Genomes and Genes
Experts and Doctors on drosophila proteins in Germany
Topic: drosophila proteins
Publications350 found, 100 shown here
- Kistner U, Wenzel B, Veh R, Cases Langhoff C, Garner A, Appeltauer U, et al. SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J Biol Chem. 1993;268:4580-3 pubmed..These features suggest a possible role for SAP90 in a guanine nucleotide-mediated signal transduction pathway at a subset of GABAergic synapses in the rat cerebellum. ..
- Valcarcel R, Weber U, Jackson D, Benes V, Ansorge W, Bohmann D, et al. Sec61beta, a subunit of the protein translocation channel, is required during Drosophila development. J Cell Sci. 1999;112 ( Pt 23):4389-96 pubmed
- Schnorrer F, Bohmann K, Nusslein Volhard C. The molecular motor dynein is involved in targeting swallow and bicoid RNA to the anterior pole of Drosophila oocytes. Nat Cell Biol. 2000;2:185-90 pubmed..We propose that Swa acts as an adaptor for the dynein complex and thereby enables dynein to transport bcd RNA along microtubules to their minus ends at the anterior pole of the oocyte. ..
- Rathke C, Baarends W, Jayaramaiah Raja S, Bartkuhn M, Renkawitz R, Renkawitz Pohl R. Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila. J Cell Sci. 2007;120:1689-700 pubmed..Finally, we show that histone modifications and removal are independent of protamine synthesis. ..
- Wicher D, Schäfer R, Bauernfeind R, Stensmyr M, Heller R, Heinemann S, et al. Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature. 2008;452:1007-11 pubmed publisher..Thereby, they provide rapid and transient as well as sensitive and prolonged odorant signalling. ..
- Münch D, Schmeichel B, Silbering A, Galizia C. Weaker ligands can dominate an odor blend due to syntopic interactions. Chem Senses. 2013;38:293-304 pubmed publisher..Our data have important implications for how odor mixtures are processed in general, and what preprocessing occurs before the information reaches the brain...
- Pengelly A, Copur Ö, Jackle H, Herzig A, Muller J. A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb. Science. 2013;339:698-9 pubmed publisher..Taken together, these analyses demonstrate that H3-K27 is the crucial physiological substrate that PRC2 modifies for Polycomb repression. ..
- Rode S, Ohm H, Zipfel J, Rumpf S. The spliceosome-associated protein Mfap1 binds to VCP in Drosophila. PLoS ONE. 2017;12:e0183733 pubmed publisher..Finally, rescue experiments with a lethal mfap1 mutant show that the VCP binding region is not essential for Mfap1 function, but may act to increase its stability or activity. ..
- Ilik I, Maticzka D, Georgiev P, Gutierrez N, Backofen R, Akhtar A. A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila. Genes Dev. 2017;31:1973-1987 pubmed publisher..Thus, we propose that roX2 lncRNA contains an MLE-dependent affinity switch to enable reversible interactions of the MSL complex to allow dosage compensation of the X chromosome...
- Knust E, Schrons H, Grawe F, Campos Ortega J. Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins. Genetics. 1992;132:505-18 pubmed..We show by germ-line transformation that these three genes are also necessary to allow epidermal development of the neuroectodermal cells. ..
- Reiter C, Schimansky T, Nie Z, Fischbach K. Reorganization of membrane contacts prior to apoptosis in the Drosophila retina: the role of the IrreC-rst protein. Development. 1996;122:1931-40 pubmed..This reorganisation is a prerequisite for the identification of death candidates. Irregular chiasmC-roughest function in retinal development demonstrates the importance of specific cell contacts for assignment of the apoptotic fate. ..
- Riechmann V, Irion U, Wilson R, Grosskortenhaus R, Leptin M. Control of cell fates and segmentation in the Drosophila mesoderm. Development. 1997;124:2915-22 pubmed..Both the domain of even-skipped function and the level of twist expression are regulated by sloppy-paired. sloppy-paired thus controls segmental allocation of mesodermal cells to different fates. ..
- Hatzfeld M. The armadillo family of structural proteins. Int Rev Cytol. 1999;186:179-224 pubmed..Instead armadillo family members exert both functions by interacting with a number of distinct cellular-binding partners. ..
- Str nkelnberg M, de Couet H, Hertenstein A, Fischbach K. Interspecies comparison of a gene pair with partially redundant function: the rst and kirre genes in D. virilis and D. melanogaster. J Mol Evol. 2003;56:187-97 pubmed publisher..These findings are discussed in the light of general evolutionary mechanisms...
- Leismann O, Lehner C. Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation. J Cell Sci. 2003;116:2453-60 pubmed..However, we also show that PIM contains a KEN-box, which is required for mitotic degradation in addition to the D-box, and that sister chromatid separation is completely inhibited by PIM with mutations in both degradation signals. ..
- Cikala M, Alexandrova O, David C, Pr schel M, Stiening B, Cramer P, et al. The phosphatidylserine receptor from Hydra is a nuclear protein with potential Fe(II) dependent oxygenase activity. BMC Cell Biol. 2004;5:26 pubmed publisher..The conservation of the protein from Hydra to human infers that our results also apply to PSR from higher animals...
- Nagel A, Krejci A, Tenin G, Bravo Patiño A, Bray S, Maier D, et al. Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors. Mol Cell Biol. 2005;25:10433-41 pubmed..In addition, we demonstrate that Hairless has a second mode of repression that antagonizes Notch intracellular domain and is independent of Gro or CtBP binding. ..
- Jauch E, Wecklein H, Stark F, Jauch M, Raabe T. The Drosophila melanogaster DmCK2beta transcription unit encodes for functionally non-redundant protein isoforms. Gene. 2006;374:142-52 pubmed..In addition, we find that CK2beta-like proteins encoded by the autosomal D. melanogaster genes CK2betates and CK2beta' cannot fully substitute for a loss of CK2beta isoforms encoded by DmCK2beta. ..
- Kopein D, Katanaev V. Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling. Mol Biol Cell. 2009;20:3865-77 pubmed publisher..g., in the context of the nervous system development, where Galpha(o) acts downstream from Frizzled and redundantly with Galpha(i) to control the asymmetry of cell divisions. ..
- Müller L, Hutter S, Stamboliyska R, Saminadin Peter S, Stephan W, Parsch J. Population transcriptomics of Drosophila melanogaster females. BMC Genomics. 2011;12:81 pubmed publisher..melanogaster. Comparison of female and male expression data indicates that the vast majority of genes differing in expression between populations do so in only one sex and suggests that most regulatory adaptation has been sex-specific. ..
- Saminadin Peter S, Kemkemer C, Pavlidis P, Parsch J. Selective sweep of a cis-regulatory sequence in a non-African population of Drosophila melanogaster. Mol Biol Evol. 2012;29:1167-74 pubmed publisher..Selection appears to have favored a quantitative increase in gene expression in the Malphigian tubule, the tissue where CG9509 is predominantly expressed. ..
- Ursel C, Fandrich U, Hoffmann A, Sieg T, Ihling C, Stubbs M. In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain. Biol Chem. 2013;394:1069-75 pubmed publisher..We determine the affinity of the prodomain for the cystine knot domain, and show that Easter performs a previously unknown secondary cleavage in each prodomain. ..
- Tögel M, Meyer H, Lehmacher C, Heinisch J, Pass G, Paululat A. The bHLH transcription factor hand is required for proper wing heart formation in Drosophila. Dev Biol. 2013;381:446-59 pubmed publisher..Finally, in a candidate-based RNAi mediated knock-down approach we identified Daughterless and Nautilus as potential dimerization partners of Hand in wing hearts. ..
- Wolff C, Pepling M, Gergen P, Klingler M. Structure and evolution of a pair-rule interaction element: runt regulatory sequences in D. melanogaster and D. virilis. Mech Dev. 1999;80:87-99 pubmed
- Harhangi H, Sun X, Wang Y, Akhmanova A, Miedema K, Heyting C, et al. RADHA--a new male germ line-specific chromosomal protein of Drosophila. Chromosoma. 1999;108:235-42 pubmed..RADHA is a basic protein with a C-terminal leucine zipper region and several segments capable of forming coiled-coil structures. ..
- Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, et al. Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J. 2000;19:6121-30 pubmed..These results indicate that the opposite action of Pontin52 and Reptin52 on beta-catenin-mediated transactivation constitutes an additional mechanism for the control of the canonical Wingless/Wnt pathway. ..
- Fischer A, Gessler M. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res. 2007;35:4583-96 pubmed..In addition, we summarize recent progress on the identification of potential target genes and the analysis of mouse models. ..
- Beermann A, Prühs R, Lutz R, Schröder R. A context-dependent combination of Wnt receptors controls axis elongation and leg development in a short germ insect. Development. 2011;138:2793-805 pubmed publisher..We identify Tc-Arr as an obligatory Wnt co-receptor for axis elongation, leg distalisation and segmentation. We discuss how Wnt signalling is regulated at the receptor and co-receptor levels in a dose-dependent fashion. ..
- Tschiersch B, Hofmann A, Krauss V, Dorn R, Korge G, Reuter G. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 1994;13:3822-31 pubmed
- Scholz H, Sadlowski E, Klaes A, Klämbt C. Control of midline glia development in the embryonic Drosophila CNS. Mech Dev. 1997;62:79-91 pubmed..In the midline glia pointedP2 in turn activates the transcription of argos, which encodes a diffusible negative regulator of EGF-receptor signalling. ..
- Klein T, Campos Ortega J. klumpfuss, a Drosophila gene encoding a member of the EGR family of transcription factors, is involved in bristle and leg development. Development. 1997;124:3123-34 pubmed..Analysis of the mutants indicates that klumpfuss is required for proper specification and differentiation of a variety of cells, including the sensory organ mother cells and those of the distal parts of tarsal segments. ..
- Hartmann C, Landgraf M, Bate M, Jackle H. Krüppel target gene knockout participates in the proper innervation of a specific set of Drosophila larval muscles. EMBO J. 1997;16:5299-309 pubmed..Their muscle pattern is normal, but the patterns of neuromuscular innervation are specifically disarranged. The results suggest that the Kr target gene ko is required for proper innervation of specific muscles by RP motoneurons. ..
- Knirr S, Breuer S, Paululat A, Renkawitz Pohl R. Somatic mesoderm differentiation and the development of a subset of pericardial cells depend on the not enough muscles (nem) locus, which contains the inscuteable gene and the intron located gene, skittles. Mech Dev. 1997;67:69-81 pubmed..Our data suggest a role for insc in the specification process of a subset of muscle progenitors/founders. Furthermore, in insc mutants the eve expressing pericardial cells of the developing heart are significantly reduced in numbers. ..
- Hoch M, Jackle H. Krüppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila. EMBO J. 1998;17:5766-75 pubmed
- Hecht A, Litterst C, Huber O, Kemler R. Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro. J Biol Chem. 1999;274:18017-25 pubmed
- Pham A, Muller S, Sauer F. Mesoderm-determining transcription in Drosophila is alleviated by mutations in TAF(II)60 and TAF(II)110. Mech Dev. 1999;84:3-16 pubmed..The results provide evidence that TAF(II)-subunits within the TFIID complex play an important role during the molecular events leading to initiation of mesoderm formation in Drosophila. ..
- Fribourg S, Gatfield D, Izaurralde E, Conti E. A novel mode of RBD-protein recognition in the Y14-Mago complex. Nat Struct Biol. 2003;10:433-9 pubmed..Heterodimerization creates a single structural platform that interacts with the NMD machinery via phylogenetically conserved residues. ..
- Fischer A, Leimeister C, Winkler C, Schumacher N, Klamt B, Elmasri H, et al. Hey bHLH factors in cardiovascular development. Cold Spring Harb Symp Quant Biol. 2002;67:63-70 pubmed
- Bogdan S, Klämbt C. Kette regulates actin dynamics and genetically interacts with Wave and Wasp. Development. 2003;130:4427-37 pubmed..Our data suggest a model where Kette fulfils a novel role in regulating F-actin organization by antagonizing Wave and activating Wasp-dependent actin polymerization. ..
- Prpic N, Janssen R, Wigand B, Klingler M, Damen W. Gene expression in spider appendages reveals reversal of exd/hth spatial specificity, altered leg gap gene dynamics, and suggests divergent distal morphogen signaling. Dev Biol. 2003;264:119-40 pubmed..Thus, the leg developmental system exhibits a propensity to evolutionary change, which probably forms the basis for the impressive diversity of arthropod leg morphologies. ..
- Hachet O, Ephrussi A. Splicing of oskar RNA in the nucleus is coupled to its cytoplasmic localization. Nature. 2004;428:959-63 pubmed..Our results reveal an important new function for splicing: regulation of messenger ribonucleoprotein complex assembly and organization for mRNA cytoplasmic localization. ..
- Will C, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, et al. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA. 2004;10:929-41 pubmed..The presence of unique U11/U12 snRNP proteins in the U12-type spliceosome provides insight into potential evolutionary relationships between the major and minor spliceosome. ..
- Bouazoune K, Brehm A. dMi-2 chromatin binding and remodeling activities are regulated by dCK2 phosphorylation. J Biol Chem. 2005;280:41912-20 pubmed..Our results reveal a potential mechanism for regulation of the dMi-2 enzyme and point toward CK2 phosphorylation as a common feature of CHD family ATPases. ..
- Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, et al. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005;438:867-72 pubmed publisher..Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus...
- Jaeger M, Rothacker B, Ilg T. Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Biochem Biophys Res Commun. 2008;372:400-6 pubmed publisher..Saturation transfer to the ribose moieties is limited to the anomeric protons of E. coli SSADH suggesting that the NAD(+)/NADP(+) adenine and nicotinamide, but not the ribose moieties are important for the binding of the coenzymes. ..
- Stark F, Pfannstiel J, Klaiber I, Raabe T. Protein kinase CK2 links polyamine metabolism to MAPK signalling in Drosophila. Cell Signal. 2011;23:876-82 pubmed publisher..We suggest that CK2 is able to monitor intracellular polyamine levels and translates this information to modulate MAPK signalling. ..
- Hakeda Suzuki S, Berger Müller S, Tomasi T, Usui T, Horiuchi S, Uemura T, et al. Golden Goal collaborates with Flamingo in conferring synaptic-layer specificity in the visual system. Nat Neurosci. 2011;14:314-23 pubmed publisher..We propose that Gogo acts as a functional partner of Fmi for R8 photoreceptor axon targeting and that the dynamic regulation of their interaction specifies synaptic-layer selection of photoreceptors. ..
- Mathew S, Rembold M, Leptin M. Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Mol Cell Biol. 2011;31:4978-93 pubmed publisher..Traf4 acts in a TNF receptor- and Jun N-terminal protein kinase (JNK)-independent manner to fine-tune the assembly of adherens junctions in the invaginating mesodermal cells...
- Susic Jung L, Hornbruch Freitag C, Kuckwa J, Rexer K, Lammel U, Renkawitz Pohl R. Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster. Dev Biol. 2012;370:86-97 pubmed publisher
- Bachmann A, Schneider M, Theilenberg E, Grawe F, Knust E. Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature. 2001;414:638-43 pubmed..The Stardust proteins represent versatile candidates as structural and possibly regulatory constituents of the SAC, a crucial element in the control of epithelial cell polarity. ..
- Helfrich Forster C, Edwards T, Yasuyama K, Wisotzki B, Schneuwly S, Stanewsky R, et al. The extraretinal eyelet of Drosophila: development, ultrastructure, and putative circadian function. J Neurosci. 2002;22:9255-66 pubmed..Thus a functional role in circadian entrainment first found in Bolwig's organ in the larva is retained in eyelet, the adult remnant of Bolwig's organ, even in the face of metamorphic restructuring. ..
- Varmark H. Functional role of centrosomes in spindle assembly and organization. J Cell Biochem. 2004;91:904-14 pubmed..It is further described how Drosophila mutants are used to address the functional interrelationships between individual centrosomal proteins and spindle formation in vivo. ..
- Lenhard T, Reiländer H. Engineering the folding pathway of insect cells: generation of a stably transformed insect cell line showing improved folding of a recombinant membrane protein. Biochem Biophys Res Commun. 1997;238:823-30 pubmed
- Ringrose L, Paro R. Remembering silence. Bioessays. 2001;23:566-70 pubmed..The authors' interpretation of these results is discussed here. ..
- Riechmann V, Gutierrez G, Filardo P, Nebreda A, Ephrussi A. Par-1 regulates stability of the posterior determinant Oskar by phosphorylation. Nat Cell Biol. 2002;4:337-42 pubmed..We show in cell-free extracts that Osk protein is intrinsically unstable and that it is stabilized after phosphorylation by Par-1. Our data indicate that posteriorly localized Par-1 regulates posterior patterning by stabilizing Osk. ..
- Marhold J, Papagiannouli F, Li M, Patel A, Mechler B. Requirements for scribble expression in newly formed gonads of Drosophila embryos. Gene Expr Patterns. 2003;3:143-6 pubmed..In contrast, Scrib1 synthesis in pole cells required contact with gonadal mesodermal cells as revealed by the absence of Scrib1 in wunen or tinman-zinc finger homeodomain-1 pseudo-gonads made only of aggregated pole cells. ..
- Wahl M, Irmler A, Hecker B, Schirmer R, Becker K. Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster. J Mol Biol. 2005;345:1119-30 pubmed..In human Trx, oxidative dimerization has been demonstrated in vitro. Therefore, this finding may indicate a difference in redox control of GR-free and GR-containing organisms. ..
- Löer B, Bauer R, Bornheim R, Grell J, Kremmer E, Kolanus W, et al. The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nat Cell Biol. 2008;10:422-8 pubmed publisher..The single murine Wech orthologue is also colocalized with Talin and ILK in muscle tissue. We propose that Wech proteins are crucial and evolutionarily conserved regulators of the integrin-cytoskeleton link. ..
- Hornbruch Freitag C, Griemert B, Buttgereit D, Renkawitz Pohl R. Drosophila Swiprosin-1/EFHD2 accumulates at the prefusion complex stage during Drosophila myoblast fusion. J Cell Sci. 2011;124:3266-78 pubmed publisher..Therefore, we hypothesise that Drosophila Swip-1 participates in the breakdown of the prefusion complex during the progression of myoblast fusion. ..
- Georgias C, Wasser M, Hinz U. A basic-helix-loop-helix protein expressed in precursors of Drosophila longitudinal visceral muscles. Mech Dev. 1997;69:115-24 pubmed..Characterisation of this expression pattern demonstrates that precursors of the outer, longitudinal muscles of the midgut are distinct in origin and morphology from precursors of the inner, circular muscles. ..
- Takke C, Dornseifer P, v Weizsäcker E, Campos Ortega J. her4, a zebrafish homologue of the Drosophila neurogenic gene E(spl), is a target of NOTCH signalling. Development. 1999;126:1811-21 pubmed..These results suggest that her4 acts as a target of notch-mediated signals that regulate primary neurogenesis. ..
- Beisswanger S, Stephan W. Evidence that strong positive selection drives neofunctionalization in the tandemly duplicated polyhomeotic genes in Drosophila. Proc Natl Acad Sci U S A. 2008;105:5447-52 pubmed publisher..Our results suggest that neofunctionalization has been achieved in the Drosophila ph genes through the action of strong positive selection and the inactivation of gene conversion in part of the gene. ..
- BACHMANN A, Kobler O, Kittel R, Wichmann C, Sierralta J, Sigrist S, et al. A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions. J Neurosci. 2010;30:5811-24 pubmed publisher..Our findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization. ..
- Conrad T, Cavalli F, Holz H, Hallacli E, Kind J, Ilik I, et al. The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex. Dev Cell. 2012;22:610-24 pubmed publisher..We propose that MOF has been especially tailored to achieve tight regulation of its enzymatic activity and enable its dual role on X and autosomes...
- Franke A, DeCamillis M, Zink D, Cheng N, Brock H, Paro R. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster. EMBO J. 1992;11:2941-50 pubmed..We propose that some Pc-G proteins act in multimeric complexes to compact the chromatin of stably repressed genes like the homeotic regulators. ..
- Vorbrüggen G, Jackle H. Epidermal muscle attachment site-specific target gene expression and interference with myotube guidance in response to ectopic stripe expression in the developing Drosophila epidermis. Proc Natl Acad Sci U S A. 1997;94:8606-11 pubmed..sr-expressing ectodermal cells generate long-range signals that interfere with the spatial orientation of the elongating myotubes. ..
- Renault N, King Jones K, Lehmann M. Downregulation of the tissue-specific transcription factor Fork head by Broad-Complex mediates a stage-specific hormone response. Development. 2001;128:3729-37 pubmed..Furthermore, they suggest that the BR-C is placed at a different position within the 20E-controlled hierarchies than previously assumed, and that at least part of its pleiotropic functions are mediated by tissue-specific regulators. ..
- Peri F, Technau M, Roth S. Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila. Development. 2002;129:2965-75 pubmed..This indicates that potent inhibitory processes prevent pipe dependent Toll activation at the dorsal side of the egg. ..
- Koelzer S, Klein T. A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila. Development. 2003;130:1973-88 pubmed..Our results further suggest that the position of the SOP in a proneural cluster is determined by very precise positional cues, which render the SOP insensitive to Dl. ..
- Burmester T, Storf J, Hasenj ger A, Klawitter S, Hankeln T. The hemoglobin genes of Drosophila. FEBS J. 2006;273:468-80 pubmed publisher..glob1 is closely related to the intracellular hemoglobin of the botfly Gasterophilus intestinalis, and the extracellular hemoglobins from the chironomid midges derive from this clade...
- Sitar T, Gallinger J, Ducka A, Ikonen T, Wohlhoefler M, Schmoller K, et al. Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly. Proc Natl Acad Sci U S A. 2011;108:19575-80 pubmed publisher..This molecular and structural mechanism of actin polymerization by Spire should apply to other actin-binding proteins that contain WH2 domains in tandem. ..
- Vömel M, Wegener C. Neurotransmitter-induced changes in the intracellular calcium concentration suggest a differential central modulation of CCAP neuron subsets in Drosophila. Dev Neurobiol. 2007;67:792-808 pubmed..Our results suggest that N(CCAP) express functional receptors for ACh, glutamate, and GABA, and indicate that these transmitters are involved in a context-dependent regulation of functionally distinct N(CCAP) subsets. ..
- Friberg A, Corsini L, Mourão A, Sattler M. Structure and ligand binding of the extended Tudor domain of D. melanogaster Tudor-SN. J Mol Biol. 2009;387:921-34 pubmed publisher..Recognition of sDMA in the C-terminal tails of spliceosomal Sm proteins suggests how Tudor-SN may interact with small nuclear ribonucleoprotein particles during the regulation of splicing. ..
- Nunes da Fonseca R, van der Zee M, Roth S. Evolution of extracellular Dpp modulators in insects: The roles of tolloid and twisted-gastrulation in dorsoventral patterning of the Tribolium embryo. Dev Biol. 2010;345:80-93 pubmed publisher..Thus, our results suggest that the role of Tsg proteins for BMP gradient formation has changed during insect evolution. ..
- Yatsenko A, Shcherbata H. Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling. Development. 2018;145: pubmed publisher..This guarantees that the germline stem cells will have their residence, thereby securing progressive oogenesis and, thus, organism reproduction. ..
- Munnes M, Patrone G, Schmitz B, Romeo G, Doerfler W. A 5'-CG-3'-rich region in the promoter of the transcriptionally frequently silenced RET protooncogene lacks methylated cytidine residues. Oncogene. 1998;17:2573-83 pubmed..However in vivo, DNA methylation of the promoter region seems not to be the predominant regulatory mechanism for the RET protooncogene. Possibly, in adults the RET gene can be occasionally activated. ..
- Walther T, Voigt J, Fink H, Bader M. Sex specific behavioural alterations in Mas-deficient mice. Behav Brain Res. 2000;107:105-9 pubmed..This implicates that the lack of Mas protein influences spatial learning and anxiety in a sex-specific manner. ..
- Hatzfeld M, Haffner C, Schulze K, Vinzens U. The function of plakophilin 1 in desmosome assembly and actin filament organization. J Cell Biol. 2000;149:209-22 pubmed
- Stanewsky R, Lynch K, Brandes C, Hall J. Mapping of elements involved in regulating normal temporal period and timeless RNA expression patterns in Drosophila melanogaster. J Biol Rhythms. 2002;17:293-306 pubmed..The results establish that, for normal rhythmicity, expression of clock genes requires regulation at the transcriptional, posttranscriptional, and posttranslational levels. ..
- Bredemeier R, Schlegel T, Ertel F, Vojta A, Borissenko L, Bohnsack M, et al. Functional and phylogenetic properties of the pore-forming beta-barrel transporters of the Omp85 family. J Biol Chem. 2007;282:1882-90 pubmed..Based on functional and phylogenetic analysis, we suggest an evolutionary scenario that explains the origin of the contemporary translocon. ..
- Reiher W, Shirras C, Kahnt J, Baumeister S, Isaac R, Wegener C. Peptidomics and peptide hormone processing in the Drosophila midgut. J Proteome Res. 2011;10:1881-92 pubmed publisher..The identification of enteroendocrine peptides in the fruit fly provides a platform to address functions of gut peptide hormones in the regulation of feeding and metabolism. ..
- Richlitzki A, Latour P, SchwÃ¤rzel M. Null EPAC mutants reveal a sequential order of versatile cAMP effects during Drosophila aversive odor learning. Learn Mem. 2017;24:210-215 pubmed publisher..Thereby we show that versatile cAMP-dependent mechanisms are engaged within a sequential order that correlate to individual trials of the training session. ..
- Wilsch Bräuninger M, Schwarz H, Nusslein Volhard C. A sponge-like structure involved in the association and transport of maternal products during Drosophila oogenesis. J Cell Biol. 1997;139:817-29 pubmed..We propose that the sponge bodies are structures that, by assembly and transport of included molecules or associated structures, are involved in localization of mRNAs in Drosophila oocytes. ..
- Peterziel H, Unsicker K, Krieglstein K. TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane. J Cell Biol. 2002;159:157-67 pubmed..Our data suggest that TGFbeta is involved in GFRalpha1 membrane translocation, thereby permitting GDNF signaling and neurotrophic effects. ..
- Müller H. Germ cell migration: as slow as molasses. Curr Biol. 2002;12:R612-4 pubmed..In Drosophila embryos, germ cells and somatic cells are formed separately. A recent analysis of the slow as molasses (slam) gene provides a potential link between somatic cell formation and germ cell migration. ..
- Banovic D, Khorramshahi O, Owald D, Wichmann C, Riedt T, Fouquet W, et al. Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions. Neuron. 2010;66:724-38 pubmed publisher..Instead, other signaling components are likely involved in DNlg1 transsynaptic functions, with essential interactions organized by the DNlg1 extracellular domain but also by the cytoplasmic domain. ..
- Schreiber J, Enderich J, Wegner M. Structural requirements for DNA binding of GCM proteins. Nucleic Acids Res. 1998;26:2337-43 pubmed..Our results give insights into the exact nature of the GCM binding sites expected in target genes and point to a role for redox regulation in the function of GCM proteins. ..
- Wegener C, Neupert S, Predel R. Direct MALDI-TOF mass spectrometric peptide profiling of neuroendocrine tissue of Drosophila. Methods Mol Biol. 2010;615:117-27 pubmed publisher..Here, we describe protocols for the use of MALDI-TOF mass spectrometry to directly analyze the peptidome of neuroendocrine tissues of insects, particularly Drosophila melanogaster, by MALDI-TOF MS. ..
- Granderath S, Bunse I, Klämbt C. gcm and pointed synergistically control glial transcription of the Drosophila gene loco. Mech Dev. 2000;91:197-208 pubmed..In addition, at least two other factors appear to repress loco expression in the ectoderm and in the CNS midline cells. ..