Experts and Doctors on endonucleases in Italy


Locale: Italy
Topic: endonucleases

Top Publications

  1. Damia G, Imperatori L, Stefanini M, D INCALCI M. Sensitivity of CHO mutant cell lines with specific defects in nucleotide excision repair to different anti-cancer agents. Int J Cancer. 1996;66:779-83 pubmed
    ..These data emphasize the importance of the CHO mutant cell lines with specific defects in the DNA repair system for investigating the mechanism of action of different anti-cancer agents. ..
  2. Toffalorio F, Giovannetti E, De Pas T, Radice D, Pelosi G, Manzotti M, et al. Expression of gemcitabine- and cisplatin-related genes in non-small-cell lung cancer. Pharmacogenomics J. 2010;10:180-90 pubmed publisher
    ..These data suggest a similar genetic susceptibility to gemcitabine-cisplatin regimens for squamous cell and adenocarcinoma and support the use of both lymph node and primary tumor for the expression profiling of NSCLC. ..
  3. Monica V, Longo M, Felice B, Scagliotti G, Papotti M, Novello S. Role of hormone receptor expression in patients with advanced-stage lung cancer treated with chemotherapy. Clin Lung Cancer. 2012;13:416-23 pubmed publisher
  4. Metro G, Zheng Z, Fabi A, Schell M, Antoniani B, Mottolese M, et al. In situ protein expression of RRM1, ERCC1, and BRCA1 in metastatic breast cancer patients treated with gemcitabine-based chemotherapy. Cancer Invest. 2010;28:172-80 pubmed publisher
    ..They were significantly associated with each other (Spearman's rho > or = .36; p < or = .007). Given their pattern of distribution, RRM1 and BRCA1 are potentially suitable markers for clinical decision making in MBC. ..
  5. Iglesias R, Citores L, Ragucci S, Russo R, Di Maro A, Ferreras J. Biological and antipathogenic activities of ribosome-inactivating proteins from Phytolacca dioica L. Biochim Biophys Acta. 2016;1860:1256-64 pubmed publisher
    ..Furthermore, the induction of cell death by different mechanisms turns these RIPs into more useful tools for cancer treatment rendering the selection of RIP-resistant mutants impossible. ..
  6. Szakal B, Branzei D. Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover. EMBO J. 2013;32:1155-67 pubmed publisher
  7. Ganzinelli M, Mariani P, Cattaneo D, Fossati R, Fruscio R, Corso S, et al. Expression of DNA repair genes in ovarian cancer samples: biological and clinical considerations. Eur J Cancer. 2011;47:1086-94 pubmed publisher
    ..The expression of DNA repair genes differed in borderline stage I, stage I and stage III ovarian carcinomas. The role of DNA repair genes in predicting the response in ovarian cancer patients seems far from being established. ..
  8. Zava S, Milani S, Sottocornola E, Berra B, Colombo I. Two active and differently N-glycosylated isoforms of human ST3Gal-V are produced from the placental mRNA variant by a leaky scanning mechanism. FEBS Lett. 2010;584:1476-80 pubmed publisher
    ..Produced by a leaky scanning mechanism, they carry different N-glycan structures and exhibit differences in their GM(3) synthase activity that might be relevant for the modulation of GM(3) cellular content. ..
  9. Manfrini N, Guerini I, Citterio A, Lucchini G, Longhese M. Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases. J Biol Chem. 2010;285:11628-37 pubmed publisher
    ..Furthermore, the helicase Sgs1 and the nucleases Exo1 and Dna2 participate in lengthening the 5'-3' resection tracts during meiosis by controlling a step subsequent to Spo11 removal. ..

More Information


  1. Doksani Y, Bermejo R, Fiorani S, Haber J, Foiani M. Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell. 2009;137:247-58 pubmed publisher
    ..Our findings have implications for those genome instability syndromes that accumulate DNA breaks during S phase and for forks encountering eroding telomeres. ..
  2. Ceppi P, Longo M, Volante M, Novello S, Cappia S, Bacillo E, et al. Excision repair cross complementing-1 and topoisomerase IIalpha gene expression in small-cell lung cancer patients treated with platinum and etoposide: a retrospective study. J Thorac Oncol. 2008;3:583-9 pubmed publisher
    ..ERCC1 and TopoIIalpha are candidate markers in predicting clinical outcome and response to treatment in LD SCLC patients and are worth of further investigation in a prospective study. ..
  3. Cartagena Lirola H, Guerini I, Manfrini N, Lucchini G, Longhese M. Role of the Saccharomyces cerevisiae Rad53 checkpoint kinase in signaling double-strand breaks during the meiotic cell cycle. Mol Cell Biol. 2008;28:4480-93 pubmed publisher
  4. Cartagena Lirola H, Guerini I, Viscardi V, Lucchini G, Longhese M. Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis. Cell Cycle. 2006;5:1549-59 pubmed
    ..Thus, checkpoint-mediated phosphorylation of Sae2 is important to support its meiotic recombination functions. ..
  5. Viscardi V, Baroni E, Romano M, Lucchini G, Longhese M. Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae. Mol Biol Cell. 2003;14:3126-43 pubmed
    ..These data suggest that sudden telomere lengthening elicits a checkpoint response that inhibits the G2/M transition. ..
  6. Sabatino M, Marabese M, Ganzinelli M, Caiola E, Geroni C, Broggini M. Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells. Mol Cancer. 2010;9:259 pubmed publisher
    ..In addition, the mechanism of resistance reported opens up the possibility of reverting the resistant phenotype using combinations with demethylating agents, molecules already employed in the clinical setting. ..
  7. Robert T, Vanoli F, Chiolo I, Shubassi G, Bernstein K, Rothstein R, et al. HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature. 2011;471:74-79 pubmed publisher
    ..We propose that Rpd3, Hda1 and Gcn5 control chromosome stability by coordinating the ATR checkpoint and double-strand-break processing with autophagy. ..
  8. Ruzzo A, Graziano F, Loupakis F, Rulli E, Canestrari E, Santini D, et al. Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy. J Clin Oncol. 2007;25:1247-54 pubmed
    ..A pharmacogenetic approach may be an innovative strategy for optimizing palliative chemotherapy in patients with advanced colorectal cancer. These findings deserve confirmation in additional prospective studies. ..