in substrate binding and recruitment to endosomes and indicate that Vps4 disassembles the MVB sorting machinery by direct effects on multiple proteins. ..
  5. Manderson A, Kay J, Hammond L, Brown D, Stow J. Subcompartments of the macrophage recycling endosome direct the differential secretion of IL-6 and TNFalpha. J Cell Biol. 2007;178:57-69 pubmed
    ..Therefore, the recycling endosome has a central role in orchestrating the differential secretion of cytokines during inflammation. ..
  6. Vajjhala P, Nguyen C, Landsberg M, Kistler C, Gan A, King G, et al. The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases. FEBS J. 2008;275:1427-49 pubmed publisher
    ..We propose that Vps4 SRH function requires an intact C-terminal helix. Co-evolution of a distinct Vps4 SRH and C-terminal helix in meiotic clade AAA ATPases supports this possibility. ..
  7. Desclozeaux M, Venturato J, Wylie F, Kay J, Joseph S, Le H, et al. Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis. Am J Physiol Cell Physiol. 2008;295:C545-56 pubmed publisher
    ..This final effect demonstrated an early and critical interdependence of Rab11 and the RE for E-cadherin targeting, apical membrane formation, and cell polarity in cysts. ..
  8. Beaumont K, Hamilton N, Moores M, Brown D, Ohbayashi N, Cairncross O, et al. The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking. Traffic. 2011;12:627-43 pubmed publisher
    ..Our findings reveal new functions for RE and Rab17 in pigmentation through a distal step in the process of melanosome release via filopodia. ..
  9. Ghai R, Bugarcic A, Liu H, Norwood S, Skeldal S, Coulson E, et al. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013;110:E643-52 pubmed publisher

More Information


  1. Shewan A, McCann R, Lamb C, Stirrat L, Kioumourtzoglou D, Adamson I, et al. Endosomal sorting of GLUT4 and Gap1 is conserved between yeast and insulin-sensitive cells. J Cell Sci. 2013;126:1576-82 pubmed publisher
    ..These findings demonstrate that the trafficking signals and their cognate molecular regulatory machinery that mediate regulated exocytosis of membrane proteins are conserved across evolution. ..
  2. Evans T, Ferguson C, Wainwright B, Parton R, Wicking C. Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic. 2003;4:869-84 pubmed
  3. Al Ejeh F, Croucher D, Ranson M. Kinetic analysis of plasminogen activator inhibitor type-2: urokinase complex formation and subsequent internalisation by carcinoma cell lines. Exp Cell Res. 2004;297:259-71 pubmed
    ..PAI-2 was subsequently degraded, presumably within lysosomes. This study is the first to provide definitive evidence for uPA/uPAR-mediated PAI-2 endocytosis. ..
  4. Wolf S, Huynh T, Bryce N, Hambley T, Wakelin L, Stewart B, et al. Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells. BMC Cell Biol. 2011;12:36 pubmed publisher
    ..Taking the evidence as a whole, suggests that endosomal vesicle trafficking influences the toxicity of AS-DACA in RMS cells. ..
  5. Bonham K, Orzalli M, Hayashi K, Wolf A, Glanemann C, Weninger W, et al. A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell. 2014;156:705-16 pubmed publisher
    ..These data establish how promiscuity, rather than specificity, can be a beneficial means of diversifying the subcellular sites of innate immune signal transduction. ..
  6. Chan A, Clairfeuille T, Landao Bassonga E, Kinna G, Ng P, Loo L, et al. Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth. Mol Biol Cell. 2016;27:1367-82 pubmed publisher
    ..Taken together, our data support a critical role for SNX27-retromer mediated transport of PTHR in normal bone development. ..