Experts and Doctors on drosophila in United States


Locale: United States
Topic: drosophila

Top Publications

  1. Matthews K, Miller D, Kaufman T. Functional implications of the unusual spatial distribution of a minor alpha-tubulin isotype in Drosophila: a common thread among chordotonal ligaments, developing muscle, and testis cyst cells. Dev Biol. 1990;137:171-83 pubmed
    ..The cell types that express alpha 85E share a requirement for extensive cell shape changes during development, suggesting that this minor alpha-tubulin may have distinct functional properties. ..
  2. Cai J, Lan Y, Appel L, Weir M. Dissection of the Drosophila paired protein: functional requirements for conserved motifs. Mech Dev. 1994;47:139-50 pubmed
  3. Edgar B. Cell cycle. Cell-cycle control in a developmental context. Curr Biol. 1994;4:522-4 pubmed
    ..Down-regulation of a cyclin specific to the G1 phase of the cell cycle, cyclin E, terminates the initial period of cell proliferation in developing Drosophila embryos. ..
  4. Jack J, Myette G. The genes raw and ribbon are required for proper shape of tubular epithelial tissues in Drosophila. Genetics. 1997;147:243-53 pubmed
    ..In double mutants raw enhances the phenotypes of all the tissues that are affected by rib but unaffected by raw alone, indicating that raw is also active in these tissues. ..
  5. Lewis E. The bithorax complex: the first fifty years. Int J Dev Biol. 1998;42:403-15 pubmed
  6. Martin M, Iyadurai S, Gassman A, Gindhart J, Hays T, Saxton W. Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport. Mol Biol Cell. 1999;10:3717-28 pubmed
    ..The shared bidirectional disruption phenotypes and the dominant genetic interactions demonstrate that cytoplasmic dynein, the dynactin complex, and conventional kinesin are interdependent in fast axonal transport. ..
  7. Springer N, Danilevskaya O, Hermon P, Helentjaris T, Phillips R, Kaeppler H, et al. Sequence relationships, conserved domains, and expression patterns for maize homologs of the polycomb group genes E(z), esc, and E(Pc). Plant Physiol. 2002;128:1332-45 pubmed
    ..The conservation of E(z) and esc homologs across kingdoms indicates that these genes likely play a conserved role in repressing gene expression. ..
  8. Webel R, Haug Collet K, Pearson B, Szerencsei R, Winkfein R, Schnetkamp P, et al. Potassium-dependent sodium-calcium exchange through the eye of the fly. Ann N Y Acad Sci. 2002;976:300-14 pubmed
    ..NCKX30C may play a critical role in modulating calcium during development as well as in the removal of calcium and maintenance of calcium homeostasis in adults. ..
  9. Presgraves D, Balagopalan L, Abmayr S, Orr H. Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila. Nature. 2003;423:715-9 pubmed publisher
    ..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...

More Information

Publications526 found, 100 shown here

  1. Badugu R, Shareef M, Kellum R. Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. J Biol Chem. 2003;278:34491-8 pubmed
    ..A mutant for the HOAP protein also suppresses centric heterochromatin-induced silencing, supporting a role for HOAP in centric heterochromatin. ..
  2. Jeong S, Rebeiz M, Andolfatto P, Werner T, True J, Carroll S. The evolution of gene regulation underlies a morphological difference between two Drosophila sister species. Cell. 2008;132:783-93 pubmed publisher
    ..We submit that there is sufficient empirical evidence to support the general prediction that functional evolutionary changes at pleiotropic loci will most often involve mutations in their discrete, modular cis-regulatory elements...
  3. Al Anzi B, Sapin V, Waters C, Zinn K, Wyman R, Benzer S. Obesity-blocking neurons in Drosophila. Neuron. 2009;63:329-41 pubmed publisher
    ..Our results show that the fly brain measures fat store levels and can induce changes in food intake and metabolism to maintain them within normal limits. ..
  4. Lin C, Paulson A, Abmayr S, Workman J. HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. PLoS ONE. 2012;7:e39758 pubmed publisher
    ..Collectively, these results show that HP1a functions to target the H3K36 demethylase dKDM4A to heterochromatic genes in Drosophila. ..
  5. Chu Y, Yang E, Schinaman J, Chahda J, Sousa Neves R. Genetic analysis of mate discrimination in Drosophila simulans. Evolution. 2013;67:2335-47 pubmed publisher
    ..Together, our results reveal part of the genetic architecture that allows D. simulans females to recognize, mate, and successfully generate progenies with D. simulans males. ..
  6. Menon K, Carrillo R, Zinn K. Development and plasticity of the Drosophila larval neuromuscular junction. Wiley Interdiscip Rev Dev Biol. 2013;2:647-70 pubmed publisher
    ..As this review is intended for a developmental biology audience, it does not cover NMJ electrophysiology in detail, and does not review genes for which mutations produce only electrophysiological but no structural phenotypes...
  7. Dunlap J. Closely watched clocks: molecular analysis of circadian rhythms in Neurospora and Drosophila. Trends Genet. 1990;6:159-65 pubmed
    ..In related work, the recent identification and molecular analysis of clock-controlled genes is revealing how biological clocks control gene expression, and may pave the way for the isolation of novel 'clock genes' in the future. ..
  8. Wilson D, Deutsch W, Kelley M. Cloning of the Drosophila ribosomal protein S3: another multifunctional ribosomal protein with AP endonuclease DNA repair activity. Nucleic Acids Res. 1993;21:2516 pubmed
  9. Hoyle H, Hutchens J, Turner F, Raff E. Regulation of beta-tubulin function and expression in Drosophila spermatogenesis. Dev Genet. 1995;16:148-70 pubmed
    ..Finally, expression of transgenic constructs is consistent with early cessation of X chromosome expression in Drosophila spermatogenesis. ..
  10. Bhadra U, Bhadra M, Birchler J. Interactions among dosage-dependent trans-acting modifiers of gene expression and position-effect variegation in Drosophila. Genetics. 1998;150:251-63 pubmed
    ..The highly multigenic nature of dosage-sensitive modulation of both gene expression and PEV suggests that dosage effects can be progressively transduced through a series of steps in a hierarchical manner...
  11. Chung S, McLean M, Rymond B. Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition. RNA. 1999;5:1042-54 pubmed
    ..Our results indicate that Clf1p acts as a scaffolding protein in spliceosome assembly and suggest that Clf1p may support the cross-intron bridge during the prespliceosome-to-spliceosome transition. ..
  12. Ruden D, Sollars V, Wang X, Mori D, Alterman M, Lu X. Membrane fusion proteins are required for oskar mRNA localization in the Drosophila egg chamber. Dev Biol. 2000;218:314-25 pubmed
    ..We found that ovaries that are mutant for syntaxin-1a, rop, and synaptotagmin are also defective in oskar mRNA localization during oogenesis. We suggest a pathway for the role of membrane assembly proteins on oskar mRNA localization. ..
  13. Savoian M, Goldberg M, Rieder C. The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants. Nat Cell Biol. 2000;2:948-52 pubmed
    ..Our results show that ZW10 protein, together with Rod, is involved in production and/or regulation of the force responsible for poleward chromosome motion. ..
  14. Gilbert D. euGenes: a eukaryote genome information system. Nucleic Acids Res. 2002;30:145-8 pubmed
    ..These summarized data are useful for integration in other projects, such as gene expression databases. euGenes provides an extensible, flexible genome information system for many organisms. ..
  15. Park M, Moon R. The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nat Cell Biol. 2002;4:20-5 pubmed
  16. Odden J, Holbrook S, Doe C. Drosophila HB9 is expressed in a subset of motoneurons and interneurons, where it regulates gene expression and axon pathfinding. J Neurosci. 2002;22:9143-9 pubmed
    ..Thus, Drosophila HB9 is required in a subset of motoneurons and interneurons for establishing proper axon projections but does not have a general role in distinguishing motoneuron and interneuron cell types. ..
  17. McDonald J, Fujioka M, Odden J, Jaynes J, Doe C. Specification of motoneuron fate in Drosophila: integration of positive and negative transcription factor inputs by a minimal eve enhancer. J Neurobiol. 2003;57:193-203 pubmed
    ..Thus, the eve enhancer integrates multiple positive and negative transcription factor inputs to restrict eve expression to a single precursor cell (GMC4-2a) and its RP2 motoneuron progeny. ..
  18. Koh Y, Rehfeld K, Ganetzky B. A Drosophila model of early onset torsion dystonia suggests impairment in TGF-beta signaling. Hum Mol Genet. 2004;13:2019-30 pubmed
    ..These results raise the possibility that a defect in TGF-beta signaling might also underlie early onset torsion dystonia in humans. ..
  19. Menon K, Sanyal S, Habara Y, Sanchez R, Wharton R, Ramaswami M, et al. The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Neuron. 2004;44:663-76 pubmed
    ..The GluRIIa glutamate receptor is upregulated in pum mutants. These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of eIF-4E expression. ..
  20. Gao S, Steffen J, Laughon A. Dpp-responsive silencers are bound by a trimeric Mad-Medea complex. J Biol Chem. 2005;280:36158-64 pubmed
    ..The slight alteration of the Dpp silencers caused them to activate transcription in response to Dpp signaling, indicating that the potential for Smad complexes to recognize specific targets need not be limited to repression. ..
  21. Goentoro L, Reeves G, Kowal C, Martinelli L, Schupbach T, Shvartsman S. Quantifying the Gurken morphogen gradient in Drosophila oogenesis. Dev Cell. 2006;11:263-72 pubmed
    ..This provides a direct characterization of the shape of the Gurken gradient and demonstrates how parameter estimation techniques can be used to quantify morphogen gradients in development. ..
  22. Bao H, Berlanga M, Xue M, Hapip S, Daniels R, Mendenhall J, et al. The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila. Mol Cell Neurosci. 2007;34:662-78 pubmed
    ..These findings shed new light on a possible role for Flamingo in progressive neurodegenerative diseases. ..
  23. Colbourne J, Eads B, Shaw J, Bohuski E, Bauer D, Andrews J. Sampling Daphnia's expressed genes: preservation, expansion and invention of crustacean genes with reference to insect genomes. BMC Genomics. 2007;8:217 pubmed
    ..This effort will soon include the first crustacean genome sequence. ..
  24. McManus C, Coolon J, Duff M, Eipper Mains J, Graveley B, Wittkopp P. Regulatory divergence in Drosophila revealed by mRNA-seq. Genome Res. 2010;20:816-25 pubmed publisher
  25. Crocker J, Potter N, Erives A. Dynamic evolution of precise regulatory encodings creates the clustered site signature of enhancers. Nat Commun. 2010;1:99 pubmed publisher
  26. McIntyre L, Lopiano K, Morse A, Amin V, Oberg A, Young L, et al. RNA-seq: technical variability and sampling. BMC Genomics. 2011;12:293 pubmed publisher
    ..We provide practical recommendations for dealing with the technical variability, without dramatic cost increases. ..
  27. Cai W, Rudolph J, Harrison S, Jin L, Frantz A, Harrison D, et al. An evolutionarily conserved Rit GTPase-p38 MAPK signaling pathway mediates oxidative stress resistance. Mol Biol Cell. 2011;22:3231-41 pubmed publisher
    ..Together, our studies establish the Rit GTPases as critical regulators of an evolutionarily conserved, p38 MAPK-dependent signaling cascade that functions as an important survival mechanism for cells in response to oxidative stress. ..
  28. Wisotsky Z, Medina A, Freeman E, Dahanukar A. Evolutionary differences in food preference rely on Gr64e, a receptor for glycerol. Nat Neurosci. 2011;14:1534-41 pubmed publisher
    ..Our results provide insight into the molecular mechanisms of feeding acceptance of yeast products and raise the possibility that Gr64e contributes to specific evolutionary variations in appetitive selectivity across Drosophila species...
  29. Huang Z, Kingsolver M, Avadhanula V, Hardy R. An antiviral role for antimicrobial peptides during the arthropod response to alphavirus replication. J Virol. 2013;87:4272-80 pubmed publisher
    ..Our data demonstrate an antiviral response involving the Imd and Jak-STAT mediated expression of dptB and attC...
  30. Wike C, Graves H, Hawkins R, Gibson M, Ferdinand M, Zhang T, et al. Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis. elife. 2016;5:e11402 pubmed publisher
    ..We propose that H3 T118ph alters the chromatin structure during specific phases of mitosis to promote timely condensin I and cohesin disassociation, which is essential for effective chromosome segregation. ..
  31. Iverson L, Tanouye M, Lester H, Davidson N, Rudy B. A-type potassium channels expressed from Shaker locus cDNA. Proc Natl Acad Sci U S A. 1988;85:5723-7 pubmed
    ..Alternative splicing of Sh gene transcripts may provide one mechanism for the generation of K+ channel diversity. ..
  32. Kopczynski C, Muskavitch M. Complex spatio-temporal accumulation of alternative transcripts from the neurogenic gene Delta during Drosophila embryogenesis. Development. 1989;107:623-36 pubmed
    ..The apparent association of these three transcripts with polysomes suggests that they accumulate within the cytoplasm at the nuclear periphery and is consistent with the hypothesis that Dl encodes multiple translational products. ..
  33. Henikoff S. A reconsideration of the mechanism of position effect. Genetics. 1994;138:1-5 pubmed
  34. Choi K, Benzer S. Rotation of photoreceptor clusters in the developing Drosophila eye requires the nemo gene. Cell. 1994;78:125-36 pubmed
    ..In another mutant, roulette, excessive rotation through varying angles occurs in many ommatidia. This defect is suppressed by nmo, indicating that nmo acts upstream in a rotation-regulating pathway. ..
  35. Lin W, Jakobi R, Traugh J. Reconstitution of heterologous and chimeric casein kinase II with recombinant subunits from human and Drosophila: identification of species-specific differences in the beta subunit. J Protein Chem. 1994;13:217-25 pubmed
    ..The N-terminal region also affected solubility and electrophoretic mobility of the beta subunit. ..
  36. Batni S, Scalzetti L, Moody S, Knox B. Characterization of the Xenopus rhodopsin gene. J Biol Chem. 1996;271:3179-86 pubmed
    ..These results locate transcriptional control elements upstream of the Xenopus rhodopsin gene and show the feasibility of embryo transfections for promoter analysis of rod-specific genes. ..
  37. Riedl A, Jacobs Lorena M. Determinants of Drosophila fushi tarazu mRNA instability. Mol Cell Biol. 1996;16:3047-53 pubmed
    ..Lack of homology between this element and other previously identified destabilization sequences suggests that FIE3 contains a novel RNA destabilization element. ..
  38. Papenbrock T, Peterson R, Lee R, Hsu T, Kuroiwa A, Awgulewitsch A. Murine Hoxc-9 gene contains a structurally and functionally conserved enhancer. Dev Dyn. 1998;212:540-7 pubmed
    ..This finding indicates that the Hoxc-9 intragenic enhancer is involved in transcriptional regulatory circuits conserved between vertebrates and arthropods. ..
  39. Zinn K, Sun Q. Slit branches out: a secreted protein mediates both attractive and repulsive axon guidance. Cell. 1999;97:1-4 pubmed
  40. Koehler K, Hassold T. Human aneuploidy: lessons from achiasmate segregation in Drosophila melanogaster. Ann Hum Genet. 1998;62:467-79 pubmed
    ..Drawing upon observations made in flies, we also propose a new model for the segregation of achiasmate chromosomes in humans...
  41. Hanrahan C, Palladino M, Ganetzky B, Reenan R. RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation. Genetics. 2000;155:1149-60 pubmed
    ..These results demonstrate that Na(+) channel diversity in Drosophila is increased by RNA editing via a mechanism analogous to that described for transcripts encoding mammalian GluRs...
  42. West A, Llamas L, Snow P, Benzer S, Bjorkman P. Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan. Proc Natl Acad Sci U S A. 2001;98:3744-9 pubmed
    ..The Mth structure is analyzed in relation to predicted Mth homologs and potential ligand binding features. ..
  43. Drewell R, Bae E, Burr J, Lewis E. Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex. Proc Natl Acad Sci U S A. 2002;99:16853-8 pubmed
    ..We also discuss a possible mechanism by which this may occur. ..
  44. Xu P, Vernooy S, Guo M, Hay B. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol. 2003;13:790-5 pubmed
    ..Deletion of mir-14 results in animals with increased levels of triacylglycerol and diacylglycerol, whereas increases in mir-14 copy number have the converse effect. We discuss possible relationships between these phenotypes. ..
  45. Dong P, Todi S, Eberl D, Boekhoff Falk G. Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes. Proc Natl Acad Sci U S A. 2003;100:10293-8 pubmed
    ..Electrophysiological analyses confirm that spalt/spalt-related mutant flies are deaf. These commonalities suggest that there is functional conservation for spalt genes between vertebrates and insects. ..
  46. Morton D. Invertebrates yield a plethora of atypical guanylyl cyclases. Mol Neurobiol. 2004;29:97-116 pubmed
  47. Choe C, Miller S, Brown S. A pair-rule gene circuit defines segments sequentially in the short-germ insect Tribolium castaneum. Proc Natl Acad Sci U S A. 2006;103:6560-4 pubmed
    ..This pair-rule gene circuit provides insight into short-germ segmentation in Tribolium that may be more generally applicable to segmentation in other arthropods. ..
  48. Kurusu M, Zinn K. Receptor tyrosine phosphatases regulate birth order-dependent axonal fasciculation and midline repulsion during development of the Drosophila mushroom body. Mol Cell Neurosci. 2008;38:53-65 pubmed publisher
    ..Lar and Ptp69D are necessary for the axonal branching decisions that create the lobes. Avoidance of the brain midline by extending medial lobe axons involves signaling through Lar. ..
  49. LeRoy G, Weston J, Zee B, Young N, Plazas Mayorca M, Garcia B. Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications. Mol Cell Proteomics. 2009;8:2432-42 pubmed publisher
  50. Salz H, Erickson J. Sex determination in Drosophila: The view from the top. Fly (Austin). 2010;4:60-70 pubmed
    ..This review describes recent advances in our understanding of Sxl regulation and function, highlighting work that challenges some of the textbook views about this classical (often cited, yet poorly understood) binary switch gene. ..
  51. Glasheen B, Robbins R, Piette C, Beitel G, Page McCaw A. A matrix metalloproteinase mediates airway remodeling in Drosophila. Dev Biol. 2010;344:772-83 pubmed publisher
  52. Holtzman S, Miller D, Eisman R, Kuwayama H, Niimi T, KAUFMAN T. Transgenic tools for members of the genus Drosophila with sequenced genomes. Fly (Austin). 2010;4:349-62 pubmed
    ..In summary, we hope to provide a set of guidelines and basic tools, based upon this work, for both insertional mutagenesis and GAL4/UAS system-based experiments in multiple species of Drosophila. ..
  53. Zhang Y, Arcia S, Perez B, Fernandez Funez P, Rincon Limas D. p?TubHA4C, a new versatile vector for constitutive expression in Drosophila. Mol Biol Rep. 2013;40:5407-15 pubmed publisher
    ..We found that the modified 0.9 kb ?Tub promoter induced similar expression levels to the intact 2.6 kb ?1t promoter, supporting the inclusion of all critical regulatory elements in the new and flexible ?TubHA4C vector. ..
  54. Grabowski D, Carney J, Kelley M. A Drosophila gene containing the opa repetitive element is exclusively expressed in adult male abdomens. Nucleic Acids Res. 1991;19:1709 pubmed
  55. Kamb A, Tseng Crank J, Tanouye M. Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity. Neuron. 1988;1:421-30 pubmed
    ..This diversity, however, fits a simple pattern in which variable 3' and 5' ends are spliced onto a central constant region to yield different cDNA types. These different Sh cDNAs encode proteins with distinct structural features. ..
  56. DELVENTHAL R, Carlson J. Bitter taste receptors confer diverse functions to neurons. elife. 2016;5: pubmed publisher
    ..The results support a model in which bitter Grs interact, exhibiting competition, inhibition, or activation. The results have broad implications for the problem of how taste systems evolve to detect new environmental dangers. ..
  57. Hannan F, Hall L. Muscarinic acetylcholine receptors in invertebrates: comparisons with homologous receptors from vertebrates. EXS. 1993;63:98-145 pubmed
  58. Brown S, Holtzman S, Kaufman T, Denell R. Characterization of the Tribolium Deformed ortholog and its ability to directly regulate Deformed target genes in the rescue of a Drosophila Deformed null mutant. Dev Genes Evol. 1999;209:389-98 pubmed
    ..This is the first demonstration of the ability of a heterologous homeotic selector protein to directly regulate a target gene independent of an endogenous Drosophila autoregulatory loop. ..
  59. Bohm R, Wang B, Brenner R, Atkinson N. Transcriptional control of Ca(2+)-activated K(+) channel expression: identification of a second, evolutionarily conserved, neuronal promoter. J Exp Biol. 2000;203:693-704 pubmed
    ..Taken together, these facts suggest that promoter choice may be a means for cells to control channel density. ..
  60. Griffin K, Stoller J, Gibson M, Chen S, Yelon D, Stainier D, et al. A conserved role for H15-related T-box transcription factors in zebrafish and Drosophila heart formation. Dev Biol. 2000;218:235-47 pubmed
    ..We discuss the possibility that the cardiac ventricular defect previously described in pandora and the midline defects described here are related. ..
  61. Zhang Q, Lu X. semang affects the development of a subset of cells in the Drosophila compound eye. Mech Dev. 2000;95:113-22 pubmed
  62. Kaufman T, Severson D, Robinson G. The Anopheles genome and comparative insect genomics. Science. 2002;298:97-8 pubmed
    ..The Anopheles gambiae genome sequence, coupled with the Drosophila melanogaster genome sequence, provides a better understanding of the insects, a group that contains our friends, foes, and competitors. ..
  63. Mirth C, Truman J, Riddiford L. The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr Biol. 2005;15:1796-807 pubmed
    ..We present evidence that in Drosophila, a component of the ring gland, the prothoracic gland (PG), assesses growth to determine when critical weight has been achieved...
  64. Liberman L, Stathopoulos A. Design flexibility in cis-regulatory control of gene expression: synthetic and comparative evidence. Dev Biol. 2009;327:578-89 pubmed publisher
    ..We propose a model for neurogenic ectoderm specification in which gene regulation occurs at the intersection of temporal and spatial transcription factor inputs...
  65. BIRKHOLZ D, Chou W, Phistry M, Britt S. rhomboid mediates specification of blue- and green-sensitive R8 photoreceptor cells in Drosophila. J Neurosci. 2009;29:2666-75 pubmed publisher
    ..This suggests that rhomboid may function in R8 cells to activate Epidermal growth factor receptor signaling in R7 cells and promote their differentiation to a signaling competent state. ..
  66. Sanokawa Akakura R, Cao W, Allan K, Patel K, Ganesh A, Heiman G, et al. Control of Alzheimer's amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila. PLoS ONE. 2010;5:e8626 pubmed publisher
    ..Finally, we also found that FKBP52 formed stable complexes with APP through its FK506 interacting domain. Taken together, these studies identify a novel role for FKBP52 in modulating toxicity of Abeta peptides. ..
  67. Parashar V, Rogina B. dSir2 mediates the increased spontaneous physical activity in flies on calorie restriction. Aging (Albany NY). 2009;1:529-41 pubmed
    ..In Drosophila, spontaneous physical activity therefore closely mimics life span in its dependence on Sir2. ..
  68. Schweitzer R, Zelzer E, Volk T. Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebrates. Development. 2010;137:2807-17 pubmed publisher
    ..We also compare these events with those of the corresponding system in the Drosophila embryo, highlighting distinct and common pathways that promote efficient locomotion while preserving the form of the organism. ..
  69. He Q, Bardet A, Patton B, Purvis J, Johnston J, Paulson A, et al. High conservation of transcription factor binding and evidence for combinatorial regulation across six Drosophila species. Nat Genet. 2011;43:414-20 pubmed publisher
    ..These results suggest that developmental enhancers can be highly evolutionarily constrained, presumably because of their complex combinatorial nature. ..
  70. Lake C, Hawley R. The molecular control of meiotic chromosomal behavior: events in early meiotic prophase in Drosophila oocytes. Annu Rev Physiol. 2012;74:425-51 pubmed publisher
    ..Finally, we correlate what is known in Drosophila oocytes with our understanding of these processes in other systems. ..
  71. Xia R, Liu Y, Yang L, Gal J, Zhu H, Jia J. Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS. Mol Neurodegener. 2012;7:10 pubmed publisher
    ..Our findings also suggest that Fus overexpression and gene deletion can cause similar degenerative phenotypes but the underlying mechanisms are likely different. ..
  72. Duerfeldt A, Peterson L, Maynard J, Ng C, Eletto D, Ostrovsky O, et al. Development of a Grp94 inhibitor. J Am Chem Soc. 2012;134:9796-804 pubmed publisher
    ..In contrast, compound 2 had no effect on cell viability or cytosolic Hsp90?/? client proteins at similar concentrations. The design, synthesis, and evaluation of 2 are described herein. ..
  73. Gao M, Arkov A. Next generation organelles: structure and role of germ granules in the germline. Mol Reprod Dev. 2013;80:610-23 pubmed publisher
  74. Chahda J, Sousa Neves R, Mizutani C. Variation in the dorsal gradient distribution is a source for modified scaling of germ layers in Drosophila. Curr Biol. 2013;23:710-6 pubmed publisher
    ..We propose that variation in mesodermal size occurs at a fast evolutionary rate and is an important mechanism to define the ventral boundary of the neuroectoderm...
  75. Gratz S, Cummings A, Nguyen J, Hamm D, Donohue L, Harrison M, et al. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics. 2013;194:1029-35 pubmed publisher
    ..This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila. ..
  76. Li X, Ghezzi A, Pohl J, Bohm A, Atkinson N. A DNA element regulates drug tolerance and withdrawal in Drosophila. PLoS ONE. 2013;8:e75549 pubmed publisher
    ..The 6b element is a homeostatic regulator of BK channel gene expression and is the first cis-acting DNA element shown to specifically affect the duration of a drug action. ..
  77. Domanitskaya E, Anllo L, Schupbach T. Phantom, a cytochrome P450 enzyme essential for ecdysone biosynthesis, plays a critical role in the control of border cell migration in Drosophila. Dev Biol. 2014;386:408-18 pubmed publisher
    ..This "egg chamber autonomous" ecdysone synthesis constitutes a useful way to regulate the individual maturation of the asynchronous egg chambers present in the Drosophila ovary. ..
  78. Lepage T, Cohen S, Diaz Benjumea F, Parkhurst S. Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature. 1995;373:711-5 pubmed
    ..These findings suggest that cyclic AMP-dependent protein kinase A is a component of the signal transduction pathway through which Hh and Ptc direct localized expression of dpp (or wg) and establish the compartment boundary organizer. ..
  79. Li K, Kaufman T. The homeotic target gene centrosomin encodes an essential centrosomal component. Cell. 1996;85:585-96 pubmed
    ..We propose that cnn provides an example of homeotic genes directly regulating the accumulation of essential cellular proteins to carry out segment-specific morphogenetic functions. ..
  80. Shumacher A, Faust C, Magnuson T. Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature. 1996;383:250-3 pubmed
    ..Mice carrying a hypomorphic eed mutation exhibit posterior transformations along the axial skeleton. These results indicate that eed is required globally for A-P patterning throughout embryogenesis. ..
  81. Penton A, Selleck S, Hoffmann F. Regulation of cell cycle synchronization by decapentaplegic during Drosophila eye development. Science. 1997;275:203-6 pubmed
    ..DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye. ..
  82. Landmesser L. Synaptic plasticity: fastening synapses by adhesion. Curr Biol. 1997;7:R28-30 pubmed
  83. Kwok Y, Zeng Q, Hurley L. Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites. Proc Natl Acad Sci U S A. 1998;95:13531-6 pubmed
  84. Hawkins C, Wang S, Hay B. A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proc Natl Acad Sci U S A. 1999;96:2885-90 pubmed
  85. Micchelli C, Blair S. Dorsoventral lineage restriction in wing imaginal discs requires Notch. Nature. 1999;401:473-6 pubmed
    ..Here we show that the formation of Notch-dependent boundary cells is required for the D/V lineage restriction. ..
  86. True J, Edwards K, Yamamoto D, Carroll S. Drosophila wing melanin patterns form by vein-dependent elaboration of enzymatic prepatterns. Curr Biol. 1999;9:1382-91 pubmed
    ..Both the prepatterning and hemolymph-supplied components of this system can change during evolution to produce color pattern diversity. ..
  87. Adryan B, Decker H, Papas T, Hsu T. Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila. Oncogene. 2000;19:2803-11 pubmed
    ..Oncogene (2000) 19, 2803 - 2811 ..
  88. Colley N. Cell biology. Actin' up with Rac1. Science. 2000;290:1902-3 pubmed
  89. Helfand S, Rogina B. Molecular genetics of aging in the fly: is this the end of the beginning?. Bioessays. 2003;25:134-41 pubmed
  90. Blair S. Lineage compartments in Drosophila. Curr Biol. 2003;13:R548-51 pubmed
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