Experts and Doctors on drosophila proteins in United States

Summary

Locale: United States
Topic: drosophila proteins

Top Publications

  1. Grabowski D, Deutsch W, Derda D, Kelley M. Drosophila AP3, a presumptive DNA repair protein, is homologous to human ribosomal associated protein P0. Nucleic Acids Res. 1991;19:4297 pubmed
  2. Merrill C, Bayraktaroglu L, Kusano A, Ganetzky B. Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila. Science. 1999;283:1742-5 pubmed
    ..The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product. ..
  3. Von Ohlen T, Doe C. Convergence of dorsal, dpp, and egfr signaling pathways subdivides the drosophila neuroectoderm into three dorsal-ventral columns. Dev Biol. 2000;224:362-72 pubmed
  4. Nagengast A, Salz H. The Drosophila U2 snRNP protein U2A' has an essential function that is SNF/U2B" independent. Nucleic Acids Res. 2001;29:3841-7 pubmed
    ..Thus together these data demonstrate that in Drosophila U2A' has an essential function that is unrelated to its role as the partner protein of SNF/U2B". ..
  5. Xue M, Zhang B. Do SNARE proteins confer specificity for vesicle fusion?. Proc Natl Acad Sci U S A. 2002;99:13359-61 pubmed
  6. Chandra S, Ahmed A, Vaessin H. The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway. Dev Biol. 2003;256:302-16 pubmed
    ..Thus, fred acts in close concert with the Notch signaling pathway. Dosage-sensitive genetic interaction also suggests a close relationship between fred and ed. ..
  7. Green M, Monser K, Clem R. Ubiquitin protein ligase activity of the anti-apoptotic baculovirus protein Op-IAP3. Virus Res. 2004;105:89-96 pubmed
    ..Thus, we conclude that Op-IAP3 is a functional E3 ubiquitin ligase, and the ability to ubiquitinate pro-apoptotic cellular proteins such as HID may play an important role in the anti-apoptotic function of Op-IAP3. ..
  8. Bayrer J, Zhang W, Weiss M. Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation. J Biol Chem. 2005;280:32989-96 pubmed
    ..The possibility that the ubiquitination machinery participates in the regulation of sexual dimorphism is discussed. ..
  9. Neuburger P, Saville K, Zeng J, Smyth K, Belote J. A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene. Genetics. 2006;173:1377-87 pubmed
    ..While Prosbeta2(1) shows a modest increase in the number of defective mitotic figures, there were no defects seen with the other two mutants, other than slightly reduced mitotic indexes. ..

More Information

Publications477 found, 100 shown here

  1. Lee H, Lundell M. Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle. Mol Cell Neurosci. 2007;36:47-58 pubmed
    ..Our observations on the regulation of Zfh-1 provide a new approach for examining the function of Zfh-1 in motor neurons and larval locomotion. ..
  2. Shpargel K, Praveen K, Rajendra T, Matera A. Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Mol Biol Cell. 2009;20:90-101 pubmed publisher
    ..Our results demonstrate the conservation of Gemin3 protein function in metazoan snRNP assembly and reveal that loss of either Smn or Gemin3 can contribute to neuromuscular dysfunction. ..
  3. Apger J, Reubens M, Henderson L, Gouge C, Ilic N, Zhou H, et al. Multiple functions for Drosophila Mcm10 suggested through analysis of two Mcm10 mutant alleles. Genetics. 2010;185:1151-65 pubmed publisher
  4. Frankel N, Davis G, Vargas D, Wang S, Payre F, Stern D. Phenotypic robustness conferred by apparently redundant transcriptional enhancers. Nature. 2010;466:490-3 pubmed publisher
    ..These results support the hypothesis that secondary enhancers contribute to phenotypic robustness in the face of environmental and genetic variability. ..
  5. Drolia R, Von Ohlen T, Chapes S. Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster. Int J Med Microbiol. 2013;303:40-9 pubmed publisher
    ..Our data suggest that in Drosophila, E. chaffeensis replicates within the hemocytes, the insect homolog of mammalian macrophages, and in the fat body, the liver homolog of mammals. ..
  6. Reenan R, Hanrahan C, Ganetzky B. The mle(napts) RNA helicase mutation in drosophila results in a splicing catastrophe of the para Na+ channel transcript in a region of RNA editing. Neuron. 2000;25:139-49 pubmed
    ..These results explain how mlen(napts) affects Na+ channel expression and provide new insights into the mechanism of RNA editing...
  7. Lo L, Dormand E, Greenwood A, Anderson D. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Development. 2002;129:1553-67 pubmed
    ..These properties may explain cellular differences between MASH1- and NGN-dependent lineages in the timing of neuronal differentiation and cell cycle exit. ..
  8. McGregor A, Orgogozo V, Delon I, Zanet J, Srinivasan D, Payre F, et al. Morphological evolution through multiple cis-regulatory mutations at a single gene. Nature. 2007;448:587-90 pubmed
    ..These data support the view that alleles of large effect that distinguish species may sometimes reflect the accumulation of multiple mutations of small effect at select genes. ..
  9. Rimkus S, Katzenberger R, Trinh A, Dodson G, Tibbetts R, Wassarman D. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev. 2008;22:1205-20 pubmed publisher
    ..Thus, we hypothesize that ATM performs a cell cycle checkpoint function to protect post-mitotic neurons from degeneration and that cell cycle re-entry causes neurodegeneration in A-T...
  10. Farzan S, Ascano M, Ogden S, Sanial M, Brigui A, Plessis A, et al. Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Curr Biol. 2008;18:1215-20 pubmed publisher
    ..Combined, these results demonstrate that Cos2 motility plays an important role in its function, regulating the amounts and activity of Ci that ultimately interpret the level of Hh to which cells are exposed. ..
  11. Matakatsu H, Blair S. The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. Curr Biol. 2008;18:1390-5 pubmed publisher
    ..We show that App encodes a member of the DHHC family, responsible for the palmitoylation of selected cytoplasmic proteins, and provide evidence that App acts by controlling the normal subcellular localization and activity of Dachs. ..
  12. Datta R, Lurye J, Kumar J. Restriction of ectopic eye formation by Drosophila teashirt and tiptop to the developing antenna. Dev Dyn. 2009;238:2202-10 pubmed publisher
    ..We also demonstrate that in addition to being expressed in coincident patterns within the developing eye, both paralogs are transcribed at very similar levels. ..
  13. Stein D, Charatsi I, Cho Y, Zhang Z, Nguyen J, DeLotto R, et al. Localization and activation of the Drosophila protease easter require the ER-resident saposin-like protein seele. Curr Biol. 2010;20:1953-8 pubmed publisher
    ..Easter transport to the perivitelline space represents a previously unappreciated control point in the signal transduction pathway that controls Drosophila embryonic dorsal-ventral polarity. ..
  14. Serano T, Karlin Mcginness M, Cohen R. The role of fs(1)K10 in the localization of the mRNA of the TGF alpha homolog gurken within the Drosophila oocyte. Mech Dev. 1995;51:183-92 pubmed
    ..From this and other data, we propose a more direct role for fs(1)K10 in the gurken mRNA localization process. ..
  15. Sanchez M, Silos Santiago I, Frisen J, He B, Lira S, Barbacid M. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 1996;382:70-3 pubmed
    ..However, ablation of the GDNF gene does not affect the differentiation and survival of dopaminergic neurons, at least during embryonic development. ..
  16. Li K, Xu E, Cecil J, Turner F, Megraw T, Kaufman T. Drosophila centrosomin protein is required for male meiosis and assembly of the flagellar axoneme. J Cell Biol. 1998;141:455-67 pubmed
    ..These results suggest that centrosomin is a necessary component of the meiotic centrosomes and the spermatid basal body. ..
  17. Faust C, Lawson K, Schork N, Thiel B, Magnuson T. The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development. 1998;125:4495-506 pubmed
    ..The data are discussed in terms of global morphogenetic movements in the mouse gastrula and a disruption of signalling activity in the anterior primitive streak. ..
  18. Saunders C, Cohen R. The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization. Mol Cell. 1999;3:43-54 pubmed
    ..We also show that gurken mRNA and protein localization is dependent on region-specific translation of gurken transcripts and identify K10 as a probable negative regulator of gurken translation. ..
  19. Mantrova E, Schulz R, Hsu T. Oogenic function of the myogenic factor D-MEF2: negative regulation of the decapentaplegic receptor gene thick veins. Proc Natl Acad Sci U S A. 1999;96:11889-94 pubmed
    ..Additionally, they demonstrate a vital function for the D-MEF2 transcription factor in multiple genetic pathways during Drosophila development. ..
  20. Bultman S, Magnuson T. Molecular and genetic analysis of the mouse homolog of the Drosophila suppressor of position-effect variegation 3-9 gene. Mamm Genome. 2000;11:251-4 pubmed
    ..However, analysis of Td/Y and sf/Y mutant stocks indicated that Suv39hl is not responsible for either mutant phenotype. ..
  21. Kusano A, Staber C, Chan H, Ganetzky B. Closing the (Ran)GAP on segregation distortion in Drosophila. Bioessays. 2003;25:108-15 pubmed
    ..This previously mysterious genetic system may now offer unique insights into novel aspects of regulation by Ran. ..
  22. Gangisetty O, Lauffart B, Sondarva G, Chelsea D, Still I. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Oncogene. 2004;23:2559-63 pubmed
    ..This raises the possibility that aberrant expression of one or more TACC proteins may affect gene regulation through their interaction with components of chromatin remodeling complexes, thus contributing to tumorigenesis. ..
  23. Eun S, Lea K, Overstreet E, Stevens S, Lee J, Fischer J. Identification of genes that interact with Drosophila liquid facets. Genetics. 2007;175:1163-74 pubmed
    ..We describe the mutant alleles and mutant phenotypes of Rala and aux. We discuss the relevance of all of these genetic interactions to the function of Liquid facets in Notch signaling. ..
  24. Brandenburg J, Schimanski B, Nogoceke E, Nguyen T, Padovan J, Chait B, et al. Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complex. EMBO J. 2007;26:4856-66 pubmed
    ..The complex was dubbed class I transcription factor A. ..
  25. Linardopoulou E, Parghi S, Friedman C, Osborn G, Parkhurst S, Trask B. Human subtelomeric WASH genes encode a new subclass of the WASP family. PLoS Genet. 2007;3:e237 pubmed
    ..Thus, human subtelomeres are not genetic junkyards, and WASH's location in these dynamic regions could have advantageous as well as pathologic consequences...
  26. Benchabane H, Hughes E, Takacs C, Baird J, Ahmed Y. Adenomatous polyposis coli is present near the minimal level required for accurate graded responses to the Wingless morphogen. Development. 2008;135:963-71 pubmed publisher
    ..We conclude that Apc activity is not present in vast excess, but instead is near the minimal level required for accurate graded responses to the Wg morphogen. ..
  27. Liu B, Becnel J, Zhang Y, Zhou L. Induction of reaper ortholog mx in mosquito midgut cells following baculovirus infection. Cell Death Differ. 2011;18:1337-45 pubmed publisher
    ..i., suggesting a possible role for apoptosis in limiting viral infection. When the execution of apoptosis was delayed by caspase inhibitors, viral gene expression became detectable in the A. aegypti larvae. ..
  28. LaFerriere H, Speichinger K, Stromhaug A, Zars T. The radish gene reveals a memory component with variable temporal properties. PLoS ONE. 2011;6:e24557 pubmed publisher
  29. Vargas D, Shah K, Batish M, Levandoski M, Sinha S, Marras S, et al. Single-molecule imaging of transcriptionally coupled and uncoupled splicing. Cell. 2011;147:1054-65 pubmed publisher
    ..This uncoupling occurs only on the perturbed introns, whereas the preceding and succeeding introns are removed cotranscriptionally. PAPERCLIP: ..
  30. DEARBORN R, Dai Y, Reed B, Karian T, Gray J, Kunes S. Reph, a regulator of Eph receptor expression in the Drosophila melanogaster optic lobe. PLoS ONE. 2012;7:e37303 pubmed publisher
    ..These results reveal a novel component of the regulatory pathway controlling expression of eph and identify reph as a novel factor in the developing visual system. ..
  31. Lang M, Braun C, Kanost M, Gorman M. Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2012;109:13337-42 pubmed publisher
    ..Given that MCO1 orthologues are present in all insect genomes analyzed to date, this discovery is an important step toward understanding iron metabolism in insects. ..
  32. Qin G, Hu X, Cebe P, Kaplan D. Mechanism of resilin elasticity. Nat Commun. 2012;3:1003 pubmed publisher
    ..Furthermore, this model offers a view of elastomeric proteins in general where beta-turn-related structures serve as fundamental units of the structure and elasticity. ..
  33. Graf E, Valakh V, Wright C, Wu C, Liu Z, Zhang Y, et al. RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. J Neurosci. 2012;32:16586-96 pubmed publisher
  34. Zhou Y, Wang Y, Schreader B, Nambu J. Drosophila morgue associates with SkpA and polyubiquitin in vivo. PLoS ONE. 2013;8:e74860 pubmed publisher
    ..Multiple regions of Morgue were subsequently shown to be required for poly-ubiquitin binding. Overall, Morgue is a novel multi-functional ubiquitin-binding protein. ..
  35. Domanitskaya E, Anllo L, Schupbach T. Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila. Dev Biol. 2014;386:408-18 pubmed publisher
    ..This "egg chamber autonomous" ecdysone synthesis constitutes a useful way to regulate the individual maturation of the asynchronous egg chambers present in the Drosophila ovary. ..
  36. Asahina K, Watanabe K, Duistermars B, Hoopfer E, González C, Eyjólfsdóttir E, et al. Tachykinin-expressing neurons control male-specific aggressive arousal in Drosophila. Cell. 2014;156:221-35 pubmed publisher
    ..Thus, the higher aggressiveness of Drosophila males reflects the sexually dimorphic expression of a neuropeptide that controls agonistic behaviors across phylogeny. ..
  37. Wieschaus E. Positional Information and Cell Fate Determination in the Early Drosophila Embryo. Curr Top Dev Biol. 2016;117:567-79 pubmed publisher
    ..In the following essay, these issues are discussed in context of the Bicoid gradient. ..
  38. Burris P, Zhang Y, Rusconi J, Corbin V. The pore-forming and cytoplasmic domains of the neurogenic gene product, BIG BRAIN, are conserved between Drosophila virilis and Drosophila melanogaster. Gene. 1998;206:69-76 pubmed
    ..The conservation of the cytoplasmic domains indicates that they are critical to BIB function. bib transcripts are found in similar patterns in both species, indicating that the developmental function(s) of BIB have also been conserved. ..
  39. Stein D, Stevens L. The torso ligand, unmasked?. Sci STKE. 2001;2001:pe2 pubmed
    ..Stein and Stevens discuss the ramifications of such a highly regulated process of ligand activation, and also prefer alternative scenarios for Torso activation. ..
  40. Yoo S, Huh J, Muro I, Yu H, Wang L, Wang S, et al. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nat Cell Biol. 2002;4:416-24 pubmed
    ..Because loss of DIAP1 is sufficient to promote caspase activation, these mechanisms should promote apoptosis. ..
  41. Sharma V, Li B, Reese J. SWI/SNF-dependent chromatin remodeling of RNR3 requires TAF(II)s and the general transcription machinery. Genes Dev. 2003;17:502-15 pubmed
    ..Thus, the general transcription machinery can contribute to nucleosome remodeling by mediating the association of SWI/SNF with promoters, thereby revealing a novel pathway for the recruitment of chromatin remodeling activities. ..
  42. McGovern V, Seeger M. Mosaic analysis reveals a cell-autonomous, neuronal requirement for Commissureless in the Drosophila CNS. Dev Genes Evol. 2003;213:500-4 pubmed
    ..These data suggest that commissural axon guidance is dependent upon regulated expression of Comm in neurons. ..
  43. Tie F, Siebold A, Harte P. The N-terminus of Drosophila ESC mediates its phosphorylation and dimerization. Biochem Biophys Res Commun. 2005;332:622-32 pubmed
    ..Thus, stability and perhaps assembly of larger ESC complexes may depend on ESC phosphorylation. ..
  44. Swan A, Schupbach T. Drosophila female meiosis and embryonic syncytial mitosis use specialized Cks and CDC20 proteins for cyclin destruction. Cell Cycle. 2005;4:1332-4 pubmed
    ..These results indicate that anaphase progression in female meiosis and the early embryo are under unique control in Drosophila. ..
  45. Michalak P, Malone J, Lee I, Hoshino D, Ma D. Gene expression polymorphism in Drosophila populations. Mol Ecol. 2007;16:1179-89 pubmed
    ..melanogaster/races/strains and predicted to be translational-inactive in Cosmopolitan due to a major deletion, was found to be up-regulated in Zimbabwe and down-regulated, but still expressed, in Cosmopolitan. ..
  46. Ja W, West A, Delker S, Bjorkman P, Benzer S, Roberts R. Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor. Nat Chem Biol. 2007;3:415-9 pubmed
    ..Our work thus provides new life span-extending ligands for a metazoan and a general approach for the design of modulators of this important class of GPCRs. ..
  47. Challa M, Malladi S, Pellock B, Dresnek D, Varadarajan S, Yin Y, et al. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 2007;26:3144-56 pubmed
    ..In summary, we demonstrate for the first time in flies that mitochondrial permeabilization not only occurs during apoptosis but also results in the release of a bona fide proapoptotic protein. ..
  48. Park S, Kang Y, Sypula J, Choi J, Oh H, Park Y. An evolutionarily conserved domain of roX2 RNA is sufficient for induction of H4-Lys16 acetylation on the Drosophila X chromosome. Genetics. 2007;177:1429-37 pubmed
  49. Brechbiel J, Gavis E. Spatial regulation of nanos is required for its function in dendrite morphogenesis. Curr Biol. 2008;18:745-750 pubmed publisher
    ..Targeting of nos mRNA to the processes of da neurons may reflect a local requirement for Nos protein in dendritic translational control. ..
  50. Kadam S, McMahon A, Tzou P, Stathopoulos A. FGF ligands in Drosophila have distinct activities required to support cell migration and differentiation. Development. 2009;136:739-47 pubmed publisher
    ..We contend that inherent properties of FGF ligands make them suitable to support specific FGF-dependent processes, and that FGF ligands are not always interchangeable. ..
  51. Xu J, Li M, Shen P. A G-protein-coupled neuropeptide Y-like receptor suppresses behavioral and sensory response to multiple stressful stimuli in Drosophila. J Neurosci. 2010;30:2504-12 pubmed publisher
    ..Our findings suggest that suppression of TRP channel-mediated neural excitation by the conserved NPF/NPFR1 system may be a major mechanism for attaining its broad anti-stress function. ..
  52. Baumann A, Fujiwara Y, Wilson T. Evolutionary divergence of the paralogs Methoprene tolerant (Met) and germ cell expressed (gce) within the genus Drosophila. J Insect Physiol. 2010;56:1445-55 pubmed publisher
    ..Our results suggest that Drosophila Met and gce experienced divergent evolutionary pressures following the duplication of an ancestral gce-like gene found in less derived holometabolous insects...
  53. Ritter A, Beckstead R. Sox14 is required for transcriptional and developmental responses to 20-hydroxyecdysone at the onset of drosophila metamorphosis. Dev Dyn. 2010;239:2685-94 pubmed publisher
    ..We also show that the Sox14-regulated gene set correlates well with Sox14 expression in a variety of larval and adult tissues. Thus, Sox14 is a critical transcription factor required for 20E signaling at the onset of metamorphosis. ..
  54. Hughes A. Evolution of the ?GRP/GNBP/?-1,3-glucanase family of insects. Immunogenetics. 2012;64:549-58 pubmed publisher
  55. Ferraro T, Esposito E, Mancini L, Ng S, Lucas T, Coppey M, et al. Transcriptional Memory in the Drosophila Embryo. Curr Biol. 2016;26:212-218 pubmed publisher
    ..We propose that transcriptional memory is a mechanism of precision, which helps coordinate gene activity during embryogenesis. ..
  56. Wiemerslage L, Lee D. Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters. J Neurosci Methods. 2016;262:56-65 pubmed publisher
    ..We suggest at least four variables should be considered when using mitochondrial structure as an experimental endpoint. ..
  57. Penton A, Selleck S, Hoffmann F. Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science. 1997;275:203-6 pubmed
    ..DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye. ..
  58. Chiu C, Ross L, Cohen B, Lester H, Gill S. The transporter-like protein inebriated mediates hyperosmotic stimuli through intracellular signaling. J Exp Biol. 2000;203:3531-46 pubmed
    ..We propose that stimulation of MasIne releases intracellular Ca(2+) in native tissues, activating Ca(2+)-dependent K(+) channels, and leading to K(+) transport. ..
  59. Tie F, Furuyama T, Prasad Sinha J, Jane E, Harte P. The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3. Development. 2001;128:275-86 pubmed
    ..We propose that histone deacetylation by this complex is a prerequisite for establishment of stable long-term silencing by other continuously required PcG complexes. ..
  60. Grosskortenhaus R, Pearson B, Marusich A, Doe C. Regulation of temporal identity transitions in Drosophila neuroblasts. Dev Cell. 2005;8:193-202 pubmed
    ..We conclude that two distinct "timers" regulate neuroblast gene expression: a hunchback --> Kruppel timer requiring cytokinesis, and a Kruppel --> pdm1 --> castor timer which is cell cycle independent. ..
  61. Cummings W, Yabuki M, Ordinario E, Bednarski D, Quay S, Maizels N. Chromatin structure regulates gene conversion. PLoS Biol. 2007;5:e246 pubmed
    ..Thus, chromatin structure regulates homology-directed repair. These results suggest that histone modifications may contribute to maintaining genomic stability by preventing recombination between repetitive sequences. ..
  62. Xie X, Fischer J. On the roles of the Drosophila KASH domain proteins Msp-300 and Klarsicht. Fly (Austin). 2008;2:74-81 pubmed
    ..However, we did find that Msp-300 has a function in egg laying, normally redundant with a function of Klar. ..
  63. Rincon Limas D, Jensen K, Fernandez Funez P. Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des. 2012;18:1108-22 pubmed
    ..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications. ..
  64. Carroll S, Weatherbee S, Langeland J. Homeotic genes and the regulation and evolution of insect wing number. Nature. 1995;375:58-61 pubmed
  65. Bhadra U, Bhadra M, Birchler J. Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila. Genetics. 1998;150:251-63 pubmed
    ..The highly multigenic nature of dosage-sensitive modulation of both gene expression and PEV suggests that dosage effects can be progressively transduced through a series of steps in a hierarchical manner...
  66. Blake K, Myette G, Jack J. ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. Dev Genes Evol. 1999;209:555-9 pubmed
    ..The actin prehair structures are absent in rib mutants and abnormally shaped in raw mutants, indicating that the two genes have different functions required for organizing the actin cytoskeleton. ..
  67. Begun D, Whitley P. Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogaster. Heredity (Edinb). 2000;85 ( Pt 2):184-90 pubmed
    ..Therefore, if Mdr65A mutants contribute to the difference between alpha-amanitin-resistant and alpha-amanitin-sensitive third chromosome lines, the underlying cause is a gene regulatory mutation. ..
  68. Whippo C, Hangarter R. Second positive phototropism results from coordinated co-action of the phototropins and cryptochromes. Plant Physiol. 2003;132:1499-507 pubmed
    ..Based on our results, we hypothesize that phototropins and cryptochromes regulate phototropism by coordinating the balance between stimulation and inhibition of growth of the hypocotyl depending on the fluence rate of blue light. ..
  69. Ogden S, Ascano M, Stegman M, Suber L, Hooper J, Robbins D. Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2. Curr Biol. 2003;13:1998-2003 pubmed
    ..This work fills in the last major gap in our understanding of the Hh signal transduction pathway by suggesting that no intermediate signal is required to connect Smo to the HSC. ..
  70. Kreahling J, Graveley B. The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA. Mol Cell Biol. 2005;25:10251-60 pubmed
    ..Thus, the iStem is a novel type of regulatory element that simultaneously controls the splicing of multiple alternative exons. ..
  71. Hersh B, Nelson C, Stoll S, Norton J, Albert T, Carroll S. The UBX-regulated network in the haltere imaginal disc of D. melanogaster. Dev Biol. 2007;302:717-27 pubmed
    ..The evolution of haltere morphology involved changes in UBX-regulated target genes, both positive and negative, throughout the wing genetic regulatory network. ..
  72. Wu S, Chiang C. The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation. J Biol Chem. 2007;282:13141-5 pubmed
    ..The dual role of Brd4 in gene activation and repression illustrates how a dynamic chromatin-binding adaptor is able to recruit distinct transcriptional regulators to modulate promoter activity through cell cycle progression. ..
  73. Xu J, Sornborger A, Lee J, Shen P. Drosophila TRPA channel modulates sugar-stimulated neural excitation, avoidance and social response. Nat Neurosci. 2008;11:676-82 pubmed publisher
    ..Our findings demonstrate how an avoidance mechanism is recruited to facilitate animal development. ..
  74. Snee M, Macdonald P. Bicaudal C and trailer hitch have similar roles in gurken mRNA localization and cytoskeletal organization. Dev Biol. 2009;328:434-44 pubmed publisher
    ..The cages sequester Gurken protein, blocking its secretion and thus interfering with signaling of the follicle cells to specify dorsal fate. ..
  75. Diaz Valencia J, Morelli M, Bailey M, Zhang D, Sharp D, Ross J. Drosophila katanin-60 depolymerizes and severs at microtubule defects. Biophys J. 2011;100:2440-9 pubmed publisher
    ..Finally, we observe that binding duration, mobility, and oligomerization are ATP dependent. ..
  76. Wang T, Blumhagen R, Lao U, Kuo Y, Edgar B. LST8 regulates cell growth via target-of-rapamycin complex 2 (TORC2). Mol Cell Biol. 2012;32:2203-13 pubmed publisher
    ..Surprisingly, however, TORC2 does not regulate cell growth via its best-characterized target, AKT. Our findings support the possible application of TORC2-specific drugs in cancer therapy. ..
  77. Csink A, Linsk R, Birchler J. Mosaic suppressor, a gene in Drosophila that modifies retrotransposon expression and interacts with zeste. Genetics. 1994;136:573-83 pubmed
    ..The mutation described here suggests a connection between the regulation of specific transcriptional units such as retrotransposons and more global synapsis dependent regulatory effects. ..
  78. Pritchard D, Schubiger G. Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio. Genes Dev. 1996;10:1131-42 pubmed
  79. Stassen N, Logsdon J, Vora G, Offenberg H, Palmer J, Zolan M. Isolation and characterization of rad51 orthologs from Coprinus cinereus and Lycopersicon esculentum, and phylogenetic analysis of eukaryotic recA homologs. Curr Genet. 1997;31:144-57 pubmed
    ..The Drosophila Rad51 protein has undergone remarkably rapid sequence divergence...
  80. POPADIC A, Abzhanov A, Rusch D, Kaufman T. Understanding the genetic basis of morphological evolution: the role of homeotic genes in the diversification of the arthropod bauplan. Int J Dev Biol. 1998;42:453-61 pubmed
    ..Overall, these preliminary studies illustrate the role that some of the Hox genes expressed in the insect head have played in the morphological evolution of hexapods and likely arthropods in general. ..
  81. Drier E, Huang L, Steward R. Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev. 1999;13:556-68 pubmed
    ..The strong conservation of the serines suggests that phosphorylation of other Rel proteins is essential for their proper nuclear targeting. ..
  82. Platero J, Ahmad K, Henikoff S. A distal heterochromatic block displays centromeric activity when detached from a natural centromere. Mol Cell. 1999;4:995-1004 pubmed
    ..Our findings suggest that centromere competence is innate to satellite-containing blocks of heterochromatin, challenging models for centromere identity in which competence is an acquired characteristic...
  83. Felts S, Owen B, Nguyen P, Trepel J, Donner D, Toft D. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. J Biol Chem. 2000;275:3305-12 pubmed
    ..In addition, TRAP1 exhibited ATPase activity that was inhibited by both geldanamycin and radicicol. Thus, TRAP1 has functions that are distinct from those of hsp90. ..
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