Experts and Doctors on drosophila melanogaster in United States

Summary

Locale: United States
Topic: drosophila melanogaster

Top Publications

  1. Kapoun A, Kaufman T. A functional analysis of 5', intronic and promoter regions of the homeotic gene proboscipedia in Drosophila melanogaster. Development. 1995;121:2127-41 pubmed
  2. Sathe S, Harte P. The extra sex combs protein is highly conserved between Drosophila virilis and Drosophila melanogaster. Mech Dev. 1995;52:225-32 pubmed
    ..These observations suggest that the esc protein is functionally compact, nearly every residue making an important contribution to its function. ..
  3. Tolar L, Pallanck L. NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking. J Neurosci. 1998;18:10250-6 pubmed
  4. Bohm R, Wang B, Brenner R, Atkinson N. Transcriptional control of Ca(2+)-activated K(+) channel expression: identification of a second, evolutionarily conserved, neuronal promoter. J Exp Biol. 2000;203:693-704 pubmed
    ..Taken together, these facts suggest that promoter choice may be a means for cells to control channel density. ..
  5. Miller D, Rogers B, Kalkbrenner A, Hamilton B, Holtzman S, Kaufman T. Cross-regulation of Hox genes in the Drosophila melanogaster embryo. Mech Dev. 2001;102:3-16 pubmed
    ..A summary of Hox gene cross-regulation by ectopically driven Hox proteins is tabulated for embryogenesis. ..
  6. Hoopengardner B, Helfand S. Temperature compensation and temporal expression mediated by an enhancer element in Drosophila. Mech Dev. 2002;110:27-37 pubmed
    ..A 120 bp region can reproduce the general features of the larger EAE fragment. The Deformed binding site is essential for temporal and spatial expression of beta-galactosidase during embryogenesis but is not required in the adult. ..
  7. Dubrovsky E, Dubrovskaya V, Berger E. Juvenile hormone signaling during oogenesis in Drosophila melanogaster. Insect Biochem Mol Biol. 2002;32:1555-65 pubmed
    ..Based on the evidence, we propose that during sexual maturation of Drosophila, JH provides a signal to the ovary that leads to the production of several maternally inherited mRNAs. ..
  8. Landis G, Bhole D, Tower J. A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Genome Biol. 2003;4:R8 pubmed
    ..Screening for conditional mutations that increase Drosophila life span has identified genes implicated in membrane transport, phospholipid metabolism and signaling, and actin cytoskeleton organization. ..
  9. McCormack T. Comparison of K+-channel genes within the genomes of Anopheles gambiae and Drosophila melanogaster. Genome Biol. 2003;4:R58 pubmed

More Information

Publications521 found, 100 shown here

  1. Horabin J, Walthall S, Vied C, Moses M. A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch. Development. 2003;130:6101-9 pubmed
    ..These data suggest that the Hh pathway impacts on the sex determination process and vice versa and that the pathway may serve more functions than the regulation of Ci. ..
  2. Jones J, Macdonald P. Oskar controls morphology of polar granules and nuclear bodies in Drosophila. Development. 2007;134:233-6 pubmed
    ..immigrans type morphology. We conclude that oskar plays a persistent and central role in the polar granules, not only initiating their formation but also controlling their organization and morphology. ..
  3. Salcedo E, Farrell D, Zheng L, Phistry M, Bagg E, Britt S. The green-absorbing Drosophila Rh6 visual pigment contains a blue-shifting amino acid substitution that is conserved in vertebrates. J Biol Chem. 2009;284:5717-22 pubmed publisher
  4. Hughes S, Gilliland W, Cotitta J, Takeo S, Collins K, Hawley R. Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila oocytes. PLoS Genet. 2009;5:e1000348 pubmed publisher
    ..We propose that these threads assist in the rejoining of homologs and the congression of the migrating achiasmate homologs back to the main chromosomal mass prior to metaphase arrest. ..
  5. Manier M, Belote J, Berben K, Novikov D, Stuart W, Pitnick S. Resolving mechanisms of competitive fertilization success in Drosophila melanogaster. Science. 2010;328:354-7 pubmed publisher
    ..We find that competitive male fertilization success derives from a multivariate process involving ejaculate-female and ejaculate-ejaculate interactions, as well as complex sperm behavior in vivo...
  6. McMahon A, Reeves G, Supatto W, Stathopoulos A. Mesoderm migration in Drosophila is a multi-step process requiring FGF signaling and integrin activity. Development. 2010;137:2167-75 pubmed publisher
    ..Our work demonstrates that complex cell migration is not necessarily a fluid process, but suggests instead that different types of movements are directed by distinct inputs in a stepwise manner...
  7. Cooke A, Prigge A, Wickens M. Translational repression by deadenylases. J Biol Chem. 2010;285:28506-13 pubmed publisher
    ..The deadenylation-independent repression requires a 5' cap structure on the mRNA; however, deadenylation does not. We suggest that mere recruitment of CAF1 is sufficient for repression, independent of deadenylation. ..
  8. Enders L, Nunney L. Sex-specific effects of inbreeding in wild-caught Drosophila melanogaster under benign and stressful conditions. J Evol Biol. 2010;23:2309-23 pubmed publisher
    ..Sexual selection exacerbated inbreeding depression, with inbred male offspring suffering a higher reproductive cost than females, independent of stress (57% vs. 14% benign, 49% vs. 11% stress). ..
  9. Tae H, Ryu D, Sureshchandra S, Choi J. ESTclean: a cleaning tool for next-gen transcriptome shotgun sequencing. BMC Bioinformatics. 2012;13:247 pubmed publisher
    ..It outperforms in cleaning read sequences from complicated sequencing protocols which use barcodes and multiple amplification primers. ..
  10. Wandler A, Guillemin K. Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila. PLoS Pathog. 2012;8:e1002939 pubmed publisher
    ..These data suggest a potential role for CagA-mediated JNK pathway activation in promoting gastric cancer progression. ..
  11. Le Thomas A, Rogers A, Webster A, Marinov G, Liao S, Perkins E, et al. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev. 2013;27:390-9 pubmed publisher
    ..Our results indicate that Piwi identifies targets complementary to the associated piRNA and induces transcriptional repression by establishing a repressive chromatin state when correct targets are found. ..
  12. Akbari O, Matzen K, Marshall J, Huang H, Ward C, Hay B. A synthetic gene drive system for local, reversible modification and suppression of insect populations. Curr Biol. 2013;23:671-7 pubmed publisher
    ..They also show that in a population in which single-locus UD(MEL) has been carried out, repeated release of wild-type males can result in population suppression, a novel method of genetic population manipulation...
  13. Shiehzadegan S, Le Vinh Thuy J, Szabla N, Angilletta M, Vandenbrooks J. More oxygen during development enhanced flight performance but not thermal tolerance of Drosophila melanogaster. PLoS ONE. 2017;12:e0177827 pubmed publisher
    ..Our results poorly support the hypothesis that oxygen supply limits performance at high temperatures, but do support the idea that hyperoxia during development improves performance of flies later in life. ..
  14. Tedford H, Maggio F, Reenan R, King G. A model genetic system for testing the in vivo function of peptide toxins. Peptides. 2007;28:51-6 pubmed
    ..The unusual phenotype of flies induced to express omega-ACTX-Hv1a recapitulates that of a hypomorphic allele of the high-voltage-activated calcium channel Dmca1D, suggesting that this is likely to be the target of omega-ACTX-Hv1a...
  15. Moses C, Helman A, Paroush Z, Von Ohlen T. Phosphorylation of Ind by MAP kinase enhances Ind-dependent transcriptional repression. Dev Biol. 2011;360:208-15 pubmed publisher
    ..While it has been often demonstrated that MAP kinase phosphorylation of transcriptional repressors attenuates their repressor activity, here we provide an example of phosphorylation enhancing repressor activity. ..
  16. Thambi N, Quan F, Wolfgang W, Spiegel A, Forte M. Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system. J Biol Chem. 1989;264:18552-60 pubmed
    ..In situ hybridization of specific probes to tissue sections indicates that the mRNAs coding for Go alpha-like proteins in Drosophila are expressed primarily in neuronal cell bodies and, at lower levels, in the eyes. ..
  17. Hassan B, Vaessin H. Daughterless is required for the expression of cell cycle genes in peripheral nervous system precursors of Drosophila embryos. Dev Genet. 1997;21:117-22 pubmed
    ..This suggests that all aspects of PNS precursor differentiation examined so far are under the transcriptional control of da. ..
  18. Merrill C, Bayraktaroglu L, Kusano A, Ganetzky B. Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila. Science. 1999;283:1742-5 pubmed
    ..The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product. ..
  19. Ogden S, Ascano M, Stegman M, Robbins D. Regulation of Hedgehog signaling: a complex story. Biochem Pharmacol. 2004;67:805-14 pubmed
    ..Here, we review what is known about regulation of individual Hh signaling components, concentrating on the mechanisms by which the Hh signal is propagated through Smo to the HSC. ..
  20. Shanower G, Muller M, Blanton J, Honti V, Gyurkovics H, Schedl P. Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. Genetics. 2005;169:173-84 pubmed
  21. Nappi A, Frey F, Carton Y. Drosophila serpin 27A is a likely target for immune suppression of the blood cell-mediated melanotic encapsulation response. J Insect Physiol. 2005;51:197-205 pubmed
    ..boulardi. ..
  22. Dalal Y, Wang H, Lindsay S, Henikoff S. Tetrameric structure of centromeric nucleosomes in interphase Drosophila cells. PLoS Biol. 2007;5:e218 pubmed
    ..This demonstration of stable half-nucleosomes in vivo provides a possible basis for the instability of centromeric nucleosomes that are deposited in euchromatic regions, which might help maintain centromere identity. ..
  23. Wright A, Fox A, Johnson K, Zinn K. Systematic screening of Drosophila deficiency mutations for embryonic phenotypes and orphan receptor ligands. PLoS ONE. 2010;5:e12288 pubmed publisher
    ..In the future, these deficiency kits will allow Drosophila researchers to rapidly and efficiently execute genome-wide anatomical screens that require examination of individual embryos at high magnification. ..
  24. Igboin C, Tordoff K, Moeschberger M, Griffen A, Leys E. Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model. Infect Immun. 2011;79:449-58 pubmed publisher
    ..This study demonstrates that the Drosophila killing model is a useful high-throughput model for characterizing the host response to P. gingivalis infection and uncovering novel interactions between the bacterium and the host. ..
  25. Von Ohlen T, Luce Fedrow A, Ortega M, Ganta R, Chapes S. Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections. Infect Immun. 2012;80:3576-86 pubmed publisher
    ..chaffeensis replication and that it may be important for the provision of CTP, uridine, and cytidine nucleotides. ..
  26. Rowley M, Nichols M, Lyu X, Ando Kuri M, Rivera I, Hermetz K, et al. Evolutionarily Conserved Principles Predict 3D Chromatin Organization. Mol Cell. 2017;67:837-852.e7 pubmed publisher
    ..The results suggest that compartmental domains are responsible for domain structure in all eukaryotes, with CTCF playing an important role in domain formation in mammals. ..
  27. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  28. Page S, Nielsen R, Teeter K, Lake C, Ong S, Wright K, et al. A germline clone screen for meiotic mutants in Drosophila melanogaster. Fly (Austin). 2007;1:172-81 pubmed
    ..This study demonstrates the utility of germline clone-based screens for the discovery of strong meiotic mutants, including mutations in essential genes, and the use of molecular genetic techniques to map the loci. ..
  29. Avanesov A, Blair S. The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi. Development. 2013;140:107-16 pubmed publisher
  30. Mason Suares H, Tie F, Yan C, Harte P. Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth. Dev Biol. 2013;380:111-24 pubmed publisher
    ..These results thus suggest that PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression. ..
  31. Butterworth F, Bownes M, Burde V. Genetically modified yolk proteins precipitate in the adult Drosophila fat body. J Cell Biol. 1991;112:727-37 pubmed
    ..The similarity of SBMM and deoxyhemoglobin S fibers is discussed. ..
  32. Zheng Y, Jung M, Oakley B. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. Cell. 1991;65:817-23 pubmed
  33. Banerjee U, Renfranz P, Hinton D, Rabin B, Benzer S. The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7. Cell. 1987;51:151-8 pubmed
    ..Possible mechanisms for generating the specificity of the sev phenotype are discussed in light of these results. ..
  34. Gnagey A, Forte M, Rosenberry T. Isolation and characterization of acetylcholinesterase from Drosophila. J Biol Chem. 1987;262:13290-8 pubmed
  35. Jacobsen T, Brennan K, Arias A, Muskavitch M. Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila. Development. 1998;125:4531-40 pubmed
  36. Murase S, Schuman E. The role of cell adhesion molecules in synaptic plasticity and memory. Curr Opin Cell Biol. 1999;11:549-53 pubmed
  37. Begun D, Whitley P. Genetics of alpha-amanitin resistance in a natural population of Drosophila melanogaster. Heredity (Edinb). 2000;85 ( Pt 2):184-90 pubmed
    ..Therefore, if Mdr65A mutants contribute to the difference between alpha-amanitin-resistant and alpha-amanitin-sensitive third chromosome lines, the underlying cause is a gene regulatory mutation. ..
  38. Porzgen P, Park S, Hirsh J, Sonders M, Amara S. The antidepressant-sensitive dopamine transporter in Drosophila melanogaster: a primordial carrier for catecholamines. Mol Pharmacol. 2001;59:83-95 pubmed
    ..The identification of a cocaine-sensitive target linked to dopaminergic neurotransmission in D. melanogaster will serve as a basis for further dissection of the genetic components of psychostimulant-mediated behavior. ..
  39. Zraly C, Feng Y, Dingwall A. Genetic and molecular analysis of region 88E9;88F2 in Drosophila melanogaster, including the ear gene related to human factors involved in lineage-specific leukemias. Genetics. 2002;160:1051-65 pubmed
    ..One of these complementation groups likely corresponds to the ear gene as judged by map location, terminal phenotype, and reduction of EAR protein levels. ..
  40. Arn E, Cha B, Theurkauf W, Macdonald P. Recognition of a bicoid mRNA localization signal by a protein complex containing Swallow, Nod, and RNA binding proteins. Dev Cell. 2003;4:41-51 pubmed
    ..The presence of three required localization components (Swallow, Modulo, and specific RNA binding activity) within the recognition complex strongly implicates it in mRNA localization. ..
  41. Chen J, Concel V, Bhatla S, Rajeshwaran R, Smith D, Varadarajan M, et al. Alternative splicing of an rnp-4f mRNA isoform retaining an evolutionarily-conserved 5'-UTR intronic element is developmentally regulated and shown via RNAi to be essential for normal central nervous system development in Drosophila melanogaster. Gene. 2007;399:91-104 pubmed
    ..Long rnp-4f mRNA knockdown via RNAi reveals a variety of CNS abnormalities, which leads us to postulate that this isoform acts upstream of other genes which have been shown to be important for normal CNS development. ..
  42. Jeffress J, Page S, Royer S, Belden E, Blumenstiel J, Anderson L, et al. The formation of the central element of the synaptonemal complex may occur by multiple mechanisms: the roles of the N- and C-terminal domains of the Drosophila C(3)G protein in mediating synapsis and recombination. Genetics. 2007;177:2445-56 pubmed
  43. Wang L, Dankert H, Perona P, Anderson D. A common genetic target for environmental and heritable influences on aggressiveness in Drosophila. Proc Natl Acad Sci U S A. 2008;105:5657-63 pubmed publisher
    ..Cyp6a20 is expressed in a subset of nonneuronal support cells associated with pheromone-sensing olfactory sensilla, suggesting that social experience may influence aggressiveness by regulating pheromone sensitivity. ..
  44. Miller M, Lekkas P, Braddock J, Farman G, Ballif B, Irving T, et al. Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila. Biophys J. 2008;95:2391-401 pubmed publisher
    ..We also speculate that a lack of MgATP due to damaged mitochondria accounts for the decreased flight performance. ..
  45. Blumenstiel J, Fu R, Theurkauf W, Hawley R. Components of the RNAi machinery that mediate long-distance chromosomal associations are dispensable for meiotic and early somatic homolog pairing in Drosophila melanogaster. Genetics. 2008;180:1355-65 pubmed publisher
    ..Thus, there appears to be at least two mechanisms that bring homologous sequences together within the nucleus: those that act between dispersed homologous sequences and those that act to align and pair homologous chromosomes. ..
  46. Gilestro G, Tononi G, Cirelli C. Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila. Science. 2009;324:109-12 pubmed publisher
    ..The decrease of synaptic markers during sleep was progressive, and sleep was necessary for their decline. Thus, sleep may be involved in maintaining synaptic homeostasis altered by waking activities. ..
  47. Luce Fedrow A, Von Ohlen T, Chapes S. Ehrlichia chaffeensis infections in Drosophila melanogaster. Infect Immun. 2009;77:4815-26 pubmed publisher
    ..chaffeensis suggests that D. melanogaster is a suitable host for E. chaffeensis. In the future, it will be a useful tool to unlock some of the in vivo mysteries of this arthropod-borne bacterium...
  48. Banerjee P, Schoenfeld B, Bell A, Choi C, Bradley M, Hinchey P, et al. Short- and long-term memory are modulated by multiple isoforms of the fragile X mental retardation protein. J Neurosci. 2010;30:6782-92 pubmed publisher
  49. Vermehren Schmaedick A, Ainsley J, Johnson W, Davies S, Morton D. Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics. 2010;186:183-96 pubmed publisher
    ..For this behavior, the identity of the neurons appeared to be critical in determining the ability to respond appropriately. ..
  50. Schwasinger Schmidt T, Kachman S, Harshman L. Evolution of starvation resistance in Drosophila melanogaster: measurement of direct and correlated responses to artificial selection. J Evol Biol. 2012;25:378-87 pubmed publisher
  51. Rakshit K, Krishnan N, Guzik E, Pyza E, Giebultowicz J. Effects of aging on the molecular circadian oscillations in Drosophila. Chronobiol Int. 2012;29:5-14 pubmed publisher
    ..These data suggest that aging alters the properties of the core transcriptional clock in flies such that both the positive and the negative limbs of the clock are attenuated. ..
  52. Hoekstra L, Montooth K. Inducing extra copies of the Hsp70 gene in Drosophila melanogaster increases energetic demand. BMC Evol Biol. 2013;13:68 pubmed publisher
    ..Physiological costs of mutations that greatly increase gene expression, such as these, may constrain their utility for adaptive evolution. ..
  53. Deshpande G, Zhou K, Wan J, Friedrich J, Jourjine N, Smith D, et al. The hedgehog pathway gene shifted functions together with the hmgcr-dependent isoprenoid biosynthetic pathway to orchestrate germ cell migration. PLoS Genet. 2013;9:e1003720 pubmed publisher
    ..Finally, potentiation of Hh by hmgcr appears to depend upon cholesterol modification. ..
  54. Wang Z, Clark C, Geisbrecht E. Analysis of mitochondrial structure and function in the Drosophila larval musculature. Mitochondrion. 2016;26:33-42 pubmed publisher
    ..In particular, we highlight methods for sample preparation and analysis of mitochondrial morphological features. ..
  55. Kim S, D Acunto V, Kokona B, Hofmann J, Cunningham N, Bistline E, et al. Sedimentation Velocity Analysis with Fluorescence Detection of Mutant Huntingtin Exon 1 Aggregation in Drosophila melanogaster and Caenorhabditis elegans. Biochemistry. 2017;56:4676-4688 pubmed publisher
  56. Seeger M, Haffley L, Kaufman T. Characterization of amalgam: a member of the immunoglobulin superfamily from Drosophila. Cell. 1988;55:589-600 pubmed
    ..The function of this protein remains elusive, as no mutations have been recovered for ama during saturation EMS mutagenesis of this chromosomal region. ..
  57. Dorer D, Henikoff S. Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila. Cell. 1994;77:993-1002 pubmed
    ..We propose that pairing of repeats underlies heterochromatin formation and is responsible for diverse gene silencing phenomena in animals and plants. ..
  58. Bazinet C, Katzen A, Morgan M, Mahowald A, Lemmon S. The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism. Genetics. 1993;134:1119-34 pubmed
    ..The sterility was efficiently rescued by an autosomal copy of the wild-type Chc gene reintroduced on a P element. These findings suggest a specialized role for clathrin in spermatogenesis. ..
  59. Parks A, Huppert S, Muskavitch M. The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster. Mech Dev. 1997;63:61-74 pubmed
    ..Within microchaeta proneural stripes, we demonstrate that Delta-Notch signalling prohibits adoption of the SOP fate by repressing expression of proneural genes. ..
  60. Zimowska G, Paddy M. Structures and dynamics of Drosophila Tpr inconsistent with a static, filamentous structure. Exp Cell Res. 2002;276:223-32 pubmed
  61. Cordova D, Delpech V, Sattelle D, Rauh J. Spatiotemporal calcium signaling in a Drosophila melanogaster cell line stably expressing a Drosophila muscarinic acetylcholine receptor. Invert Neurosci. 2003;5:19-28 pubmed
    ..In contrast, ionomycin induced the formation of a "calcium ring" at the cell periphery, consistent with external calcium influx. ..
  62. Zraly C, Marenda D, Dingwall A. SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. Genetics. 2004;168:199-214 pubmed
    ..Thus, in addition to important functions of the Brm complex in G1-S control, the complex also appears to be important for transcription of genes required for cell cycle progression. ..
  63. Yampolsky L, Allen C, Shabalina S, Kondrashov A. Persistence time of loss-of-function mutations at nonessential loci affecting eye color in Drosophila melanogaster. Genetics. 2005;171:2133-8 pubmed
    ..In both cases, deleterious alleles are apparently eliminated by selection against heterozygous individuals, which show no visible phenotypic differences from wild type. ..
  64. Dunlap J. Physiology. Running a clock requires quality time together. Science. 2006;311:184-6 pubmed
  65. Graze R, McIntyre L, Main B, Wayne M, Nuzhdin S. Regulatory divergence in Drosophila melanogaster and D. simulans, a genomewide analysis of allele-specific expression. Genetics. 2009;183:547-61, 1SI-21SI pubmed publisher
    ..In addition, two genes, with critical roles in sex determination and micro RNA processing, Sxl and loqs, were identified as misexpressed in hybrid female heads, potentially contributing to hybrid incompatibility. ..
  66. Zhang Z, Palli S. Identification of a cis-regulatory element required for 20-hydroxyecdysone enhancement of antimicrobial peptide gene expression in Drosophila melanogaster. Insect Mol Biol. 2009;18:595-605 pubmed publisher
    ..These studies suggest that 20-hydroxyecdysone regulates the expression of AMP genes through a conserved cis-regulatory element. ..
  67. Lin N, Li X, Cui K, Chepelev I, Tie F, Liu B, et al. A barrier-only boundary element delimits the formation of facultative heterochromatin in Drosophila melanogaster and vertebrates. Mol Cell Biol. 2011;31:2729-41 pubmed publisher
    ..This suggests that the mechanism by which it functions to spatially restrict the formation of repressive chromatin marked by trimethylated H3K27 has also been conserved widely during evolution. ..
  68. Pina C, Pignoni F. Tubby-RFP balancers for developmental analysis: FM7c 2xTb-RFP, CyO 2xTb-RFP, and TM3 2xTb-RFP. Genesis. 2012;50:119-23 pubmed publisher
  69. Ye X, Deng Y, Lai Z. Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila. Dev Biol. 2012;369:115-23 pubmed publisher
    ..Thus, Hippo signaling not only blocks cell division and promotes apoptosis, but also regulates cellular growth by inhibiting the Akt pathway activity. ..
  70. Heckscher E, Lockery S, Doe C. Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature. J Neurosci. 2012;32:12460-71 pubmed publisher
    ..This work lays a foundation for use of Drosophila larva as a model system for studying the genetics and development of rhythmic behavior. ..
  71. Pool J, Corbett Detig R, Sugino R, Stevens K, Cardeño C, Crepeau M, et al. Population Genomics of sub-saharan Drosophila melanogaster: African diversity and non-African admixture. PLoS Genet. 2012;8:e1003080 pubmed publisher
  72. Teets N, Denlinger D. Autophagy in Antarctica: combating dehydration stress in the world's southernmost insect. Autophagy. 2013;9:629-31 pubmed publisher
    ..g., sestrins and proteasomal genes, are concurrently upregulated. This suggests that autophagy and related processes are key elements regulating stress tolerance in this extreme environment. ..
  73. Jung S, Lee J, Chae H, Seong J, Park Y, Park Z, et al. Identification of a novel insect neuropeptide, CNMa and its receptor. FEBS Lett. 2014;588:2037-41 pubmed publisher
    ..Although CNMa is conserved in most arthropods, Lepidoptera lack the CNMa gene. However, they retain the CNMaR gene. Bombyx CNMaR showed low sensitivity to Drosophila CNMa, hinting toward the existence of additional CNMaR ligand(s). ..
  74. Wen D, Rivera Pérez C, Abdou M, Jia Q, He Q, Liu X, et al. Methyl farnesoate plays a dual role in regulating Drosophila metamorphosis. PLoS Genet. 2015;11:e1005038 pubmed publisher
  75. Boppana S, Kendall N, Akinrinsola O, White D, Patel K, Lawal H. Immunolocalization of the vesicular acetylcholine transporter in larval and adult Drosophila neurons. Neurosci Lett. 2017;643:76-83 pubmed publisher
    ..Together, these findings help establish the vesicular localization of VAChT in cholinergic neurons in Drosophila and present an important molecular tool with which to dissect the function of the transporter in vivo. ..
  76. Henkemeyer M, Bennett R, Gertler F, Hoffmann F. DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Mol Cell Biol. 1988;8:843-53 pubmed
    ..These results show that the abl gene is highly conserved through evolution and encodes a functional tyrosine protein kinase required for Drosophila development. ..
  77. Swanson W, Wong A, Wolfner M, Aquadro C. Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selection. Genetics. 2004;168:1457-65 pubmed publisher
  78. Dasari S, Viele K, Turner A, Cooper R. Influence of PCPA and MDMA (ecstasy) on physiology, development and behavior in Drosophila melanogaster. Eur J Neurosci. 2007;26:424-38 pubmed
    ..The actions of acute MDMA exposure suggest a 5-HT agonist action or possible dumping of 5-HT from neurons. ..
  79. Marunde M, Samarajeewa D, Anderson J, Li S, Hand S, Menze M. Improved tolerance to salt and water stress in Drosophila melanogaster cells conferred by late embryogenesis abundant protein. J Insect Physiol. 2013;59:377-86 pubmed publisher
    ..36 g H2O/g DW vs.1.02 g H2O/g DW). Thus, AfLEA1.3 exerts a protective influence on mitochondrial function and increases viability of Kc167 cells during water stress. ..
  80. Talbert P, LeCiel C, Henikoff S. Modification of the Drosophila heterochromatic mutation brownDominant by linkage alterations. Genetics. 1994;136:559-71 pubmed
    ..These results support the notion that heterochromatin formation at a genetic locus depends on its location within the nucleus. ..
  81. Faurobert E, Chen C, Hurley J, Teng D. Drosophila neurocalcin, a fatty acylated, Ca2+-binding protein that associates with membranes and inhibits in vitro phosphorylation of bovine rhodopsin. J Biol Chem. 1996;271:10256-62 pubmed
    ..in vitro inhibition of rhodopsin phosphorylation therefore appears to be an assayable property of a subset of recoverin-like proteins. ..
  82. Surdej P, Jacobs Lorena M. Developmental regulation of bicoid mRNA stability is mediated by the first 43 nucleotides of the 3' untranslated region. Mol Cell Biol. 1998;18:2892-900 pubmed
    ..quot; Similar mechanisms may regulate a class of developmentally important maternal genes whose mRNA has a temporal profile similar to that of bicoid. ..
  83. Horowitz J, Vernace V, Myers J, Stachowiak M, Hanlon D, Fraley G, et al. Immunodetection of Parkin protein in vertebrate and invertebrate brains: a comparative study using specific antibodies. J Chem Neuroanat. 2001;21:75-93 pubmed
  84. Brown S, Parrish J, Denell R, Beeman R. Genetic control of early embryogenesis in the red flour beetle, Tribolium castaneum. Am Zool. 1994;34:343-52 pubmed
    ..Nevertheless, differences between Tribolium and Drosophila in the dynamics of even-skipped expression and the fushi tarazu mutant phenotype indicate divergence in the regulation and roles of these genes. ..
  85. Friedman K, Heller A. Guanosine distribution and oxidation resistance in eight eukaryotic genomes. J Am Chem Soc. 2004;126:2368-71 pubmed
    ..The G distribution in the Encephalitozoon (parasite) genome was not protective relative to that of the standard genome. ..
  86. Costa A, Wang Y, Dockendorff T, Erdjument Bromage H, Tempst P, Schedl P, et al. The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev Cell. 2005;8:331-42 pubmed
    ..We show that dFMR1 functions as a negative regulator in the orb autoregulatory circuit, downregulating orb mRNA translation. ..
  87. Al Anzi B, Tracey W, Benzer S. Response of Drosophila to wasabi is mediated by painless, the fly homolog of mammalian TRPA1/ANKTM1. Curr Biol. 2006;16:1034-40 pubmed
    ..Our results suggest that the stinging sensation of isothiocyanate is caused by activation of an evolutionarily conserved molecular pathway that is also used for nociception. ..
  88. Ramos D, Kamal F, Wimmer E, Cartwright A, Monteiro A. Temporal and spatial control of transgene expression using laser induction of the hsp70 promoter. BMC Dev Biol. 2006;6:55 pubmed
    ..This technique will also be useful in evolutionary developmental biology as it will enable the study of the evolution of gene function across a variety of organisms. ..
  89. Tie F, Stratton C, Kurzhals R, Harte P. The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27. Mol Cell Biol. 2007;27:2014-26 pubmed
    ..Our data suggest that one of the roles of ESC (and ESCL and EED) in PRC2 complexes is to enable E(Z) to utilize histone H3 as a substrate by physically linking enzyme and substrate. ..
  90. Hackney J, Pucci C, Naes E, Dobens L. Ras signaling modulates activity of the ecdysone receptor EcR during cell migration in the Drosophila ovary. Dev Dyn. 2007;236:1213-26 pubmed
    ..Our results indicate that tissue-specific modulation of EcR activity by the Ras signaling pathway refines temporal ecdysone signals that regulate FC differentiation and cadherin-mediated epithelial cell shape changes. ..
  91. Heo J, Ja W, Benzer S, Goddard W. The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster. Biochemistry. 2008;47:12740-9 pubmed publisher
    ..The elucidation of the ligand binding site may be useful in analyzing likely binding sites in other class B GPCRs. ..
  92. Chang K, MIN K. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A. 2009;106:17117-22 pubmed publisher
    ..These findings imply that restoring the level of any one of these genes may reduce endocytic defects seen in DS. ..